Showing 1-30 of 397 resultados for "D7008"
Philippe Foubert et al.
Cell transplantation, 24(7), 1343-1361 (2013-09-28)
Endothelial progenitor cell (EPC) transplantation has beneficial effects for therapeutic neovascularization. We therefore assessed the effect of a therapeutic strategy based on EPC administration in the healing of radiation-induced damage. To improve cell therapy for clinical use, we used pretreatment...
Márton Pipicz et al.
British journal of pharmacology, 172(14), 3472-3483 (2015-04-02)
Rapid ventricular pacing (RVP) applied before an index ischaemia has anti-ischaemic effects. Here, we investigated whether RVP applied after index ischaemia attenuates reperfusion injury and whether peroxynitrite, reperfusion injury salvage kinase (RISK) and survival activating factor enhancement (SAFE) pathways as...
Anna Maria Mileo et al.
Oxidative medicine and cellular longevity, 2015, 363827-363827 (2015-07-17)
Polyphenolic extracts from the edible part of artichoke (Cynara scolymus L.) have been shown to be potential chemopreventive and anticancer dietary compounds. High doses of polyphenolic extracts (AEs) induce apoptosis and decrease the invasive potential of the human breast cancer...
Makiko Oboshi et al.
PloS one, 10(5), e0126611-e0126611 (2015-05-12)
Deep vein thrombosis (DVT) is a major cause of pulmonary thromboembolism and sudden death. Thus, it is important to consider the pathophysiology of DVT. Recently, iron has been reported to be associated with thrombotic diseases. Hence, in this study, we...
Lucas M Kangussu et al.
Fundamental & clinical pharmacology, 29(2), 150-163 (2015-01-27)
This study aimed to investigate the modulation of nitric oxide/reactive oxygen species in sodium nitroprusside relaxation in mice aorta. Sodium nitroprusside induced relaxation in endothelium-intact (e+) and endothelium-denuded (e-) aortas with greater potency in e+ than in e-. The nitric...
Sarbari Saha et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 141, 111367-111367 (2020-04-27)
Benzo[a]pyrene (B[a]P), a polycyclic aromatic hydrocarbon, is a potent neurotoxic agent that is responsible for impaired neuronal development and is associated with aging. Here, it was demonstrated that extracts of Bacopa monnieri (BM), a traditional Ayurvedic medicine, diminished the B[a]P-induced...
Jianli Chen et al.
Cancer chemotherapy and pharmacology, 75(6), 1217-1227 (2015-04-22)
This study was performed to determine whether or not in cervical, ovarian and lung cancer cell lines, free radicals (ROS) play a role in cisplatin cytotoxicity and activation of the mitochondrial and JNK/p38 pathways. The role of the enzyme, dihydrodiol...
Xin-Wei Liu et al.
Neuroscience letters, 595, 74-80 (2015-04-14)
Melatonin plays a neuroprotective role in different CNS injuries. However, the molecular mechanisms underlying neuroprotection by melatonin are not well understood. Here, we studied the effects of melatonin in hypoxia-induced N2a cells and our results demonstrated that melatonin not only...
Sarah A C Falcão et al.
PLoS neglected tropical diseases, 9(3), e0003601-e0003601 (2015-03-11)
Neutrophils are the first line of defense against invading pathogens and are rapidly recruited to the sites of Leishmania inoculation. During Leishmania braziliensis infection, depletion of inflammatory cells significantly increases the parasite load whereas co-inoculation of neutrophils plus L. braziliensis...
Katherine E Liu et al.
PloS one, 10(6), e0129667-e0129667 (2015-06-24)
BNIP3 is a dual function protein, able to activate autophagy and induce cell death. Upon expression of BNIP3, which is upregulated by hypoxia, the protein induces mitochondrial dysfunction, often leading to cell death. However, some highly respiring cells and cancer...
Bainian Chen et al.
Cardiovascular diabetology, 13, 88-88 (2014-06-03)
The present study was to investigate the role of calpain in reactive oxygen species (ROS) production in endothelial cells and endothelium-dependent vascular dysfunction under experimental conditions of diabetes. Exposure to high glucose activated calpain, induced apoptosis and reduced nitric oxide...
Tian Zhang et al.
JPEN. Journal of parenteral and enteral nutrition, 43(1), 96-106 (2018-05-16)
The objectives of this study were to address the role of autophagy in the pathogenesis of parenteral nutrition (PN)-associated liver disease (PNALD) and its possible mechanism in vivo. Five-week-old male Sprague Dawley rats were fed Shoobree chow (Xietong Organism, Jiangsu...
Daniel J Garama et al.
Molecular and cellular biology, 35(21), 3646-3656 (2015-08-19)
Increased production of mitochondrion-derived reactive oxygen species (ROS) is characteristic of a metabolic shift observed during malignant transformation. While the exact sources and roles of ROS in tumorigenesis remain to be defined, it has become clear that maintaining redox balance...
Satoshi Matsuzaki et al.
Biochemistry, 54(11), 2011-2021 (2015-02-27)
Biguanides are widely used antihyperglycemic agents for diabetes mellitus and prediabetes treatment. Complex I is the rate-limiting step of the mitochondrial electron transport chain (ETC), a major source of mitochondrial free radical production, and a known target of biguanides. Complex...
Rajagopalan Geetha et al.
Molecular and cellular biochemistry, 407(1-2), 263-279 (2015-06-17)
A previous study from our laboratory showed that troxerutin (TX) provides cardioprotection by mitigating lipid abnormalities in a high-fat high-fructose diet (HFFD)-fed mice model of metabolic syndrome (MS). The present study aims to investigate the reversal effect of TX on...
Quan Cao et al.
Molecular medicine reports, 17(5), 7249-7257 (2018-03-24)
Curcumin, isolated from rhizome of turmeric, has been widely studied as a potential therapeutic drug for cancer. However, protective effects of curcumin on chronic heart failure (CHF) have not been fully studied. In the present study, the effects of curcumin...
Min Chen et al.
PloS one, 10(6), e0128455-e0128455 (2015-06-02)
Remote ischemic preconditioning is often performed by limb ischemic preconditioning (LIPC), which has been demonstrated to be beneficial to various cells, including endothelial cells. The mechanisms underlying the protection have not been well clarified. The present study was designed to...
Wei Mee Loh et al.
Vascular pharmacology, 71, 151-158 (2015-04-15)
Des-aspartate angiotensin I (DAA-I), an endogenous nonapeptide, counteracts several effects of angiotensin II on vascular tone. The aim of this study was to investigate the acute protective effect of DAA-I on endothelial function in the spontaneously hypertensive rat (SHR) as...
Z T Gu et al.
Scientific reports, 5, 11497-11497 (2015-06-25)
In this study, We demonstrated that Bax mitochondrial translocation plays a vital role in the initiation of the mitochondrial signaling pathway upon activation by heat stress. In addition, both p53 mitochondrial translocation and Ca(2+) signal mediated MPTP opening activate Bax...
A Bravo et al.
Andrologia, 47(6), 662-668 (2014-07-26)
Calcium (Ca(2+) ) regulates a number of essential processes in spermatozoa. Ca(2+) is taken up by mitochondria via the mitochondrial calcium uniporter (mCU). Oxygen-bridged dinuclear ruthenium amine complex (Ru360) has been used to study mCU because it is a potent...
Atsuko Nakayama et al.
PloS one, 10(9), e0137106-e0137106 (2015-09-04)
Oxidative stress has been implicated in cardiac remodeling (cardiac fibrosis and hypertrophy), which impairs cardiac function and metabolism; therefore, it is anticipated antioxidative compounds will have protective properties against cardiac remodeling. Luteolin (3',4',5,7-tetrahydroxyflavone), a widely distributed flavonoid found in many...
Jialin Duan et al.
Scientific reports, 5, 18123-18123 (2015-12-10)
Hyperglycemia-induced reactive oxygen species (ROS) generation and Ca(2+) overload contribute to the development of diabetic cardiomyopathy. In this study, we aimed to study the protective effects of Chikusetsu saponin IVa (CHS) from Aralia taibaiensis against hyperglycemia-induced myocardial injuries. Treatment of...
Cira Rubies et al.
Scientific reports, 9(1), 11443-11443 (2019-08-09)
Obstructive sleep apnea syndrome (OSA) promotes aortic dilatation, increased stiffness and accelerated atherosclerosis, but the mechanisms of vascular remodelling are not known. We aimed to assess vascular remodelling, its mechanisms, and the effect of mesenchymal stem cells (MSC) infusions in...
Neha Kaushik et al.
Scientific reports, 5, 8587-8587 (2015-02-27)
In this study, we assessed the role of different reactive oxygen species (ROS) generated by soft jet plasma and chemical-induced ROS systems with regard to cell death in T98G, A549, HEK293 and MRC5 cell lines. For a comparison with plasma...
Joseph M Kulinski et al.
Virology, 483, 264-274 (2015-05-24)
Gammaherpesviruses are cancer-associated pathogens that establish life-long infection in most adults. Insufficiency of Ataxia-Telangiectasia mutated (ATM) kinase leads to a poor control of chronic gammaherpesvirus infection via an unknown mechanism that likely involves a suboptimal antiviral response. In contrast to...
Dalise Zancheta et al.
Life sciences, 122, 78-86 (2014-12-24)
This study aimed to evaluate the effects of Wortmannin, an inhibitor of phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt), on aortic hyporeactivity to Phenylephrine (Phe) and nitric oxide bioavailability associated with pregnancy in hypertensive rats. The intact aortic rings of pregnant...
Yongxing Lai et al.
Redox biology, 34, 101503-101503 (2020-03-23)
Ischemic stroke can induce changes in mitochondrial morphology and function. As a regulatory gene in mitochondria, optic atrophy 1 (OPA1) plays a pivotal role in the regulation of mitochondrial dynamics and other related functions. However, its roles in cerebral ischemia-related...
Ricardo Cabezas et al.
Neurotoxicity research, 27(4), 355-367 (2014-12-18)
Rotenone is one of the most-studied neurotoxic substances as it induces oxidative stress processes both in cellular and animal models. Rotenone affects ATP generation, reactive oxygen species (ROS) production, and mitochondrial membrane potential in neurons and astrocyte-like cells. Previous epidemiologic...
Dong-Hee Choi et al.
PloS one, 10(1), e0116814-e0116814 (2015-01-27)
The molecular mechanism underlying the selective vulnerability of neurons to oxidative damage caused by ischemia-reperfusion (I/R) injury remains unknown. We sought to determine the role of NADPH oxidase 1 (Nox1) in cerebral I/R-induced brain injury and survival of newborn cells...
Jacqueline Chor-Wing Tam et al.
Journal of diabetes and its complications, 28(4), 436-447 (2014-04-16)
Diabetic foot ulcer is closely associated with peripheral vascular disease. Enhancement of tissue oxidative stress, reduction of nitric oxide (NO) and angiogenic growth factors, and abnormal matrix metalloproteinase (MMP) activity are pathophysiological factors in post-ischemic neovascularization and diabetic wound healing....

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