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Lin Wang et al.
PloS one, 9(4), e94276-e94276 (2014-04-15)
The basic strategy to construct tissue engineered bone graft (TEBG) is to combine osteoblastic cells with three dimensional (3D) scaffold. Based on this strategy, we proposed the "Totally Vitalized TEBG" (TV-TEBG) which was characterized by abundant and homogenously distributed cells...
Shabir Ahmad Lone et al.
BMC complementary medicine and therapies, 20(1), 131-131 (2020-05-01)
The global prevalence of fungal diseases is increasing rapidly, which affects more than a billion people every year with significant mortality rate. On the other hand, the development of new drugs to treat these fungal infections is slow, while the...
James R Ferrell et al.
Biointerphases, 10(2), 021001-021001 (2015-03-27)
The generation of air-based plasmas under atmospheric plasma conditions was studied to assess their antimicrobial efficacy against commonly found pathogenic bacteria. The mixture of initial gases supplied to the plasma was found to be critical for the formation of bactericidal...
H-L Piao et al.
European review for medical and pharmacological sciences, 19(12), 2153-2161 (2015-07-15)
In the early pregnancy, large number of decidual natural killer (dNK) cells are present in decidua, which exhibit distinctive phenotype and functions from peripheral blood NK cells (pNK)1. Unlike the cytotoxic pNK cells, dNK cells display more pronounced characteristics of...
A D White et al.
Clinical and vaccine immunology : CVI, 22(9), 992-1003 (2015-06-26)
Nine million cases of tuberculosis (TB) were reported in 2013, with a further 1.5 million deaths attributed to the disease. When delivered as an intradermal (i.d.) injection, the Mycobacterium bovis BCG vaccine provides limited protection, whereas aerosol delivery has been...
Concepción M Aguilera et al.
International journal of molecular sciences, 16(4), 7723-7737 (2015-04-10)
Characterization of the genes expressed in adipose tissue (AT) is key to understanding the pathogenesis of obesity and to developing treatments for this condition. Our objective was to compare the gene expression in visceral AT (VAT) between obese and normal-weight...
Krystal A Fontaine et al.
Journal of virology, 89(4), 2358-2366 (2014-12-17)
Viruses rely on host cellular metabolism to provide the energy and biosynthetic building blocks required for their replication. Dengue virus (DENV), a member of the Flaviviridae family, is one of the most important arthropod-borne human pathogens worldwide. We analyzed global...
Lei Zhang et al.
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 33, 1-4 (2014-12-30)
The purpose of this study was to determine the species distribution and to monitor the antifungal susceptibility profiles of clinical Candida isolates collected in China from 2009 to 2013. The antifungal susceptibilities of 952 Candida isolates were tested. Candida albicans...
Ruizhi Zheng et al.
International journal of environmental research and public health, 12(11), 13662-13677 (2015-11-01)
The study was to investigate the prevalence of metabolic health in subjects with obesity in the Chinese population and to identify the determinants related to metabolic abnormality in obese individuals. 5013 subjects were recruited from seven provincial capitals in China....
Takahito Miyake et al.
Glia, 63(10), 1870-1882 (2015-05-27)
Microglia, the resident immune cells in the brain, survey the environment of the healthy brain. Microglial migration is essential for many physiological and pathophysiological processes. Although microglia express some members of the transient receptor potential (TRP) channel family, there is...
Philipp A Jaeger et al.
Applied and environmental microbiology, 81(16), 5639-5649 (2015-06-14)
Agar, a seaweed extract, has been the standard support matrix for microbial experiments for over a century. Recent developments in high-throughput genetic screens have created a need to reevaluate the suitability of agar for use as colony support, as modern...
Phing-How Lou et al.
Anesthesia and analgesia, 120(2), 329-340 (2014-12-02)
The IV anesthetic, propofol, when administered as fat emulsion-based formulation (Diprivan) promotes insulin resistance, but the direct effects of propofol and its solvent, Intralipid, on cardiac insulin resistance are unknown. Hearts of healthy and type-2 diabetic rats (generated by fructose...
Lucian Farcal et al.
PloS one, 10(5), e0127174-e0127174 (2015-05-23)
Nanomaterials (NMs) display many unique and useful physico-chemical properties. However, reliable approaches are needed for risk assessment of NMs. The present study was performed in the FP7-MARINA project, with the objective to identify and evaluate in vitro test methods for...
Kyra-Melinda Alexacou et al.
Bioorganic & medicinal chemistry, 19(17), 5125-5136 (2011-08-09)
Electrophilic halogenation of C-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl) 1,4-dimethoxybenzene (1) afforded regioselectively products halogenated at the para position to the D-glucosyl moiety (8, 9) that were deacetylated to 3 (chloride) and 16 (bromide). For preparing meta regioisomers, 1 was efficiently oxidized with CAN to...
Frederika Maria Byrne et al.
Journal of diabetes research, 2015, 752481-752481 (2015-03-12)
Chronic pain is a common complication of diabetes. The aim of the present study was to characterise pain behaviour in a high fat diet/streptozotocin (HFD/STZ) model of diabetes in the rat, investigate spinal mechanisms, and determine the effects of antidiabetic...
Hiroyuki Tamiya et al.
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, 21(5), 385-391 (2015-03-05)
The incidence of Aspergillus infection has been increasing in the past few years. Also, new Aspergillus fumigatus-related species, namely Aspergillus lentulus, Aspergillus udagawae, and Aspergillus viridinutans, were shown to infect humans. These fungi exhibit marked morphological similarities to A. fumigatus...
Woojung Lee et al.
International journal of molecular medicine, 36(2), 527-533 (2015-06-03)
In the present study, the anti-diabetic effects of amorphastilbol (APH) from Amorpha fruticosa (AF) were evaluated in high-fat-diet (HFD) mice. HFD-induced blood glucose and insulin levels are significantly reduced in AF extract or APH treatment groups. HFD-induced weight gain was...
Pierre-Yves Collart-Dutilleul et al.
Nanoscale research letters, 9(1), 564-564 (2014-11-12)
The way cells explore their surrounding extracellular matrix (ECM) during development and migration is mediated by lamellipodia at their leading edge, acting as an actual motor pulling the cell forward. Lamellipodia are the primary area within the cell of actin...
Hongde An et al.
Journal of microbiology (Seoul, Korea), 53(9), 606-615 (2015-08-02)
One of the laccase isoforms in the brown rot fungus Postia placenta is thought to contribute to the production of hydroxyl radicals, which play an important role in lignocellulose degradation. However, the presence of at least two laccase isoforms in...
Catherine O'Sullivan et al.
Journal of cell science, 128(21), 3878-3887 (2015-09-12)
Globoid cell leukodystrophy (Krabbe disease) is a rare infantile neurodegenerative disorder. Krabbe disease is caused by deficiency in the lysosomal enzyme galactocerebrosidase (GALC) resulting in accumulation, in the micromolar range, of the toxic metabolite galactosylsphingosine (psychosine) in the brain. Here...
Rachael K Nelson et al.
Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme, 39(7), 811-818 (2014-04-30)
Although regular exercise is associated with reduced cardiometabolic disease risk among overweight adults, it remains unclear whether much of the health benefits of exercise are derived from the most recent session(s) of exercise or if they are the result of...
Daifeng Cheng et al.
Scientific reports, 4, 7489-7489 (2014-12-17)
Reproduction is an important life process in insects; however, few studies have attempted to demonstrate the association between reproductive activity and energy metabolism. To address this problem, we focused on the reproductive changes in Bactrocera dorsalis males. We analyzed B....
Ramu Adela et al.
PloS one, 10(4), e0125270-e0125270 (2015-04-22)
We have previously reported that increased glucose levels were associated with higher serum nitric oxide (NO) levels in fructose-fed insulin resistant rats. However, the relationship between hyperglycemia and serum NO level was not clear. Therefore, the present study was designed...
S A Kim et al.
Journal of food protection, 78(12), 2233-2239 (2015-11-29)
This study investigated changes in the microbial composition of microbrewed beer during the manufacturing processes and identified potential microbial hazards, effective critical quality control points, and potential contamination routes. Comprehensive quantitative (aerobic plate count, lactic acid bacteria, fungi, acetic acid...
Yujiao Fu et al.
Molecular pharmacology, 88(1), 161-170 (2015-02-27)
The timely resolution of inflammation prevents continued tissue damage after an initial insult. In the brain, the death of activated microglia by apoptosis has been proposed as one mechanism to resolve brain inflammation. How microglial death is regulated after activation...
Junfeng Han et al.
PloS one, 10(6), e0129226-e0129226 (2015-06-16)
Glucagon regulates glucose homeostasis by controlling glycogenolysis and gluconeogenesis in the liver. Exaggerated and dysregulated glucagon secretion can exacerbate hyperglycemia contributing to type 2 diabetes (T2D). Thus, it is important to understand how glucagon receptor (GCGR) activity and signaling is...
Ranjith Rajendran et al.
BMC microbiology, 14, 303-303 (2014-12-06)
Biofilm formation by Candida albicans has shown to be highly variable and is directly associated with pathogenicity and poor clinical outcomes in patients at risk. The aim of this study was to test the hypotheses that the extracellular DNA release...
Xiao-Rong Ni et al.
Reproductive sciences (Thousand Oaks, Calif.), 22(3), 271-277 (2014-09-18)
Polycystic ovary syndrome (PCOS) is a common endocrine disorder affecting women of reproductive age. Insulin resistance/hyperinsulinemia is a prevalent finding in women with PCOS, which indicates that insulin resistance/hyperinsulinemia may be an important player in the pathogenesis of the PCOS....
Di-Fei Wang et al.
Molecular medicine reports, 12(2), 2695-2700 (2015-05-13)
In the present study, a glucosamine-induced model of insulin-resistant skeletal muscle cells was established in order to investigate the effect of inhibition of phosphatase and tensin homolog (PTEN)/5'-adenosine monophosphate-activated protein kinase (AMPK) on these cells. The glucosamine-induced insulin-resistant skeletal muscle...
Anchalee Samphao et al.
Talanta, 142, 35-42 (2015-05-25)
An amperometric biosensor based on chemisorption of glucose oxidase (GOx) on Au seeds decorated on magnetic core Fe3O4 nanoparticles (Fe3O4@Au) and their immobilization on screen-printed carbon electrode bulk-modified with manganese oxide (SPCE{MnO2}) was designed for the determination of glucose. The...
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