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Nour Z Atwany et al.
Biology, 9(8) (2020-08-13)
Regulatory T cells (Tregs) are key players in the regulation of inflammatory responses. In this study, two natural molecules, namely, sparteine sulfate (SS) and harpagoside (Harp), were investigated for their ability to induce Tregs in human peripheral blood mononuclear cells...
Ariana Jacome et al.
Molecular therapy : the journal of the American Society of Gene Therapy, 17(6), 1083-1092 (2009-03-12)
Previous clinical trials based on the genetic correction of purified CD34(+) cells with gamma-retroviral vectors have demonstrated clinical efficacy in different monogenic diseases, including X-linked severe combined immunodeficiency, adenosine deaminase deficient severe combined immunodeficiency and chronic granulomatous disease. Similar protocols...
Mitomycin derivatives. 1. Preparation of mitosane and mitosene compounds and their biological activities.
S Kinoshita et al.
Journal of medicinal chemistry, 14(2), 103-109 (1971-02-01)
Tobias Dörr et al.
PLoS genetics, 5(12), e1000760-e1000760 (2009-12-17)
Bacteria can survive antibiotic treatment without acquiring heritable antibiotic resistance. We investigated persistence to the fluoroquinolone ciprofloxacin in Escherichia coli. Our data show that a majority of persisters to ciprofloxacin were formed upon exposure to the antibiotic, in a manner...
Dodanim Talavera-Adame et al.
Stem cell reviews, 7(3), 532-543 (2011-02-08)
Endothelial cells (ECs) represent the major component of the embryonic pancreatic niche and play a key role in the differentiation of insulin-producing β cells in vivo. However, it is unknown if ECs promote such differentiation in vitro. We investigated whether...
Kohji Yamakage et al.
Mutation research. Genetic toxicology and environmental mutagenesis, 770, 95-104 (2014-10-26)
The DNA-damaging and tumour-promoting effects of two 2-alkylcyclobutanones (2-ACBs), which are found in irradiated fat-containing foods, were investigated by use of the comet assay and in an azoxymethane (AOM)-induced colon-carcinogenesis study in rats, respectively. We conducted genotoxicity tests of 2-dodecylcyclobutanone...
Sham M Sondhi et al.
Bioorganic & medicinal chemistry letters, 20(7), 2306-2310 (2010-03-02)
Heterocyclic benzimidazole derivatives 3a-h, 5a-c and 7a-d have been synthesized by condensation of succinic acid (1) homophthalic acid (4) and 2,3-pyrazinedicarboxlic acid (6) with various substituted diamines under microwave irradiation in good yields. Structures assigned to 3a-h, 5a-c and 7a-d...
D Hompes et al.
Journal of surgical oncology, 109(6), 527-532 (2014-01-01)
Oxaliplatin and Mitomycin C (MMC) are both suitable as intraperitoneal chemotherapy agents in HIPEC for peritoneal carcinomatosis (PC) of colorectal cancer (CRC). Patient cohorts from two different HIPEC-centers underwent cytoreductive surgery and HIPEC with Oxaliplatin (39 patients) and MMC (56...
W S Johnson et al.
Bioorganic & medicinal chemistry, 3(6), 851-860 (1995-06-01)
The clinically used natural antitumor agent mitomycin C (MC) is known to alkylate DNA monofunctionally and bifunctionally, resulting in the cross-linking of DNA. These reactions occur selectively with guanines at the CpG sequence. We show, confirming a previous report (Millard...
Katalin Kiss et al.
PloS one, 10(5), e0128059-e0128059 (2015-05-27)
Diabetes mellitus is linked to pancreatic cancer. We hypothesized a role for pancreatic stellate cells (PSC) in the hyperglycemia induced deterioration of pancreatic cancer and therefore studied two human cell lines (RLT-PSC, T3M4) in hyperglycemic environment. The effect of chronic...
Lisa D Boxer et al.
Genes & development, 28(18), 2013-2026 (2014-09-18)
ZNF750 controls epithelial homeostasis by inhibiting progenitor genes while inducing differentiation genes, a role underscored by pathogenic ZNF750 mutations in cancer and psoriasis. How ZNF750 accomplishes these dual gene regulatory impacts is unknown. Here, we characterized ZNF750 as a transcription...
B Kocatürk et al.
Journal of thrombosis and haemostasis : JTH, 13(9), 1683-1693 (2015-07-17)
Procoagulant full-length tissue factor (flTF) and its minimally coagulant alternatively spliced isoform (asTF), promote breast cancer (BrCa) progression via different mechanisms. We previously showed that flTF and asTF are expressed by BrCa cells, resulting in autoregulation in a cancer milieu....
Catriona Donovan et al.
Nucleic acids research, 43(10), 5002-5016 (2015-04-29)
In host cells, viral replication is localized at specific subcellular sites. Viruses that infect eukaryotic and prokaryotic cells often use host-derived cytoskeletal structures, such as the actin skeleton, for intracellular positioning. Here, we describe that a prophage, CGP3, integrated into...
Marta Vergara-Irigaray et al.
Infection and immunity, 77(9), 3978-3991 (2009-07-08)
Staphylococcus aureus can establish chronic infections on implanted medical devices due to its capacity to form biofilms. Analysis of the factors that assemble cells into a biofilm has revealed the occurrence of strains that produce either a polysaccharide intercellular adhesin/poly-N-acetylglucosamine...
C Di Giorgio et al.
Journal of natural medicines, 69(3), 267-277 (2015-02-11)
DIG, a liquid herbal preparation made from a mixture of diluted mother tinctures of Berberis vulgaris, Taraxacum officinale and Arctium lappa, was assessed for its antimutagenic properties against mitomycin C. The micronucleus assay on Chinese hamster ovary (CHO)-K1 cells was...
Jaeyop Lee et al.
Journal of immunological methods, 425, 21-26 (2015-06-10)
Different dendritic cell (DC) subsets co-exist in humans and coordinate the immune response. Having a short life, DCs must be constantly replenished from their progenitors in the bone marrow through hematopoiesis. Identification of a DC-restricted progenitor in mouse has improved...
[Concurrent radiochemotherapy with 5-FU/mitomycin remains standard treatment for anal carcinoma. Long-term results of the phase III RTOG 98-11 trial].
C Nieder
Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 189(6), 512-513 (2013-04-24)
Fang Gu et al.
Biochemical and biophysical research communications, 441(1), 18-24 (2013-10-16)
Vascular endothelial growth factor (VEGF-A) stimulating angiogenesis is required for tumor growth and progression. The conventional VEGF-A isoforms have been considered as pro-angiogenic factors. Another family of VEGF-A isoforms generated by alternative splicing, termed VEGFxxxb isoforms, has anti-angiogenic property, exemplified...
Cassandra Ringuette Goulet et al.
BMC cancer, 19(1), 137-137 (2019-02-13)
Cancer-associated fibroblasts (CAFs), activated by tumour cells, are the predominant type of stromal cells in cancer tissue and play an important role in interacting with neoplastic cells to promote cancer progression. Epithelial-mesenchymal transition (EMT) is a key feature of metastatic...
Ashok Kumar Narsani et al.
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP, 23(3), 199-202 (2013-03-06)
To determine the re-recurrence and the postoperative complications in recurrent pterygium cases treated by intraoperative 0.02% Mitomycin C (MMC) and conjunctival autograft (CAG). Quasi-experimental. Department of Ophthalmology, Liaquat University of Medical and Health Sciences, Jamshoro, Hyderabad and Chandka Medical College...
Gaëlle Breton et al.
The Journal of experimental medicine, 212(3), 401-413 (2015-02-18)
Two subsets of conventional dendritic cells (cDCs) with distinct cell surface markers and functions exist in mouse and human. The two subsets of cDCs are specialized antigen-presenting cells that initiate T cell immunity and tolerance. In the mouse, a migratory...
Kun Liu et al.
International journal of molecular medicine, 36(3), 817-824 (2015-07-15)
The aim of this study was to investigate the role of microRNAs (miRNAs or miRs) in vascular smooth muscle cell (VSMC) proliferation and to elucidate the underlying molecular mechanisms. In a previous study, using microarray analysis, differentially expressed miRNAs were...
Yue Zhang et al.
PLoS pathogens, 11(10), e1005167-e1005167 (2015-10-16)
During Yersinia pseudotuberculosis infection of C57BL/6 mice, an exceptionally large CD8+ T cell response to a protective epitope in the type III secretion system effector YopE is produced. At the peak of the response, up to 50% of splenic CD8+...
FANCD2 is required for the repression of germline transposable elements.
Yan Nie et al.
Reproduction (Cambridge, England), 159(6), 659-668 (2020-03-13)
Tania Durré et al.
Nature communications, 9(1), 5178-5178 (2018-12-07)
The development of new lymphatic vessels occurs in many cancerous and inflammatory diseases through the binding of VEGF-C to its receptors, VEGFR-2 and VEGFR-3. The regulation of VEGFR-2/VEGFR-3 heterodimerisation and its downstream signaling in lymphatic endothelial cells (LECs) remain poorly...
Magdalena Bachmann et al.
Pharmacological research, 164, 105326-105326 (2020-12-19)
The two-pore potassium channel TASK-3 has been shown to localize to both the plasma membrane and the mitochondrial inner membrane. TASK-3 is highly expressed in melanoma and breast cancer cells and has been proposed to promote tumor formation. Here we...
Joseph A Fraietta et al.
Antimicrobial agents and chemotherapy, 58(12), 7056-7071 (2014-09-17)
In the absence of universally available antiretroviral (ARV) drugs or a vaccine against HIV-1, microbicides may offer the most immediate hope for controlling the AIDS pandemic. The most advanced and clinically effective microbicides are based on ARV agents that interfere...
Yubing Peng et al.
Journal of Cancer, 6(8), 776-785 (2015-07-18)
Most prostate cancers originate from the prostatic peripheral zone (PZ). We tested the hypothesis that the stromal cells from PZ and transitional zone (TZ) have differential effects on the ability of tumorigenesis. Stromal cells isolated from the PZ and TZ...
Liany Luna-Dulcey et al.
Anti-cancer drugs, 31(1), 35-43 (2019-09-07)
Triple-negative breast cancer subtype is the most aggressive type of breast cancer due to the lack of specific therapeutic targets, having limited treatment options, low survival prognosis and high recurrence rates. In this work, we describe the effects of a...
Seunghee Lee et al.
Age (Dordrecht, Netherlands), 36(6), 9724-9724 (2014-12-04)
Previously, AIMP3 (aminoacyl-tRNAsynthetase-interacting multifunctional protein-3) was shown to be involved in the macromolecular tRNA synthetase complex or to act as a tumor suppressor. In this study, we report a novel role of AIMP3/p18 in the cellular aging of human mesenchymal...
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