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Michael E Frohbergh et al.
Tissue engineering. Part A, 21(5-6), 970-981 (2014-10-23)
Our long-term goal is to develop smart biomaterials that can facilitate regeneration of critical-size craniofacial lesions. In this study, we tested the hypothesis that biomimetic scaffolds electrospun from chitosan (CTS) will promote tissue repair and regeneration in a critical size
Sarah J Hatsell et al.
Science translational medicine, 7(303), 303ra137-303ra137 (2015-09-04)
Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disorder characterized by episodically exuberant heterotopic ossification (HO), whereby skeletal muscle is abnormally converted into misplaced, but histologically normal bone. This HO leads to progressive immobility with catastrophic consequences, including death by
Swati Mishra et al.
Journal of biomedical materials research. Part A, 103(10), 3237-3249 (2015-03-18)
Three-dimensional (3D) patterning and engineering of biomaterials and biointerfaces have helped bioengineers harness the full potential of cell immobilization for different biomedical applications. However, the bioengineering of an efficient cell immobilized tool, having application in cell biology and tissue engineering
Staci L Solin et al.
Scientific reports, 5, 13745-13745 (2015-09-09)
Investigating the in vivo role of tumor suppressor genes in cancer is technically challenging due to their essential requirement during early animal development. To address this bottleneck, we generated genetic mosaic adult zebrafish using TALEN genome editing and demonstrate somatic
Zheng Cheng et al.
PloS one, 9(11), e112719-e112719 (2014-11-15)
Activation of the cholinergic anti-inflammatory pathway, which relies on the α7nAchR (alpha 7 nicotinic acetylcholine receptor), has been shown to decrease proinflammatory cytokines. This relieves inflammatory responses and improves the prognosis of patients with experimental sepsis, endotoxemia, ischemia/reperfusion injury, hemorrhagic
Brent P Goodman et al.
Journal of clinical neuromuscular disease, 14(2), 78-81 (2012-11-23)
Inclusion body myositis is the most common idiopathic inflammatory myopathy in elderly individuals. It typically causes proximal and distal limb weakness with forearm flexors and quadriceps being the most severely affected muscles. Axial musculature is infrequently involved. Here, we report
Kathy Saraiva-Pava et al.
World journal of gastroenterology, 21(21), 6526-6542 (2015-06-16)
To establish a cellular model correctly mimicking the gastric epithelium to overcome the limitation in the study of Helicobacter pylori (H. pylori) infection. Aiming to overcome this limitation, clones of the heterogenic cancer-derived NCI-N87 cell line were isolated, by stably-transducing
Radoslaw Kwapiszewski et al.
Analytical and bioanalytical chemistry, 406(18), 4551-4556 (2014-05-13)
Interest in the microfluidic environment, owing to its unique physical properties, is increasing in much innovative chemical, biological, or medicinal research. The possibility of exploiting and using new phenomena makes the microscale a powerful tool to improve currently used macroscopic
Chang Hoon Moon et al.
Investigational new drugs, 32(3), 400-411 (2013-11-10)
CKD-516 is a benzophenone analog in which the B ring is modified by replacement with a carbonyl group. The study assessed CKD-516 as a vascular disrupting agent or anti-cancer drug. To assess the effect of S516 on vascularization, we analyzed
K F Wong et al.
American journal of clinical pathology, 141(2), 280-284 (2014-01-18)
To report the demonstration of double minutes with MYC amplification in a case of myeloproliferative neoplasm with monocytosis in transformation by a combination of standard karyotyping and interphase and metaphase fluorescence in situ hybridization (FISH). To determine the lineage involvement
Matthias Klemm et al.
PloS one, 10(7), e0131640-e0131640 (2015-07-21)
Fluorescence lifetime imaging ophthalmoscopy (FLIO) is a new technique for measuring the in vivo autofluorescence intensity decays generated by endogenous fluorophores in the ocular fundus. Here, we present a software package called FLIM eXplorer (FLIMX) for analyzing FLIO data. Specifically
Julian C Lui et al.
Pediatric research, 77(3), 406-415 (2014-12-19)
In juvenile mammals, the epiphyses of long bones grow by chondrogenesis within the articular cartilage. A better understanding of the molecular mechanisms that regulate the growth of articular cartilage may give insight into the antecedents of joint disease, such as
L S Herculano et al.
The journal of physical chemistry. B, 117(6), 1932-1937 (2013-02-05)
Eosin Y is known to be a powerful probe of biological molecules and an efficient photosensitizing agent for the production of singlet molecular oxygen. Under continuous laser excitation, degradation through photobleaching is observed in aqueous solutions of eosin Y; this
Jason K F Wong et al.
PloS one, 9(11), e112672-e112672 (2014-11-11)
Repaired tendons may be complicated by progressive fibrosis, causing adhesion formation or tendon softening leading to tendon rupture and subsequent reduced range of motion. There are few therapies available which improve the gliding of damaged tendons in the hand. We
Patrick T Brown et al.
Cell and tissue research, 358(1), 149-164 (2014-06-15)
Embryonic stem cells (ESCs) and mesenchymal stem cells (MSCs) have been studied for years as primary cell sources for regenerative biology and medicine. MSCs have been derived from cell and tissue sources, such as bone marrow (BM), and more recently
J Filipowska et al.
Biomedical materials (Bristol, England), 9(6), 065001-065001 (2014-10-21)
In this study, 3D porous bioactive composite scaffolds were produced and evaluated for their physico-chemical and biological properties. Polymer poly-L-lactide-co-glycolide (PLGA) matrix scaffolds were modified with sol-gel-derived bioactive glasses (SBGs) of CaO-SiO2-P2O5 systems. We hypothesized that SBG incorporation into PLGA
Jae Ho Choi et al.
Journal of agricultural and food chemistry, 63(5), 1468-1476 (2015-01-16)
We investigated the inhibitory effects of Platycodon grandiflorum root-derived saponins (Changkil saponins: CKS) on ovalbumin-induced airway inflammation in mice. CKS suppressed leukocytes number, IgE, Th1/Th2 cytokines, and MCP-1 chemokine secretion in bronchoalveolar lavage fluid. Also, ovalbumin-increased MUC5AC, MMP-2/9, and TIMP-1/-2
M M Reis et al.
Animal : an international journal of animal bioscience, 9(9), 1500-1508 (2015-05-21)
This experiment compared growth, physiological, and reproductive responses of beef heifers with (MI) or without (CON) access to a creep-feeder, as a manner to stimulate metabolic imprinting while nursing their dams. On day 0, 60 Angus × Hereford heifers were
F Gani et al.
SADJ : journal of the South African Dental Association = tydskrif van die Suid-Afrikaanse Tandheelkundige Vereniging, 67(7), 370-373 (2013-08-21)
Orthokeratinised jaw cyst (OJC) is an entity distinct from odontogenic keratocyst (OKC) that has not been fully characterised at the molecular level. To compare the proliferative activity of the epithelial linings of OKC and OJC immunohistochemically, using Ki-67 and cyclin
Toshihisa Yashiro et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(48), 17212-17217 (2014-11-19)
Males and females are in conflict over genetic transmission in the evolution of parthenogenesis, because it enhances female reproductive output but deprives the males' genetic contribution. For males, any trait that coerces females into sexual reproduction should increase their fitness.
Jianyun Dong et al.
Chemical research in toxicology, 28(3), 518-531 (2015-01-31)
1,2:3,4-Diepoxybutane (DEB) is a major carcinogenic metabolite of 1,3-butadiene (BD), which has been shown to cause DNA strand breaks in cells through its potential genotoxicity. The adverse effect of DEB on male reproductive cells in response to DNA damage has
Mihaela Necula et al.
The Journal of biological chemistry, 282(14), 10311-10324 (2007-02-08)
Alzheimer disease is characterized by the abnormal aggregation of amyloid beta peptide into extracellular fibrillar deposits known as amyloid plaques. Soluble oligomers have been observed at early time points preceding fibril formation, and these oligomers have been implicated as the
Jeong-Hae Choi et al.
Archives of dermatological research, 306(7), 635-643 (2014-04-15)
The barrier system of the skin not only defends against antigens and harmful substances, but also hinders the permeation of medicines and cosmetics into the dermis. Several strategies have been developed to enhance the absorption ability of skin, including the
Xiangguo Qiu et al.
Journal of virology, 88(21), 12703-12714 (2014-08-22)
Infections with Marburg virus (MARV) and Ebola virus (EBOV) cause severe hemorrhagic fever in humans and nonhuman primates (NHPs) with fatality rates up to 90%. A number of experimental vaccine and treatment platforms have previously been shown to be protective
Yelena Golubeva et al.
Methods in molecular biology (Clifton, N.J.), 931, 213-257 (2012-10-03)
Laser capture microdissection (LCM) allows the precise procurement of enriched cell populations from a heterogeneous tissue, or live cell culture, under direct microscopic visualization. Histologically enriched cell populations can be procured by harvesting cells of interest directly or isolating specific
Sebastiano La Maestra et al.
International journal of hygiene and environmental health, 218(1), 117-122 (2014-09-28)
Although the adverse effects of active smoking on sperm quality and fertilization ability are well established, little is known about possible effects of involuntary exposures to cigarette smoke (CS). We designed an experimental study aimed at evaluating the induction of
Nathan G Greeneltch et al.
The journal of physical chemistry. A, 116(48), 11863-11869 (2012-10-30)
This work demonstrates the development of near-infrared surface-enhanced Raman spectroscopy (NIR-SERS) for the identification of eosin Y, an important historical dye. NIR-SERS benefits from the absence of some common sources of SERS signal loss including photobleaching and plasmonic heating, as
Nina-Fee Hübner et al.
Aesthetic plastic surgery, 38(5), 976-984 (2014-07-13)
This preliminary ex vivo study aimed to clarify the pathophysiologic mechanisms of fat tissue depletion by subcutaneous drug application. Therefore, the lipolytic effects of phosphatidylcholine plus deoxycholate (Lipostabil) (L) and of deoxycholate (DC) alone were compared with those of sodium
Pascal Stuelsatz et al.
Developmental biology, 397(1), 31-44 (2014-09-23)
Extraocular muscles (EOMs) are highly specialized skeletal muscles that originate from the head mesoderm and control eye movements. EOMs are uniquely spared in Duchenne muscular dystrophy and animal models of dystrophin deficiency. Specific traits of myogenic progenitors may be determinants
Seong-Jin Yu et al.
PloS one, 10(7), e0132487-e0132487 (2015-07-18)
Recent studies have indicated that type 2 cannabinoid receptor (CB2R) agonists reduce neurodegeneration after brain injury through anti-inflammatory activity. The purpose of this study was to examine the time-dependent interaction of CB2R and inflammation in stroke brain. Adult male rats
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