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Louise S Dalbøge et al.
The Journal of pharmacology and experimental therapeutics, 350(2), 353-360 (2014-06-07)
Antidiabetic treatments aiming to preserve or even to increase β-cell mass are currently gaining increased interest. Here we investigated the effect of chronic treatment with the novel glucagon-like peptide-1 (GLP-1)-gastrin dual agonist ZP3022 (HGEGTFTSDLSKQMEEEAVRLFIEWLKN-8Ado-8Ado-YGWLDF-NH2) on glycemic control, β-cell mass and
Kacy Greenhalgh et al.
Cell reports, 27(5), 1621-1632 (2019-05-03)
By modulating the human gut microbiome, prebiotics and probiotics (combinations of which are called synbiotics) may be used to treat diseases such as colorectal cancer (CRC). Methodological limitations have prevented determining the potential combinatorial mechanisms of action of such regimens. We expanded
Yulin Ren et al.
Journal of medicinal chemistry, 49(9), 2829-2837 (2006-04-28)
The rapid increase of obesity-associated diabetes has created urgent demands for more effective antidiabetic therapies and pharmaceuticals that are able to address the problems of hyperglycemia and weight gain simultaneously. Our previous studies indicated that the alpha- and beta-anomers of
Feng-Shiun Shie et al.
PloS one, 10(8), e0134531-e0134531 (2015-08-06)
Diabesity-associated metabolic stresses modulate the development of Alzheimer's disease (AD). For further insights into the underlying mechanisms, we examine whether the genetic background of APPswe/PS1dE9 at the prodromal stage of AD affects peripheral metabolism in the context of diabesity. We
Mallory L Hammock et al.
Advanced materials (Deerfield Beach, Fla.), 26(35), 6138-6144 (2014-07-23)
Organic field-effect transistor (OFET) sensors can meet the need for portable and real-time diagnostics. An electronicreadout enzyme-linked immunosorbent assay using OFETs for the detection of a panel of three biomarkers in complex media to create a pre-eclampsia prognostic is demonstrated
Joyce Y Buikhuisen et al.
Cancers, 13(4) (2021-03-07)
Colorectal cancer (CRC) is a heterogeneous disease that can currently be subdivided into four distinct consensus molecular subtypes (CMS) based on gene expression profiling. The CMS4 subtype is marked by high expression of mesenchymal genes and is associated with a
Hong-Xiang Yan et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 76, 156-164 (2015-05-16)
This paper put forward a deconvolution-based method for designing and optimizing tanshinone IIA sustained-release pellets (TA-SRPs) with improved efficacy in the treatment of variant angina. TA-SRPs were prepared by coating TA ternary solid dispersion immediate-release pellets (TA-tSD-IRPs) with the blends
Christoph Malkmus et al.
PLoS neglected tropical diseases, 14(11), e0008503-e0008503 (2020-11-06)
Onchocerciasis also known as river blindness is a neglected tropical disease and the world's second-leading infectious cause of blindness in humans; it is caused by Onchocerca volvulus. Current treatment with ivermectin targets microfilariae and transmission and does not kill the
Adryana Clementino et al.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics (2021-09-05)
Polymeric nanoparticles are being extensively investigated as an approach for brain delivery of drugs, especially for their controlled release and targeting capacity. Nose-to-brain administration of nanoparticles, bypassing the blood brain barrier, offers a promising strategy to deliver drugs to the
Tomoe Kanbara et al.
Neuroscience letters, 580, 119-124 (2014-08-17)
It has begun to be understood that μ-opioid receptor (MOR) produces ligand-biased agonism, which contributes to differential physiological functions of MOR agonists. We previously demonstrated that in oxaliplatin-induced neuropathy in rats, morphine and oxycodone exhibited antinociceptive effects while antinociception of
Alejo Efeyan et al.
Nature, 517(7534), 302-310 (2015-01-17)
The ability to sense and respond to fluctuations in environmental nutrient levels is a requisite for life. Nutrient scarcity is a selective pressure that has shaped the evolution of most cellular processes. Different pathways that detect intracellular and extracellular levels
Vincent C Luca et al.
Science (New York, N.Y.), 347(6224), 847-853 (2015-02-24)
Notch receptors guide mammalian cell fate decisions by engaging the proteins Jagged and Delta-like (DLL). The 2.3 angstrom resolution crystal structure of the interacting regions of the Notch1-DLL4 complex reveals a two-site, antiparallel binding orientation assisted by Notch1 O-linked glycosylation.
Eran Mick et al.
eLife, 9 (2020-05-29)
Mitochondrial dysfunction is associated with activation of the integrated stress response (ISR) but the underlying triggers remain unclear. We systematically combined acute mitochondrial inhibitors with genetic tools for compartment-specific NADH oxidation to trace mechanisms linking different forms of mitochondrial dysfunction
Deborah M Muoio
Cell, 159(6), 1253-1262 (2014-12-07)
Normal energy metabolism is characterized by periodic shifts in glucose and fat oxidation, as the mitochondrial machinery responsible for carbon combustion switches freely between alternative fuels according to physiological and nutritional circumstances. These transitions in fuel choice are orchestrated by
Karl Herholz
Expert review of neurotherapeutics, 10(11), 1667-1673 (2010-10-28)
Assessment of regional cerebral glucose metabolism by (18)F-2-fluoro-2-deoxy-D-glucose (FDG)-PET at resting state is a standard functional technique to assess cerebral function. Group studies identified significant regional metabolic impairment in asymptomatic individuals at increased risk for dementia. Substantial impairment of FDG
Maria Luisa Rojo et al.
Life sciences, 108(2), 116-121 (2014-06-15)
A high consumption of fructose leads not only to peripheral changes in insulin sensitivity and vascular function, but also to central changes in several brain regions. Given the role of the endogenous cannabinoid system in the control of energy intake
Erica E Alexeev et al.
BMC physiology, 15, 3-3 (2015-06-05)
There is increasing evidence that poor growth of preterm infants is a risk factor for poor long-term development, while the effects of early postnatal growth restriction are not well known. We utilized a rat model to examine the consequences of
Peter Stein et al.
Metabolism: clinical and experimental, 63(10), 1296-1303 (2014-08-12)
Canagliflozin is a sodium glucose co-transporter 2 inhibitor approved for treating patients with type 2 diabetes. This study evaluated renal and non-renal effects of canagliflozin on postprandial plasma glucose (PG) excursion in patients with type 2 diabetes inadequately controlled with
Tomoe Kanbara et al.
Journal of pharmacological sciences, 126(3), 264-273 (2014-10-28)
Oxaliplatin is a chemotherapeutic agent that induces chronic refractory neuropathy. To determine whether opioids effectively relieve this chronic neuropathy, we investigated the efficacies of morphine, oxycodone, and fentanyl, and the mechanisms underlying opioid antinociception, in oxaliplatin-induced neuropathy in rats. Rats
Notch signaling maintains T cell memories.
Aaron M Miller et al.
Nature medicine, 21(1), 16-18 (2015-01-09)
Cathryn M Kolka et al.
Metabolism: clinical and experimental, 64(2), 330-337 (2014-12-04)
Insulin injected directly into skeletal muscle diffuses rapidly through the interstitial space to cause glucose uptake, but this is blocked in insulin resistance. As glucotoxicity is associated with endothelial dysfunction, the observed hyperglycemia in diet-induced obese dogs may inhibit insulin
Yuzhang Zhu et al.
Biochemical and biophysical research communications, 447(4), 707-714 (2014-04-29)
Accumulating clinical evidence suggests that hyperuricemia is strongly associated with abnormal glucose metabolism and insulin resistance. However, how high uric acid (HUA) level causes insulin resistance remains unclear. We aimed to determine the direct role of HUA in insulin resistance
Wilhelmina G Leen et al.
Neurology, 81(24), e178-e181 (2013-12-11)
Analysis of CSF is daily routine in patients with acute neurologic disorders like CNS infections. In those patients, the finding of a low CSF glucose may influence further diagnostic workup and therapeutic choices. The interpretation of a low CSF glucose
James M Clegg et al.
Bio-protocol, 10(13), e3674-e3674 (2021-03-05)
Organotypic slice culture is a powerful technique for exploring the embryonic development of the mammalian brain. In this protocol we describe a basic slice culture technique we have used for two sets of experiments: axon guidance transplant assays and bead
P V Zhuravlev et al.
Gigiena i sanitariia, (1)(1), 56-58 (2013-06-29)
Due to intensive anthropogenic pollution of water environment generally accepted indicators of epidemic security of water bodies--common bacteria (CB) and thermotolerant coliform bacteria (TCB) do not always permit to obtain an objective characterization of bacterial contamination of tap water. From
Henrik Ahlenius et al.
Methods in molecular biology (Clifton, N.J.), 633, 241-252 (2010-03-06)
Neural stem cells are defined as cells that either gives rise to or derives from the cells of the central nervous system and have the unique properties of stem cells, i.e. self-renewal and multipotentiality. One of the widely used methods
Brian M Zid et al.
Nature, 514(7520), 117-121 (2014-08-15)
A universal feature of the response to stress and nutrient limitation is transcriptional upregulation of genes that encode proteins important for survival. Under many such conditions, the overall protein synthesis level is reduced, thereby dampening the stress response at the
Mark-Steven Steiner et al.
Chemical Society reviews, 40(9), 4805-4839 (2011-06-16)
This critical review covers the present state of the art in optical sensing of glucose. Following an introduction into the significance of (continuous) sensing of glucose and a brief look back, we discuss methods based on (a) monitoring the optical
Josephine Shaw et al.
Lab on a chip, 12(15), 2656-2663 (2012-05-26)
Common techniques used to synchronize eukaryotic cells in the cell cycle often impose metabolic stress on the cells or physically select for size rather than age. To address these deficiencies, a minimally perturbing method known as the "baby machine" was
Ross M Tanis et al.
Biochimica et biophysica acta, 1853(1), 213-221 (2014-12-03)
While the 3T3-L1 adipocyte model is routinely used for the study of obesity and diabetes, the mitochondrial respiratory profile in normal versus high glucose has not been examined in detail. We matured adipocytes in normal (5mM) or high (30 mM)
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