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Robert H Oakley et al.
The Journal of biological chemistry, 292(14), 5825-5844 (2017-02-23)
Glucocorticoids are primary stress hormones that regulate many physiological processes, and synthetic derivatives of these molecules are widely used in the clinic. The molecular factors that govern tissue specificity of glucocorticoids, however, are poorly understood. The actions of glucocorticoids are
Suresh Ramakrishna et al.
PloS one, 7(5), e37772-e37772 (2012-06-05)
We previously reported that the USP17 deubiquitinating enzyme having hyaluronan binding motifs (HABMs) interacts with human SDS3 (suppressor of defective silencing 3) and specifically deubiquitinates Lys-63 branched polyubiquitination of SDS3 resulting in negative regulation of histone deacetylase (HDAC) activity in
Ye Liu et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(31), 12656-12669 (2013-08-02)
Axon degeneration is a critical pathological feature of many neurodegenerative diseases. Misregulation of local axonal ion homeostasis has been recognized as an important yet understudied mechanism for axon degeneration. Here we report a chemically induced, recessive mouse mutation, vacillator (vac)
Rieko Kojima et al.
Cell reports, 26(3), 518-528 (2019-01-17)
Mitochondria are dynamic organelles that constantly fuse and divide to maintain their proper morphology, which is essential for their normal functions. Energy production, a central role of mitochondria, demands highly folded structures of the mitochondrial inner membrane (MIM) called cristae
Lavanya H Palavalli Parsons et al.
eLife, 10 (2021-01-22)
PARP-7 (TiPARP) is a mono(ADP-ribosyl) transferase whose protein substrates and biological activities are poorly understood. We observed that PARP7 mRNA levels are lower in ovarian cancer patient samples compared to non-cancerous tissue, but PARP-7 protein nonetheless contributes to several cancer-related
Yong Shen et al.
Molecular and cellular biology (2018-07-18)
The organization of the five β-type globin genes on chromosome 11 reflects the timing of expression during erythroid development, with the embryonic ε-globin gene located at the 5'end, followed by the two fetal γ-globin genes, and the adult β- and
Tong Sun et al.
The Journal of biological chemistry, 291(22), 11518-11528 (2016-03-16)
Twist1 is a basic helix-loop-helix transcription factor that strongly promotes epithelial-to-mesenchymal transition, migration, invasion, and metastasis of cancer cells. The MAPK-phosphorylated Twist1 on its serine 68 (Ser(P)(68)-Twist1) has a significantly enhanced stability and function to drive cancer cell invasion and
Lingna Xu et al.
eLife, 9 (2020-07-11)
Endoplasmic reticulum (ER)-mitochondria contact sites (ERMCSs) are crucial for multiple cellular processes such as calcium signaling, lipid transport, and mitochondrial dynamics. However, the molecular organization, functions, regulation of ERMCS, and the physiological roles of altered ERMCSs are not fully understood
Chris Williams et al.
The EMBO journal, 31(2), 391-402 (2011-11-17)
Ubiquitin-conjugating enzymes (E2s) coordinate distinct types of ubiquitination via specific E3 ligases, to a large number of protein substrates. While many E2 enzymes need only the presence of an E3 ligase for substrate ubiquitination, a number of E2s require additional
Jing Qi et al.
Cancer research, 76(2), 453-462 (2016-01-09)
Many oncoproteins are considered undruggable because they lack enzymatic activities. In this study, we present a small-molecule-based anticancer agent that acts by inhibiting dimerization of the oncoprotein survivin, thereby promoting its degradation along with spontaneous apoptosis in cancer cells. Through
Sebastiaan T A Koenders et al.
Chembiochem : a European journal of chemical biology, 21(13), 1911-1917 (2020-01-28)
Aldehyde dehydrogenases (ALDHs) convert aldehydes into carboxylic acids and are often upregulated in cancer. They have been linked to therapy resistance and are therefore potential therapeutic targets. However, only a few selective and potent inhibitors are currently available for this
Laura M McLane et al.
Cell reports, 35(6), 109120-109120 (2021-05-13)
The transcription factors T-bet and Eomesodermin (Eomes) regulate CD8 T cell exhaustion through undefined mechanisms. Here, we show that the subcellular localization of T-bet and Eomes dictate their regulatory activity in exhausted T cells (TEXs). TEXs had a higher ratio of nuclear
Jinyong Kim et al.
The Journal of biological chemistry, 280(13), 12246-12254 (2005-01-22)
CCAAT/enhancer-binding protein epsilon (C/EBPepsilon) is a neutrophil-specific transcription factor whose activity is controlled by juxtaposed activating and regulatory domains. We previously determined that the function of the major regulatory domain (RD1) in C/EBPepsilon was dependent on the integrity of a
Diana Toczydlowska-Socha et al.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 373(1762) (2018-11-07)
The 5'-cap structure, characteristic for RNA polymerase II-transcribed RNAs, plays important roles in RNA metabolism. In humans, RNA cap formation includes post-transcriptional modification of the first transcribed nucleotide by RNA cap1 methyltransferase (CMTr1). Here, we report that CMTr1 activity is
Erica M Hildebrand et al.
PLoS genetics, 12(3), e1005930-e1005930 (2016-03-18)
The exclusive localization of the histone H3 variant CENP-A to centromeres is essential for accurate chromosome segregation. Ubiquitin-mediated proteolysis helps to ensure that CENP-A does not mislocalize to euchromatin, which can lead to genomic instability. Consistent with this, overexpression of
Vidhya Krishnamoorthy et al.
Biochemical and biophysical research communications, 503(4), 2478-2484 (2018-09-14)
Heterochromatin protein 1 (HP1) isoforms are conserved non-histone chromatin-binding proteins that play an important role in packaging of heterochromatin and gene regulation. The functions of HP1 isoforms α and β are influenced by the nuclear lamins. Cells expressing disease-causing lamin
Rigel Suzuki et al.
EMBO reports, 17(6), 842-857 (2016-04-27)
The majority of transmembrane proteins are integrated into the endoplasmic reticulum (ER) by virtue of a signal sequence-mediated co-translational process. However, a substantial portion of transmembrane proteins fails to reach the ER, leading to mislocalized cytosolic polypeptides. Their appropriate recognition
Michael Y He et al.
Communications biology, 4(1), 878-878 (2021-07-17)
Angiogenesis underlies development, physiology and pathogenesis of cancer, eye and cardiovascular diseases. Inhibiting aberrant angiogenesis using anti-angiogenic therapy (AAT) has been successful in the clinical treatment of cancer and eye diseases. However, resistance to AAT inevitably occurs and its molecular
Yang Xiang et al.
Nature, 543(7646), 573-576 (2017-03-16)
Cell proliferation and survival require the faithful maintenance and propagation of genetic information, which are threatened by the ubiquitous sources of DNA damage present intracellularly and in the external environment. A system of DNA repair, called the DNA damage response
Young Hun Kim et al.
Autophagy, 1-18 (2020-10-06)
Nuclear protein HMGB1 is secreted in response to various stimuli and functions as a danger-associated molecular pattern. Extracellular HMGB1 induces inflammation, cytokine production, and immune cell recruitment via activation of various receptors. As HMGB1 does not contain an endoplasmic reticulum-targeting
Michela Palmieri et al.
Human molecular genetics, 20(19), 3852-3866 (2011-07-15)
In metazoans, lysosomes are the center for the degradation of macromolecules and play a key role in a variety of cellular processes, such as autophagy, exocytosis and membrane repair. Defects of lysosomal pathways are associated with lysosomal storage disorders and
Somya Vats et al.
Molecular biology of the cell, 30(17), 2283-2295 (2019-06-13)
Autophagy is an evolutionarily conserved intracellular lysosomal degradation pathway. It is a multistep process involving de novo formation of double membrane autophagosomes that capture cytosolic constituents (cargo) and eventually fuse with lysosomes wherein the cargo gets degraded and resulting simpler
Guotao Li et al.
Artificial cells, nanomedicine, and biotechnology, 1-11 (2018-05-10)
Percutaneous ethanol injection (PEI) therapy was used in liver cancer treatment, however, the therapeutic ethanol in PEI easily flew away from injected solid tumours and hinder the treatment effect. In this paper, injectable supramolecular gels formed by self-assembly of low
Damayanti Chakraborty et al.
Proceedings of the National Academy of Sciences of the United States of America, 113(46), E7212-E7221 (2016-11-04)
The hemochorial placenta develops from the coordinated multilineage differentiation of trophoblast stem (TS) cells. An invasive trophoblast cell lineage remodels uterine spiral arteries, facilitating nutrient flow, failure of which is associated with pathological conditions such as preeclampsia, intrauterine growth restriction
Jiro Fukae et al.
FEBS letters, 583(3), 521-525 (2009-01-17)
Mutations in parkin gene are responsible for autosomal recessive Parkinson's disease (ARPD) and its loss-of-function is assumed to affect parkin ubiquitin ligase activity. Accumulation of its substrate may induce dopaminergic neurodegeneration in the substantia nigra (SN) of ARPD. Here, we
Chiho Koi et al.
Oncotarget, 8(63), 106429-106442 (2018-01-02)
It was reported that statins, inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase that are used to prevent hypercholesterolemia, have antitumor activity in several cancers. In this study, we investigated the cell viability of statins in Cisplatin-resistant HCP4 and PCDP5 cells compared
Siew Kit Ng et al.
Nucleic acids research, 41(21), 9786-9799 (2013-08-29)
Long double-stranded RNA may undergo hyper-editing by adenosine deaminases that act on RNA (ADARs), where up to 50% of adenosine residues may be converted to inosine. However, although numerous RNAs may undergo hyper-editing, the role for inosine-containing hyper-edited double-stranded RNA
Franck Ladam et al.
eLife, 7 (2018-06-19)
TALE factors are broadly expressed embryonically and known to function in complexes with transcription factors (TFs) like Hox proteins at gastrula/segmentation stages, but it is unclear if such generally expressed factors act by the same mechanism throughout embryogenesis. We identify
Xuejie Min et al.
Molecular oncology, 12(9), 1480-1497 (2018-07-14)
Although identified as a growth factor, the mechanism by which hepatoma-derived growth factor (HDGF) promotes cancer development remains unclear. We found that nuclear but not cytoplasmic HDGF is closely associated with prognosis of hepatocellular carcinoma (HCC). RNA-sequencing analysis further demonstrated
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