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Janice K Kiecolt-Glaser et al.
Psychoneuroendocrinology, 52, 239-250 (2014-12-17)
Longitudinal studies have implicated both marital distress and depression in the development of the metabolic syndrome, a risk factor for diabetes and cardiovascular disease. This study addressed the impact of hostile marital interactions and a mood disorder history on obesity-related...
H-T Dou et al.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 34(4), 753-762 (2014-12-05)
The purpose of this study was to investigate the molecular characteristics of 83 clinical Cryptococcus neoformans/C. gattii species complex isolated in Beijing, China, between 2007 and 2013. Restriction fragment length polymorphism of the gene URA5 (URA5-RFLP), multilocus sequence typing (MLST)...
Analise Z Reeves et al.
Antimicrobial agents and chemotherapy, 59(1), 444-449 (2014-11-12)
As the prevalence of multidrug-resistant and extensively drug-resistant tuberculosis strains continues to rise, so does the need to develop accurate and rapid molecular tests to complement time-consuming growth-based drug susceptibility testing. Performance of molecular methods relies on the association of...
Limin Gu et al.
Investigative ophthalmology & visual science, 55(12), 8208-8222 (2014-10-23)
Retinal neuronal cell dysfunction and even cell death are associated with increased excitotoxic glutamate (Glu) level in the retina. Our aim was to study a causative mechanism of Glu on retinal cell death and explore the neuroprotective role of erythropoietin...
Rohini Raman et al.
Neuropathology and applied neurobiology, 41(2), 201-226 (2014-04-23)
Amyotrophic lateral sclerosis (ALS) and primary lateral sclerosis (PLS) are two syndromic variants within the motor neurone disease spectrum. As PLS and most ALS cases are sporadic (SALS), this limits the availability of cellular models for investigating pathogenic mechanisms and...
E M Faioni et al.
Thrombosis and haemostasis, 112(6), 1182-1189 (2014-08-12)
Arachidonic acid (AA), when cleaved from phospholipids by cytosolic phospholipase A2 alpha (cPLA2a), generates eicosanoids, with pro-hemostatic, pro-inflammatory, vasoactive and gastro-protective functions. We describe a patient (27-year-old man) and his twin-sister with early-onset bleeding diathesis and recurrent gastro-intestinal (GI) ulcers....
Tadahiro Suzuki et al.
Toxins, 7(1), 187-200 (2015-01-23)
Host plants excrete a glucosylation enzyme onto the plant surface that changes mycotoxins derived from fungal secondary metabolites to glucosylated products. Deoxynivalenol-3-glucoside (DON3G) is synthesized by grain uridine diphosphate-glucosyltransferase, and is found worldwide, although information on its toxicity is lacking....
Debra Rossouw et al.
Applied and environmental microbiology, 75(20), 6600-6612 (2009-08-25)
Commercial wine yeast strains of the species Saccharomyces cerevisiae have been selected to satisfy many different, and sometimes highly specific, oenological requirements. As a consequence, more than 200 different strains with significantly diverging phenotypic traits are produced globally. This genetic...
Monsicha Pongpom et al.
Infection and immunity, 83(3), 923-933 (2014-12-24)
In Aspergillus nidulans, the AcuK and AcuM transcription factors form a complex that regulates gluconeogenesis. In Aspergillus fumigatus, AcuM governs gluconeogenesis and iron acquisition in vitro and virulence in immunosuppressed mice. However, the function of AcuK was previously unknown. Through...
Carlo Giuseppe Rizzello et al.
Applied and environmental microbiology, 81(9), 3192-3204 (2015-03-01)
Triticum turgidum subsp. durum was grown according to four farming systems: conventional (CONV), organic with cow manure (OMAN) or green manure (OLEG), and without inputs (NOINPUT). Some chemical and technological characteristics differed between CONV and organic flours. As shown by...
Phing-How Lou et al.
Anesthesia and analgesia, 120(2), 329-340 (2014-12-02)
The IV anesthetic, propofol, when administered as fat emulsion-based formulation (Diprivan) promotes insulin resistance, but the direct effects of propofol and its solvent, Intralipid, on cardiac insulin resistance are unknown. Hearts of healthy and type-2 diabetic rats (generated by fructose...
Frederika Maria Byrne et al.
Journal of diabetes research, 2015, 752481-752481 (2015-03-12)
Chronic pain is a common complication of diabetes. The aim of the present study was to characterise pain behaviour in a high fat diet/streptozotocin (HFD/STZ) model of diabetes in the rat, investigate spinal mechanisms, and determine the effects of antidiabetic...
Ken-ichi Sato et al.
Natural product communications, 8(7), 987-998 (2013-08-29)
This report describes the stereocontrolled total synthesis of the multi-functionalized cyclitol derivative, tetrodotoxin, containing eight asymmetric carbons and different types of branched-chains, from myo-inositol and D-glucose using three different methods. The tetrodotoxin derivatives possess a relatively small molecular weight but...
Krystal A Fontaine et al.
Journal of virology, 89(4), 2358-2366 (2014-12-17)
Viruses rely on host cellular metabolism to provide the energy and biosynthetic building blocks required for their replication. Dengue virus (DENV), a member of the Flaviviridae family, is one of the most important arthropod-borne human pathogens worldwide. We analyzed global...
Shilu Yin et al.
Plastic and reconstructive surgery, 135(1), 127-138 (2014-10-07)
Recent literature has revealed that water-jet-assisted liposuction offers a new method of conventional liposuction techniques by using the gentle spray of fluid. However, there has not yet been a systematic, randomized, controlled study to demonstrate its effect on the vitality...
Pierre-Yves Collart-Dutilleul et al.
Nanoscale research letters, 9(1), 564-564 (2014-11-12)
The way cells explore their surrounding extracellular matrix (ECM) during development and migration is mediated by lamellipodia at their leading edge, acting as an actual motor pulling the cell forward. Lamellipodia are the primary area within the cell of actin...
Ramu Adela et al.
PloS one, 10(4), e0125270-e0125270 (2015-04-22)
We have previously reported that increased glucose levels were associated with higher serum nitric oxide (NO) levels in fructose-fed insulin resistant rats. However, the relationship between hyperglycemia and serum NO level was not clear. Therefore, the present study was designed...
Rachael K Nelson et al.
Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme, 39(7), 811-818 (2014-04-30)
Although regular exercise is associated with reduced cardiometabolic disease risk among overweight adults, it remains unclear whether much of the health benefits of exercise are derived from the most recent session(s) of exercise or if they are the result of...
Daifeng Cheng et al.
Scientific reports, 4, 7489-7489 (2014-12-17)
Reproduction is an important life process in insects; however, few studies have attempted to demonstrate the association between reproductive activity and energy metabolism. To address this problem, we focused on the reproductive changes in Bactrocera dorsalis males. We analyzed B....
Medicine. Why does gastric bypass surgery work?
Hans-Rudolf Berthoud
Science (New York, N.Y.), 341(6144), 351-352 (2013-07-28)
Linda Vignozzi et al.
The journal of sexual medicine, 11(12), 2890-2902 (2014-09-23)
Estrogen receptor (ER) α is critical in mediating the harmful effects of hyperestrogenism in fetal or neonatal life on the developing penis. In contrast, little is known on the impact of an excess of estrogens on penile function in adulthood....
Jinzeng Yang
Progress in molecular biology and translational science, 121, 133-163 (2014-01-01)
As the single largest organ in the body, the skeletal muscle is the major site of insulin-stimulated glucose uptake in the postprandial state. Skeletal muscles provide the physiological foundation for physical activities and fitness. Reduced muscle mass and strength is...
Chrissy M Leopold Wager et al.
Journal of immunology (Baltimore, Md. : 1950), 193(8), 4060-4071 (2014-09-10)
Nonprotective immune responses to highly virulent Cryptococcus neoformans strains, such as H99, are associated with Th2-type cytokine production, alternatively activated macrophages, and inability of the host to clear the fungus. In contrast, experimental studies show that protective immune responses against...
K A Taylor et al.
Journal of thrombosis and haemostasis : JTH, 12(6), 987-998 (2014-03-25)
Pannexin-1 (Panx1) forms an anion-selective channel with a permeability up to ~1 kDa and represents a non-lytic, non-vesicular ATP release pathway in erythrocytes, leukocytes and neurons. Related connexin gap junction proteins have been reported in platelets; however, the expression and...
Yasuhiro Shimada et al.
Carbohydrate research, 407, 10-15 (2015-02-24)
Poly-trans-[(2-carboxyethyl)germasesquioxane], Ge-132, is a water-soluble organic germanium compound with many reported physiological functions. The hydrolysate of Ge-132, 3-(trihydroxygermyl)propanoic acid, can interact with diol compounds; therefore, it can possibly interact with diol-containing sugar compounds, which have important physiological functions in sugar...
Susanne Herbst et al.
EMBO molecular medicine, 7(3), 240-258 (2015-02-01)
Transplant recipients on calcineurin inhibitors are at high risk of invasive fungal infection. Understanding how calcineurin inhibitors impair fungal immunity is a key priority for defining risk of infection. Here, we show that the calcineurin inhibitor tacrolimus impairs clearance of...
Ioannis A Papaioannou et al.
Current genetics, 60(3), 135-148 (2013-11-22)
Group-I introns are widespread--though irregularly distributed--in eukaryotic organisms, and they have been extensively used for discrimination and phylogenetic analyses. Within the Verticillium genus, which comprises important phytopathogenic fungi, a group-I intron was previously identified in the SSU-rRNA (18S) gene of...
Saunders Handbook of Veterinary Drugs - E-Book: Small and Large Animal (2010)
Jeniel E Nett et al.
Infection and immunity, 82(12), 4931-4940 (2014-09-04)
Indwelling urinary catheters are commonly used in the management of hospitalized patients. Candida can adhere to the device surface and propagate as a biofilm. These Candida biofilm communities differ from free-floating Candida, exhibiting high tolerance to antifungal therapy. The significance...
Weight-loss surgery: A gut-wrenching question.
Virginia Hughes
Nature, 511(7509), 282-284 (2014-07-18)
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