Showing 1-30 of 34 resultados for "P2278"
Dursun Gündüz et al.
Thrombosis and haemostasis, 117(2), 371-381 (2016-12-03)
The P2Y
J Sawynok et al.
Neuropharmacology, 30(8), 871-877 (1991-08-01)
Morphine was injected into the periaqueductal gray region of the rat and 8-phenyltheophylline, an adenosine receptor antagonist, was injected intrathecally 15 or 30 min later, to determine whether supraspinally-administered morphine activated descending mechanisms to release adenosine (or a nucleotide which...
Simin Khavandgar et al.
Neurobiology of learning and memory, 78(2), 390-405 (2002-11-15)
Pretraining administration of morphine (5 mg/kg, intraperitonically) in a step-down passive avoidance task led to state-dependent learning with impaired retrieval on the test day that was dose-dependently restored by pretest administration of morphine (0.5, 1, 3, and 5 mg/kg). This...
J Chorostowska-Wynimko et al.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 58 Suppl 5(Pt 1), 95-103 (2008-03-28)
Recent evidence suggests that theophylline, apart from bronchodilatation, derives its therapeutic activity in asthma from anti-inflammatory effects. Free oxygen radicals play important role in the perpetuation of inflammatory processes underlying bronchoconstriction and airway hyperresponsiveness in asthmatics. In our previous studies...
S Chen et al.
Sheng li xue bao : [Acta physiologica Sinica], 52(4), 313-317 (2002-04-16)
The effects of microinjection of adenosine (Ado) into area postrema (AP) on mean arterial pressure (MAP), heart rate (HR) and renal sympathetic nerve activity (RSNA) were examined in 53 anesthetized Sprague Dawley rats. The results obtained are as follows. (1)...
Anna Capasso et al.
Current drug safety, 4(2), 97-102 (2009-05-16)
The effects exerted by P1 and P2 as well as by A1 and A2 agonists and antagonists purinoceptor on the acute opiate withdrawal induced by morphine were investigated in vitro. Following a 4 min in vitro exposure to morphine, the...
Zhi Ming et al.
Hepatology (Baltimore, Md.), 44(4), 813-822 (2006-09-29)
Acute liver injury is associated with renal insufficiency, whose mechanism may be related to activation of the hepatorenal reflex. We previously showed that intrahepatic adenosine is involved in activation of the hepatorenal reflex to restrict urine production in both healthy...
John M Haynes et al.
Clinical and experimental pharmacology & physiology, 30(5-6), 329-335 (2003-07-16)
1. The effects of ATP, the stable ATP analogues alpha,beta-methylene ATP (alpha,beta-mATP), 2-methylthioATP (2meSATP) and adenosine tetraphosphate (ATP4), the pyrimidine nucleotide uridine 5'-triphosphate (UTP) and the alpha1-adrenoceptor agonist phenylephrine were examined on the isolated perfused uterine vasculature of dioestrous, oestradiol-treated...
A Tasatargil et al.
Autonomic & autacoid pharmacology, 23(2), 117-124 (2003-09-27)
1. The aim of the present study was to investigate the role of several possible neurotransmitters in mediating non-adrenergic, non-cholinergic (NANC) relaxation, and the effects of phosphodiesterase (PDE) III and V inhibitors on adrenergic and NANC relaxation in branch pulmonary...
J E Coelho et al.
Neuroscience, 138(4), 1195-1203 (2006-01-31)
Activation of A1 adenosine receptors is important for both the neuromodulatory and neuroprotective effects of adenosine. However, short periods of global ischemia decrease A1 adenosine receptor density in the brain and it is not known if a parallel loss of...
Dursun Gündüz et al.
Journal of molecular and cellular cardiology, 52(5), 962-970 (2012-01-24)
ATP can differentially affect the micro- and macrovascular endothelial barrier. It has been shown that it can both increase and/or decrease macromolecule permeability of microvascular endothelial cells and microvessels, in vivo. We hypothesised that the barrier stabilising effect is mediated...
P Ghildyal et al.
The Journal of physiology, 575(Pt 2), 469-480 (2006-05-06)
At sites of purinergic neurotransmission, synaptic ecto-ATPase is believed to limit the actions of ATP following its neural release. However, details of the modulation by this enzyme of the ATP-mediated conductance change and the possible mechanisms mediating this modulation remain...
Dursun Gündüz et al.
Cardiovascular research, 71(4), 764-773 (2006-07-14)
Ischemia-reperfusion provokes barrier failure of the coronary microvasculature, leading to myocardial edema development that jeopardizes functional recovery of the heart during reperfusion. Here, we tested whether adenosine 5'-triphosphate (ATP), either exogenously applied or spontaneously released during reperfusion, protects the endothelial...
Arda Tasatargil et al.
Journal of cardiovascular pharmacology, 47(5), 673-679 (2006-06-16)
We prepared diet-induced hyperhomocysteinemia (hHcy) in adult male Wistar rats and investigated the effects of hHcy on the adenosinergic and adrenergic responses in vitro and in vivo. The responsiveness of right atria from hHcy rats to the negative chronotropic effects...
Ana Rita Pinheiro et al.
Cell communication and signaling : CCS, 11, 70-70 (2013-09-21)
Chronic musculoskeletal pain involves connective tissue remodeling triggered by inflammatory mediators, such as bradykinin. Fibroblast cells signaling involve changes in intracellular Ca2+ ([Ca2+]i). ATP has been related to connective tissue mechanotransduction, remodeling and chronic inflammatory pain, via P2 purinoceptors activation....
Masaaki Nomura et al.
Molecular carcinogenesis, 44(1), 67-76 (2005-07-27)
We found that caffeine significantly inhibited epidermal growth factor (EGF)- and 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced cell transformation in the JB6 mouse epidermal cell line. The tumor promoter-induced cell transformation was also blocked by treatment with an adenosine A1 receptor antagonist, 8-phenyltheophylline (8-PTH)....
Tomoyuki Matsusaka et al.
Cardiovascular research, 54(3), 568-575 (2002-05-29)
Clinical impact of magnesium (Mg) therapy remains controversial in acute myocardial infarction. We investigated the infarct size limiting effects of Mg and its mechanism in rabbits. Anesthetized rabbits underwent 30 min coronary occlusion and 3 h reperfusion in ten groups:...
Kenji Sakamoto et al.
Brain research, 1015(1-2), 154-160 (2004-06-30)
Brief ischemia was reported to protect various cells against injury induced by subsequent ischemia-reperfusion, and this phenomenon is known as ischemic preconditioning. The aims of the present study were to clarify whether early ischemic preconditioning could be observed in the...
Jin Tang et al.
Molecular medicine reports, 11(6), 4397-4402 (2015-02-13)
Fibroblasts are the effector cells of collagen secretion in renal interstitial fibrosis (RIF), and their proliferation and activation are essential for the development of RIF. Hypoxic ischemia in local tissues has been identified in chronic kidney diseases (CKDs), with adenosine...
Yuji Odagaki et al.
Purinergic signalling, 14(2), 177-190 (2018-03-02)
Adenosine signaling plays a complex role in multiple physiological processes in the brain, and its dysfunction has been implicated in pathophysiology of neuropsychiatric diseases such as schizophrenia and affective disorders. In the present study, the coupling between adenosine A1 receptor...
Daphne Merkus et al.
American journal of physiology. Heart and circulatory physiology, 285(1), H424-H433 (2003-03-15)
In dogs, only combined blockade of vasodilator pathways [via adenosine receptors, nitric oxide synthase (NOS) and ATP-sensitive K+ (KATP) channels] results in impairment of metabolic vasodilation, which suggests a redundancy design of coronary flow regulation. Conversely, in swine and humans...
Zsolt Székelyhidi et al.
Bioorganic & medicinal chemistry letters, 15(13), 3241-3246 (2005-06-01)
SR protein-specific kinase-1 (SRPK-1) has been identified as a validated target for hepatitis B virus (HBV). A series of novel tricyclic quinoxaline derivatives was designed and synthesised as potential kinase inhibitory antiviral agents and was found to be active and...
W R Ezzat et al.
The American journal of physiology, 252(4 Pt 2), H836-H845 (1987-04-01)
Pressure-flow autoregulation, although weak, was seen in the hepatic artery (HA) of every cat that also showed dilation to infused adenosine. Several means of quantitating autoregulation are described and evaluated, and all indices showed that the selective adenosine antagonists, 8-phenyltheophylline...
F V Härtel et al.
Cardiovascular research, 74(3), 487-496 (2007-04-06)
Extracellular ATP stabilizes the endothelial barrier and inactivates the contractile machinery of endothelial cells. This inactivation relies on dephosphorylation of the regulatory myosin light chain (MLC) due to an activation of the MLC phosphatase (MLCP). To date, activation and function...
Gregory M Dick et al.
American journal of physiology. Heart and circulatory physiology, 294(5), H2371-H2381 (2008-04-01)
We previously demonstrated a role for voltage-dependent K(+) (K(V)) channels in coronary vasodilation elicited by myocardial metabolism and exogenous H(2)O(2), as responses were attenuated by the K(V) channel blocker 4-aminopyridine (4-AP). Here we tested the hypothesis that K(V) channels participate...
Jay H Traverse et al.
Circulation research, 100(11), 1643-1649 (2007-05-05)
K(+)(ATP) channels are important metabolic regulators of coronary blood flow (CBF) that are activated in the setting of reduced levels of ATP or perfusion pressure. In the normal heart, blockade of K(+)(ATP) channels results in a approximately 20% reduction in...
D E Pafundo et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 287(4), R833-R843 (2004-06-26)
In trout hepatocytes, hypotonic swelling is followed by a compensatory shrinkage called regulatory volume decrease (RVD). It has been postulated that extracellular ATP and other nucleotides may interact with type 2 receptors (P(2)) to modulate this response. In addition, specific...
Yasuhiro Kimura et al.
American journal of physiology. Gastrointestinal and liver physiology, 289(6), G1007-G1014 (2005-07-16)
Adenosine modulates the intestinal functions of secretion, motility, and immunity, yet little is known about the regulation of nutrient absorption. Therefore, we measured the carrier-mediated uptake of tracer D-[(14)C]glucose (2 microM) by everted sleeves of the mouse intestine after a...
Phedias Diamandis et al.
Nature chemical biology, 3(5), 268-273 (2007-04-10)
The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain cancer. However, the complete repertoire of signaling pathways that governs the...
F A Santos et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 40(10), 1453-1457 (2002-10-22)
We examined the scratch (itch) inducing effect of 1,8-cineole (cineole), a monoterpene oxide present in many plant essential oils and the possible role of mast cells in the response. Subcutaneous injection of cineole (10, 20 and 40 microl/site) or the...

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