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Bernd Schröder et al.
Traffic (Copenhagen, Denmark), 8(12), 1676-1686 (2007-09-28)
We searched for novel proteins in lysosomal membranes, tentatively participating in molecular transport across the membrane and/or in interactions with other compartments. In membranes purified from placental lysosomes, we identified 58 proteins, known to reside at least partially in the...
Aranganathan Shanmuganathan et al.
Protein expression and purification, 88(2), 196-200 (2013-01-15)
PAPf39 is a 39 residue peptide fragment from human prostatic acidic phosphatase that forms amyloid fibrils in semen. These fibrils have been implicated in facilitating HIV transmission. To enable structural studies of PAPf39 by NMR spectroscopy, efficient methods allowing the...
J Guo et al.
Journal of dental research, 93(5), 508-513 (2014-03-08)
Porphyromonas endodontalis and its main virulence factor, lipopolysaccharide (LPS), are associated with the development of periapical diseases and alveolar bone loss. Calcium hydroxide is commonly used for endodontic therapy. However, the effects of calcium hydroxide on the virulence of P....
H G Yu et al.
The Journal of cell biology, 145(3), 425-435 (1999-05-04)
We have identified a maize homologue of yeast MAD2, an essential component in the spindle checkpoint pathway that ensures metaphase is complete before anaphase begins. Combined immunolocalization of MAD2 and a recently cloned maize CENPC homologue indicates that MAD2 localizes...
P Virkkunen et al.
Biochemical and biophysical research communications, 202(1), 49-57 (1994-07-15)
Structural comparison of human and rat prostate-specific acid phosphatase (hPAP and rPAP) genes indicate that the exon number is different between these species. The hPAP gene contains 10 exons, whereas the rPAP gene was 11 exons. However, exons 2-9 of...
Takaaki Tomofuji et al.
Lipids in health and disease, 12, 1-1 (2013-01-09)
Dyslipidemia increases circulating levels of oxidized low-density lipoprotein (OxLDL) and this may induce alveolar bone loss through toll-like receptor (TLR) 2 and 4. The purpose of this study was to investigate the effects of dyslipidemia on osteoclast differentiation associated with...
Teun J De Vries et al.
Journal of cellular physiology, 230(1), 210-225 (2014-06-26)
Osteoclasts and macrophages share progenitors that must receive decisive lineage signals driving them into their respective differentiation routes. Macrophage colony stimulation factor M-CSF is a common factor; bone is likely the stimulus for osteoclast differentiation. To elucidate the effect of...
Sonsoles Botella et al.
The Journal of clinical endocrinology and metabolism, 98(11), E1740-E1748 (2013-09-05)
Bone turnover markers (BTMs) may identify changes in bone remodeling within a relatively short time interval before changes in bone mineral density can be detected. New markers such as osteoprotegerin, receptor activator of nuclear factor-κB ligand, and sclerostin have emerged...
Sneha Shah et al.
Genes & development, 28(3), 231-244 (2014-02-05)
Numerous noncoding transcripts of unknown function have recently been identified. In this study, we report a novel mechanism that relies on transcription of noncoding RNA prt (pho1-repressing transcript) regulating expression of the pho1 gene. A product of this gene, Pho1...
J J Stepan et al.
Biochemical and biophysical research communications, 168(2), 792-800 (1990-04-30)
Tartrate-resistant acid phosphatase type-5 was purified to apparent homogeneity from human osteoclastomas by sequential chromatography on CM-Sepharose, Phenyl-Sepharose, concanavalin A-Sepharose, FPLC Superose-12, and FPLC Mono-S. The purification over the original tissue extract was 1167-fold, with a yield of 16%. An...
Jess Liu et al.
Developmental biology, 381(1), 256-275 (2013-06-25)
Egg yolk phosvitin is one of the most highly phosphorylated extracellular matrix proteins known in nature with unique physico-chemical properties deemed to be critical during ex-vivo egg embryo development. We have utilized our unique live mouse calvarial bone organ culture...
Abigail K Elias et al.
Biochimica et biophysica acta, 1844(9), 1591-1598 (2014-06-21)
Semen-derived enhancer of viral infection (SEVI) is the term given to the amyloid fibrils formed by a 39-amino acid fragment (PAP248-286) of prostatic acidic phosphatase (PAP) found in human semen. SEVI enhances human immunodeficiency virus (HIV) infectivity by four to...
Hao Yuan et al.
Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 72(4), 764-772 (2014-03-19)
In surgery-first accelerated orthognathic surgery, the clinical phenomenon of accelerated orthodontic tooth movement after osteotomy is a benefit compared with the conventional approach. However, because much of the literature on this phenomenon is based on empirical evidence and case reports...
J Dissing et al.
The Journal of biological chemistry, 266(31), 20619-20625 (1991-11-05)
The pair of isozymes, Bf and Bs, encoded by the human red cell acid phosphatase ACP1*B allele has been sequenced. Similar but not identical primary structures were observed. Both isozymes consist of a single peptide chain of 157 amino acid...
Youjun Zhang et al.
FEBS letters, 588(20), 3726-3731 (2014-09-01)
Changes in carbon flow and sink/source activities can affect floral, architectural, and reproductive traits of plants. In potato, overexpression (OE) of the purple acid phosphatase 2 of Arabidopsis (AtPAP2) resulted in earlier flowering, faster growth rate, increased tubers and tuber...
Koichiro Komatsu et al.
The Journal of endocrinology, 219(2), 145-158 (2013-10-08)
Bisphosphonates (BPs) are a major class of antiresorptive drug, and their molecular mechanisms of antiresorptive action have been extensively studied. Recent studies have suggested that BPs target bone-forming cells as well as bone-resorbing cells. We previously demonstrated that local application...
M V Stogov et al.
Klinicheskaia laboratornaia diagnostika, (11)(11), 21-22 (2013-01-12)
The article deals with the results of study of chemical composition of solitary cysts and blood serum of 27 patients. The results demonstrated that qualitative composition of f content of unicameral bone cysts is identical to chemical composition of blood...
Mikio Kawamura et al.
Anticancer research, 34(7), 3425-3429 (2014-07-02)
The present study investigated the clinical significance of tartrate-resistant acid phosphatase type-5 (ACP5) expression in gastric cancer. In 150 specimens of gastric cancer and adjacent normal mucosa, expression of ACP5 protein and mRNA and was determined by immunohistochemical staining and...
A TaqI site identifies the *A allele at the ACP1 locus.
G F Sensabaugh et al.
Human molecular genetics, 2(7), 1079-1079 (1993-07-01)
Zuzana Novotná et al.
FEBS letters, 554(1-2), 50-54 (2003-11-05)
Phospholipase D (PLD) forms the major family of phospholipases that was first discovered and cloned in plants. In this report we have shown, for the first time, that C2 phosphatidylinositol-4,5-bisphosphate (PIP2)-dependent PLD(s) from 5 day hypocotyls of Brassica oleracea associated...
Y Y Wo et al.
The Journal of biological chemistry, 267(15), 10856-10865 (1992-05-25)
Low molecular weight phosphotyrosyl protein phosphatases of human placenta and human red cell were purified and sequenced by a combination of Edman degradation and tandem mass spectrometry. Screening of a human placental lambda gt11 cDNA library yielded overlapping cDNA clones...
Lei Lu et al.
Journal of oral & facial pain and headache, 28(1), 68-79 (2014-02-01)
To investigate the changes in condylar cartilage and subchondral bone of the temporomandibular joint (TMJ) in a mouse model of incisor malocclusion. By bonding a single (single group) or a pair (pair group) of metal tube(s) to the left incisor(s)...
G M Yousef et al.
Genomics, 74(3), 385-395 (2001-06-21)
Acid phosphatases are enzymes capable of hydrolyzing orthophosphoric acid esters in an acid medium. Prostatic acid phosphatase has served as a tumor marker for metastatic prostate cancer for many years. We have cloned a new human acid phosphatase gene (named...
Marta Ferreira Bastos et al.
The International journal of oral & maxillofacial implants, 29(1), 221-231 (2014-01-24)
To evaluate the effects of caffeine and/or estrogen deficiency on trabecular bone area (TBA) and bone healing in rats. Rats were divided into groups (n=15/group) as follows: control, caffeine, ovariectomy (OVX), and caffeine/OVX. Critical-sized defects were created in the tibiae...
Noriyuki Okonogi et al.
International journal of radiation oncology, biology, physics, 87(5), 968-974 (2013-10-22)
To prospectively investigate the changes in bone mineral density (BMD) after pelvic radiation therapy in patients with uterine cervical cancer. Of 52 cervical cancer patients who received pelvic RT in our university hospital between 2009 and 2011, 46 patients without...
J J Stĕpán et al.
Biochemical and biophysical research communications, 165(3), 1027-1034 (1989-12-29)
Tartrate-resistant acid phosphatases types 5a and 5b were purified from human hairy cell leukemia spleen by sequential chromatography on Phenyl-Sepharose, CM-Sepharose, concanavalin A-Sepharose, FPLC Superose-12 and FPLC Mono-S. The purification over the original tissue extract was 1150- and 3300-fold, with...
Epidermal growth factor receptor (EGFR) signaling is a key mediator of hormone-induced leukocyte infiltration in the pubertal female mammary gland.
Aupperlee MD, Zhao Y, Tan YS, et al.
Endocrinology, 155(6), 2301-2313 (2014)
Jakob Madsen Pedersen et al.
PLoS genetics, 8(12), e1003128-e1003128 (2013-01-04)
To investigate the role of DNA topoisomerases in transcription, we have studied global gene expression in Saccharomyces cerevisiae cells deficient for topoisomerases I and II and performed single-gene analyses to support our findings. The genome-wide studies show a general transcriptional...
Zuxiong Chen et al.
The Prostate, 74(10), 1059-1067 (2014-05-24)
Protein glycosylation is a common posttranslational modification and glycan structural changes have been observed in several malignancies including prostate cancer. We hypothesized that altered glycosylation could be related to differences in gene expression levels of glycoprotein synthetic enzymes between normal...
Peter Dan Broulík et al.
Nutrition (Burbank, Los Angeles County, Calif.), 29(9), 1166-1169 (2013-07-09)
Intake of multivitamin preparations is very common in developed countries. However, excessive intake of vitamin A was associated with increased bone fragility. The aim of this study was to determine if chronic administration of the active metabolite of vitamin A...
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