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Jennifer C Ryan et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 307(12), R1488-R1492 (2014-10-24)
Clinical studies indicate that hepatic drug transport may be altered in chronic kidney disease (CKD). Uremic solutes associated with CKD have been found to alter the expression and/or activity of hepatocyte transporters in experimental animals and in cultured cells. However
Ting-Ru Lin et al.
Micromachines, 10(6) (2019-06-19)
This paper reports a biomimetic microfluidic device capable of reconstituting physiological physical microenvironments in lungs during fetal development for cell culture. The device integrates controllability of both hydrostatic pressure and cyclic substrate deformation within a single chip to better mimic
Malene Brohus et al.
The Biochemical journal, 476(2), 193-209 (2018-12-12)
The Ca2+ sensor calmodulin (CaM) regulates cardiac ryanodine receptor (RyR2)-mediated Ca2+ release from the sarcoplasmic reticulum. CaM inhibits RyR2 in a Ca2+-dependent manner and aberrant CaM-dependent inhibition results in life-threatening cardiac arrhythmias. However, the molecular details of the CaM-RyR2 interaction
Hongjin Wang et al.
Phytomedicine : international journal of phytotherapy and phytopharmacology, 78, 153300-153300 (2020-09-01)
The initial factor in the occurrence, development, and prognosis of cerebral ischemia is vascular dysfunction in the brain, and vascular remodeling of the brain is the key therapeutic target and strategy for ischemic tissue repair. Catalpol is the main active
Harri Elamaa et al.
eLife, 7 (2018-11-18)
The maintenance of fluid homeostasis is necessary for function of the neural retina; however, little is known about the significance of potential fluid management mechanisms. Here, we investigated angiopoietin-4 (Angpt4, also known as Ang3), a poorly characterized ligand for endothelial
Dimitris N Xanthos et al.
Molecular pain, 8, 44-44 (2012-06-21)
Changes in the blood-central nervous system barriers occur under pathological conditions including inflammation and contribute to central manifestations of various diseases. After short-lasting peripheral and neurogenic inflammation, the evidence is mixed whether there are consistent blood-spinal cord changes. In the
Samantha Herretes et al.
Investigative ophthalmology & visual science, 56(4), 2348-2357 (2015-02-07)
The primary objective of the present study was to identify the kinetics and origin of ocular infiltrating T cells in a preclinical model of graft-versus-host disease (GVHD) that induces eye tissue damage. Graft-versus-host disease was induced using an major histocompatibility
Rami B Kassab et al.
Interdisciplinary toxicology, 10(2), 61-65 (2018-08-21)
The health benefits of berberine have been recognized for years. Even so, its effects on human neutrophils, the first line of immune defense, have not been reported. The purpose of this study was to investigate the effects of berberine on
Annalisse Bertsch et al.
Frontiers in bioengineering and biotechnology, 8, 956-956 (2020-08-28)
The aim of this work was to obtain a bioingredient (BI) with bioactive properties through the solid fermentation of a wheat bran-whey permeate (WB/WP) mixture with three strains of Lacticaseibacillus rhamnosus (R0011, ATCC 9595, and RW-9595M) in mono or co-culture
Anna N Miller et al.
The Journal of bone and joint surgery. American volume, 98(8), 658-664 (2016-04-22)
Approximately 2 million patients in the United States annually undergo total joint arthroplasty with reaming and placement of intramedullary nails, resulting in extravasation of bone marrow and fat into the circulatory system and potentially causing fat embolism syndrome. Acute and
Pam Satjawatcharaphong et al.
Optometry and vision science : official publication of the American Academy of Optometry, 92(9), e334-e341 (2015-07-21)
To identify patient characteristics at a baseline ocular surface evaluation that correlate with improvement in dry eye symptoms at a follow-up visit after treatment with the LipiFlow Thermal Pulsation System. Thirty-two patients completed a comprehensive baseline ocular surface evaluation and
Kibaek Choe et al.
The Journal of clinical investigation, 125(11), 4042-4052 (2015-10-06)
Lacteals are lymphatic vessels located at the center of each intestinal villus and provide essential transport routes for lipids and other lipophilic molecules. However, it is unclear how absorbed molecules are transported through the lacteal. Here, we used reporter mice
Philippe Régnier et al.
Marine drugs, 13(5), 2857-2874 (2015-05-12)
Astaxanthin, a powerful antioxidant, is a good candidate for the prevention of intracellular oxidative stress. The aim of the study was to compare the antioxidant activity of astaxanthin present in two natural extracts from Haematococcus pluvialis, a microalgae strain, with
Mari Johannessen Walquist et al.
Mediators of inflammation, 2017, 3835851-3835851 (2017-11-10)
Intake of long-chain omega-3 polyunsaturated fatty acids (LC-n3-PUFA) is commonly recognized to reduce cardiovascular disease (CVD). In previous studies, cold-pressed whale oil (CWO) and cod liver oil (CLO) were given as a dietary supplement to healthy volunteers. Even though CWO
Kristin M Fischer et al.
Journal of glaucoma, 23(9), 613-615 (2013-02-23)
To establish the validity of a fluorophotometric protocol based on 2 time points to facilitate aqueous humor flow rate calculations in minimally cooperative species. A standard canine fluorophotometry protocol was followed in 6 dogs. Fluorescein concentrations were obtained at 4
Timothy C Chang et al.
Journal of visualized experiments : JoVE, (71)(71), e4409-e4409 (2013-01-29)
Probe-based confocal laser endomicroscopy (CLE) is an emerging optical imaging technology that enables real-time in vivo microscopy of mucosal surfaces during standard endoscopy. With applications currently in the respiratory and gastrointestinal tracts, CLE has also been explored in the urinary
Maria M Shchepinova et al.
Biochimica et biophysica acta, 1837(1), 149-158 (2013-10-01)
In our search for fluorescent uncouplers of oxidative phosphorylation, three esters of fluorescein, n-butyl-, n-octyl-, and n-dodecyl-oxycarbonyl-fluorescein (C4-FL, C8-FL, C12-FL) were synthesized and characterized. With increasing liposomal lipid content, the long-chain alkyl derivatives of fluorescein (C8-FL, C12-FL and commercially available
Johanna Schaffenrath et al.
Fluids and barriers of the CNS, 18(1), 34-34 (2021-07-30)
Genetic variation in a population has an influence on the manifestation of monogenic as well as multifactorial disorders, with the underlying genetic contribution dependent on several interacting variants. Common laboratory mouse strains used for modelling human disease lack the genetic
Marta P Pereira Morais et al.
Scientific reports, 3, 1437-1437 (2013-03-28)
Glycated proteins are important biomarkers for age-related disorders, however their analysis is challenging because of the complexity of the protein-carbohydrate adducts. Here we report a method that enables the detection and identification of individual glycated proteins in complex samples using
The potential of microfluidic lung epithelial wounding: towards in vivo-like alveolar microinjuries.
M Felder et al.
Integrative biology : quantitative biosciences from nano to macro, 6(12), 1132-1140 (2014-09-11)
Idiopathic pulmonary fibrosis (IPF) remains a major clinical challenge to date. Repeated alveolar epithelial microinjuries are considered as the starting point and the key event in both the development and the progression of IPF. Various pro-fibrotic agents have been identified
Beau J Fenner et al.
Investigative ophthalmology & visual science, 54(13), 8013-8019 (2013-11-14)
To determine the reliability of single- and double-zone corneal fluorescent staining compared with five-zone analysis for the prediction of dry eye disease. Prospective study of 510 subjects with dry eye disease characterized using corneal fluorescein staining, Schirmer scores, and tear
Simon Cheong et al.
Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 72(12), 2461-2468 (2014-09-30)
Bisphosphonates (BPs) are widely used for the management of bone diseases such as osteoporosis and bone malignancy. However, osteonecrosis of the jaws (ONJ) is a serious complication of BP treatment. ONJ lesions mainly occur after extraction of teeth deemed unrestorable
Yusuke Okuno et al.
The journal of physical chemistry. B, 120(4), 715-723 (2016-01-09)
Photochemically induced dynamic nuclear polarization (photo-CIDNP) is a powerful approach for sensitivity enhancement in NMR spectroscopy. In liquids, intermolecular photo-CIDNP depends on the transient bimolecular reaction between photoexcited dye and sample of interest. Hence the extent of polarization is sample-concentration
Seyed M Mirvakili et al.
Nano letters, 20(7), 4816-4822 (2020-06-02)
On-demand delivery of substances has been demonstrated for various applications in the fields of chemistry and biomedical engineering. Single-pulse release profile has been shown previously for micro/nanoparticles in different form factors. However, to obtain a sustained release, a pulsatile release
Jorawer S Singh et al.
Experimental eye research, 115, 239-245 (2013-07-09)
Corneal endothelial cells form a leaky barrier on the posterior surface of the cornea, allowing influx of nutrient-carrying aqueous humor through the paracellular space and efflux of excess fluid. Corneal edema arises when the density of these non-proliferative endothelial cells
Si Hyung Jin et al.
Lab on a chip, 15(18), 3677-3686 (2015-08-08)
We present a programmable microfluidic static droplet array (SDA) device that can perform user-defined multistep combinatorial protocols. It combines the passive storage of aqueous droplets without any external control with integrated microvalves for discrete sample dispensing and dispersion-free unit operation.
Jacob A Berry et al.
Cell, 161(7), 1656-1667 (2015-06-16)
Early studies from psychology suggest that sleep facilitates memory retention by stopping ongoing retroactive interference caused by mental activity or external sensory stimuli. Neuroscience research with animal models, on the other hand, suggests that sleep facilitates retention by enhancing memory
Chie Sotozono et al.
American journal of ophthalmology, 158(5), 983-993 (2014-07-19)
To evaluate the therapeutic benefits of tear-exchangeable, limbal, rigid contact lenses (limbal CLs) in patients with Stevens-Johnson syndrome- or toxic epidermal necrolysis-associated ocular sequelae. Noncomparative, retrospective, interventional case series. We enrolled 53 eyes of 42 patients (mean age, 51.8 ±
Vladimir Ararat Hovhannisyan et al.
Journal of biomedical optics, 23(9), 1-7 (2018-06-03)
Using multiphoton microscopy (MPM), we demonstrated that effective inducing of two-photon excited luminescence and second-harmonic generation signals in nano/microparticles of clinoptilolite type of zeolite (CZ) by femtosecond near-infrared laser excitation can be successfully utilized in multiphoton imaging of the drug
Hélène David et al.
Frontiers in cardiovascular medicine, 7, 615507-615507 (2021-02-16)
Aims: Microvascular alterations occurring after myocardial infarction (MI) may represent a risk factor for multi-organ failure. Here we used in vivo photoacoustic (PA) imaging to track and define the changes in vascular oxygen saturation (sO2) occurring over time after experimental
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