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Aya D Pusic et al.
Experimental neurology, 264, 43-54 (2014-12-17)
Multiple sclerosis and migraine with aura are clinically correlated and both show imaging changes suggestive of myelin disruption. Furthermore, cortical myelin loss in the cuprizone animal model of multiple sclerosis enhances susceptibility to spreading depression, the likely underlying cause of
Mio Okada et al.
Journal of breath research, 8(4), 046004-046004 (2014-11-02)
Transplantation of insulin (INS)-secreting cells differentiated in vitro from stem cells promises a safer and easier treatment of severe diabetes mellitus. A volatile bioactive compound, hydrogen sulfide (H2S), promotes cell differentiation; human tooth-pulp stem cells undergo hepatic differentiation. The aim
Eva Herzog et al.
Anesthesiology, 122(2), 387-398 (2014-11-25)
Edoxaban is an oral, selective direct factor Xa inhibitor approved in Japan for venous thromboembolism prevention after orthopedic surgery. Data are lacking regarding reversal strategies for edoxaban; this study assessed whether four-factor prothrombin complex concentrate (Beriplex/Kcentra; CSL Behring GmbH, Marburg
Stefan Vallo et al.
Translational oncology, 8(3), 210-216 (2015-06-10)
Combination chemotherapy with gemcitabine and cisplatin in patients with metastatic urothelial cancer of the bladder frequently results in the development of acquired drug resistance. Availability of cell culture models with acquired resistance could help to identify candidate treatments for an
Rudy J Valentine et al.
Archives of biochemistry and biophysics, 562, 62-69 (2014-08-31)
Recent studies have highlighted the importance of an inhibitory phosphorylation site, Ser(485/491), on the α-subunit of AMP-activated protein kinase (AMPK); however, little is known about the regulation of this site in liver and skeletal muscle. We examined whether the inhibitory
David Cruz-Garcia et al.
The Journal of cell biology, 207(6), 695-703 (2014-12-17)
Upon starvation, Grh1, a peripheral membrane protein located at endoplasmic reticulum (ER) exit sites and early Golgi in Saccharomyces cerevisiae under growth conditions, relocates to a compartment called compartment for unconventional protein secretion (CUPS). Here we report that CUPS lack
Louise S Dalbøge et al.
The Journal of pharmacology and experimental therapeutics, 350(2), 353-360 (2014-06-07)
Antidiabetic treatments aiming to preserve or even to increase β-cell mass are currently gaining increased interest. Here we investigated the effect of chronic treatment with the novel glucagon-like peptide-1 (GLP-1)-gastrin dual agonist ZP3022 (HGEGTFTSDLSKQMEEEAVRLFIEWLKN-8Ado-8Ado-YGWLDF-NH2) on glycemic control, β-cell mass and
Natalie J Wood et al.
Journal of materials science. Materials in medicine, 26(6), 201-201 (2015-07-01)
Dental implants are an increasingly popular solution to missing teeth. Implants are prone to colonisation by pathogenic oral bacteria which can lead to inflammation, destruction of bone and ultimately implant failure. The aim of this study was to investigate the
Regulation of glucose homeostasis using radiogenetics and magnetogenetics in mice.
Ingo B Leibiger et al.
Nature medicine, 21(1), 14-16 (2015-01-09)
Nadya Shusharina et al.
International journal of radiation oncology, biology, physics, 89(1), 137-144 (2014-04-15)
To investigate the spatial correlation between high uptake regions of 2-deoxy-2-[(18)F]-fluoro-D-glucose positron emission tomography ((18)F-FDG PET) before and after therapy in recurrent lung cancer. We enrolled 106 patients with inoperable lung cancer into a prospective study whose primary objectives were
Ross M Tanis et al.
Biochimica et biophysica acta, 1853(1), 213-221 (2014-12-03)
While the 3T3-L1 adipocyte model is routinely used for the study of obesity and diabetes, the mitochondrial respiratory profile in normal versus high glucose has not been examined in detail. We matured adipocytes in normal (5mM) or high (30 mM)
María Velasco-Estevez et al.
Glia, 68(2), 356-375 (2019-10-10)
Piezo1 is a mechanosensitive ion channel that facilitates the translation of extracellular mechanical cues to intracellular molecular signaling cascades through a process termed, mechanotransduction. In the central nervous system (CNS), mechanically gated ion channels are important regulators of neurodevelopmental processes
Trupti Shetty et al.
STAR protocols, 2(2), 100533-100533 (2021-05-25)
Mitochondrial metabolism is a critical mechanism that is deregulated in numerous retinal diseases. Here, we elaborate a protocol to quantify oxygen consumption rate as a measure of mitochondrial respiration directly from mouse retinal tissue pieces. Our procedure combines the use
Mark-Steven Steiner et al.
Chemical Society reviews, 40(9), 4805-4839 (2011-06-16)
This critical review covers the present state of the art in optical sensing of glucose. Following an introduction into the significance of (continuous) sensing of glucose and a brief look back, we discuss methods based on (a) monitoring the optical
Josephine Shaw et al.
Lab on a chip, 12(15), 2656-2663 (2012-05-26)
Common techniques used to synchronize eukaryotic cells in the cell cycle often impose metabolic stress on the cells or physically select for size rather than age. To address these deficiencies, a minimally perturbing method known as the "baby machine" was
Tania Valencia et al.
Cancer cell, 26(1), 121-135 (2014-07-09)
The tumor microenvironment plays a critical role in cancer progression, but the precise mechanisms by which stromal cells influence the epithelium are poorly understood. Here we show that p62 levels were reduced in the stroma of several tumors and that
Kenneth W Walker et al.
The Journal of biological chemistry, 295(30), 10446-10455 (2020-06-11)
Transthyretin (TTR) is an abundant homotetrameric serum protein and was selected here for engineering higher-valency molecules because of its compact size, simple structure, and natural propensity to tetramerize. To demonstrate this utility, we fused TTR to the C terminus of
Kacy Greenhalgh et al.
Cell reports, 27(5), 1621-1632 (2019-05-03)
By modulating the human gut microbiome, prebiotics and probiotics (combinations of which are called synbiotics) may be used to treat diseases such as colorectal cancer (CRC). Methodological limitations have prevented determining the potential combinatorial mechanisms of action of such regimens. We expanded
Magnus Dalén et al.
Journal of cardiovascular translational research, 8(6), 381-384 (2015-07-08)
Endomyocardial delivery in the setting of active left ventricular assist device (LVAD) support has rarely been studied. The objective was to establish a protocol for endomyocardial injections during LVAD support without compromising mechanical circulation. LVAD implantation was performed in four
Joyce Y Buikhuisen et al.
Cancers, 13(4) (2021-03-07)
Colorectal cancer (CRC) is a heterogeneous disease that can currently be subdivided into four distinct consensus molecular subtypes (CMS) based on gene expression profiling. The CMS4 subtype is marked by high expression of mesenchymal genes and is associated with a
Longbo Zhang et al.
Cells, 10(3) (2021-04-04)
Rab27a is an evolutionarily conserved small GTPase that regulates vesicle trafficking, and copy number variants of RAB27a are associated with increased risk of autism. However, the function of Rab27a on brain development is unknown. Here, we identified a form of
Yunqing Tang et al.
Scientific reports, 5, 11073-11073 (2015-06-23)
Single molecule localization based super-resolution fluorescence microscopy offers significantly higher spatial resolution than predicted by Abbe's resolution limit for far field optical microscopy. Such super-resolution images are reconstructed from wide-field or total internal reflection single molecule fluorescence recordings. Discrimination between
Arianna Pompilio et al.
Frontiers in microbiology, 8, 2591-2591 (2018-01-10)
Laia Chavarria et al.
NMR in biomedicine, 28(1), 17-23 (2014-10-11)
Intracranial hypertension is a severe complication of acute liver failure (ALF) secondary to brain edema. The pathogenesis of cerebral edema in ALF is not clear, but seems to be related to energy metabolism in which lactate may have an important
Feng-Shiun Shie et al.
PloS one, 10(8), e0134531-e0134531 (2015-08-06)
Diabesity-associated metabolic stresses modulate the development of Alzheimer's disease (AD). For further insights into the underlying mechanisms, we examine whether the genetic background of APPswe/PS1dE9 at the prodromal stage of AD affects peripheral metabolism in the context of diabesity. We
Yulin Ren et al.
Journal of medicinal chemistry, 49(9), 2829-2837 (2006-04-28)
The rapid increase of obesity-associated diabetes has created urgent demands for more effective antidiabetic therapies and pharmaceuticals that are able to address the problems of hyperglycemia and weight gain simultaneously. Our previous studies indicated that the alpha- and beta-anomers of
Fernando G Vieira et al.
PloS one, 10(8), e0135570-e0135570 (2015-08-20)
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by loss of motor neurons. The mechanisms leading to motor neuron degeneration in ALS are unclear. However, there is evidence for involvement of endoplasmic reticulum (ER) stress and the unfolded
Hye Young Jung et al.
Journal of biomedical nanotechnology, 9(5), 901-906 (2013-06-28)
An enzyme stimulated deposition of prussian blue onto the gold-coated magnetic microparticles is described. We propose to synthesize the continuous outer gold layer on the magnetic particle for a gold working electrode and its superparamagnetic property. In-depth characterization of the
Natalia Sumption et al.
PloS one, 10(8), e0134046-e0134046 (2015-08-08)
Human exposure to high-linear energy transfer α-particles includes environmental (e.g. radon gas and its decay progeny), medical (e.g. radiopharmaceuticals) and occupational (nuclear industry) sources. The associated health risks of α-particle exposure for lung cancer are well documented however the risk
Astrid M Alsema et al.
Frontiers in molecular neuroscience, 13, 134-134 (2020-11-17)
Microglia are the tissue-resident macrophages of the central nervous system (CNS). Recent studies based on bulk and single-cell RNA sequencing in mice indicate high relevance of microglia with respect to risk genes and neuro-inflammation in Alzheimer's disease (AD). Here, we
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