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Peter Baluk et al.
The American journal of pathology, 190(12), 2355-2375 (2020-10-12)
Despite many reports about pulmonary blood vessels in lung fibrosis, the contribution of lymphatics to fibrosis is unknown. We examined the mechanism and consequences of lymphatic remodeling in mice with lung fibrosis after bleomycin injury or telomere dysfunction. Widespread lymphangiogenesis...
Lyme disease.
Eugene D Shapiro
The New England journal of medicine, 371(7), 684-684 (2014-08-15)
Juan Lafuente-Barquero et al.
eLife, 9 (2020-08-05)
DNA:RNA hybrids constitute a well-known source of recombinogenic DNA damage. The current literature is in agreement with DNA:RNA hybrids being produced co-transcriptionally by the invasion of the nascent RNA molecule produced in cis with its DNA template. However, it has...
Rohit Prakash et al.
Nature communications, 12(1), 4255-4255 (2021-07-14)
Homology-directed repair (HDR), a critical DNA repair pathway in mammalian cells, is complex, leading to multiple outcomes with different impacts on genomic integrity. However, the factors that control these different outcomes are often not well understood. Here we show that...
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Yamila Romer et al.
The American journal of tropical medicine and hygiene, 91(6), 1156-1160 (2014-10-29)
Rickettsia parkeri, a newly recognized tick-borne pathogen of humans in the Americas, is a confirmed cause of spotted fever group rickettsiosis in Argentina. Until recently, almost all cases of R. parkeri rickettsiosis in Argentina have originated from the Paraná River...
Ken Hiratsuka et al.
Scientific reports, 9(1), 913-913 (2019-01-31)
The derivation of kidney tissues from human pluripotent stem cells (hPSCs) and its application for replacement therapy in end-stage renal disease have been widely discussed. Here we report that consecutive transfections of two sets of synthetic mRNAs encoding transcription factors...
Chao Shen et al.
Cell stem cell, 27(1), 64-80 (2020-05-14)
N6-methyladenosine (m6A), the most abundant internal modification in mRNA, has been implicated in tumorigenesis. As an m6A demethylase, ALKBH5 has been shown to promote the development of breast cancer and brain tumors. However, in acute myeloid leukemia (AML), ALKBH5 was...
Timothy B Ware et al.
Nature chemical biology, 16(2), 170-178 (2020-01-15)
C1 domains are lipid-binding modules that regulate membrane activation of kinases, nucleotide exchange factors and other C1-containing proteins to trigger signal transduction. Despite annotation of typical C1 domains as diacylglycerol (DAG) and phorbol ester sensors, the function of atypical counterparts...
Stephen E D Webb et al.
Methods (San Diego, Calif.), 88, 76-80 (2015-05-20)
Although considerable progress has been made in imaging distances in cells below the diffraction limit using FRET and super-resolution microscopy, methods for determining the separation of macromolecules in the 10-50 nm range have been elusive. We have developed fluorophore localisation...
Pablo Palazón-Riquelme et al.
EMBO reports, 19(10) (2018-09-13)
The assembly and activation of the inflammasomes are tightly regulated by post-translational modifications, including ubiquitin. Deubiquitinases (DUBs) counteract the addition of ubiquitin and are essential regulators of immune signalling pathways, including those acting on the inflammasome. How DUBs control the...
Qian Li et al.
Reproductive sciences (Thousand Oaks, Calif.), 27(5), 1164-1174 (2020-01-17)
Microarray has indicated a huge number of miRNAs exist in reproductive tissues and cells. Moreover, the expression of miRNA in the reproductive system varies under the strict monitoring of different regulations. To understand the role of miRNA-mediated post-transcriptional gene regulation...
ZNF121 interacts with ZBRK1 and BRCA1 to regulate their target genes in mammary epithelial cells
Luo A, et al.
FEBS Open Bio, 8(12), 1943-1952 (2018)
Chiara M Toselli et al.
Scientific reports, 9(1), 3594-3594 (2019-03-07)
The mechanisms underlying zebrafish pancreatic islet vascularization have not been well characterized. We sought to determine the angiogenic factors responsible for islet vascularization and assess whether an absence of endothelial cells affects beta-cell and alpha-cell formation. We used a double...
Thomas J Ellison et al.
PloS one, 9(11), e111502-e111502 (2014-11-18)
The availability of reliable recombinant reporter virus systems has been a great boon to the study of Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8). Unexpectedly, we found that expression of the ostensibly constitutive green fluorescent protein (GFP) marker was progressively lost during unselected...
Megan P Stogsdill et al.
American journal of respiratory cell and molecular biology, 49(1), 128-134 (2013-03-26)
Receptors for advanced glycation end-products (RAGE) are multiligand surface receptors detected abundantly in pulmonary tissue. Our previous work revealed increased RAGE expression in cells and lungs exposed to tobacco smoke and RAGE-mediated cytokine expression via proinflammatory mechanisms involving NF-κB. RAGE...
Remy Chait et al.
PloS one, 5(12), e15179-e15179 (2011-01-07)
Antibiotics increase the frequency of resistant bacteria by providing them a competitive advantage over sensitive strains. Here, we develop a versatile assay for differential chemical inhibition of competing microbial strains, and use it to identify compounds that preferentially inhibit tetracycline-resistant...
Elizabeth A Perry et al.
Nature metabolism, 3(1), 33-42 (2021-01-20)
Mitochondrial diseases (MDs) are a heterogeneous group of disorders resulting from mutations in nuclear or mitochondrial DNA genes encoding mitochondrial proteins1,2. MDs cause pathologies with severe tissue damage and ultimately death3,4. There are no cures for MDs and current treatments...
Nan Song et al.
Anatomical record (Hoboken, N.J. : 2007), 303(5), 1337-1345 (2019-09-11)
The NAD+ -dependent protein deacetylase silent information regulator 1 (SIRT1) targets multiple proteins for deacetylation, and it has been implicated in a variety of cellular pathways and human diseases. However, it remains unclear how the abundance of SIRT1 is regulated....
Karthik Arumugam et al.
Cell reports, 33(10), 108474-108474 (2020-12-10)
Bi-species, fusion-mediated, somatic cell reprogramming allows precise, organism-specific tracking of unknown lineage drivers. The fusion of Tcf7l1-/- murine embryonic stem cells with EBV-transformed human B cell lymphocytes, leads to the generation of bi-species heterokaryons. Human mRNA transcript profiling at multiple...
Priyanka Sharma et al.
Molecular cell, 73(1), 84-96 (2018-11-26)
The post-translational modification of key residues at the C-terminal domain of RNA polymerase II (RNAP2-CTD) coordinates transcription, splicing, and RNA processing by modulating its capacity to act as a landing platform for a variety of protein complexes. Here, we identify...
Ming Sun et al.
Cancer research, 79(19), 4937-4950 (2019-08-17)
Chromosomal passenger complex (CPC) has been demonstrated to be a potential target of cancer therapy by inhibiting Aurora B or survivin in different types of cancer including neuroblastoma. However, chemical inhibition of either Aurora B or survivin does not target...
Tatiana Traboulsi et al.
Oncogene, 38(7), 1019-1037 (2018-09-08)
Antiestrogens (AEs) are widely used for treatment of estrogen receptor alpha (ERα)-positive breast cancer, but display variable degrees of partial agonism in estrogen target tissues and breast cancer (BC) cells. The fact that BC cells resistant to selective ER modulators...
Antonio Marzio et al.
Molecular cell, 73(2), 224-237 (2018-12-18)
The BRCA1-BRCA2-RAD51 axis is essential for homologous recombination repair (HRR) and is frequently disrupted in breast cancers. PARP inhibitors (PARPis) are used clinically to treat BRCA-mutated breast tumors. Using a genetic screen, we identified EMI1 as a modulator of PARPi...
Anna M van Ziel et al.
Journal of neurochemistry, 152(2), 208-220 (2019-08-24)
The unfolded protein response (UPR) is one of the major cell-autonomous proteostatic stress responses. The UPR has been implicated in the pathogenesis of neurodegenerative diseases and is therefore actively investigated as therapeutic target. In this respect, cell non-autonomous effects of...
Clément Larrue et al.
Nature communications, 12(1), 422-422 (2021-01-20)
Drug tolerant/resistant leukemic stem cell (LSC) subpopulations may explain frequent relapses in acute myeloid leukemia (AML), suggesting that these relapse-initiating cells (RICs) persistent after chemotherapy represent bona fide targets to prevent drug resistance and relapse. We uncover that calcitonin receptor-like...
Mai Sato et al.
The Journal of cell biology, 220(2) (2021-01-07)
Cancer cells develop strong genetic dependencies, enabling survival under oncogenic stress. MYC is a key oncogene activated across most cancers, and identifying associated synthetic lethality or sickness can provide important clues about its activity and potential therapeutic strategies. On the...
Theresa Kühnel et al.
Heliyon, 6(1), e03261-e03261 (2020-02-06)
Transcriptional interference and transcription through regulatory elements (transcriptional read-through) are implicated in gene silencing and the establishment of DNA methylation. Transcriptional read-through is needed to seed DNA methylation at imprinted genes in the germ line and can lead to aberrant...
An adolescent with a swollen nerve.
Euna Koo et al.
JAMA ophthalmology, 133(1), 97-98 (2015-01-09)
Samantha Kent et al.
Cell reports, 33(2), 108248-108248 (2020-10-15)
Compartmentalization by liquid-liquid phase separation is implicated in transcription. It remains unclear whether and how transcriptional condensates accelerate the search of transcriptional regulatory factors for their target sites. Furthermore, the molecular mechanisms by which regulatory factors nucleate on chromatin to...
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