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Yukako Yamamoto et al.
Neuropeptides, 51, 25-29 (2015-05-10)
The N-terminal glutamine residue, exposed by enzymatic cleavage of precursor proteins, is known to be modified to a pyroglutamyl residue with a cyclic structure in not only endogenous but also food-derived peptides. We investigated the effects of wheat-derived pyroglutamyl peptides
Núria Monfort et al.
Drug testing and analysis, 7(9), 819-830 (2015-03-03)
A fast screening method for the detection of more than 60 stimulants in urine was developed. The method consisted of a dilution of the urine (1:5 v/v) and analysis by ultra high performance liquid chromatography coupled to tandem mass spectrometry
Andrea Anesi et al.
BMC plant biology, 15, 191-191 (2015-08-08)
The definition of the terroir concept is one of the most debated issues in oenology and viticulture. The dynamic interaction among diverse factors including the environment, the grapevine plant and the imposed viticultural techniques means that the wine produced in
Esther See et al.
International journal of pharmaceutics, 473(1-2), 528-535 (2014-08-01)
To facilitate the development of a liposomal formulation for cancer therapy, the physicochemical properties of asulacrine (ASL), an anticancer drug candidate, were characterized. Nano-liposomes were prepared by thin-film hydration in conjugation with active drug loading using ammonium sulphate and post-insertion
Navneeta Bansal et al.
Clinica chimica acta; international journal of clinical chemistry, 436, 97-103 (2014-05-31)
To address the shortcomings of urine cytology and cystoscopy for screening and grading of urinary bladder cancer (BC) we applied a serum-based proteomics approach as a surrogate tactic for rapid BC probing. This study was performed on 90 sera samples
Hae-Won Lee et al.
Talanta, 132, 630-634 (2014-12-06)
The blooms of toxic phototrophic microorganisms, such as microalgae and cyanobacteria, which are typically found in freshwater and marine environments, are becoming more frequent and problematic in aquatic systems. Due to accumulation of toxic algae, harmful algal blooms (HABs) exert
Gustavo Jabor Gozzi et al.
Drug design, development and therapy, 9, 3481-3495 (2015-07-15)
Ketonic indeno[1,2-b]indole-9,10-dione derivatives, initially designed as human casein kinase II (CK2) inhibitors, were recently shown to be converted into efficient inhibitors of drug efflux by the breast cancer resistance protein ABCG2 upon suited substitutions including a N (5)-phenethyl on C-ring
Hyun-Kyung Na et al.
Toxicology letters, 232(2), 429-437 (2014-12-03)
Tobacco smoking is a well-known cause of various diseases, however, its toxic mechanisms for diseases are not completely understood, yet. Therefore, we performed biological monitoring to find tobacco smoking-responsive mechanisms including oxidative stress in Korean men (N=36). Whole genome microarray
Carina Bäcktorp et al.
Journal of pharmaceutical sciences, 104(4), 1409-1420 (2015-02-26)
We have developed a predictive method, based on quantum chemical calculations, that qualitatively predicts N-oxidation by hydrogen peroxides in drug structures. The method uses linear correlations of two complementary approaches to estimate the activation barrier without calculating it explicitly. This
Yaqian Zhang et al.
Journal of dairy science, 98(12), 8433-8444 (2015-10-28)
A simple and rapid multi-class multi-residue analytical method was developed for the screening and quantification of veterinary drugs in milk by ultra-performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry (UPLC-QTOF-MS). A total of 90 veterinary drugs investigated belonged to
Pradipbhai D Kalariya et al.
Journal of pharmaceutical and biomedical analysis, 102, 353-365 (2014-12-03)
The present study reports the degradation behavior of a new antidepressant drug, vilazodone, under various stress conditions as per International Conference on Harmonization guidelines (ICH, Q1A(R2). The investigation involved monitoring decomposition of the drug under hydrolytic (acidic, basic and neutral)
M Lupi et al.
Nanotechnology, 25(33), 335706-335706 (2014-07-31)
One of the major drawbacks that limits the clinical application of nanoparticles is the lack of preliminary investigations related to their biocompatibility, biodegradability and biodistribution. In this work, biodegradable PEGylated polymer nanoparticles (NPs) have been synthesized by using macromonomers based
Balakrishnan S Moorthy et al.
Molecular pharmaceutics, 11(6), 1869-1879 (2014-05-13)
Solid state amide hydrogen/deuterium exchange with mass spectrometric analysis (ssHDX-MS) was used to assess the conformation of myoglobin (Mb) in lyophilized formulations, and the results correlated with the extent of aggregation during storage. Mb was colyophilized with sucrose (1:1 or
Thomas G Hammond et al.
The Journal of pharmacology and experimental therapeutics, 350(2), 387-402 (2014-06-07)
Covalent protein modifications by electrophilic acyl glucuronide (AG) metabolites are hypothetical causes of hypersensitivity reactions associated with certain carboxylate drugs. The complex rearrangements and reactivities of drug AG have been defined in great detail, and protein adducts of carboxylate drugs
Zhigang Wang et al.
Journal of pharmaceutical and biomedical analysis, 107, 1-6 (2015-01-06)
The metabolism of gentiopicroside in vivo was studied by LC/MS following 2,4-dinitrophenylhydrazine derivatization for the first time. The ionization efficiency of the major metabolites erythrocentaurin and gentiopicral were greatly enhanced by the new analytical method developed, and they were successfully
Zohar Ben-Simhon et al.
PloS one, 10(11), e0142777-e0142777 (2015-11-19)
Color is an important determinant of pomegranate fruit quality and commercial value. To understand the genetic factors controlling color in pomegranate, chemical, molecular and genetic characterization of a "white" pomegranate was performed. This unique accession is lacking the typical pomegranate
Tomeu Viver et al.
Systematic and applied microbiology, 38(4), 266-275 (2015-03-11)
The culturable fraction of aerobic, heterotrophic and extremely halophilic microbiota retrieved from sediment and brine samples of eight sampling sites in the Mediterranean, Canary Islands and Chile was studied by means of a tandem approach combining large-scale cultivation, MALDI-TOF MS
Anna Hallmann et al.
Journal of pharmaceutical and biomedical analysis, 117, 311-315 (2015-09-26)
The aim of this study was to identify and quantify natural steroid hormones (17β-estradiol E2, estriol E3, estrone E1, testosterone T) and xenoestrogen (17α-ethinylestradiol EE2) in gills and gonads of Mytilus trossulus from the Gulf of Gdańsk, Poland, using the
Keith G Davies et al.
The Journal of experimental biology, 218(Pt 5), 778-785 (2015-01-27)
Ambient exposure to a short synthetic peptide has enhanced fecundity (number of offspring) in invertebrates and vertebrates, ostensibly by disinhibiting reproduction. In separate experiments, nematodes (Caenorhabditis elegans) and guppy fish (Poecilia reticulata) were exposed via their aqueous environment to a
Francesca Scebba et al.
Ecotoxicology and environmental safety, 123, 45-52 (2015-09-02)
Quantum dots (QDs), namely semiconductor nanocrystals, due to their particular optical and electronic properties, have growing applications in device technology, biotechnology and biomedical fields. Nevertheless, the possible threat to human health and the environment have attracted increasing attention as the
Christopher J Stewart et al.
Scientific reports, 5, 17141-17141 (2015-11-26)
The development of the preterm gut microbiome is important for immediate and longer-term health following birth. We aimed to determine if modifications to the preterm gut on the neonatal intensive care unit (NICU) impacted the gut microbiota and metabolome long-term.
So Jung An et al.
Vaccine, 33(13), 1614-1619 (2015-02-11)
The majority of conjugate vaccines focus on inducing an antibody response to the polysaccharide antigen and the carrier protein is present primarily to induce a T-cell dependent response. In this study conjugates consisting of poly(ribosylribitolphosphate) (PRP) purified from Haemophilus influenzae
Adam M Gonzalez et al.
Journal of sports science & medicine, 14(2), 322-332 (2015-05-20)
This study compared caffeine pharmacokinetics, glycerol concentrations, metabolic rate, and performance measures following ingestion of a time-release caffeine containing supplement (TR-CAF) versus a regular caffeine capsule (CAF) and a placebo (PL). Following a double-blind, placebo-controlled, randomized, cross-over design, ten males
Ioannis Kasioulis et al.
Molecular biology of the cell, 25(8), 1216-1233 (2014-02-21)
The lysine demethylase Kdm3a (Jhdm2a, Jmjd1a) is required for male fertility, sex determination, and metabolic homeostasis through its nuclear role in chromatin remodeling. Many histone-modifying enzymes have additional nonhistone substrates, as well as nonenzymatic functions, contributing to the full spectrum
Bulent Erol et al.
The Kaohsiung journal of medical sciences, 31(9), 454-462 (2015-09-13)
Ischemia-reperfusion injury can cause renal damage, and phosphodiesterase inhibitors are reported to regulate antioxidant activity. We investigated the prevention of renal damage using tadalafil after renal ischemia reperfusion (I/R) injury in rats. A total of 21 adult male Wistar albino
Weiwei Ye et al.
Journal of chromatographic science, 53(5), 716-724 (2014-09-23)
DB-6, with an IUPAC name of (Z)-5-(2,4-di-tert-butyl-6-((2,4-dioxothiazolidin-5-ylidene)methyl)phenyl)-5'-methyl-7,7'-dimethoxy-[4,4'-bibenzo[d][1,3]dioxole]-5,5'-dicarboxylate, is an investigational agent for acute liver failure. The focus of this study is the identification and characterization of major unknown impurities in DB-6 bulk drug samples. Four major impurities of DB-6 were
DeQing Cao et al.
Drug and chemical toxicology, 38(1), 44-49 (2014-03-22)
A Type II pyrethroid pesticide β-cypermethrin is widely used in agriculture and domestic applications for pest control. However, the effect of β-cypermethrin on the glutamate neurotransmitter has not been well-documented. In the current study, mice were treated with 20, 40
Hyunji Lee et al.
Applied microbiology and biotechnology, 99(22), 9473-9481 (2015-06-11)
The enzyme ferulic acid decarboxylase (FADase) from Enterobacter sp. Px6-4 catalyzes the decarboxylation reaction of lignin monomers and phenolic compounds such as p-coumaric acid, caffeic acid, and ferulic acid into their corresponding 4-vinyl derivatives, that is, 4-vinylphenol, 4-vinylcatechol, and 4-vinylguaiacol
Claudia Rasche et al.
Journal of chromatography. A, 1403, 21-31 (2015-06-06)
Some steps of the QuEChERS method for the analysis of pesticides with GC-MS/MS in cereals and dried fruits were improved or simplified. For the latter, a mixing vessel with stator-rotor-system proved to be advantageous. The extraction procedure of dried fruits
Yunzhe Ma et al.
Journal of pharmaceutical sciences, 103(11), 3621-3630 (2014-09-13)
This study demonstrates for the first time the ability to coat solid dispersions on microneedles as a means to deliver water-insoluble drugs through the skin. Polyethylene glycol (PEG) was selected as the hydrophilic matrix, and lidocaine base was selected as
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