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Hui Gong et al.
International journal of molecular sciences, 16(6), 12482-12498 (2015-06-06)
Plasma urotensin II (UII) has been observed to be raised in patients with acute myocardial infarction; suggesting a possible cardiac protective role for this peptide. However, the molecular mechanism is unclear. Here, we treated cultured cardiomyocytes with H2O2 to induce
Gražvydas Lukinavičius et al.
Nature communications, 6, 8497-8497 (2015-10-02)
Cell-permeable DNA stains are popular markers in live-cell imaging. Currently used DNA stains for live-cell imaging are either toxic, require illumination with blue light or are not compatible with super-resolution microscopy, thereby limiting their utility. Here we describe a far-red
Huey-Chun Huang et al.
International journal of molecular sciences, 16(5), 10470-10490 (2015-05-12)
The effects of essential oil from Eucalyptus camaldulensis flowers oil on melanogenesis and the oil's antioxidant characteristics were investigated. Assays of mushroom and cellular tyrosinase activities and melanin content of mouse melanoma cells were performed spectrophotometrically, and the expression of
Svetlana N Rubtsova et al.
PloS one, 10(7), e0133578-e0133578 (2015-07-25)
Using confocal microscopy, we analyzed the behavior of IAR-6-1, IAR1170, and IAR1162 transformed epithelial cells seeded onto the confluent monolayer of normal IAR-2 epithelial cells. Live-cell imaging of neoplastic cells stably expressing EGFP and of normal epithelial cells stably expressing
Anna Maria Wróbel et al.
Toxicology letters, 238(2), 110-116 (2015-08-09)
In the present study, we examined cAMP levels and activation of the MAPK/ERK1/2 and PI3K/Akt signaling pathways in response to the actions of parabens on GPR30 in MCF-7 and MCF-10A cells. Cells were exposed to methyl-, propyl- or butylparaben at
T A McDonald et al.
Leukemia, 15(1), 10-20 (2001-03-13)
High background levels of phenol and hydroquinone are present in the blood and urine of virtually all individuals, but vary widely. Phenol and hydroquinone have been strongly implicated in producing leukemia associated with benzene exposure, because they reproduce the hematotoxicity
Neha Chandrasekaran et al.
Journal of peptide science : an official publication of the European Peptide Society, 21(8), 630-635 (2015-04-10)
The adsorption of proteins at solid-liquid interfaces is important in biosensor and biomaterial applications. Marine mussels affix themselves to surfaces using a highly cross-linked, protein-based adhesive containing a high proportion of L-3,4-dihydroxyphenylalanine (DOPA) residues. In this work, the effect of
Piyasuda Thepnok et al.
Biochemical and biophysical research communications, 450(4), 1276-1282 (2014-07-08)
Many zinc cluster proteins have been shown to play a role in the transcriptional regulation of glucose-repressible genes during glucose exhaustion and diauxic shift. Here, we studied an additional member of this family called Yer184c (herein called Tog1) for transcriptional
Hideyuki Takeshima et al.
Cancer letters, 357(1), 328-338 (2014-12-03)
A field for cancerization, or a field defect, is formed by the accumulation of genetic and epigenetic alterations in normal-appearing tissues, and is involved in various cancers, especially multiple cancers. Epigenetic alterations are frequently present in chronic inflammation-exposed tissues, but
Gabriela de Almeida Leonardi et al.
Genetics and molecular biology, 38(2), 191-198 (2015-08-15)
Eucalyptus urograndis is a hybrid eucalyptus of major economic importance to the Brazilian pulp and paper industry. Although widely used in forest nurseries around the country, little is known about the biochemical changes imposed by environmental stress in this species.
X Han et al.
Cancer gene therapy, 22(3), 122-129 (2015-01-24)
MicroRNAs (miRNAs) are important regulators that play key roles in tumorigenesis and tumor progression. In this study, we investigate whether let-7b acts as a tumor suppressor to inhibit invasion and metastasis in gastric cancers. We analyzed the expression of let-7b
Arvind Panday et al.
Nucleic acids research, 43(12), 5759-5770 (2015-05-17)
DNA is packaged into condensed chromatin fibers by association with histones and architectural proteins such as high mobility group (HMGB) proteins. However, this DNA packaging reduces accessibility of enzymes that act on DNA, such as proteins that process DNA after
Yohei Abe et al.
Nature communications, 6, 7052-7052 (2015-05-08)
Histone 3 lysine 9 (H3K9) demethylase JMJD1A regulates β-adrenergic-induced systemic metabolism and body weight control. Here we show that JMJD1A is phosphorylated at S265 by protein kinase A (PKA), and this is pivotal to activate the β1-adrenergic receptor gene (Adrb1)
Yu-Rong Zhao et al.
Chinese journal of natural medicines, 13(6), 438-444 (2015-06-16)
In our previous study, we have elucidated the chemical profile of YGS40, a fraction of Yi-Gan San (YGS), used for the treatment of Alzheimer's disease (AD). Oxidative stress-induced apoptosis is implicated in neurodegenerative disorders such as AD. The aim of
Jennifer Mahony et al.
Applied and environmental microbiology, 81(10), 3299-3305 (2015-03-10)
Lactococcal bacteriophages represent one of the leading causes of dairy fermentation failure and product inconsistencies. A new member of the lactococcal 949 phage group, named WRP3, was isolated from cheese whey from a Sicilian factory in 2011. The genome sequence
Babett Steglich et al.
PLoS genetics, 11(3), e1005101-e1005101 (2015-03-24)
In eukaryotic cells, local chromatin structure and chromatin organization in the nucleus both influence transcriptional regulation. At the local level, the Fun30 chromatin remodeler Fft3 is essential for maintaining proper chromatin structure at centromeres and subtelomeres in fission yeast. Using
Nirton C S Vieira et al.
Materials science & engineering. C, Materials for biological applications, 33(7), 3899-3902 (2013-08-06)
This paper reports on the use of the crude extract of avocado (CEA) fruit (Persea americana) as a source of tyrosinase enzyme. CEA was immobilized via layer by layer (LbL) technique onto indium tin oxide (ITO) substrates and applied in
Saikh Mohammad Wabaidur et al.
Journal of separation science, 38(15), 2597-2606 (2015-05-20)
An ultra high performance liquid chromatography with mass spectrometry method has been developed for the simultaneous separation, identification and determination of 22 phenolic constituents in honey from various floral sources from Yemen. Solid-phase extraction was used for extraction of the
IARC monographs on the evaluation of carcinogenic risks to humans, 47, 263-287 (1989-01-01)
Christiane Rollenhagen et al.
PloS one, 10(6), e0131919-e0131919 (2015-06-30)
Establishment of a productive HIV-1 infection in the female reproductive tract likely depends on the balance between anti-viral and pro-inflammatory responses leading to activation and proliferation of HIV target cells. Immune modulators that boost anti-viral and depress pro-inflammatory immune responses
Xiao Yan Chen et al.
Applied and environmental microbiology, 80(18), 5752-5760 (2014-07-13)
Enterotoxigenic Escherichia coli (ETEC) is a major cause of diarrhea in piglets; ETEC cells colonize the intestinal mucosa with adhesins and deliver toxins that cause fluid loss. This study determined the antiadhesive properties of bacterial exopolysaccharides (reuteran and levan) and
Jung-Ho Shin et al.
PLoS genetics, 10(6), e1004429-e1004429 (2014-06-27)
Magnesium is an essential divalent metal that serves many cellular functions. While most divalent cations are maintained at relatively low intracellular concentrations, magnesium is maintained at a higher level (∼0.5-2.0 mM). Three families of transport proteins were previously identified for
Hwan-Jin Hwang et al.
Metabolism: clinical and experimental, 64(9), 1175-1182 (2015-07-01)
Leukocyte cell-derived chemotaxin 2 (LECT2) is a recently discovered novel hepatokine, leading to skeletal muscle insulin resistance by activating c-Jun N-terminal kinase (JNK). However, its role in atherosclerotic inflammatory reactions has not been examined. Therefore, we investigated the function of
Ákos Hornyák et al.
The journal of gene medicine, 17(6-7), 116-131 (2015-05-02)
Despite spectacular successes in hepatitis B and C therapies, severe hepatic impairment is still a major treatment problem. The clinically tested infectious bursal disease virus (IBDV) superinfection therapy promises an innovative, interferon-free solution to this great unmet need, provided that
Christos Andreadis et al.
Nucleic acids research, 42(20), 12650-12667 (2014-10-11)
DNA damage response and repair proteins are centrally involved in genome maintenance pathways. Yet, little is known about their functional role under non-DNA damage-inducing conditions. Here we show that Rad9 checkpoint protein, known to mediate the damage signal from upstream
Celena Scheede-Bergdahl et al.
Diabetes & vascular disease research, 11(5), 324-334 (2014-06-07)
Matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMP) play a critical role during vascular remodelling, in both health and disease. Impaired MMP regulation is associated with many diabetes-related complications. This study examined whether exercise-induced regulation of MMPs is maintained in
Artyom A Alekseyenko et al.
Genes & development, 29(14), 1507-1523 (2015-07-30)
NUT midline carcinoma (NMC), a subtype of squamous cell cancer, is one of the most aggressive human solid malignancies known. NMC is driven by the creation of a translocation oncoprotein, BRD4-NUT, which blocks differentiation and drives growth of NMC cells.
Alberto Angrisani et al.
Insect biochemistry and molecular biology, 61, 69-78 (2015-02-03)
Small nucleolar RNAs constitute a significant portion of the eukaryotic small ncRNA transcriptome and guide site-specific methylation or pseudouridylation of target RNAs. In addition, they can play diverse regulatory roles on gene expression, acting as precursors of smaller fragments able
Yu Zhou et al.
Ophthalmic genetics, 36(1), 43-49 (2014-11-25)
Genetic factors have been studied extensively for their role in the pathogenesis of primary open angle glaucoma (POAG). This study was conducted to investigate whether manganese superoxide dismutase (SOD2) variants play a significant role in POAG in a Chinese population.
Mir Ali Farajzadeh et al.
Biomedical chromatography : BMC, 29(12), 1921-1931 (2015-05-28)
In present study, a simultaneous derivatization and air-assisted liquid-liquid microextraction method combined with gas chromatography-nitrogen phosphorous detection has been developed for the determination of some phenolic compounds in biological samples. The analytes are derivatized and extracted simultaneously by a fast
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