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Chiung-Fen Chang et al.
Water science and technology : a journal of the International Association on Water Pollution Research, 67(7), 1434-1441 (2013-04-05)
Magnetic TiO2 (MT) composites were prepared and applied to degrading phenol, which is one of the listed priority pollutants. The effects of heat treatment under preparation on the photocatalytic activity of MT composites have been investigated by varying the soaking
Evert Njomen et al.
Protein and peptide letters, 22(10), 869-876 (2015-07-29)
Nuclear translocation of IGFBP3 by importin-β1 is a prerequisite for IGFBP3-induced apoptosis. The neuroprotective peptide humanin (HN) counteracts IGFBP3-induced cell death. However, the mechanism by which humanin protects cells is currently unknown. The natural synthesis of this peptide decreases with
Simon Kaja et al.
Experimental eye research, 138, 159-166 (2015-06-07)
Optic nerve head astrocytes (ONHAs) are the major glia cell type in the non-myelinated optic nerve head where they contribute critically to extracellular matrix synthesis during development and throughout life. In glaucoma, and in related disorders affecting the optic nerve
Marie A Colucci et al.
Journal of medicinal chemistry, 50(23), 5780-5789 (2007-10-20)
NAD(P)H:quinone oxidoreductase 1 is a proposed target in pancreatic cancer. We describe the synthesis of a series of indolequinones, based on the 5- and 6-methoxy-1,2-dimethylindole-4,7-dione chromophores with a range of phenolic leaving groups at the (indol-3-yl)methyl position. The ability of
Michelle Carroll-Turpin et al.
Toxicological sciences : an official journal of the Society of Toxicology, 147(1), 235-245 (2015-06-28)
Pulmonary arterial hypertension (PAH) is a cardiovascular disorder characterized by elevated pulmonary artery pressure as a result of arterial wall thickening. Patients are 3-4 times more likely to be women than men. This gender discrepancy demonstrates a need for an
Ross M Tanis et al.
Biochimica et biophysica acta, 1853(1), 213-221 (2014-12-03)
While the 3T3-L1 adipocyte model is routinely used for the study of obesity and diabetes, the mitochondrial respiratory profile in normal versus high glucose has not been examined in detail. We matured adipocytes in normal (5mM) or high (30 mM)
Rihui Su et al.
Journal of chromatography. A, 1405, 23-31 (2015-06-17)
In this work, polymerized high internal phase emulsion (polyHIPE) monoliths were prepared and applied as monolithic adsorbent materials for proconcentration of trace polycyclic aromatic hydrocarbons (PAHs) from large-volume water samples. The monolithic polyHIPE columns were prepared by in situ polymerization
Kyung Min Jeong et al.
Archives of pharmacal research, 38(12), 2143-2152 (2015-11-05)
Deep eutectic solvents (DESs) were investigated as tunable, environmentally benign, yet superior extraction media to enhance the extraction of anthocyanins from grape skin, which is usually discarded as waste. Ten DESs containing choline chloride as hydrogen bond acceptor combined with
Nihal Kuş et al.
The journal of physical chemistry. A, 119(24), 6296-6308 (2015-05-31)
The structure, infrared spectrum, and photochemistry of 5-hydroxyquinoline (5HQ) were studied by matrix isolation infrared spectroscopy, complemented by theoretical calculations performed at the DFT(B3LYP)/6-311++G(d,p) level of approximation. According to the calculations, the trans conformer of 5HQ (with the OH group
Masamitsu Konno et al.
PloS one, 10(7), e0132789-e0132789 (2015-07-16)
Noncoding microRNAs inhibit translation and lower the transcript stability of coding mRNA, however miR-369 s, in aberrant silencing genomic regions, stabilizes target proteins under cellular stress. We found that in vitro differentiation of embryonic stem cells led to chromatin methylation
Cynthia D Selassie et al.
Journal of medicinal chemistry, 48(23), 7234-7242 (2005-11-11)
In this comprehensive study on the caspase-mediated apoptosis-inducing effect of 51 substituted phenols in a murine leukemia cell line (L1210), we determined the concentrations needed to induce caspase activity by 50% (I50) and utilized these data to develop the following
Kristina Heyne et al.
Cell cycle (Georgetown, Tex.), 14(16), 2619-2633 (2015-06-24)
Humans and primates are long-lived animals with long reproductive phases. One factor that appears to contribute to longevity and fertility in humans, as well as to cancer-free survival, is the transcription factor and tumor suppressor p53, controlled by its main
Natalie S Goddard et al.
PloS one, 10(8), e0136329-e0136329 (2015-08-20)
Pleistocene aridification in central North America caused many temperate forest-associated vertebrates to split into eastern and western lineages. Such divisions can be cryptic when Holocene expansions have closed the gaps between once-disjunct ranges or when local morphological variation obscures deeper
C-C Lu et al.
Veterinary journal (London, England : 1997), 204(1), 23-31 (2015-04-07)
Myxomatous mitral valve disease (MMVD) is the single most common acquired heart disease of the dog and is particularly common in small pedigree breed dogs such as the Cavalier King Charles spaniel (CKCS). There are limited data on the mitral
T A McDonald et al.
Leukemia, 15(1), 10-20 (2001-03-13)
High background levels of phenol and hydroquinone are present in the blood and urine of virtually all individuals, but vary widely. Phenol and hydroquinone have been strongly implicated in producing leukemia associated with benzene exposure, because they reproduce the hematotoxicity
María Cordero-Vaca et al.
Analytical and bioanalytical chemistry, 407(16), 4615-4627 (2015-05-01)
Four different crosslinked polymeric ionic liquid (PIL)-based sorbent coatings were evaluated in an automated direct-immersion solid-phase microextraction method (automated DI-SPME) in combination with gas chromatography (GC). The crosslinked PIL coatings were based on vinyl-alkylimidazolium- (ViCnIm-) or vinylbenzyl-alkylimidazolium- (ViBzCnIm-) IL monomers
Christopher A Quinto et al.
Nanoscale, 7(29), 12728-12736 (2015-07-15)
Superparamagnetic iron oxide (SPIO) nanoparticles have the potential for use as a multimodal cancer therapy agent due to their ability to carry anticancer drugs and generate localized heat when exposed to an alternating magnetic field, resulting in combined chemotherapy and
Ageliki Tsagaratou et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(32), E3306-E3315 (2014-07-30)
The discovery of Ten Eleven Translocation proteins, enzymes that oxidize 5-methylcytosine (5mC) in DNA, has revealed novel mechanisms for the regulation of DNA methylation. We have mapped 5-hydroxymethylcytosine (5hmC) at different stages of T-cell development in the thymus and T-cell
Leonardo Joaquim van Zyl et al.
Archives of virology, 160(9), 2269-2282 (2015-07-01)
The study of extremophilic phages may reveal new phage families as well as different mechanisms of infection, propagation and lysis to those found in phages from temperate environments. We describe a novel siphovirus, GVE3, which infects the thermophile Geobacillus thermoglucosidasius.
Nelson F Eng et al.
The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale, 26(3), 137-144 (2015-08-04)
Helicobacter pylori plays a significant role in gastritis and ulcers. It is a carcinogen as defined by the WHO, and infection can result in adenocarcinomas and mucosa-associated lymphoid tissue lymphomas. In Canada, rates of antimicrobial resistance are relatively unknown, with
Tian-Yao Yang et al.
Environmental toxicology and pharmacology, 39(1), 157-166 (2014-12-20)
MeHg is one of the environmental pollutants that lead to oxidative stress and an indirect excitotoxicity caused by altered glutamate (Glu) concentration. However, little was known of the interaction. Therefore, we developed a rat model of MeHg poisoning to explore
Neha Chandrasekaran et al.
Journal of peptide science : an official publication of the European Peptide Society, 21(8), 630-635 (2015-04-10)
The adsorption of proteins at solid-liquid interfaces is important in biosensor and biomaterial applications. Marine mussels affix themselves to surfaces using a highly cross-linked, protein-based adhesive containing a high proportion of L-3,4-dihydroxyphenylalanine (DOPA) residues. In this work, the effect of
Hichem Alimi et al.
General physiology and biophysics, 32(1), 115-127 (2013-03-28)
Rhus tripartitum (sumac) is an Anacardiaceae tree with a wide phytotherapeutic application including the use of its roots in the management of gastric ulcer. In the present study the Rhus tripartitum root barks extract (RTE) was phytochemical studied, in vitro
Feng Li et al.
Molecular bioSystems, 11(12), 3253-3263 (2015-10-13)
Genome-wide expression profiling during development provides useful information to uncover the potential molecular mechanisms of development in mammals. Recent studies have revealed that a subset of lncRNAs can regulate major biological processes during development. Here, we sequenced four tissues, including
Hui Gong et al.
International journal of molecular sciences, 16(6), 12482-12498 (2015-06-06)
Plasma urotensin II (UII) has been observed to be raised in patients with acute myocardial infarction; suggesting a possible cardiac protective role for this peptide. However, the molecular mechanism is unclear. Here, we treated cultured cardiomyocytes with H2O2 to induce
Huey-Chun Huang et al.
International journal of molecular sciences, 16(5), 10470-10490 (2015-05-12)
The effects of essential oil from Eucalyptus camaldulensis flowers oil on melanogenesis and the oil's antioxidant characteristics were investigated. Assays of mushroom and cellular tyrosinase activities and melanin content of mouse melanoma cells were performed spectrophotometrically, and the expression of
Gražvydas Lukinavičius et al.
Nature communications, 6, 8497-8497 (2015-10-02)
Cell-permeable DNA stains are popular markers in live-cell imaging. Currently used DNA stains for live-cell imaging are either toxic, require illumination with blue light or are not compatible with super-resolution microscopy, thereby limiting their utility. Here we describe a far-red
Svetlana N Rubtsova et al.
PloS one, 10(7), e0133578-e0133578 (2015-07-25)
Using confocal microscopy, we analyzed the behavior of IAR-6-1, IAR1170, and IAR1162 transformed epithelial cells seeded onto the confluent monolayer of normal IAR-2 epithelial cells. Live-cell imaging of neoplastic cells stably expressing EGFP and of normal epithelial cells stably expressing
Anna Maria Wróbel et al.
Toxicology letters, 238(2), 110-116 (2015-08-09)
In the present study, we examined cAMP levels and activation of the MAPK/ERK1/2 and PI3K/Akt signaling pathways in response to the actions of parabens on GPR30 in MCF-7 and MCF-10A cells. Cells were exposed to methyl-, propyl- or butylparaben at
Elisabet Cuyàs et al.
Oncotarget, 6(14), 12279-12296 (2015-05-20)
Metabolic flexibility might be particularly constrained in tumors bearing mutations in isocitrate dehydrogenase 1 (IDH1) leading to the production of the oncometabolite 2-hydroxygluratate (2HG). To test the hypothesis that IDH1 mutations could generate metabolic vulnerabilities for therapeutic intervention, we utilized
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