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Keiko Danzaki et al.
European journal of immunology, 46(11), 2669-2678 (2016-11-05)
Osteopontin (OPN) is a protein, generally considered to play a pro-tumorigenic role, whereas several reports have demonstrated the anti-tumorigenic function of OPN during tumor development. These opposing anti- and pro-tumorigenic functions are not fully understood. Here, we report that host-derived
Natalie A Dye et al.
Development (Cambridge, England), 144(23), 4406-4421 (2017-10-19)
Quantitative analysis of the dynamic cellular mechanisms shaping the
Yurui Duan et al.
The Journal of biological chemistry, 295(37), 12868-12884 (2020-06-26)
Diabetic nephropathy (DN) is a complication of diabetes that is increasing in prevalence in China. Extracellular vesicles (EVs) carrying microRNAs (miRs) may represent a useful tool in the development of therapies for DN. Here, we report that EVs released by
Hyo-Geun Lee et al.
Marine drugs, 19(2) (2021-02-12)
Sargassum horneri (S. horneri) is a well-known brown seaweed widely distributed worldwide. Several biological activities of S. horneri have been reported. However, its effects on lipid metabolism and the underlying mechanisms remain elusive. In the present study, we examined the
Ling Ren et al.
Genes, 11(6) (2020-06-04)
Intramuscular fat (IMF) is one of the major factors determining beef quality. IMF formation is influenced by multiple conditions including genetic background, age and nutrition. In our previous investigation, bta-miR-210 was found to be increased during adipogenesis using miRNA-seq. In
E Sjögren et al.
European journal of pain (London, England), 22(5), 889-903 (2018-01-30)
The transient receptor potential vanilloid receptor 1 (TRPV1) is a nonselective cation channel involved in the mediation of peripheral pain to the central nervous system. As such, the TRPV1 is an accessible molecular target that lends itself well to the
A J C Dennison et al.
Soft matter, 12(3), 824-829 (2015-11-06)
The carefully controlled permeability of cellular membranes to biological molecules is key to life. In degenerative diseases associated with protein misfolding and aggregation, protein molecules or their aggregates are believed to permeate these barriers and threaten membrane integrity. We used
Alessandro Carrer et al.
Cancer discovery, 9(3), 416-435 (2019-01-11)
Pancreatic ductal adenocarcinoma (PDA) has a poor prognosis, and new strategies for prevention and treatment are urgently needed. We previously reported that histone H4 acetylation is elevated in pancreatic acinar cells harboring Kras mutations prior to the appearance of premalignant
M L Alves da Silva et al.
Journal of tissue engineering and regenerative medicine, 9(6), 714-723 (2013-10-25)
Paracrine signalling from chondrocytes has been reported to increase the synthesis and expression of cartilage extracellular matrix (ECM) by stem cells. The use of conditioned medium obtained from chondrocytes for stimulating stem cells chondrogenic differentiation may be a very interesting
Payam Vahmani et al.
Lipids, 51(11), 1231-1239 (2016-10-25)
During ruminal biohydrogenation of α-linolenic acid, a non-conjugated non-methylene interrupted dienoic acid is formed containing a t10 double bond, namely t10,c15-18:2. The present study was designed to examine whether t10,c15-18:2 would exert similar anti-adipogenic effects compared to t10,c12-18:2 in 3T3-L1
Guihua Du et al.
Development (Cambridge, England), 147(8) (2020-03-20)
Continual spermatogenesis relies on the actions of an undifferentiated spermatogonial population that is composed of stem cells and progenitors. Here, using mouse models, we explored the role of RNA-binding proteins (RBPs) in regulation of the biological activities of this population.
Yosuke Watanabe et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34(4), 5827-5837 (2020-03-07)
Reactive oxygen species (ROS) increase during adipogenesis and in obesity. Oxidants react with cysteine residues of proteins to form glutathione (GSH) adducts, S-glutathionylation, that are selectively removed by glutaredoxin-1 (Glrx). We have previously reported that Glrx knockout mice had increased
Sophie Dekoninck et al.
Cell, 181(3), 604-620 (2020-04-08)
During embryonic and postnatal development, organs and tissues grow steadily to achieve their final size at the end of puberty. However, little is known about the cellular dynamics that mediate postnatal growth. By combining in vivo clonal lineage tracing, proliferation kinetics
Lianchun Fan et al.
Stem cells and development, 17(3), 585-597 (2008-06-26)
Although embryonic germ (EG) cell-mediated gene transfer has been successful in the mouse for more than a decade, this approach is limited in other species due to the difficulty of isolating the small numbers of progenitors of germ cell lineage
Jiani Wang et al.
PloS one, 15(4), e0231796-e0231796 (2020-04-15)
Antimicrobial peptide expression is associated with disease activity in inflammatory bowel disease (IBD) patients. IBD patients have abnormal expression of elafin, a human elastase-specific protease inhibitor and antimicrobial peptide. We determined elafin expression in blood, intestine, and mesenteric fat of
Yusuke Ogihara et al.
Scientific reports, 7, 40047-40047 (2017-01-07)
The facile synthesis of ZnS-AgInS
Abeer Dagra et al.
NPJ Parkinson's disease, 7(1), 76-76 (2021-08-20)
Pathophysiological damages and loss of function of dopamine neurons precede their demise and contribute to the early phases of Parkinson's disease. The presence of aberrant intracellular pathological inclusions of the protein α-synuclein within ventral midbrain dopaminergic neurons is one of
Dan Huang et al.
Molecular cell, 79(6), 934-949 (2020-08-22)
Although ADP-ribosylation of histones by PARP-1 has been linked to genotoxic stress responses, its role in physiological processes and gene expression has remained elusive. We found that NAD+-dependent ADP-ribosylation of histone H2B-Glu35 by small nucleolar RNA (snoRNA)-activated PARP-1 inhibits AMP
Dharsan K Soundarrajan et al.
PLoS computational biology, 17(11), e1009543-e1009543 (2021-11-02)
Information flow within and between cells depends significantly on calcium (Ca2+) signaling dynamics. However, the biophysical mechanisms that govern emergent patterns of Ca2+ signaling dynamics at the organ level remain elusive. Recent experimental studies in developing Drosophila wing imaginal discs
Aidan B Grosas et al.
Journal of molecular biology, 432(20), 5593-5613 (2020-08-23)
One of the most crowded biological environments is the eye lens which contains a high concentration of crystallin proteins. The molecular chaperones αB-crystallin (αBc) with its lens partner αA-crystallin (αAc) prevent deleterious crystallin aggregation and cataract formation. However, some forms
Mi Yang et al.
Theriogenology, 148, 68-75 (2020-03-08)
Spermatogonial stem cells (SSCs) are defined as the tissue-specific stem cells in the testes that produce sperm and support life-long spermatogenesis. A culture microenvironment could convert mouse SSCs from unipotent to pluripotent states; however, the underlying mechanism is unclear. NANOG
Haopeng Xiao et al.
Cell, 180(5), 968-983 (2020-02-29)
Mammalian tissues engage in specialized physiology that is regulated through reversible modification of protein cysteine residues by reactive oxygen species (ROS). ROS regulate a myriad of biological processes, but the protein targets of ROS modification that drive tissue-specific physiology in vivo
Ci-Xiang Zhou et al.
Oncotarget, 7(2), 1288-1299 (2015-11-26)
MicroRNAs have been integrated into tumorigenic programs as either oncogenes or tumor suppressor genes. The miR-630 was reported to be deregulated and involved in tumor progression of several human malignancies. However, its expression regulation shows diversity in different kinds of
Loyal A Goff et al.
Experimental hematology, 36(10), 1354-1369 (2008-07-29)
Human multipotent mesenchymal stromal cells (MSC) have the potential to differentiate into multiple cell types, although little is known about factors that control their fate. Differentiation-specific microRNAs may play a key role in stem cell self-renewal and differentiation. We propose
Elie Baho et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 39(23), 4489-4510 (2019-04-03)
By virtue of their extensive axonal arborization and perisomatic synaptic targeting, cortical inhibitory parvalbumin (PV) cells strongly regulate principal cell output and plasticity and modulate experience-dependent refinement of cortical circuits during development. An interesting aspect of PV cell connectivity is
Takuya Hirose et al.
Stem cells (Dayton, Ohio), 39(8), 1091-1100 (2021-03-31)
Stem cell-based products have clinical and industrial applications. Thus, there is a need to develop quality control methods to standardize stem cell manufacturing. Here, we report a deep learning-based automated cell tracking (DeepACT) technology for noninvasive quality control and identification
Michael Cangkrama et al.
EMBO molecular medicine, 12(4), e11466-e11466 (2020-03-10)
Cancer-associated fibroblasts (CAFs) are key regulators of tumorigenesis and promising targets for next-generation therapies. We discovered that cancer cell-derived activin A reprograms fibroblasts into pro-tumorigenic CAFs. Mechanistically, this occurs via Smad2-mediated transcriptional regulation of the formin mDia2, which directly promotes
Alison L Kearney et al.
eLife, 10 (2021-07-14)
The phosphoinositide 3-kinase (PI3K)-Akt network is tightly controlled by feedback mechanisms that regulate signal flow and ensure signal fidelity. A rapid overshoot in insulin-stimulated recruitment of Akt to the plasma membrane has previously been reported, which is indicative of negative
Nadia B Hassounah et al.
Molecular cancer research : MCR, 15(10), 1421-1430 (2017-06-15)
Primary cilia are chemosensors that play a dual role to either activate or repress Hedgehog signaling, depending on presence or absence of ligand, respectively. While inhibition of ciliogenesis has been shown to be characteristic of breast cancers, the functional consequence
Felix Weis et al.
Nature communications, 9(1), 4420-4420 (2018-10-26)
Understanding the structural biology of the insulin receptor and how it signals is of key importance in the development of insulin analogs to treat diabetes. We report here a cryo-electron microscopy structure of a single insulin bound to a physiologically
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