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e6003
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Swati Mishra et al.
Journal of biomedical materials research. Part A, 103(10), 3237-3249 (2015-03-18)
Three-dimensional (3D) patterning and engineering of biomaterials and biointerfaces have helped bioengineers harness the full potential of cell immobilization for different biomedical applications. However, the bioengineering of an efficient cell immobilized tool, having application in cell biology and tissue engineering
Staci L Solin et al.
Scientific reports, 5, 13745-13745 (2015-09-09)
Investigating the in vivo role of tumor suppressor genes in cancer is technically challenging due to their essential requirement during early animal development. To address this bottleneck, we generated genetic mosaic adult zebrafish using TALEN genome editing and demonstrate somatic
Patrick T Brown et al.
Cell and tissue research, 358(1), 149-164 (2014-06-15)
Embryonic stem cells (ESCs) and mesenchymal stem cells (MSCs) have been studied for years as primary cell sources for regenerative biology and medicine. MSCs have been derived from cell and tissue sources, such as bone marrow (BM), and more recently
J Filipowska et al.
Biomedical materials (Bristol, England), 9(6), 065001-065001 (2014-10-21)
In this study, 3D porous bioactive composite scaffolds were produced and evaluated for their physico-chemical and biological properties. Polymer poly-L-lactide-co-glycolide (PLGA) matrix scaffolds were modified with sol-gel-derived bioactive glasses (SBGs) of CaO-SiO2-P2O5 systems. We hypothesized that SBG incorporation into PLGA
F Gani et al.
SADJ : journal of the South African Dental Association = tydskrif van die Suid-Afrikaanse Tandheelkundige Vereniging, 67(7), 370-373 (2013-08-21)
Orthokeratinised jaw cyst (OJC) is an entity distinct from odontogenic keratocyst (OKC) that has not been fully characterised at the molecular level. To compare the proliferative activity of the epithelial linings of OKC and OJC immunohistochemically, using Ki-67 and cyclin
Osseointegrative properties of electrospun hydroxyapatite-containing nanofibrous chitosan scaffolds.
Michael E Frohbergh et al.
Tissue engineering. Part A, 21(5-6), 970-981 (2014-10-23)
Our long-term goal is to develop smart biomaterials that can facilitate regeneration of critical-size craniofacial lesions. In this study, we tested the hypothesis that biomimetic scaffolds electrospun from chitosan (CTS) will promote tissue repair and regeneration in a critical size
Matthias Klemm et al.
PloS one, 10(7), e0131640-e0131640 (2015-07-21)
Fluorescence lifetime imaging ophthalmoscopy (FLIO) is a new technique for measuring the in vivo autofluorescence intensity decays generated by endogenous fluorophores in the ocular fundus. Here, we present a software package called FLIM eXplorer (FLIMX) for analyzing FLIO data. Specifically
Seong-Jin Yu et al.
PloS one, 10(7), e0132487-e0132487 (2015-07-18)
Recent studies have indicated that type 2 cannabinoid receptor (CB2R) agonists reduce neurodegeneration after brain injury through anti-inflammatory activity. The purpose of this study was to examine the time-dependent interaction of CB2R and inflammation in stroke brain. Adult male rats
K F Wong et al.
American journal of clinical pathology, 141(2), 280-284 (2014-01-18)
To report the demonstration of double minutes with MYC amplification in a case of myeloproliferative neoplasm with monocytosis in transformation by a combination of standard karyotyping and interphase and metaphase fluorescence in situ hybridization (FISH). To determine the lineage involvement
Ji-Eun Baek et al.
Biochemical and biophysical research communications, 451(3), 442-448 (2014-08-12)
The transcription factors, Runx2 and Osterix (Osx), act downstream in the BMP2 pathway, and they are essential for osteoblast differentiation and bone formation. While Runx2 expression is normal in Osx-null mice, Osx is not expressed in Runx2-null mice, indicating that
Radoslaw Kwapiszewski et al.
Analytical and bioanalytical chemistry, 406(18), 4551-4556 (2014-05-13)
Interest in the microfluidic environment, owing to its unique physical properties, is increasing in much innovative chemical, biological, or medicinal research. The possibility of exploiting and using new phenomena makes the microscale a powerful tool to improve currently used macroscopic
Maria Q Gaunsbaek et al.
ORL; journal for oto-rhino-laryngology and its related specialties, 76(5), 288-301 (2014-12-17)
To investigate the presence of surfactant protein (SP) A, B, C and D in nasal airways and to determine whether the proteins exert their main functions in nasal secretions or in the deeper layers of the nasal mucosa. Volunteers were
L S Herculano et al.
The journal of physical chemistry. B, 117(6), 1932-1937 (2013-02-05)
Eosin Y is known to be a powerful probe of biological molecules and an efficient photosensitizing agent for the production of singlet molecular oxygen. Under continuous laser excitation, degradation through photobleaching is observed in aqueous solutions of eosin Y; this
Jason K F Wong et al.
PloS one, 9(11), e112672-e112672 (2014-11-11)
Repaired tendons may be complicated by progressive fibrosis, causing adhesion formation or tendon softening leading to tendon rupture and subsequent reduced range of motion. There are few therapies available which improve the gliding of damaged tendons in the hand. We
Leah L Zagore et al.
Molecular and cellular biology, 35(23), 4030-4042 (2015-09-24)
RNA binding proteins (RBPs) are increasingly recognized as essential factors in tissue development and homeostasis. The polypyrimidine tract binding (PTB) protein family of RBPs are important posttranscriptional regulators of gene expression. In the nervous system, the function and importance of
Hubert Pausch et al.
PLoS genetics, 10(1), e1004044-e1004044 (2014-01-07)
Genetic variants underlying reduced male reproductive performance have been identified in humans and model organisms, most of them compromising semen quality. Occasionally, male fertility is severely compromised although semen analysis remains without any apparent pathological findings (i.e., idiopathic subfertility). Artificial
Savitri Krishnamurthy et al.
Archives of pathology & laboratory medicine, 137(12), 1733-1739 (2013-08-21)
Whole slide imaging (WSI) is now used for educational purposes, for consultation, and for archiving and quantitation of immunostains. However, it is not routinely used for the primary diagnosis of hematoxylin-eosin-stained tissue sections. To compare WSI using the Aperio digital
Julian C Lui et al.
Pediatric research, 77(3), 406-415 (2014-12-19)
In juvenile mammals, the epiphyses of long bones grow by chondrogenesis within the articular cartilage. A better understanding of the molecular mechanisms that regulate the growth of articular cartilage may give insight into the antecedents of joint disease, such as
Brent P Goodman et al.
Journal of clinical neuromuscular disease, 14(2), 78-81 (2012-11-23)
Inclusion body myositis is the most common idiopathic inflammatory myopathy in elderly individuals. It typically causes proximal and distal limb weakness with forearm flexors and quadriceps being the most severely affected muscles. Axial musculature is infrequently involved. Here, we report
Jianyun Dong et al.
Chemical research in toxicology, 28(3), 518-531 (2015-01-31)
1,2:3,4-Diepoxybutane (DEB) is a major carcinogenic metabolite of 1,3-butadiene (BD), which has been shown to cause DNA strand breaks in cells through its potential genotoxicity. The adverse effect of DEB on male reproductive cells in response to DNA damage has
V A Kuttappan et al.
Poultry science, 92(2), 331-338 (2013-01-10)
White striping is a condition in broiler chickens characterized grossly by the occurrence of white striations, seen parallel to the direction of muscle fibers, on broiler breast fillets and thighs. Based on visual evaluation of the intensity of white striping
Han Shih et al.
Macromolecular rapid communications, 34(3), 269-273 (2013-02-07)
The utility of visible-light-mediated polymerization in tissue engineering has been limited due to the necessary use of potentially cytotoxic coinitiator and comonomer. Here, we report a visible-light-mediated thiol-ene hydrogelation scheme using eosin-Y as the only photoinitiator. Under visible light exposure
Gry H Dihazi et al.
Scientific reports, 5, 13951-13951 (2015-09-12)
Elucidation of the mechanisms underlying the nephrogenesis will boost enormously the regenerative medicine. Here we performed 2-D gel-based comparative proteome analyses of rat embryonic kidney from different developmental stages. Out of 288 non-redundant identified proteins, 102 were common in all
Tomohiro Nishimura et al.
PloS one, 9(8), e105423-e105423 (2014-08-22)
Ezrin is a membrane-associated cytoplasmic protein that serves to link cell-membrane proteins with the actin-based cytoskeleton, and also plays a role in regulation of the functional activities of some transmembrane proteins. It is expressed in placental trophoblasts. We hypothesized that
Yevgen Chornenkyy et al.
Molecular cancer therapeutics, 14(11), 2560-2568 (2015-09-10)
Pediatric high-grade astrocytomas (pHGA) and diffuse intrinsic pontine gliomas (DIPG) are devastating malignancies for which no effective therapies exist. We investigated the therapeutic potential of PARP1 inhibition in preclinical models of pHGA and DIPG. PARP1 levels were characterized in pHGA
A comparison of lyophilized amniotic membrane with cryopreserved amniotic membrane for the reconstruction of rabbit corneal epithelium.
Ahn J, et al.
Biotechnology and Bioprocess Engineering: BBE, 10, 262-269 (2005)
Mihaela Necula et al.
The Journal of biological chemistry, 282(14), 10311-10324 (2007-02-08)
Alzheimer disease is characterized by the abnormal aggregation of amyloid beta peptide into extracellular fibrillar deposits known as amyloid plaques. Soluble oligomers have been observed at early time points preceding fibril formation, and these oligomers have been implicated as the
Shannon K Esher et al.
Fungal genetics and biology : FG & B, 82, 9-21 (2015-06-27)
Random insertional mutagenesis screens are important tools in microbial genetics studies. Investigators in fungal systems have used the plant pathogen Agrobacterium tumefaciens to create tagged, random mutations for genetic screens in their fungal species of interest through a unique process
Stephanie Supper et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 88(2), 361-373 (2014-05-27)
Chitosan (CS)-based thermosensitive solutions that turn into semi-solid hydrogels upon injection at body temperature have increasingly drawn attention over the last decades as an attractive new type of in situ forming depot (ISFD) drug delivery system. Despite the great potential
Bo Fu et al.
Scientific reports, 5, 8029-8029 (2015-01-27)
Novel molecularly targeted agents that block the development and metastasis of human brain metastatic breast cancer hold great promise for their translational value. In this study, we constructed a novel targeting composite peptide BRBP1-TAT-KLA comprising of three elements: a brain
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