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" no prazo de Papéis
Daisuke Asanuma et al.
Nature communications, 6, 6463-6463 (2015-03-15)
Fluorescence-guided diagnostics is one of the most promising approaches for facile detection of cancer in situ. Here we focus on β-galactosidase, which is overexpressed in primary ovarian cancers, as a molecular target for visualizing peritoneal metastases from ovarian cancers. As
Tian-Tian Zhang et al.
Food & function, 6(8), 2588-2597 (2015-06-30)
The anti-cancer activities of Thonningianin A on the HepG-2 human hepatocellular carcinoma cell line were evaluated by MTT assay, flow cytometry, quantitative real-time PCR and western blotting. Results showed that Thonningianin A effectively inhibited the proliferation of HepG-2 cells by
Ruijin Li et al.
Journal of hazardous materials, 287, 392-401 (2015-02-14)
Epidemiological studies suggested that ambient fine particulate matter (PM2.5) exposure was associated with cardiovascular disease. However, the underlying mechanism, especially the mitochondrial damage mechanism, of PM2.5-induced heart acute injury is still unclear. In this study, the alterations of mitochondrial morphology
Yong-Xi Chen et al.
PloS one, 9(11), e112936-e112936 (2014-11-19)
Renal fibrosis is the final common pathway of chronic kidney disease (CKD). Moesin is a member of Ezrin/Radixin/Moesin (ERM) protein family but its role in renal fibrosis is not clear. Human proximal tubular cells (HK-2) were stimulated with or without
Yi Liu et al.
Toxicology and applied pharmacology, 282(1), 9-19 (2014-12-03)
The incidence of lung diseases, including cancer, caused by cigarette smoke is increasing, but the molecular mechanisms of gene regulation induced by cigarette smoke remain unclear. This report describes a long noncoding RNA (lncRNA) that is induced by cigarette smoke
Yan Han et al.
Chemical & pharmaceutical bulletin, 63(11), 882-889 (2015-11-03)
Novel tranylcypromine/hydroxylcinnamic acid hybrids 15a, b, and 19a-l were designed and synthesized by connecting tranylcypromine with hydroxylcinnamic acid, and their biological activities were evaluated. The in vitro assay of their inhibitory activities against lysine-specific demethylase 1 (LSD1) showed that most
Zhao Yang et al.
Molecular immunology, 65(2), 293-301 (2015-02-28)
Much evidence demonstrates that microglia mediated inflammatory responses play an important role in brain injury in ischemia. miRNA is the important factor in regulation of inflammation. However, the effect of miRNA in microglia mediated inflammatory responses has not been well
Shiyu Tao et al.
PloS one, 9(10), e111596-e111596 (2014-10-31)
It is widely accepted that lipopolysaccharide and volatile fatty acids (VFA) accumulate in the digestive tract of ruminants fed diets containing high portions of grain. Compared to the ruminal epithelium, the hindgut epithelium is composed of a monolayer structure that
Kevin X Liu et al.
Brain : a journal of neurology, 138(Pt 5), 1167-1181 (2015-03-11)
Amyotrophic lateral sclerosis is a devastating neurodegenerative disorder characterized by the progressive loss of spinal motor neurons. While the aetiological mechanisms underlying the disease remain poorly understood, oxidative stress is a central component of amyotrophic lateral sclerosis and contributes to
Chuntuan Li et al.
Cancer cell international, 15, 65-65 (2015-07-02)
Phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin (PI3K/Akt/mTOR) pathway is a therapy target of cancer. We aimed to confirm the effect of dual PI3K/mTOR inhibitor NVP-BEZ235 on cell proliferation and apoptosis in Burkitt lymphoma (BL) cells. Two human BL cell lines, CA46
Jun Jiang et al.
Molecules (Basel, Switzerland), 19(11), 18690-18704 (2014-11-19)
Central-icaritin (CIT) is a flavonoid aglycone first discovered in our laboratory, which is an isomeric aglycone of icaritin (IT). We wanted to know whether CIT also had anti-osteoporosis activity. In this study, CIT was investigated in an ovariectomized rat (OVX)
Nathalie Vigneron et al.
Analytical biochemistry, 482, 7-15 (2015-04-29)
Because of its crucial role in various cellular processes, the proteasome is the focus of intensive research for the development of proteasome inhibitors to treat cancer and autoimmune diseases. Here, we describe a new and easy assay to measure the
Virender Kumar et al.
Molecular pharmaceutics, 12(4), 1289-1298 (2015-02-14)
Successful treatment of pancreatic ductal adenocarcinoma (PDAC) remains a challenge due to the desmoplastic microenvironment that promotes both tumor growth and metastasis and forms a barrier to chemotherapy. Hedgehog (Hh) signaling is implicated in initiation and progression of PDAC and
E Stragier et al.
Molecular psychiatry, 20(3), 405-412 (2014-04-30)
High ethanol intake is well known to induce both anxiolytic and anxiogenic effects, in correlation with chromatin remodeling in the amygdaloid brain region and deficits in cell proliferation and survival in the hippocampus of rodents. Whether only moderate but chronic
Dorottya Kalapis et al.
PLoS biology, 13(11), e1002291-e1002291 (2015-11-07)
Translational errors occur at high rates, and they influence organism viability and the onset of genetic diseases. To investigate how organisms mitigate the deleterious effects of protein synthesis errors during evolution, a mutant yeast strain was engineered to translate a
Yi Guan et al.
Fungal genetics and biology : FG & B, 82, 85-94 (2015-07-15)
Two Ras ATPases (Ras1 and Ras2) are well known to regulate antagonistically or cooperatively various cellular events in many fungi. Here we show the significance of a novel Ras homolog (Ras3) for Beauveria bassiana. Ras3 possesses five domains and two
Bing Wang et al.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 35(5), 781-793 (2015-01-08)
The consequences of therapeutic hypothermia for neonatal hypoxic-ischemic encephalopathy are poorly understood. Adverse effects from suboptimal rewarming could diminish neuroprotection from hypothermia. Therefore, we tested whether rewarming is associated with apoptosis. Piglets underwent hypoxia-asphyxia followed by normothermic or hypothermic recovery
Hyeon-Jun Shin et al.
Scientific reports, 5, 15798-15798 (2015-11-03)
Necrosis, unregulated cell death, is characterized by plasma membrane rupture as well as nuclear and cellular swelling. However, it has recently been reported that necrosis is a regulated form of cell death mediated by poly-(ADP-ribose) polymerase 1 (PARP1). PARP1 is
Hiroaki Taketa et al.
Scientific reports, 5, 11468-11468 (2015-06-23)
In vitro fabricated biological tissue would be a valuable tool to screen newly synthesized drugs or understand the tissue development process. Several studies have attempted to fabricate biological tissue in vitro. However, controlling the growth and morphology of the fabricated
Linbao Zhang et al.
Developmental and comparative immunology, 51(1), 29-38 (2015-02-24)
Antimicrobial peptides (AMPs) are important mediators of the primary host defense system against microbial invasion. In the present study, we cloned and characterized a member of the invertebrate defensin from the clam Venerupis philippinarum, designated VpDef. Amino acid sequence analysis
Paula Szalai et al.
Experimental cell research, 333(1), 21-38 (2015-02-17)
LC3, a mammalian homologue of yeast Atg8, is assumed to play an important part in bulk sequestration and degradation of cytoplasm (macroautophagy), and is widely used as an indicator of this process. To critically examine its role, we followed the
Francesca Toselli et al.
Alcoholism, clinical and experimental research, 39(5), 790-797 (2015-04-16)
The tissue-specific expression of cytochrome P450 enzymes (CYP, P450) in the human brain may influence the therapeutic response to, and side effects of, neuroactive drugs including alcohol. However, the distribution of many P450s, especially poorly characterized CYP2 forms, within specific
Dongfeng Qu et al.
PloS one, 10(8), e0134212-e0134212 (2015-08-19)
Doublecortin-like kinase 1 (Dclk1), a microtubule-associated kinase, marks the fifth lineage of intestinal epithelial cells called tuft cells that function as tumor stem cells in Apc mutant models of colon cancer. In order to determine the role of Dclk1 in
Nishanth V Menon et al.
ACS applied materials & interfaces, 7(31), 17095-17103 (2015-07-18)
As an alternative to complex and costly in vivo models, microfluidic in vitro models are being widely used to study various physiological phenomena. It is of particular interest to study cell migration in a controlled microenvironment because of its vital
Ning Zhang et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 69, 306-310 (2015-02-11)
Thyroid cancers are the most common malignant tumors of the endocrine system. The survival-promoting role of autophagy in tumor cells has been received universally. This study aimed to explore autophagy-related protein light chain 3 (LC3)-II expression levels in thyroid diseases
Bo Wang et al.
Parasites & vectors, 8, 424-424 (2015-08-19)
Fruit flies and mammals protect themselves against infection by mounting immune and metabolic responses that must be balanced against the metabolic needs of the pathogens. In this context, p38 mitogen-activated protein kinase (MAPK)-dependent signaling is critical to regulating both innate
Aaron B Sullivan et al.
Infection and immunity, 83(4), 1629-1640 (2015-02-11)
Pseudomonas aeruginosa is invasive or cytotoxic to host cells, depending on the type III secretion system (T3SS) effectors encoded. While the T3SS is known to be involved in disease in vivo, how it participates remains to be clarified. Here, mouse
Yongzhang Liu et al.
Oncotarget, 5(22), 11209-11224 (2014-12-20)
ATP-dependent Lon protease within mitochondrial matrix contributes to the degradation of abnormal proteins. The oxidative or hypoxic stress which represents the stress phenotype of cancer leads to up-regulation of Lon. However, the role of Lon in bladder cancer remains undefined.
Woong Jin Bae et al.
BMC complementary and alternative medicine, 14, 367-367 (2014-10-02)
Idiopathic infertility is a significant number of causes of male infertility. Empirical treatments are used for idiopathic male infertility, and antioxidant supplementation is a kind of management of oxidative stress related infertility. We investigated the antioxidant effects of the modified
X Teng et al.
Oral diseases, 21(2), 185-194 (2014-03-13)
Heightened levels of sEcad are found in the serum of patients with cancer and correlate with an unfavorable prognosis and later-stages of disease. In this study, we explored whether sEcad is elevated in human OPSCC specimens and FaDu cells. Additionally
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