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Feng Geng et al.
Journal of biomedical nanotechnology, 10(7), 1205-1216 (2014-05-09)
Pharmacokinetics and bio-distribution are crucial factors affecting the performance of an intravenous drug. In this study, we explore the combined use of glucose and polyethylene glycol (PEG) ligands to further improve gold nanoparticle (GNP) pharmacokinetics and bio-distribution, with the aim...
Shereen F Mossallam et al.
Experimental parasitology, 144, 14-21 (2014-06-15)
Through increased awareness and improved diagnostics, microsporidiosis has now been identified in a broader range of human populations; however current therapies are inconsistently effective. Recently, probiotics were determined as means for the control of intestinal parasitic infections through their secretory...
Celina Yang et al.
Journal of nanoscience and nanotechnology, 14(7), 4813-4819 (2014-04-25)
The applications of nanoparticles (NPs) for improved therapeutics are at the forefront of cancer nanotechnology. Gold nanoparticles (GNPs) have been extensively used due to their ability to act as both an anticancer drug carrier in chemotherapy and as a dose...
Tonguc O Tasci et al.
Journal of chromatography. A, 1365, 164-172 (2014-09-24)
Compared to other sub-techniques of field flow fractionation (FFF), cyclical electrical field flow fractionation (CyElFFF) is a relatively new method with many opportunities remaining for improvement. One of the most important limitations of this method is the separation of particles...
E Jortzik et al.
Biochimica et biophysica acta, 1844(8), 1415-1426 (2014-01-21)
Glioblastoma, an aggressive brain tumor, has a poor prognosis and a high risk of recurrence. An improved chemotherapeutic approach is required to complement radiation therapy. Gold(I) complexes bearing phosphole ligands are promising agents in the treatment of cancer and disturb...
Huang Gao et al.
Science (New York, N.Y.), 346(6215), 1352-1356 (2014-12-17)
We report a low-cost, high-throughput benchtop method that enables thin layers of metal to be shaped with nanoscale precision by generating ultrahigh-strain-rate deformations. Laser shock imprinting can create three-dimensional crystalline metallic structures as small as 10 nanometers with ultrasmooth surfaces...
Yuying Zhang et al.
Journal of visualized experiments : JoVE, (95)(95), e52058-e52058 (2015-01-16)
Fluorescent nanoparticles (NPs) with desirable chemical, optical and mechanical properties are promising tools to label intracellular organelles. Here, we introduce a method using gold-BSA-rhodamine NPs to label the endo-lysosomal system of eukaryotic cells and monitor manipulations of host cellular pathways...
Catalysis: Gold unleashes the power of three.
Christopher M B K Kourra et al.
Nature, 517(7535), 440-441 (2015-01-23)
Kaili Niu et al.
Journal of nanoscience and nanotechnology, 14(7), 5151-5156 (2014-04-25)
An immunochromatographic test strip using gold nanoparticles-staphylococcus aureus monoclonal antibody conjugates was developed for the rapid and convenient detection of staphylococcus aureus based on a double-antibody sandwich format. The detection limit and the detection rate of this test strip is...
Ying Sun et al.
Journal of nanoscience and nanotechnology, 14(6), 4078-4081 (2014-04-18)
Colloidal gold is extensively used for molecular sensing because that the surface plasmon resonance (SPR) bands are affected by changes in the dielectric properties in the close vicinity of these structures due to the binding of ligands to the corresponding...
Cathleen M Crudden et al.
Nature chemistry, 6(5), 409-414 (2014-04-24)
Since the first report of thiol-based self-assembled monolayers (SAMs) 30 years ago, these structures have been examined in a huge variety of applications. The oxidative and thermal instabilities of these systems are widely known, however, and are an impediment to...
Yuyun Zhao et al.
Nanoscale, 5(18), 8340-8350 (2013-07-31)
Widespread antibiotic resistance calls for new strategies. Nanotechnology provides a chance to overcome antibiotic resistance by multiple antibiotic mechanisms. This paper reviews the progress in activating gold nanoparticles with nonantibiotic or antibiotic molecules to combat bacterial resistance, analyzes the gap...
Hong C Shen et al.
Drug discovery today. Technologies, 10(1), e3-14 (2013-09-21)
Gold-catalyzed transformations allow efficient access to a wide scope of heterocyclic structures that serve as building blocks and pharmacophores in medicinal chemistry. Compared with other transition metal and Lewis acid catalysis, gold catalysis presents mechanistic divergence, excellent functional group tolerance...
Guojun Weng et al.
Journal of nanoscience and nanotechnology, 14(6), 4072-4077 (2014-04-18)
Gold nanorods of different aspect ratios had been synthesized using seed mediated growth method. The formed gold nanorods had been characterized by the absorption and transmission electron microscopy (TEM) measurements. The obtained gold nanorods were used to study the quenched...
Bernhard F Gibbs et al.
Journal of biomedical nanotechnology, 10(7), 1259-1266 (2014-05-09)
In this study we demonstrate for the first time a new approach for highly specific targeting of viable human leukocytes by functionalised gold nanoconjugates made on the basis of citrate-stabilised gold nanoparticles. This immobilisation involves highly specific recognition of the...
Maria Jose Santos-Martinez et al.
Journal of biomedical nanotechnology, 10(6), 1004-1015 (2014-04-23)
The increasing use of gold nanoparticles in medical diagnosis and treatment has raised the concern over their blood compatibility. The interactions of nanoparticles with blood components may lead to platelet aggregation and endothelial dysfunction. Therefore, medical applications of gold nanoparticles...
Roya Najafi et al.
International journal of food microbiology, 189, 89-97 (2014-08-19)
A combined capture and detection method comprising of nano-immunomagnetic separation (NIMS) and surface enhanced Raman spectroscopy (SERS) was developed to detect Escherichia coli O157 from liquid media including apple juice. The capture antibodies (cAbs) were immobilized on magnetite-gold (Fe3O4/Au) magnetic...
Lin Luo et al.
Journal of nanoscience and nanotechnology, 14(6), 4036-4042 (2014-04-18)
A novel immunosensor of human immune globulin (IgG) was fabricated based on the fluorescence transfer between luminescent semiconductor quantum dots (QDs) and gold nanoparticles (AuNPs). AuNPs and CdSe/ZnS QDs were respectively labeled with immune reaction pair:IgG and goat anti-human immunoglobulin...
Samudra Sengupta et al.
Nature chemistry, 6(5), 415-422 (2014-04-24)
Non-mechanical nano- and microscale pumps that function without the aid of an external power source and provide precise control over the flow rate in response to specific signals are needed for the development of new autonomous nano- and microscale systems....
Astrid van der Horst et al.
International journal of radiation oncology, biology, physics, 89(3), 641-648 (2014-05-08)
Because of low soft-tissue contrast of cone beam computed tomography (CBCT), fiducial markers are often used for radiation therapy patient setup verification. For pancreatic cancer patients, biliary stents have been suggested as surrogate fiducials. Using intratumoral fiducials as standard for...
Roberto Cao-Milán et al.
Expert opinion on drug delivery, 11(5), 741-752 (2014-02-25)
Gold nanoparticles display a unique combination of chemical inertness, surface chemistry and size- and shape-dependent electronic and optical properties, which render them ideal for clinical applications. The present article describes recent advancements on the application of gold nanoparticles in vaccine...
Hongyan Zhao et al.
Journal of nanoscience and nanotechnology, 14(6), 4357-4362 (2014-04-18)
The influence of 12 nm spherical silver nanoparticles (AgNPs) and 20 nm spherical gold nanoparticles (AuNPs) on the luminescence of europium complex Eu(TTFA)3 were studied. When 350 nm is chosen as the incident light, the maximum enhancement factor of the...
Yun Zhang et al.
Natural product reports, 31(4), 489-503 (2014-01-31)
Novel organic reactions drive the advance of chemical synthesis in the same way that enabling technologies drive new scientific discoveries. One area of organic methodology that has undergone significant growth during the last decade is that of homogeneous gold-catalyzed transformations....
Amin Majdalawieh et al.
Journal of nanoscience and nanotechnology, 14(7), 4757-4780 (2014-04-25)
In the last decade, gold and silver nanomaterials have received considerable attention due to their attractive electronic and chemical properties and their potential applications in the development of new technologies. Recent advances in the study of various gold and silver...
Jiajing Zhang et al.
Journal of nanoscience and nanotechnology, 14(6), 4124-4138 (2014-04-18)
Gold nanostructures with promising applications in biomedical field have attracted great attention. However, some fundamental questions other than the development of novel applications should be elucidated before they can actually serve as biomedicines in the clinic. Bio-safety is one of...
Changwon Lee et al.
Journal of nanoscience and nanotechnology, 14(6), 4325-4330 (2014-04-18)
Amine and carboxylic groups rich gelatin was used as reducing and stabilizing agent to form highly stable gold nanoparticles for surface-enhanced Raman scattering (SERS) applications. The size of the particle was determined to be 13 nm by TEM with mono-dispersity....
Monic Shah et al.
Journal of nanoscience and nanotechnology, 14(1), 344-362 (2014-04-16)
This article reviews some of the recent biological applications of gold nanoparticles (GNPs) which have been discovered lately by individual studies all around the world. GNPs have emerged as a promising candidates for various biological applications due to their unique...
Amelie Heuer-Jungemann et al.
Nanoscale, 5(20), 9503-9510 (2013-08-29)
In the past decade gold nanoparticle-nucleic acid conjugates became progressively important for biomedical applications. Fluorophores attached to nucleic acid-gold nanoparticle conjugates have opened up a new era of biological sensing. The most promising advancement in this field was the invention...
Priyatha Premnath et al.
Journal of biomedical nanotechnology, 10(6), 1061-1067 (2014-04-23)
Hybrid biomaterials are a combination of two or more different materials that work synergistically to produce superior properties. Nano structuring of such hybrid materials has also posed complications. In this study, we present, for the first time a nanofibrous hybrid...
Stacey N Barnaby et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(27), 9739-9744 (2014-06-21)
Small interfering RNA (siRNA) is a powerful and highly effective method to regulate gene expression in vitro and in vivo. However, the susceptibility to serum nuclease-catalyzed degradation is a major challenge and it remains unclear whether the strategies developed to...
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