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Sharad Mangal et al.
International journal of pharmaceutics, 479(2), 338-348 (2015-01-13)
In this study, polyvinylpyrrolidone (PVP) was spray dried with l-leucine (PVP-Leu) to create a prototype multifunctional interactive excipient. The physico-chemical and bulk properties such as particle size, surface composition, surface energy and bulk cohesion of PVP-Leu was measured and compared
Marcello Locatelli et al.
Journal of chromatography. A, 1388, 79-86 (2015-02-24)
This paper reports the validation of a quantitative high performance liquid chromatography-photodiode array (HPLC-PDA) method for the simultaneous analysis, in mouse plasma, of eperisone hydrochloride and paracetamol by protein precipitation using zinc sulphate-methanol-acetonitrile. The analytes were resolved on a Gemini
Shengdong Wang et al.
Liver international : official journal of the International Association for the Study of the Liver, 34(7), 1068-1073 (2013-10-15)
Acetaminophen (APAP) is widely used as an antipyretic agent which is safe at therapeutic doses. However, overdose of APAP induces fatal and non-fatal hepatic necroses. The chemical reactive metabolites of APAP initiate toxicity and inflammatory response within the liver and
Peggy Gandia et al.
Journal of clinical pharmacology, 43(11), 1235-1243 (2003-10-11)
This study evaluated the effect of simulated weightlessness on gastric emptying, using acetaminophen as a probe and -6 degrees head-down bed rest to simulate zero gravity. Eighteen volunteers were given 1 g of acetaminophen orally before the bed rest and
Syusuke Sano et al.
International journal of pharmaceutics, 468(1-2), 234-242 (2014-04-09)
The impact of different active pharmaceutical ingredients (APIs) loading on the properties of orally disintegrating tablets (ODTs) prepared according to our previously reported microwave (MW) treatment process was evaluated using famotidine (FAM), acetaminophen (AAP), and ibuprofen (IBU). None of the
Antonio Martinez-Gimeno et al.
Expert review of respiratory medicine, 7(2), 113-122 (2013-04-04)
During the last few decades, a huge epidemiological effort has been made all over the world in order to cast some light on the origin of asthma (or 'wheezing disorders' as a general term) and its recent increase in prevalence.
H O Topçu et al.
European journal of obstetrics, gynecology, and reproductive biology, 182, 81-85 (2014-09-30)
To determine the effects of different intra-abdominal pressure values on visceral pain following gynecologic laparoscopic surgery in the Trendelenburg position. This randomized, controlled prospective trial was conducted at a tertiary education hospital and included 150 patients who underwent gynecologic laparoscopy
Julia Dinger et al.
Toxicology letters, 230(1), 28-35 (2014-08-12)
Drugs of abuse are not tested for cytochrome P450 (CYP) inhibition potential before distribution. Therefore, a cocktail assay should be developed for testing the inhibition potential for all relevant CYPs. The following CYP test substrates and selective inhibitors were incubated
Luz María Martínez et al.
International journal of pharmaceutics, 477(1-2), 294-305 (2014-12-03)
There is a special interest in having pharmaceutical active ingredients in the amorphous state due to their increased solubility and therefore, higher bioavailability. Nevertheless, not all of them present stable amorphous phases. In particular, paracetamol is an active ingredient widely
Mona Darwish et al.
Clinical therapeutics, 37(2), 390-401 (2014-12-30)
A hydrocodone extended-release (ER) formulation was developed to provide sustained pain relief with twice-daily dosing. Developed using the CIMA abuse-deterrence technology platform (CIMA Labs Inc, Brooklyn Park, Minnesota), this formulation also provides resistance against rapid release of hydrocodone when tablets
Nabil A Khan et al.
Journal of opioid management, 9(3), 225-230 (2013-06-19)
Addiction to painkillers or other substances in pediatric and adolescent cases of noncancer chronic pain is an understudied phenomenon, even amidst documented increases in rates of prescription opioid use and misuse. Case studies can inform the training of clinicians in
Patrick Scheiermann et al.
Scientific reports, 5, 8521-8521 (2015-02-18)
Overdosing of the analgesic acetaminophen (APAP, paracetamol) is a major cause of acute liver injury. Whereas toxicity is initiated by hepatocyte necrosis, course of disease is regulated by mechanisms of innate immunity having the potential to serve in complex manner
Yoko Nishimura et al.
Journal of applied toxicology : JAT, 35(2), 173-180 (2014-08-06)
Cardiotoxicity is one of the major safety concerns in drug development. Therefore, detecting and monitoring cardiotoxicity throughout preclinical and clinical studies is important for pharmaceutical companies. The present study was conducted in order to explore a plasma miRNA biomarker for
PKCs: pernicious kinase culprits in acetaminophen pathogenesis.
Cynthia Ju et al.
Hepatology (Baltimore, Md.), 59(4), 1229-1231 (2014-03-29)
Dany Spaggiari et al.
Analytical and bioanalytical chemistry, 406(20), 4875-4887 (2014-06-05)
The cocktail approach is an advantageous strategy used to monitor the activities of several cytochromes P450 (CYPs) in a single test to increase the throughput of in vitro phenotyping studies. In this study, a cocktail mixture was developed with eight
Sebastiano Mercadante et al.
Critical reviews in oncology/hematology, 87(2), 140-145 (2013-02-12)
The aim of this review was to assess the value of NSAIDs and paracetamol in patients with cancer pain to update a previous review performed ten years ago on this topic. The approach was analytic and based on clinical considerations
Takako Ohkura et al.
Drug metabolism and pharmacokinetics, 29(5), 373-378 (2014-04-04)
We investigated the utility of three-dimensional (3D) spheroid cultures of human hepatocytes in discovering drug metabolites. Metabolites of acetaminophen, diclofenac, lamotrigine, midazolam, propranolol and salbutamol were analyzed by liquid chromatography-tandem mass spectrometry (LC/MS/MS) to measure enzyme activities in this system
Eda Ozcelik et al.
Pharmacognosy magazine, 10(Suppl 2), S217-S224 (2014-07-06)
Liver diseases have become a major problem of the worldwide. More than 50% of all cases of liver failure can be attributed to drugs. Among these, acetaminophen is the most common cause. The aim of this study was to investigate
F Franceschi et al.
European review for medical and pharmacological sciences, 17(16), 2129-2135 (2013-07-31)
Pain is the most common reason people see doctors in developed Countries and a very common cause of access in Emergency Department (ED). The combination acetaminophen/codeine represents the standard medication in the second step of the WHO analgesic scale and
Treatment of paracetamol overdose.
Benjamin Kessler et al.
Lancet (London, England), 383(9926), 1382-1382 (2014-04-25)
Katarina Rubin et al.
Drug metabolism and disposition: the biological fate of chemicals, 43(1), 119-125 (2014-11-06)
The suppression of hepatic cytochrome P450 (P450) expression during inflammatory and infectious diseases and the relief of this suppression by successful disease treatment have been previously demonstrated to impact drug disposition. To address this clinically relevant phenomenon preclinically, the effect
[Effectiveness of analgesic combinations in the self-medication].
Eve C A Morgenstern et al.
MMW Fortschritte der Medizin, 155(9), 49-51 (2013-08-21)
Harley T Syyong et al.
American journal of respiratory cell and molecular biology, 52(3), 304-314 (2014-07-24)
A characteristic feature of asthma is exaggerated airway narrowing, termed airway hyper-responsiveness (AHR) due to contraction of airway smooth muscle (ASM). Although smooth muscle (SM)-specific asthma susceptibility genes have been identified, it is not known whether asthmatic ASM is phenotypically
Genetics of drug-induced hepatotoxicity toxicity in Gilbert's syndrome.
Ali Raza et al.
The American journal of gastroenterology, 108(12), 1936-1937 (2013-12-05)
The ability of a retrospective review of electronic health records to fully capture the frequency of supratherapeutic dosing of acetaminophen--reply.
Li Zhou et al.
JAMA internal medicine, 173(11), 1036-1036 (2013-06-12)
Rodney N Nishimoto
Anesthesia progress, 61(3), 99-102 (2014-09-06)
This was judged to be the first place winning submission for the American Dental Society of Anesthesiology Student Essay Award. Acetaminophen is an old drug that is now available in an intravenous formulation. Its advantages and disadvantages are reviewed, including
Elias Begas et al.
Journal of chromatographic science, 52(7), 590-595 (2013-06-27)
Methotrexate (MTX) is a dihydrofolate reductase inhibitor that is used for the treatment of tumors and autoimmune diseases. Several automated binding assays are used in clinical practice and numerous chromatographic methods have been developed toward higher specificity and sensitivity. In
Abdelmonaim Azzouz et al.
Food chemistry, 178, 63-69 (2015-02-24)
A sensitive, selective, efficient gas chromatography-mass spectrometry method for the simultaneous determination of 22 pharmacologically active substances (antibacterials, nonsteroidal antiinflammatories, antiseptics, antiepileptics, lipid regulators, β-blockers and hormones) in eggs and honey was developed. The sample pretreatment includes precipitation of proteins
Sébastien Anthérieu et al.
Toxicology and applied pharmacology, 276(1), 63-72 (2014-02-15)
Drinking water can be contaminated with pharmaceuticals. However, it is uncertain whether this contamination can be harmful for the liver, especially during obesity. Hence, the goal of our study was to determine whether chronic exposure to low doses of pharmaceuticals
Chaoqun Tan et al.
Journal of hazardous materials, 276, 452-460 (2014-06-16)
Magnetic nano-scaled particles Fe3O4 were studied for the activation of peroxymonosulfate (PMS) to generate active radicals for degradation of acetaminophen (APAP) in water. The Fe3O4 MNPs were found to effectively catalyze PMS for removal of APAP, and the reactions well
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