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Robert J Salmond et al.
Journal of immunology (Baltimore, Md. : 1950), 195(10), 4615-4622 (2015-10-11)
Ag-dependent activation of naive T cells induces dramatic changes in cellular metabolism that are essential for cell growth, division, and differentiation. In recent years, the serine/threonine kinase mechanistic target of rapamycin (mTOR) has emerged as a key integrator of signaling
Judith R Kelsen et al.
Gastroenterology, 149(6), 1415-1424 (2015-07-21)
Very early onset inflammatory bowel disease (VEO-IBD), IBD diagnosed at 5 years of age or younger, frequently presents with a different and more severe phenotype than older-onset IBD. We investigated whether patients with VEO-IBD carry rare or novel variants in
Shihong Zhang et al.
Journal of virology, 89(16), 8304-8317 (2015-06-05)
T cell responses play a critical role in controlling or clearing viruses. Therefore, strategies to prevent or treat infections include boosting T cell responses. T cells specific for various pathogens have been reported in unexposed individuals and an influence of
N-glycan engineering of a plant-produced anti-CD20-hIL-2 immunocytokine significantly enhances its effector functions
Marusic C, et al,
Biotechnology and Bioengineering, 115(3), 565-576 (2018)
Peter D Kurktschiev et al.
The Journal of experimental medicine, 211(10), 2047-2059 (2014-09-17)
The transcription factor T-bet regulates the production of interferon-γ and cytotoxic molecules in effector CD8 T cells, and its expression correlates with improved control of chronic viral infections. However, the role of T-bet in infections with differential outcome remains poorly
Katharina Kreymborg et al.
Cancer immunology research, 3(8), 849-854 (2015-07-01)
The costimulatory molecules B7-H3 and B7-H4 are overexpressed in a variety of human tumors and have been hypothesized as possible biomarkers and immunotherapeutic targets. Despite this potential, the predominating uncertainty about their functional implication in tumor-host interaction hampers their evaluation
Elisabetta Volpe et al.
The Journal of allergy and clinical immunology, 134(2), 373-381 (2014-06-10)
Thymic stromal lymphopoietin (TSLP) is a major proallergic cytokine that promotes TH2 responses through dendritic cell (DC) activation. Whether it also plays a role in human autoimmune inflammation and associated pathways is not known. In this study we investigated the
Dandan Wang et al.
Arthritis & rheumatology (Hoboken, N.J.), 66(8), 2234-2245 (2014-04-24)
Allogeneic mesenchymal stem cells (MSCs) exhibit therapeutic effects in human autoimmune diseases such as systemic lupus erythematosus (SLE), but the underlying mechanisms remain largely unknown. The aim of this study was to investigate how allogeneic MSCs mediate immunosuppression in lupus
Natalia Sumption et al.
PloS one, 10(8), e0134046-e0134046 (2015-08-08)
Human exposure to high-linear energy transfer α-particles includes environmental (e.g. radon gas and its decay progeny), medical (e.g. radiopharmaceuticals) and occupational (nuclear industry) sources. The associated health risks of α-particle exposure for lung cancer are well documented however the risk
Michael L Freeman et al.
Journal of virology, 88(14), 7862-7869 (2014-05-03)
CD8 and CD4 T cells are each critically important for immune control of murine gammaherpesvirus 68 (γHV68) infection. In immunocompetent mice, acute γHV68 infection results in lifelong latency, but in the absence of CD4 T cell help, mice succumb to
Mariana Borsa et al.
Virology journal, 12, 77-77 (2015-05-16)
The unfolded protein response (UPR) is one of the pathways triggered to ensure quality control of the proteins assembled in the endoplasmic reticulum (ER) when cell homeostasis is compromised. This mechanism is primarily composed of three transmembrane proteins serving as
Ambra Sarracino et al.
mBio, 9(6) (2018-11-15)
Posttranscriptional regulation of HIV-1 replication is finely controlled by viral and host factors. Among the former, Rev controls the export of partially spliced and unspliced viral RNAs from the nucleus and their translation in the cytoplasm or incorporation into new
Yan Shen et al.
Annals of hematology, 93(12), 2019-2028 (2014-07-18)
Cytokine-induced killer (CIK) cells, one of the feasible and effective methods of adoptive immunotherapy, have shown anti-leukemia activity in vivo and in vitro. But the strategy exhibits limited cytotoxic activity in clinical studies. In this study, CIK cells were transfected
Daniela Wojta-Stremayr et al.
PloS one, 10(5), e0126034-e0126034 (2015-05-07)
A variety of adjuvants fostering humoral immunity are known as of today. However, there is a lack of adjuvants or adjuvant strategies, which directly target T cellular effector functions and memory. We here determined whether systemically toxic cytokines such as
Diana Seidel et al.
Cancer immunology, immunotherapy : CII, 64(5), 621-634 (2015-02-26)
The disialoganglioside GD2 is a well-established target antigen for passive immunotherapy in neuroblastoma (NB). Despite the recent success of passive immunotherapy with the anti-GD2 antibody ch14.18 and cytokines, treatment of high-risk NB remains challenging. We expanded the approach of GD2-specific
Larisa Pereboeva et al.
Cancer immunology, immunotherapy : CII, 64(5), 551-562 (2015-02-14)
The standard treatment of high-grade glioma presents a combination of radiotherapy, chemotherapy and surgery. Immunotherapy is proposed as a potential adjunct to standard cytotoxic regimens to target remaining microscopic disease following resection. We have shown ex vivo expanded/activated γδ T
Riki Okita et al.
Oncology reports, 34(6), 2864-2870 (2015-10-28)
EGFR/HER2 are frequently expressed in MPM tissues, however, no studies have shown the clinical benefit of using EGFR/HER2-targeting drugs in patients with malignant pleural mesothelioma (MPM). It was reported that the tyrosine kinase inhibitor (TKI) lapatinib enhanced trastuzumab-mediated antibody-dependent cellular
Sol A Ban et al.
Journal of clinical immunology, 34(8), 941-953 (2014-09-11)
Idiopathic CD4 lymphopenia constitutes a heterogeneous group of immunodeficiencies with characteristically low CD4+ T-cell counts with largely unknown genetic etiology. We here sought to determine the underlying molecular cause in an index family with two patients suffering from combined immunodeficiency
Rosa Molfetta et al.
European journal of immunology, 44(9), 2761-2770 (2014-05-23)
The NKG2D activating receptor on human NK cells mediates "altered self" recognition, as its ligands (NKG2DLs) are upregulated on target cells in a variety of stress conditions. Evidence collected in the past years shows that, even though expression of NKG2DLs
Interleukin 2, 37-37 (2012)
Sandra A Jacobs et al.
Cell transplantation, 23(9), 1099-1110 (2013-04-09)
Human multipotent adult progenitor cells (hMAPCs) are isolated from bone marrow with a more extensive expansion capacity compared to human mesenchymal stem cells (hMSCs) and with the ability to differentiate into endothelium. Like hMSCs, hMAPCs inhibit T-cell proliferation induced by
Carla Marusic et al.
Plant biotechnology journal, 14(1), 240-251 (2015-04-17)
Anti-CD20 murine or chimeric antibodies (Abs) have been used to treat non-Hodgkin lymphomas (NHLs) and other diseases characterized by overactive or dysfunctional B cells. Anti-CD20 Abs demonstrated to be effective in inducing regression of B-cell lymphomas, although in many cases
Sandra García-Gallego et al.
European journal of medicinal chemistry, 98, 139-148 (2015-05-26)
The development of novel strategies to prevent HIV-1 infection is of outstanding relevance. Metal complexes of Cu(2+), Ni(2+), Co(2+) and Zn(2+) derived from sulfonated and carboxylated poly(propylene imine) dendrimers with ethylenediamine core were evaluated as tunable antiviral agents against HIV-1.
Masateru Hiyoshi et al.
Retrovirology, 12, 73-73 (2015-08-21)
Adult T-cell leukemia (ATL) is caused by human T-cell leukemia virus type 1 (HTLV-1) infection. However, there are no therapies to prevent ATL development in high-risk asymptomatic carriers. To develop a therapy targeting HTLV-1-infected cells that are known to express
Association of Interleukin-2-330T/G and Interleukin-10-1082A/G Genetic Polymorphisms with B-Cell Non-Hodgkin Lymphoma in a Cohort of Egyptians
Rahman HAA, et al.
Turkish journal of haematology : official journal of Turkish Society of Haematology, 35(2), 99-99 (2018)
J Pega et al.
Journal of virology, 89(18), 9581-9590 (2015-07-15)
Foot-and-mouth disease (FMD) is a highly contagious viral disease affecting biungulate species. Commercial vaccines, formulated with inactivated FMD virus (FMDV), are regularly used worldwide to control the disease. Here, we studied the generation of antibody responses in local lymphoid tissues
Karolina Malecek et al.
Journal of immunology (Baltimore, Md. : 1950), 193(5), 2587-2599 (2014-07-30)
Adoptive immunotherapy with Ag-specific T lymphocytes is a powerful strategy for cancer treatment. However, most tumor Ags are nonreactive "self" proteins, which presents an immunotherapy design challenge. Recent studies have shown that tumor-specific TCRs can be transduced into normal PBLs
Ludovic Desvignes et al.
The Journal of clinical investigation, 125(6), 2347-2362 (2015-05-06)
Chronic infections induce a complex immune response that controls pathogen replication, but also causes pathology due to sustained inflammation. Ca2+ influx mediates T cell function and immunity to infection, and patients with inherited mutations in the gene encoding the Ca2+
Association of- 330 interleukin-2 gene polymorphism with oral cancer
Singh PK, et al.
The Indian Journal of Medical Research, 146(6), 730-730 (2017)
Laura Geffner et al.
PloS one, 9(5), e97837-e97837 (2014-05-20)
In human tuberculosis (TB), CD8+ T cells contribute to host defense by the release of Th1 cytokines and the direct killing of Mycobacterium tuberculosis (Mtb)-infected macrophages via granule exocytosis pathway or the engagement of receptors on target cells. Previously we
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