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Kun Wang et al.
Biochemical pharmacology, 75(11), 2204-2213 (2008-04-11)
A panel of retinoids and carotenoids was screened as potential inducers of CYP3A4 through the RXR/VDR-mediated signaling pathway. Transient transfection assays revealed that 3 out of 12 retinoids screened transactivated RXRalpha/VDR and induced CYP3A4 reporter activity. These three retinoids are
Dimitrios Iliopoulos et al.
Science signaling, 2(92), ra62-ra62 (2009-10-15)
Although Akt is known to play a role in human cancer, the relative contribution of its three isoforms to oncogenesis remains to be determined. We expressed each isoform individually in an Akt1(-/-)/Akt2(-/-)/Akt3(-/-) cell line. MicroRNA profiling of growth factor-stimulated cells
Marcia V Fournier et al.
Cancer research, 69(10), 4545-4552 (2009-05-07)
Phosphatase and tensin homologue deleted on chromosome 10 (PTEN) is a dual-function phosphatase with tumor suppressor function compromised in a wide spectrum of cancers. Because tissue polarity and architecture are crucial modulators of normal and malignant behavior, we postulated that
Valerie L R M Verstraeten et al.
Histochemistry and cell biology, 135(3), 251-261 (2011-02-26)
A thorough understanding of fat cell biology is necessary to counter the epidemic of obesity. Although molecular pathways governing adipogenesis are well delineated, the structure of the nuclear lamina and nuclear-cytoskeleton junction in this process are not. The identification of
Muslima Chowdhury et al.
Proceedings of the National Academy of Sciences of the United States of America, 105(41), 15872-15877 (2008-10-07)
Ig class switch recombination (CSR) is initiated by activation-induced cytidine deaminase (AID) mediated deamination of the switch (S) regions; the resultant mismatch is processed to yield the DNA breaks required for recombination. Whereas many of the pathways involved in the
Anna Dubrovska et al.
Proceedings of the National Academy of Sciences of the United States of America, 106(1), 268-273 (2009-01-01)
Characterization of the molecular pathways that are required for the viability and maintenance of self-renewing tumor-initiating cells may ultimately lead to improved therapies for cancer. In this study, we show that a CD133(+)/CD44(+) population of cells enriched in prostate cancer
Per Magnus Haram et al.
Cardiovascular research, 81(4), 723-732 (2008-12-03)
The recent development of a rat model that closely resembles the metabolic syndrome allows to study the mechanisms of amelioration of the syndrome by exercise training. Here, we compared the effectiveness for reducing cardiovascular risk factors by exercise training programmes
Delong Meng et al.
The Journal of biological chemistry, 295(10), 2890-2899 (2020-02-06)
Nutrient sensing by cells is crucial, and when this sensing mechanism is disturbed, human disease can occur. mTOR complex 1 (mTORC1) senses amino acids to control cell growth, metabolism, and autophagy. Leucine, arginine, and methionine signal to mTORC1 through the
Aya Kobayashi et al.
The Journal of experimental medicine, 208(13), 2641-2655 (2011-11-30)
Metastatic disease is the major cause of cancer deaths, and recurrent tumors at distant organs are a critical issue. However, how metastatic tumor cells become dormant and how and why tumors recur in target organs are not well understood. In
Teresa F Pais et al.
Journal of neuroinflammation, 5, 43-43 (2008-10-11)
Microglia are macrophage-like cells that constantly sense the microenvironment within the central nervous system (CNS). In the event of neuronal stress or injury, microglial cells rapidly react and change their phenotype. This response may lead to a deleterious type of
Sandeep Dayal et al.
PloS one, 6(9), e24571-e24571 (2011-09-29)
Antibodies are assembled by a highly orchestrated series of recombination events during B cell development. One of these events, class switch recombination, is required to produce the IgG, IgE and IgA antibody isotypes characteristic of a secondary immune response. The
Jana Cinova et al.
PloS one, 6(1), e16169-e16169 (2011-01-21)
Celiac disease (CD) is a chronic inflammatory disorder of the small intestine that is induced by dietary wheat gluten proteins (gliadins) in genetically predisposed individuals. The overgrowth of potentially pathogenic bacteria and infections has been suggested to contribute to CD
D E Johns et al.
Journal of dental research, 87(6), 548-552 (2008-05-27)
Tissue-engineering of the temporomandibular joint (TMJ) disc aims to provide patients with TMJ disorders an option to replace diseased tissue with autologous, functional tissue. This study examined clinically relevant cell sources by comparing costal chondrocytes, dermal fibroblasts, a mixture of
Fábio S Lira et al.
Lipids in health and disease, 10, 37-37 (2011-03-01)
It is well known that high fat diets (HFDs) induce obesity and an increase in proinflammatory adipokines. Interleukin-6 (IL-6) is considered the major inflammatory mediator in obesity. Obesity is associated with a vitamin deficiency, especially of vitamins E and D3.
Shanmugam Sivabalan et al.
International archives of medicine, 1(1), 7-7 (2008-05-27)
The role of cortisol and its increased action/availability is implicated in the pathogenesis of insulin resistance associated with obesity and metabolic syndrome but the mechanism of increased action/availability is not known. Availability of several other lipophilic hormones, drugs and pollutants
Jun Zhang et al.
EMBO reports, 21(9), e49898-e49898 (2020-07-11)
Nutrient sensing by the mTOR complex 1 (mTORC1) requires its translocation to the lysosomal membrane. Upon amino acids removal, mTORC1 becomes cytosolic and inactive, yet its precise subcellular localization and the mechanism of inhibition remain elusive. Here, we identified Aster-C
Luce Perie et al.
Journal of lipid research, 62, 100102-100102 (2021-08-14)
Forkhead box transcription factors have been shown to be involved in various developmental and differentiation processes. In particular, members of the FoxP family have been previously characterized in depth for their participation in the regulation of lung and neuronal cell
Ming Wu et al.
PloS one, 4(12), e8040-e8040 (2009-12-04)
A major challenge in systems biology is to develop a detailed dynamic understanding of the functions and behaviors in a particular cellular system, which depends on the elements and their inter-relationships in a specific network. Computational modeling plays an integral
Insulin mutations impair beta-cell development in a patient-derived iPSC model of neonatal diabetes
Balboa D, et al.
eLife, 7, e38519-e38519 (2018)
Huili Li et al.
Molecular cancer, 10, 100-100 (2011-08-23)
The transcription factor, CCAAT enhancer binding protein-β (C/EBPβ), is expressed as several distinct protein isoforms (LAP1, LAP2 and LIP) that have opposing actions in cellular proliferation and differentiation. Increases in the ratio of LIP/LAP are associated with aggressive, metastatic breast
Chen Yanting et al.
Journal of dairy science, 101(2), 1601-1615 (2017-11-21)
Differentiation and lipid metabolism of adipocytes have a great influence on milk performance, health, and feed efficiency of dairy cows. The effects of dietary long-chain fatty acids (FA) on adipogenesis and lipogenesis of dairy cows are often confounded by other
Dose-and type-dependent effects of long-chain fatty acids on adipogenesis and lipogenesis of bovine adipocytes
Yanting C, et al.
Journal of Dairy Science, 101(2), 1601-1615 (2018)
Manuel Sanchez-Alavez et al.
Diabetes, 59(1), 43-50 (2009-10-23)
Temperature and nutrient homeostasis are two interdependent components of energy balance regulated by distinct sets of hypothalamic neurons. The objective is to examine the role of the metabolic signal insulin in the control of core body temperature (CBT). The effect
Pascal P H Hommelberg et al.
Cellular and molecular life sciences : CMLS, 68(7), 1215-1225 (2010-09-08)
Palmitate activates the NF-κB pathway, and induces accumulation of lipid metabolites and insulin resistance in skeletal muscle cells. Little information is available whether and how these processes are causally related. Therefore, the objectives were to investigate whether intra-cellular lipid metabolites
Youngjoo Kwon et al.
PloS one, 6(4), e18872-e18872 (2011-04-29)
Epithelial ovarian cancer is an aggressive and deadly disease and understanding its invasion mechanisms is critical for its treatment. We sought to study the penetration/invasion of ovarian tumor cells into extracellular matrices (ECMs) using a fibroblast-derived three-dimensional (3D) culture model
Jason Aoto et al.
Neuron, 60(2), 308-320 (2008-10-30)
Normal brain function requires that the overall synaptic activity in neural circuits be kept constant. Long-term alterations of neural activity lead to homeostatic regulation of synaptic strength by a process known as synaptic scaling. The molecular mechanisms underlying synaptic scaling
Deon G Uffort et al.
The Journal of investigative dermatology, 129(1), 148-154 (2008-08-01)
Tumor expression of inducible nitric oxide synthase (iNOS) predicts poor outcomes for melanoma patients. We have reported the regulation of melanoma iNOS by the mitogen-activated protein kinase (MAPK) pathway. In this study, we test the hypothesis that NF-kappaB mediates this
Milessa Silva Afonso et al.
Arteriosclerosis, thrombosis, and vascular biology, 41(4), 1360-1373 (2021-03-05)
[Figure: see text].
Z Chen et al.
British journal of pharmacology, 158(2), 486-493 (2009-07-01)
Dopamine inhibits renal cell Na(+),K(+)-ATPase activity and cell sodium transport by promoting the internalization of active molecules from the plasma membrane, whereas angiotensin II (ATII) stimulates its activity by recruiting new molecules to the plasma membrane. They achieve such effects
Long-jiang Shao et al.
Cancer research, 68(13), 5143-5151 (2008-07-03)
Maspin is a key tumor suppressor gene in prostate and breast cancers with diverse biological functions. However, how maspin regulates prostate tumor progression is not fully understood. In this study, we have used maspin heterozygous knockout mice to determine the
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