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P4333

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Eunice E To et al.
Nature communications, 8(1), 69-69 (2017-07-14)
The imminent threat of viral epidemics and pandemics dictates a need for therapeutic approaches that target viral pathology irrespective of the infecting strain. Reactive oxygen species are ancient processes that protect plants, fungi and animals against invading pathogens including bacteria....
Takanori Katsube et al.
Mutation research, 813, 18-26 (2016-12-25)
Both ionizing radiation (IR) and psychological stress (PS) cause detrimental effects on humans. A recent study showed that chronic restraint-induced PS (CRIPS) diminished the functions of Trp53 and enhanced radiocarcinogenesis in Trp53-heterozygous (Trp53
Christian Boehler et al.
Scientific reports, 6, 19574-19574 (2016-01-23)
On-demand release of bioactive substances with high spatial and temporal control offers ground-breaking possibilities in the field of life sciences. However, available strategies for developing such release systems lack the possibility of combining efficient control over release with adequate storage...
Hannah E Greenwood et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 25(8), 2471-2482 (2019-01-18)
Drug resistance is a major obstacle for the effective treatment of patients with high-grade serous ovarian cancer (HGSOC). Currently, there is no satisfactory way to identify patients with HGSOC that are refractive to the standard of care. Here, we propose...
Cecilie F Kjelgaard-Petersen et al.
Arthritis & rheumatology (Hoboken, N.J.), 70(9), 1419-1428 (2018-04-19)
Rheumatoid arthritis (RA) is a chronic and degenerative autoimmune joint disease that leads to disability, reduced quality of life, and increased mortality. Although several synthetic and biologic disease-modifying antirheumatic drugs are available, there is still a medical need for novel...
Wenzhu Lu et al.
International journal of biological sciences, 16(6), 1071-1085 (2020-03-07)
The transcription factor c-Myc and two cullin family members CUL4A/4B function as oncogenes in colorectal cancer. Our recent publication reveals that c-Myc specifically activates the expression of CUL4A/4B through binding to their promoters. However, the underlying mechanism of how c-Myc...
A Islam et al.
European cells & materials, 37, 153-174 (2019-02-21)
Mesenchymal stromal cells (MSCs), given their regenerative potential, are being investigated as a potential therapeutic tool for cartilage lesions. MSCs express several bioactive molecules which act in a paracrine fashion to modulate the tissue microenvironment. Yet, little is known about...
Andrew R Findlay et al.
Neurology. Genetics, 5(2), e318-e318 (2019-05-28)
To understand DNAJB6's function in skeletal muscle and identify therapeutic targets for limb-girdle muscular dystrophy 1D (LGMD1D). DNAJB6 knockout (KO) myoblasts were generated with Crispr/cas9 technology, and differentially accumulated proteins were identified using stable isotope labeling, followed by quantitative mass...
Highly sensitive single domain antibody-quantum dot conjugates for detection of HER2 biomarker in lung and breast cancer cells.
Rakovich TY, Mahfoud OK, Mohamed BM, et al.
ACS Nano, 8(6), 5682-5695 (2014)
Anna M Schläfli et al.
Scientific reports, 11(1), 9011-9011 (2021-04-29)
ALK inhibitors effectively target EML4-ALK positive non-small cell lung cancer, but their effects are hampered by treatment resistance. In the present study, we asked whether ALK inhibition affects autophagy, and whether this may influence treatment response. Whereas the impact of...
Morad Kamand et al.
Stem cell research, 51, 102185-102185 (2021-02-02)
Autism is a complex neuropsychiatric disorder defined by significant challenges in communication skills and social behavior as well as repetitive conduct and interests. Recent advances in stem cell technologies allow in vitro modeling of the underlying molecular disease mechanisms. Using...
Michael Devos et al.
The Journal of experimental medicine, 217(7) (2020-04-22)
Aberrant detection of endogenous nucleic acids by the immune system can cause inflammatory disease. The scaffold function of the signaling kinase RIPK1 limits spontaneous activation of the nucleic acid sensor ZBP1. Consequently, loss of RIPK1 in keratinocytes induces ZBP1-dependent necroptosis...
Abdullah Yalçin et al.
Turkish journal of biology = Turk biyoloji dergisi, 44(2), 93-102 (2020-04-08)
Type 2 diabetes mellitus is characterized by insulin resistance and hypersecretion of insulin from the pancreas to compensate for decreased insulin sensitivity in the peripheral tissues. In later stages of the disease insulin-secreting beta cell degeneration commences and patients require...
Thibault Rosazza et al.
Journal of cell science, 134(5) (2020-06-06)
Leishmania spp. are obligate intracellular parasites that infect phagocytes, notably macrophages. No information is available on how Leishmania parasites respond to pyroptosis of their host cell, which is known to limit microbial infection. Here, we analyzed the pyroptotic process and...
Tiago J Dantas et al.
The Journal of cell biology, 193(2), 307-318 (2011-04-13)
The principal microtubule-organizing center in animal cells, the centrosome, contains centrin, a small, conserved calcium-binding protein unique to eukaryotes. Several centrin isoforms exist and have been implicated in various cellular processes including nuclear export and deoxyribonucleic acid (DNA) repair. Although...
Ingrid E Frohner et al.
Science signaling, 13(616) (2020-01-30)
The methyl-esterification of the C-terminal leucine of the protein phosphatase 2A (PP2A) catalytic (C) subunit is essential for the assembly of specific trimeric PP2A holoenzymes, and this region of the C subunit also contains two threonine and tyrosine phosphorylation sites....
Gabriella Marucci et al.
Life sciences, 205, 155-163 (2018-05-16)
A3 adenosine receptor (A3AR) signalling activation seems to mediate anticancer effect, and it has been targeted for drug development. The identification of potent and selective A3AR agonists could be crucial for cancer drug development. In the present study was determined...
Gerrit Müller et al.
Autophagy, 16(8), 1380-1395 (2019-11-02)
Oxidative stress and Th17 cytokines are important mediators of inflammation. Treatment with beta-adrenoceptor (ADRB) antagonists (beta-blockers) is associated with induction or aggravation of psoriasis-like skin inflammation, yet the underlying mechanisms are poorly understood. Herein, we identify lysosomotropic beta-blockers as critical...
Ralph M Jeuken et al.
Journal of biomedical materials research. Part B, Applied biomaterials, 108(8), 3370-3382 (2020-07-03)
Focal knee resurfacing implants (FKRIs) are intended to treat cartilage defects in middle-aged patients. Most FKRIs are metal-based, which hampers follow-up of the joint using magnetic resonance imaging and potentially leads to damage of the opposing cartilage. The purpose of...
Luciano A Masullo et al.
Nature communications, 9(1), 3281-3281 (2018-08-18)
The theoretically unlimited spatial resolution of fluorescence nanoscopy often comes at the expense of time, contrast and increased dose of energy for recording. Here, we developed MoNaLISA, for Molecular Nanoscale Live Imaging with Sectioning Ability, a nanoscope capable of imaging...
Hongji Yan et al.
ACS applied materials & interfaces, 12(17), 19324-19336 (2020-04-18)
Mucins are multifunctional glycosylated proteins that are increasingly investigated as building blocks of novel biomaterials. An attractive feature is their ability to modulate the immune response, in part by engaging with sialic acid binding receptors on immune cells. Once assembled...
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Pablo Palazón-Riquelme et al.
EMBO reports, 19(10) (2018-09-13)
The assembly and activation of the inflammasomes are tightly regulated by post-translational modifications, including ubiquitin. Deubiquitinases (DUBs) counteract the addition of ubiquitin and are essential regulators of immune signalling pathways, including those acting on the inflammasome. How DUBs control the...
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Paris Avgoustou et al.
ACS pharmacology & translational science, 3(4), 706-719 (2020-08-25)
The hormone adrenomedullin has both physiological and pathological roles in biology. As a potent vasodilator, adrenomedullin is critically important in the regulation of blood pressure, but it also has several roles in disease, of which its actions in cancer are...
Johan M Lorenzen et al.
European heart journal, 36(32), 2184-2196 (2015-04-23)
Osteopontin (OPN) is a multifunctional cytokine critically involved in cardiac fibrosis. However, the underlying mechanisms are unresolved. Non-coding RNAs are powerful regulators of gene expression and thus might mediate this process. OPN and miR-21 were significantly increased in cardiac biopsies...
Katarina Cisarova et al.
PLoS genetics, 16(12), e1009201-e1009201 (2021-01-01)
Conjunctival melanoma (CJM) is a rare but potentially lethal and highly-recurrent cancer of the eye. Similar to cutaneous melanoma (CM), it originates from melanocytes. Unlike CM, however, CJM is relatively poorly characterized from a genomic point of view. To fill...
Zhenyu Pan et al.
Frontiers in oncology, 10, 387-387 (2020-04-25)
Background: Leptomeningeal metastasis (LM) has frequently been observed in patients with lung adenocarcinoma. So far, its diagnosis and disease course monitoring are still extremely difficult. Moreover, there is no effective treatment regimen for LM due to a lack knowledge on...
Han Wang et al.
Stem cells and development, 24(21), 2536-2546 (2015-07-02)
Definitive endoderm (DE) is a vital precursor for internal organs such as liver and pancreas. Efficient protocol to differentiate human embryonic stem cells (hESCs) or induced pluripotent stem cells (iPSCs) to DE is essential for regenerative medicine and for modeling...
Yan Zhou Tran et al.
Molecular & cellular proteomics : MCP, 19(6), 928-943 (2020-04-03)
Drug resistance is a major obstacle to curative cancer therapies, and increased understanding of the molecular events contributing to resistance would enable better prediction of therapy response, as well as contribute to new targets for combination therapy. Here we have...
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