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Juliane C Campos et al.
Autophagy, 13(8), 1304-1317 (2017-06-10)
We previously reported that facilitating the clearance of damaged mitochondria through macroautophagy/autophagy protects against acute myocardial infarction. Here we characterize the impact of exercise, a safe strategy against cardiovascular disease, on cardiac autophagy and its contribution to mitochondrial quality control
Human longevity and 11p15. 5: a study in 1321 centenarians
Lescai F, et al.
European Journal of Human Genetics, 17(11), 1515-1515 (2009)
Expression of glucocorticoid receptor alpha and its regulation in the bovine endometrium: Possible role in cyclic prostaglandin F2alpha production
Kuse M, et al.
Journal of Reproduction and Development, 59(4), 346-352 (2013)
Loyal A Goff et al.
Experimental hematology, 36(10), 1354-1369 (2008-07-29)
Human multipotent mesenchymal stromal cells (MSC) have the potential to differentiate into multiple cell types, although little is known about factors that control their fate. Differentiation-specific microRNAs may play a key role in stem cell self-renewal and differentiation. We propose
L De Matteis et al.
Journal of animal physiology and animal nutrition, 101(3), 511-520 (2016-04-16)
The link between energy availability, turnover of energy substrates and the onset of inflammation in dairy cows is complex and poorly investigated. To clarify this, plasma inflammatory variables were measured in mid-lactating dairy cows allocated to three groups: hyperinsulinemic hypoglycaemic
Qian-Ru Zhao et al.
Journal of neurochemistry, 147(1), 40-57 (2018-06-20)
Neuritin is a neurotrophic factor that is activated by neural activity and neurotrophins. Its major function is to promote neurite growth and branching; however, the underlying mechanisms are not fully understood. To address this issue, this study investigated the effects
Lianchun Fan et al.
Stem cells and development, 17(3), 585-597 (2008-06-26)
Although embryonic germ (EG) cell-mediated gene transfer has been successful in the mouse for more than a decade, this approach is limited in other species due to the difficulty of isolating the small numbers of progenitors of germ cell lineage
Dominik Brokatzky et al.
The EMBO journal, 38(11) (2019-04-14)
Apoptosis is a frequent form of programmed cell death, but the apoptotic signaling pathway can also be engaged at a low level, in the absence of cell death. We here report that such sub-lethal engagement of mitochondrial apoptosis signaling causes
Metabolic endotoxemia initiates obesity and insulin resistance.
Cani P D, et al.
Diabetes, 56(7), 1761-1772 (2007)
M C M B Vernay et al.
Journal of dairy science, 95(5), 2540-2549 (2012-05-01)
The metabolic load during periods of high milk production in dairy cows causes a variety of changes of metabolite blood concentrations including dramatically decreased glucose levels. These changes supposedly impair the immune system. The goal of this study was, therefore
Tamara Soto et al.
Experimental eye research, 202, 108342-108342 (2020-11-05)
B-N-methylamino-L-alanine (BMAA), a cyanotoxin produced by most cyanobacteria, has been proposed to cause long term damages leading to neurodegenerative diseases, including Amyotrophic Lateral Sclerosis/Parkinsonism Dementia complex (ALS/PDC) and retinal pathologies. Previous work has shown diverse mechanisms leading to BMAA-induced degeneration;
Minnie Rangarajan et al.
Journal of bacteriology, 190(8), 2920-2932 (2008-02-12)
We previously described a cell surface anionic polysaccharide (APS) in Porphyromonas gingivalis that is required for cell integrity and serum resistance. APS is a phosphorylated branched mannan that shares a common epitope with posttranslational additions to some of the Arg-gingipains.
Yuki Yamamoto et al.
Reproduction, fertility, and development, 28(6), 673-681 (2014-11-06)
Endothelin (EDN) is a possible regulating factor of oviductal motility, which is important for the transport of gametes and embryo. To clarify the factors that control the secretion of EDN in the bovine oviduct, the expression of EDNs, EDN-converting enzymes
Expression of VEGF and its receptors in the bovine endometrium throughout the estrous cycle: effects of VEGF on prostaglandin production in endometrial cells
Tasak Y, et al.
Journal of Reproduction and Development, 56(2), 223-229 (2010)
Akihiro Naito et al.
Cancer science, 99(8), 1584-1588 (2008-08-30)
The growth of LNCaP, a human prostate adenocarcinoma cell line, and MCF-7, a human breast adenocarcinoma cell line, is initially hormone dependent. We previously demonstrated that LNrho0-8 and MCFrho0, derived from LNCaP and MCF-7 by depleting mitochondrial DNA (mtDNA), exhibited
Lianguo Kang et al.
Oncology reports, 21(1), 185-192 (2008-12-17)
The isothiocyanates (ITCs) have long been known to possess chemopreventive activities for a variety of neoplasms including breast cancer, but the molecular mechanism by which ITCs prevent breast cancer development has not been established. In this study, we investigated the
Sarfraz Ahmad et al.
Molecular therapy : the journal of the American Society of Gene Therapy, 17(6), 1101-1108 (2009-04-02)
Prostate stem cell antigen (PSCA) is a cell surface antigen expressed in normal human prostate and over expressed in prostate cancer. Elevated levels of PSCA protein in prostate cancer correlate with increased tumor stage/grade, with androgen independence and have higher
Ian S Zagon et al.
Archives of ophthalmology (Chicago, Ill. : 1960), 127(11), 1468-1473 (2009-11-11)
To determine if topical application of naltrexone hydrochloride (NTX), an opioid antagonist, restores tear production and corneal sensation in rats with diabetes mellitus. Type 1 diabetes was induced with streptozotocin in rats. Tear production was measured by the Schirmer test
J J Gross et al.
Journal of animal science, 93(7), 3395-3401 (2015-10-07)
Cortisol in dairy cows is released in an episodic manner underlying a circadian rhythm. The involvement of cortisol in numerous adaptive processes to cope with adverse conditions such as pain and inflammation is well characterized. Recent studies described contradictory effects
Effects of nutritional programing on growth and metabolism caused by albumen removal in an avian model
Willems E, et al.
The Journal of Endocrinology, 225(2), 89-100 (2015)
Angel Gu et al.
Experimental cell research, 315(10), 1668-1682 (2009-03-17)
CEACAM1 (carcinoembryonic antigen-related cell adhesion molecule 1), a type I transmembrane glycoprotein involved in cell-cell adhesion has been shown to act as an angiogenic factor for mouse and human endothelial cells. Based on the ability of CEACAM1 to initiate lumen
Jason C Dugas et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 28(33), 8294-8305 (2008-08-15)
One of the difficulties in studying cellular interactions in the CNS is the lack of effective methods to purify specific neuronal populations of interest. We report the development of a novel purification scheme, cholera toxin beta (CTB) immunopanning, in which
Jodhbir S Mehta et al.
Molecular vision, 14, 1277-1281 (2008-07-12)
To analyze for the presence of lipids in conjunctival fibroblasts of a patient with Schnyder corneal dystrophy (SCD). A proband with SCD was identified, and the pedigree was examined. The proband underwent an automated lamellar therapeutic keratoplasty (ALTK). At the
Huili Li et al.
Molecular cancer, 10, 100-100 (2011-08-23)
The transcription factor, CCAAT enhancer binding protein-β (C/EBPβ), is expressed as several distinct protein isoforms (LAP1, LAP2 and LIP) that have opposing actions in cellular proliferation and differentiation. Increases in the ratio of LIP/LAP are associated with aggressive, metastatic breast
The molecular mechanism of insulin action.
Kahn C R
Annual Review of Medicine, 36(1), 429-451 (1985)
Stephanie Dille et al.
PloS one, 9(7), e103220-e103220 (2014-07-30)
Chlamydia grows inside a cytosolic vacuole (the inclusion) that is supplied with nutrients by the host through vesicular and non-vesicular transport. It is unclear in many respects how Chlamydia organizes this transport. One model posits that the Chlamydia-induced fragmentation of
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