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Judit Moldvay et al.
Magyar onkologia, 57(1), 33-38 (2013-04-11)
Hungary is a world leader in lung cancer deaths, so it is particularly important that patients could have access to modern treatments. The aim of our analysis was to find how drug treatments are used in Hungary and how they
Norah Terrault
The American journal of gastroenterology, 108(6), 949-951 (2013-06-06)
Improvements in the outcomes of patients transplanted for hepatitis B virus (HBV) have been substantial in the past two decades. With current therapies, the vast majority of transplant recipients are protected against recurrent and/or progressive liver disease. Effective prophylactic therapies
Martin Ferus et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(3), 657-662 (2014-12-10)
The coincidence of the Late Heavy Bombardment (LHB) period and the emergence of terrestrial life about 4 billion years ago suggest that extraterrestrial impacts could contribute to the synthesis of the building blocks of the first life-giving molecules. We simulated
Jingji Zhang et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(31), 9602-9607 (2015-07-22)
We used a cell-free system with pure Escherichia coli components to study initial codon selection of aminoacyl-tRNAs in ternary complex with elongation factor Tu and GTP on messenger RNA-programmed ribosomes. We took advantage of the universal rate-accuracy trade-off for all
N R Jena et al.
Free radical biology & medicine, 53(1), 81-94 (2012-05-16)
DNA damage by endogenous and exogenous agents is a serious concern, as the damaged products can affect genome integrity severely. Damage to DNA may arise from various factors such as DNA base modifications, strand break, inter- and intrastrand crosslinks, and
Samuel C Suarez et al.
Mutation research, 745-746, 46-54 (2013-03-19)
DNA polymerase η (pol η) plays a critical role in suppressing mutations caused by the bypass of cis-syn cyclobutane pyrimidine dimers (CPD) that escape repair. There is evidence this is also the case for the oxidative lesion 7,8-dihydro-8-oxo-guanine (8-oxoG). Both
Ye Li et al.
Journal of biological rhythms, 30(6), 519-532 (2015-10-09)
The chicken pineal gland synthesizes and releases melatonin rhythmically in light/dark (LD) cycles, with high melatonin levels during the dark phase, and in constant darkness (DD) for several cycles before it gradually damps to arrhythmicity in DD. Daily administration of
Matthew D Cahn et al.
Journal of experimental zoology. Part A, Ecological genetics and physiology, 323(6), 359-367 (2015-04-08)
Vertebrate pigmentation is known to be influenced by oxidative stress, but few studies have tested the hypothesis that structural coloration can be similarly affected. We tested whether fish iridophores, which produce structural color using guanine stacks, might be affected by
S Neidle et al.
Pharmacology & therapeutics, 85(3), 133-139 (2000-03-31)
The ribonucleoprotein telomerase is responsible for maintaining the length of telomeric ends of chromosomes in tumour cells. It is activated in over 85% of the tumour cells, and is emerging as a major target for cancer chemotherapy. A range of
Kristoffer Derwinger et al.
Anticancer research, 33(6), 2447-2451 (2013-06-12)
The enzyme thymidine phosphorylase (TYMP) has tumor-promoting functions and its expression is often elevated in tumors. TYMP gene expression in tumorous and mucosal tissues was assessed using real-time polymerase chain reaction, in a study of patients with rectal cancer where
Petr V Sergiev et al.
Nucleic acids research, 35(7), 2295-2301 (2007-03-29)
Five nearly universal methylated guanine-(N2) residues are present in bacterial rRNA in the ribosome. To date four out of five ribosomal RNA guanine-(N2)-methyltransferases are described. RsmC(YjjT) methylates G1207 of the 16S rRNA. RlmG(YgjO) and RlmL(YcbY) are responsible for the 23S
Mechanisms of formation, genotoxicity, and mutation of guanine oxidation products.
William L Neeley et al.
Chemical research in toxicology, 19(4), 491-505 (2006-04-13)
D Ramírez et al.
Molecular and cellular endocrinology, 411, 28-37 (2015-04-22)
Melanocortins are neuropeptides with well recognized anti-inflammatory and anti-apoptotic effects in the brain. Of the five melanocortin receptors (MCR), MC4R is abundantly expressed in the brain and is the only MCR present in astrocytes. We have previously shown that MC4R
Chun-Liang Tung et al.
Experimental cell research, 322(2), 345-354 (2014-02-18)
Elevated heat shock protein 90 (Hsp90) expression has been linked to poor prognosis in patients with non-small cell lung cancer (NSCLC). The multitargeted antifolate pemetrexed has demonstrated certain clinical activities against NSCLC. However, the efficacy of the combination of pemtrexed
Tsung-Hui Hu et al.
Transplantation, 97 Suppl 8, S53-S59 (2014-05-23)
Antiviral prophylaxis with hepatitis B immunoglobulin (HBIg) plus lamivudine reduces the risk of hepatitis B virus (HBV) recurrence after HBV-related liver transplant (LT). However, HBIg is expensive, and lamivudine therapy is limited by drug resistance. This study assessed a pilot
J C Wang et al.
European review for medical and pharmacological sciences, 17(9), 1162-1166 (2013-05-22)
Either combination treatment or monotherapy using agents with a high genetic barrier are recommended for the retreatment of chronic hepatitis B (CHB) patients. In search of reasonable treatment, we compared the efficacy and safety of lamivudine (LAM) plus adefovir (ADV)
Taous Saraoui et al.
Food microbiology, 53(Pt A), 70-78 (2015-11-28)
Listeria monocytogenes is a pathogenic Gram positive bacterium and the etiologic agent of listeriosis, a severe food-borne disease. Lactococcus piscium CNCM I-4031 has the capacity to prevent the growth of L. monocytogenes in contaminated peeled and cooked shrimp. To investigate
Melania Minoia et al.
Molecular and cellular biology, 34(19), 3570-3578 (2014-07-16)
The C289G mutation of the parkin E3-ubiquitin protein ligase (PARK2) is associated with autosomal recessive juvenile onset Parkinson's disease and was found to be associated with protein aggregation. Members of the human small heat shock proteins (HSPBs) have been implicated
Xiaohua Gao et al.
Environmental health perspectives, 123(4), 331-336 (2014-10-25)
It has been proposed that cadmium (Cd) is an environmental "metalloestrogen" and that its action is mediated via the estrogen receptor (ER). Cd mimics the effects of estrogen in the rat uterus, and blood Cd concentrations positively correlate with ER
Melanie M Hoefer et al.
Experimental neurology, 263, 221-234 (2014-09-24)
Methamphetamine (METH) abuse is frequent in individuals infected with human immunodeficiency virus type-1 (HIV-1) and is suspected to aggravate HIV-associated neurocognitive disorders (HAND). METH is a psychostimulant that compromises several neurotransmitter systems and HIV proteins trigger neuronal injury but the
Matthew S Chang et al.
Transplantation, 95(7), 960-965 (2013-04-03)
Lamivudine (LAM) has been shown to prevent de novo hepatitis B virus (HBV) infection in recipients of hepatitis B core antibody (HBcAb)-positive liver transplants (LT) but primarily in small studies with limited follow-up. We conducted a retrospective cohort study of
Moriya Iwaizumi et al.
Mutation research, 747-748, 19-27 (2013-05-07)
Human DNA mismatch repair (MMR) recognizes and binds 5-fluorouracil (5FU) incorporated into DNA and triggers a MMR-dependent cell death. Absence of MMR in a patient's colorectal tumor abrogates 5FU's beneficial effects on survival. Changes in the tumor microenvironment like low
Huiying Song et al.
Journal of chromatography. A, 1369, 83-91 (2014-12-03)
An intrinsic performance comparison is made of the reduction in analysis time that can be obtained when switching from HPLC to UHPLC column formats in HILIC and reversed-phase conditions. A detailed overview of the packing characteristics of both stationary phase
Gunnar Boysen et al.
Mutation research, 678(2), 76-94 (2009-05-26)
DNA alkylation or adduct formation occurs at nucleophilic sites in DNA, mainly the N7-position of guanine. Ever since identification of the first N7-guanine adduct, several hundred studies on DNA adducts have been reported. Major issues addressed include the relationships between
Jeremy S Toma et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(3), 1291-1306 (2015-01-23)
Induced pluripotent cell-derived motoneurons (iPSCMNs) are sought for use in cell replacement therapies and treatment strategies for motoneuron diseases such as amyotrophic lateral sclerosis (ALS). However, much remains unknown about the physiological properties of iPSCMNs and how they compare with
Jyoti D Patel et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 31(34), 4349-4357 (2013-10-23)
PointBreak (A Study of Pemetrexed, Carboplatin and Bevacizumab in Patients With Nonsquamous Non-Small Cell Lung Cancer) compared the efficacy and safety of pemetrexed (Pem) plus carboplatin (C) plus bevacizumab (Bev) followed by pemetrexed plus bevacizumab (PemCBev) with paclitaxel (Pac) plus
Clinical response to crizotinib retreatment after acquisition of drug resistance.
Hiromichi Matsuoka et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 31(19), e322-e323 (2013-05-30)
Paweł Krawczyk et al.
Journal of cancer research and clinical oncology, 140(12), 2047-2057 (2014-07-17)
We presented retrospective analysis of up to five polymorphisms in TS, MTHFR and ERCC1 genes as molecular predictive markers for homogeneous Caucasian, non-squamous NSCLC patients treated with pemetrexed and platinum front-line chemotherapy. The following polymorphisms in DNA isolated from 115
Zamira Gibb et al.
Biology of reproduction, 93(4), 104-104 (2015-09-01)
The spermatozoa of many stallions do not tolerate being cooled, restricting the commercial viability of these animals and necessitating the development of a chemically defined room temperature (RT) storage medium. This study examined the impact of two major modulators of
Jae-Eun Kim et al.
American journal of physiology. Renal physiology, 308(7), F749-F764 (2015-02-05)
Mature microRNA (miRNA) acts as an important posttranscriptional regulator. We aimed to profile vasopressin-responsive miRNAs in kidney inner medullary collecting duct cells and to identify aquaporin-2 (AQP2)-targeting miRNAs. Microarray chip assay was carried out in inner medullary collecting duct tubule
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