Showing 1-30 of 228 resultados for "G11950"
Zac Chatterton et al.
Clinical chemistry, 60(7), 995-1003 (2014-05-16)
DNA methylation biomarkers capable of diagnosis and subtyping have been found for many cancers. Fifteen such markers have previously been identified for pediatric acute lymphoblastic leukemia (ALL). Validation of these markers is necessary to assess their clinical utility for molecular...
Mechanisms of formation, genotoxicity, and mutation of guanine oxidation products.
William L Neeley et al.
Chemical research in toxicology, 19(4), 491-505 (2006-04-13)
Judit Moldvay et al.
Magyar onkologia, 57(1), 33-38 (2013-04-11)
Hungary is a world leader in lung cancer deaths, so it is particularly important that patients could have access to modern treatments. The aim of our analysis was to find how drug treatments are used in Hungary and how they...
Martin Ferus et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(3), 657-662 (2014-12-10)
The coincidence of the Late Heavy Bombardment (LHB) period and the emergence of terrestrial life about 4 billion years ago suggest that extraterrestrial impacts could contribute to the synthesis of the building blocks of the first life-giving molecules. We simulated...
J C Wang et al.
European review for medical and pharmacological sciences, 17(9), 1162-1166 (2013-05-22)
Either combination treatment or monotherapy using agents with a high genetic barrier are recommended for the retreatment of chronic hepatitis B (CHB) patients. In search of reasonable treatment, we compared the efficacy and safety of lamivudine (LAM) plus adefovir (ADV)...
Yoshitaka Ogita et al.
The Journal of biological chemistry, 290(33), 20245-20256 (2015-07-08)
The Ras family of small GTPases function in a wide variety of biological processes as "molecular switches" by cycling between inactive GDP-bound and active GTP-bound forms. Di-Ras1 and Di-Ras2 were originally identified as small GTPases forming a distinct subgroup of...
Michaela Vorlíčková et al.
Methods (San Diego, Calif.), 57(1), 64-75 (2012-03-28)
Circular dichroism (CD) is remarkably sensitive to the conformational states of nucleic acids; therefore, CD spectroscopy has been used to study most features of DNA and RNA structures. Quadruplexes are among the significant noncanonical nucleic acids architectures that have received...
Sushil Tripathi et al.
BMC systems biology, 9, 40-40 (2015-07-25)
The gastrointestinal peptide hormones cholecystokinin and gastrin exert their biological functions via cholecystokinin receptors CCK1R and CCK2R respectively. Gastrin, a central regulator of gastric acid secretion, is involved in growth and differentiation of gastric and colonic mucosa, and there is...
Kristoffer Derwinger et al.
Anticancer research, 33(6), 2447-2451 (2013-06-12)
The enzyme thymidine phosphorylase (TYMP) has tumor-promoting functions and its expression is often elevated in tumors. TYMP gene expression in tumorous and mucosal tissues was assessed using real-time polymerase chain reaction, in a study of patients with rectal cancer where...
Wuxiang Mao et al.
Nucleic acids research, 43(1), e3-e3 (2014-10-31)
Structural features of nucleic acids have become an integral part of current biomedical research. Highly selective and readily performed methods with little toxicity that target guanosines in non-duplex nucleic acids are needed, which led us to search for an effective...
Laura S Nyskohus et al.
Mutation research, 758(1-2), 80-86 (2013-10-22)
Azoxymethane (AOM) is an alkylating agent that generates mutagenic and carcinogenic O(6)-methylguanine (O(6)meG) adducts in DNA. O(6)meG has been detected in human colonic DNA; hence, understanding the innate cellular events occurring in response to the formation of O(6)meG is important...
Tsung-Hui Hu et al.
Transplantation, 97 Suppl 8, S53-S59 (2014-05-23)
Antiviral prophylaxis with hepatitis B immunoglobulin (HBIg) plus lamivudine reduces the risk of hepatitis B virus (HBV) recurrence after HBV-related liver transplant (LT). However, HBIg is expensive, and lamivudine therapy is limited by drug resistance. This study assessed a pilot...
Matthew S Chang et al.
Transplantation, 95(7), 960-965 (2013-04-03)
Lamivudine (LAM) has been shown to prevent de novo hepatitis B virus (HBV) infection in recipients of hepatitis B core antibody (HBcAb)-positive liver transplants (LT) but primarily in small studies with limited follow-up. We conducted a retrospective cohort study of...
Xiaohua Gao et al.
Environmental health perspectives, 123(4), 331-336 (2014-10-25)
It has been proposed that cadmium (Cd) is an environmental "metalloestrogen" and that its action is mediated via the estrogen receptor (ER). Cd mimics the effects of estrogen in the rat uterus, and blood Cd concentrations positively correlate with ER...
Melanie M Hoefer et al.
Experimental neurology, 263, 221-234 (2014-09-24)
Methamphetamine (METH) abuse is frequent in individuals infected with human immunodeficiency virus type-1 (HIV-1) and is suspected to aggravate HIV-associated neurocognitive disorders (HAND). METH is a psychostimulant that compromises several neurotransmitter systems and HIV proteins trigger neuronal injury but the...
D Ramírez et al.
Molecular and cellular endocrinology, 411, 28-37 (2015-04-22)
Melanocortins are neuropeptides with well recognized anti-inflammatory and anti-apoptotic effects in the brain. Of the five melanocortin receptors (MCR), MC4R is abundantly expressed in the brain and is the only MCR present in astrocytes. We have previously shown that MC4R...
Moriya Iwaizumi et al.
Mutation research, 747-748, 19-27 (2013-05-07)
Human DNA mismatch repair (MMR) recognizes and binds 5-fluorouracil (5FU) incorporated into DNA and triggers a MMR-dependent cell death. Absence of MMR in a patient's colorectal tumor abrogates 5FU's beneficial effects on survival. Changes in the tumor microenvironment like low...
Huiying Song et al.
Journal of chromatography. A, 1369, 83-91 (2014-12-03)
An intrinsic performance comparison is made of the reduction in analysis time that can be obtained when switching from HPLC to UHPLC column formats in HILIC and reversed-phase conditions. A detailed overview of the packing characteristics of both stationary phase...
Gunnar Boysen et al.
Mutation research, 678(2), 76-94 (2009-05-26)
DNA alkylation or adduct formation occurs at nucleophilic sites in DNA, mainly the N7-position of guanine. Ever since identification of the first N7-guanine adduct, several hundred studies on DNA adducts have been reported. Major issues addressed include the relationships between...
Chun-Liang Tung et al.
Experimental cell research, 322(2), 345-354 (2014-02-18)
Elevated heat shock protein 90 (Hsp90) expression has been linked to poor prognosis in patients with non-small cell lung cancer (NSCLC). The multitargeted antifolate pemetrexed has demonstrated certain clinical activities against NSCLC. However, the efficacy of the combination of pemtrexed...
Zamira Gibb et al.
Biology of reproduction, 93(4), 104-104 (2015-09-01)
The spermatozoa of many stallions do not tolerate being cooled, restricting the commercial viability of these animals and necessitating the development of a chemically defined room temperature (RT) storage medium. This study examined the impact of two major modulators of...
Clinical response to crizotinib retreatment after acquisition of drug resistance.
Hiromichi Matsuoka et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 31(19), e322-e323 (2013-05-30)
Jingji Zhang et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(31), 9602-9607 (2015-07-22)
We used a cell-free system with pure Escherichia coli components to study initial codon selection of aminoacyl-tRNAs in ternary complex with elongation factor Tu and GTP on messenger RNA-programmed ribosomes. We took advantage of the universal rate-accuracy trade-off for all...
N R Jena et al.
Free radical biology & medicine, 53(1), 81-94 (2012-05-16)
DNA damage by endogenous and exogenous agents is a serious concern, as the damaged products can affect genome integrity severely. Damage to DNA may arise from various factors such as DNA base modifications, strand break, inter- and intrastrand crosslinks, and...
Samuel C Suarez et al.
Mutation research, 745-746, 46-54 (2013-03-19)
DNA polymerase η (pol η) plays a critical role in suppressing mutations caused by the bypass of cis-syn cyclobutane pyrimidine dimers (CPD) that escape repair. There is evidence this is also the case for the oxidative lesion 7,8-dihydro-8-oxo-guanine (8-oxoG). Both...
Ye Li et al.
Journal of biological rhythms, 30(6), 519-532 (2015-10-09)
The chicken pineal gland synthesizes and releases melatonin rhythmically in light/dark (LD) cycles, with high melatonin levels during the dark phase, and in constant darkness (DD) for several cycles before it gradually damps to arrhythmicity in DD. Daily administration of...
T Spiro et al.
Forum (Genoa, Italy), 10(3), 274-285 (2000-09-29)
The chloroethylating nitrosoureas (lomustine, fotemustine, cystemustine (BCNU) and methylating agents temozolomide (TMZ), dacarbazine (DTIC), procarbazine) have documented activity in metastatic malignant melanoma with single agent response rates of 15-25%. Chloroethylating agents form chloroethyl adducts at the O6 position of guanine...
Melania Minoia et al.
Molecular and cellular biology, 34(19), 3570-3578 (2014-07-16)
The C289G mutation of the parkin E3-ubiquitin protein ligase (PARK2) is associated with autosomal recessive juvenile onset Parkinson's disease and was found to be associated with protein aggregation. Members of the human small heat shock proteins (HSPBs) have been implicated...
Taous Saraoui et al.
Food microbiology, 53(Pt A), 70-78 (2015-11-28)
Listeria monocytogenes is a pathogenic Gram positive bacterium and the etiologic agent of listeriosis, a severe food-borne disease. Lactococcus piscium CNCM I-4031 has the capacity to prevent the growth of L. monocytogenes in contaminated peeled and cooked shrimp. To investigate...
Norah Terrault
The American journal of gastroenterology, 108(6), 949-951 (2013-06-06)
Improvements in the outcomes of patients transplanted for hepatitis B virus (HBV) have been substantial in the past two decades. With current therapies, the vast majority of transplant recipients are protected against recurrent and/or progressive liver disease. Effective prophylactic therapies...

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