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Mark G LeSage et al.
The AAPS journal, 8(1), E65-E75 (2006-04-06)
In contrast to current pharmacotherapies, immunologic approaches to treating tobacco dependence target the drug itself rather than the brain. This approach involves the use of nicotine-specific antibodies that bind nicotine in serum, resulting in a decrease in nicotine distribution to
Delia Dempsey et al.
Clinical pharmacology and therapeutics, 76(1), 64-72 (2004-07-02)
Nicotine and a variety of other drugs and toxins are metabolized by cytochrome P450 (CYP) 2A6. Our objective was to evaluate the use of oral nicotine with measurement of the trans-3'-hydroxycotinine (3HC)/cotinine (COT) metabolite ratio as a noninvasive probe of
Natalie Walker et al.
The New England journal of medicine, 371(25), 2353-2362 (2014-12-18)
Placebo-controlled trials indicate that cytisine, a partial agonist that binds the nicotinic acetylcholine receptor and is used for smoking cessation, almost doubles the chances of quitting at 6 months. We investigated whether cytisine was at least as effective as nicotine-replacement
James H Fallon et al.
The international journal of neuropsychopharmacology, 8(1), 17-26 (2004-12-08)
Biological factors responsible for nicotine initiation and dependence are largely unknown. Men and women smoke differently, and may smoke for different reasons. Brain metabolic response to nicotine may explain gender differences in nicotine use. We used FDG-PET to measure brain
Steven Ross Johnson
Modern healthcare, 43(38), 6-7 (2013-12-18)
The rise of e-cigarettes in the past decade has been accompanied by a debate over the public health consequences of using the devices. Many see them as beneficial. "T'his is basically what I would call a harm-reduction strategy," says Dr.
Nicotine is out: nicotinic agonists may have utility as analgesics.
Pamela Flood et al.
Anesthesia and analgesia, 119(2), 232-233 (2014-07-22)
Irina Stepanov et al.
International journal of cancer, 134(10), 2278-2283 (2013-11-19)
The tobacco-specific nitrosamines N'-nitrosonornicotine (NNN) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) are potent carcinogens for the rat esophagus and lung, respectively. Consistent with the animal carcinogenicity data, we previously reported a remarkably strong association between prospectively measured urinary total NNN, a biomarker of
Thomas Schettgen et al.
Rapid communications in mass spectrometry : RCM, 22(17), 2629-2638 (2008-07-31)
Mercapturic acids are highly important and specific biomarkers of exposure to carcinogenic substances in occupational and environmental medicine. We have developed and validated a reliable, specific and very sensitive method for the simultaneous determination of five mercapturic acids derived from
Elena Munarini et al.
Tumori, 99(5), 578-582 (2013-12-24)
According to recent assessments from the Italian Istituto Superiore della Sanità, information and assistance to smokers are still far from satisfactory. We evaluated the impact of a new smoking cessation service located in pharmacies. Smokers' individual characteristics were also considered.
Magalie Lenoir et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(24), 9937-9949 (2013-06-14)
Repeated exposure to nicotine and other psychostimulant drugs produces persistent increases in their psychomotor and physiological effects (sensitization), a phenomenon related to the drugs' reinforcing properties and abuse potential. Here we examined the role of peripheral actions of nicotine in
Yoshihiko Kakinuma et al.
Translational research : the journal of laboratory and clinical medicine, 164(1), 32-45 (2014-05-09)
We have recently identified that donepezil, an anti-Alzheimer drug, accelerates angiogenesis in a murine hindlimb ischemia (HLI) model. However, the precise mechanisms are yet to be fully elucidated, particularly whether the effects are derived from endothelial cells alone or from
E-cigarettes, smokers and health policies.
S Nardini et al.
Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace, 79(1), 6-7 (2013-06-08)
Christian Ginzkey et al.
Toxicology letters, 229(1), 303-310 (2014-07-02)
Human nasal miniorgan cultures (MOC) are a useful tool in ecogenotoxicology. Repetitive exposure to nicotine showed reversible DNA damage, and stable CYP2A6 expression was demonstrated in nasal MOC in previous investigations. The aim of the present study was to evaluate
Teen drug use gets supersize study.
Sara Reardon
Nature, 512(7513), 123-124 (2014-08-15)
C Feyerabend et al.
British medical journal (Clinical research ed.), 284(6321), 1002-1004 (1982-04-03)
Nicotine concentrations were measured in saliva and urine samples collected from 82 smokers and 56 non-smokers after a morning at work. Each subject answered a series of questions related to their recent intentional or passive exposure to tobacco smoke. All
Jonathan P Winickoff et al.
Pediatrics, 132(1), 109-117 (2013-06-26)
To test whether routine pediatric outpatient practice can be transformed to assist parents in quitting smoking. Cluster RCT of 20 pediatric practices in 16 states that received either CEASE intervention or usual care. The intervention gave practices training and materials
Linda Richter et al.
American journal of public health, 103(8), e14-e16 (2013-06-15)
Addiction is a complex brain disease with frequently overlapping expressions involving nicotine, alcohol, and other drugs. Yet current health care practices, public policies, and national treatment data too often exclude nicotine or address its use as completely separate from other
Mayumi Abe
Nihon rinsho. Japanese journal of clinical medicine, 71(3), 406-415 (2013-05-02)
Cigarette smoking dominates among Japanese smokers. A smoker takes a small amount of nicotine into the body by one aspiration of cigarette; this amount is not large enough to cause acute symptoms. The way of consuming one cigarette by about
Fumio Moriya et al.
Legal medicine (Tokyo, Japan), 6(3), 164-169 (2004-07-03)
We measured nicotine and cotinine levels in blood and urine from 31 forensic autopsy cases. Initially, we developed a sensitive and reproducible gas chromatographic method with a minimum limit of detection of 2.1 ng/ml for both nicotine and cotinine. Calibration
S Miksys et al.
Journal of neural transmission. Supplementum, (70)(70), 177-180 (2006-10-05)
Brain expression of cytochromes P450 2B6, 2D6 and 2E1 is higher in smokers, and is induced by nicotine in animals. These enzymes can metabolize many of the neurotoxins associated with Parkinson's disease. Since smoking is known to be protective against
Shunnosuke Handa
Nihon rinsho. Japanese journal of clinical medicine, 71(3), 482-486 (2013-05-02)
For the habitual smokers with nicotine dependence, it is difficult for them to quit smoking. The nicotine replacement therapy (NRT) is a helpful measure for the persons who want to quit smoking. The concept, medication and practice of the NRT
Cytisine versus nicotine for smoking cessation.
Witold Zatoński et al.
The New England journal of medicine, 372(11), 1072-1072 (2015-03-12)
Mary Beth Flanders Stepans et al.
Biological research for nursing, 8(2), 104-114 (2006-09-28)
The American Academy of Pediatrics recently removed nicotine from the list of drugs contraindicated during breastfeeding. The objective of this study was to evaluate the feasibility of determining the effect of a smoking hygiene intervention on infants of breastfeeding mothers
Hideki Tanaka et al.
Life sciences, 78(15), 1733-1740 (2005-11-04)
Several studies have indicated that one of the causes of alveolar bone destruction with periodontitis is lipopolysaccharide (LPS) from the cell wall of Gram-negative bacteria in plaque and that tobacco smoking may be an important risk factor for the development
Patrik Maurer et al.
European journal of immunology, 35(7), 2031-2040 (2005-06-23)
Nicotine is the principal addictive component in tobacco, and following uptake acts in the central nervous system. The smoking-cessation efforts of most smokers fail because a single slip often delivers sufficient nicotine to the brain to reinstate the drug-seeking behaviour.
Iwona Zieleń et al.
Przeglad lekarski, 69(10), 1098-1102 (2013-02-21)
Tobacco smoking in Poland is fairly widespread on a large scale. Research suggests that the early twenty-first century, the percentage of female daily smokers aged 20 and above was 26%, and men the same age 43%. In addition, epidemiological studies
The FDA, e-cigarettes, and the demise of combusted tobacco.
Nathan K Cobb et al.
The New England journal of medicine, 371(16), 1469-1471 (2014-10-16)
More on nicotine poisoning in infants.
Robert A Bassett et al.
The New England journal of medicine, 371(9), 880-880 (2014-08-28)
Shahrdad Lotfipour et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(18), 7728-7741 (2013-05-03)
Baseline and nicotine-modulated behaviors were assessed in mice harboring a null mutant allele of the nicotinic acetylcholine receptor (nAChR) subunit gene α2 (Chrna2). Homozygous Chrna2(-/-) mice are viable, show expected sex and Mendelian genotype ratios, and exhibit no gross neuroanatomical
E-cigarettes affect cells.
Daniel Cressey
Nature, 508(7495), 159-159 (2014-04-11)
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