Filtros aplicados

Palavra-chave:'phr1005'

Exibindo 1-30 of 344 resultados for "

phr1005

" no prazo de Papéis

Application of IL-36 receptor antagonist weakens CCL20 expression and impairs recovery in the late phase of murine acetaminophen-induced liver injury.

Patrick Scheiermann et al.

Scientific reports, 5, 8521-8521 (2015-02-18)

Overdosing of the analgesic acetaminophen (APAP, paracetamol) is a major cause of acute liver injury. Whereas toxicity is initiated by hepatocyte necrosis, course of disease is regulated by mechanisms of innate immunity having the potential to serve in complex manner

The association between acetaminophen and asthma: should its pediatric use be banned?

Antonio Martinez-Gimeno et al.

Expert review of respiratory medicine, 7(2), 113-122 (2013-04-04)

During the last few decades, a huge epidemiological effort has been made all over the world in order to cast some light on the origin of asthma (or 'wheezing disorders' as a general term) and its recent increase in prevalence.

Simultaneous determination of eperisone hydrochloride and paracetamol in mouse plasma by high performance liquid chromatography-photodiode array detector.

Marcello Locatelli et al.

Journal of chromatography. A, 1388, 79-86 (2015-02-24)

This paper reports the validation of a quantitative high performance liquid chromatography-photodiode array (HPLC-PDA) method for the simultaneous analysis, in mouse plasma, of eperisone hydrochloride and paracetamol by protein precipitation using zinc sulphate-methanol-acetonitrile. The analytes were resolved on a Gemini

Plasma miR-208 as a useful biomarker for drug-induced cardiotoxicity in rats.

Yoko Nishimura et al.

Journal of applied toxicology : JAT, 35(2), 173-180 (2014-08-06)

Cardiotoxicity is one of the major safety concerns in drug development. Therefore, detecting and monitoring cardiotoxicity throughout preclinical and clinical studies is important for pharmaceutical companies. The present study was conducted in order to explore a plasma miRNA biomarker for

Panaxatriol saponin ameliorated liver injury by acetaminophen via restoring thioredoxin-1 and pro-caspase-12.

Shengdong Wang et al.

Liver international : official journal of the International Association for the Study of the Liver, 34(7), 1068-1073 (2013-10-15)

Acetaminophen (APAP) is widely used as an antipyretic agent which is safe at therapeutic doses. However, overdose of APAP induces fatal and non-fatal hepatic necroses. The chemical reactive metabolites of APAP initiate toxicity and inflammatory response within the liver and

Impact of active ingredients on the swelling properties of orally disintegrating tablets prepared by microwave treatment.

Syusuke Sano et al.

International journal of pharmaceutics, 468(1-2), 234-242 (2014-04-09)

The impact of different active pharmaceutical ingredients (APIs) loading on the properties of orally disintegrating tablets (ODTs) prepared according to our previously reported microwave (MW) treatment process was evaluated using famotidine (FAM), acetaminophen (AAP), and ibuprofen (IBU). None of the

Single- and multiple-dose pharmacokinetics of a hydrocodone bitartrate extended-release tablet formulated with abuse-deterrence technology in healthy, naltrexone-blocked volunteers.

Mona Darwish et al.

Clinical therapeutics, 37(2), 390-401 (2014-12-30)

A hydrocodone extended-release (ER) formulation was developed to provide sustained pain relief with twice-daily dosing. Developed using the CIMA abuse-deterrence technology platform (CIMA Labs Inc, Brooklyn Park, Minnesota), this formulation also provides resistance against rapid release of hydrocodone when tablets

Development of an in vitro cytochrome P450 cocktail inhibition assay for assessing the inhibition risk of drugs of abuse.

Julia Dinger et al.

Toxicology letters, 230(1), 28-35 (2014-08-12)

Drugs of abuse are not tested for cytochrome P450 (CYP) inhibition potential before distribution. Therefore, a cocktail assay should be developed for testing the inhibition potential for all relevant CYPs. The following CYP test substrates and selective inhibitors were incubated

Evaluation of the Multi-ImmunoTox Assay composed of 3 human cytokine reporter cells by examining immunological effects of drugs.

Yutaka Kimura et al.

Toxicology in vitro : an international journal published in association with BIBRA, 28(5), 759-768 (2014-03-08)

We established a luciferase reporter assay system, the Multi-ImmunoTox Assay (MITA), to evaluate the effects on key predictivein vitro components of the human immune system. The system is composed of 3 stable reporter cell lines transfected with 3 luciferase genes

Influence of simulated weightlessness on the oral pharmacokinetics of acetaminophen as a gastric emptying probe in man: a plasma and a saliva study.

Peggy Gandia et al.

Journal of clinical pharmacology, 43(11), 1235-1243 (2003-10-11)

This study evaluated the effect of simulated weightlessness on gastric emptying, using acetaminophen as a probe and -6 degrees head-down bed rest to simulate zero gravity. Eighteen volunteers were given 1 g of acetaminophen orally before the bed rest and

Clinical question: are non-steroidal anti-inflammatories superior to acetaminophen for sprains/strains?

Heather Wheeler et al.

The Journal of the Oklahoma State Medical Association, 107(3), 109-110 (2014-05-08)

HepaRG cells as human-relevant in vitro model to study the effects of inflammatory stimuli on cytochrome P450 isoenzymes.

Katarina Rubin et al.

Drug metabolism and disposition: the biological fate of chemicals, 43(1), 119-125 (2014-11-06)

The suppression of hepatic cytochrome P450 (P450) expression during inflammatory and infectious diseases and the relief of this suppression by successful disease treatment have been previously demonstrated to impact drug disposition. To address this clinically relevant phenomenon preclinically, the effect

Ultrastructure of human tracheal smooth muscle from subjects with asthma and nonasthmatic subjects. Standardized methods for comparison.

Harley T Syyong et al.

American journal of respiratory cell and molecular biology, 52(3), 304-314 (2014-07-24)

A characteristic feature of asthma is exaggerated airway narrowing, termed airway hyper-responsiveness (AHR) due to contraction of airway smooth muscle (ASM). Although smooth muscle (SM)-specific asthma susceptibility genes have been identified, it is not known whether asthmatic ASM is phenotypically

PKCs: pernicious kinase culprits in acetaminophen pathogenesis.

Cynthia Ju et al.

Hepatology (Baltimore, Md.), 59(4), 1229-1231 (2014-03-29)

Detection, identification and quantification by 1H NMR of adulterants in 150 herbal dietary supplements marketed for improving sexual performance.

Véronique Gilard et al.

Journal of pharmaceutical and biomedical analysis, 102, 476-493 (2014-12-03)

One hundred and fifty dietary supplements (DS) marketed to increase sexual performance were analyzed. All these formulations were claimed to contain only natural compounds, plant extracts and/or vitamins. (1)H NMR spectroscopy was used for detecting the presence of adulterants and

Undetected Ultracet™ dependence in an adolescent with nonmalignant back pain.

Nabil A Khan et al.

Journal of opioid management, 9(3), 225-230 (2013-06-19)

Addiction to painkillers or other substances in pediatric and adolescent cases of noncancer chronic pain is an understudied phenomenon, even amidst documented increases in rates of prescription opioid use and misuse. Case studies can inform the training of clinicians in

The role of physico-chemical and bulk characteristics of co-spray dried L-leucine and polyvinylpyrrolidone on glidant and binder properties in interactive mixtures.

Sharad Mangal et al.

International journal of pharmaceutics, 479(2), 338-348 (2015-01-13)

In this study, polyvinylpyrrolidone (PVP) was spray dried with l-leucine (PVP-Leu) to create a prototype multifunctional interactive excipient. The physico-chemical and bulk properties such as particle size, surface composition, surface energy and bulk cohesion of PVP-Leu was measured and compared

Stabilization of amorphous paracetamol based systems using traditional and novel strategies.

Luz María Martínez et al.

International journal of pharmaceutics, 477(1-2), 294-305 (2014-12-03)

There is a special interest in having pharmaceutical active ingredients in the amorphous state due to their increased solubility and therefore, higher bioavailability. Nevertheless, not all of them present stable amorphous phases. In particular, paracetamol is an active ingredient widely

A prospective randomized trial of postoperative pain following different insufflation pressures during gynecologic laparoscopy.

H O Topçu et al.

European journal of obstetrics, gynecology, and reproductive biology, 182, 81-85 (2014-09-30)

To determine the effects of different intra-abdominal pressure values on visceral pain following gynecologic laparoscopic surgery in the Trendelenburg position. This randomized, controlled prospective trial was conducted at a tertiary education hospital and included 150 patients who underwent gynecologic laparoscopy

FDA asks physicians to stop prescribing high-dose acetaminophen products.

Mike Mitka

JAMA, 311(6), 563-563 (2014-02-13)

[Effectiveness of analgesic combinations in the self-medication].

Eve C A Morgenstern et al.

MMW Fortschritte der Medizin, 155(9), 49-51 (2013-08-21)

MD-2 is required for disulfide HMGB1-dependent TLR4 signaling.

Huan Yang et al.

The Journal of experimental medicine, 212(1), 5-14 (2015-01-07)

Innate immune receptors for pathogen- and damage-associated molecular patterns (PAMPs and DAMPs) orchestrate inflammatory responses to infection and injury. Secreted by activated immune cells or passively released by damaged cells, HMGB1 is subjected to redox modification that distinctly influences its

Treatment of paracetamol overdose.

Benjamin Kessler et al.

Lancet (London, England), 383(9926), 1382-1382 (2014-04-25)

CSF Glucose Concentrations in Infants with Febrile Convulsions and the Possible Effect of Acetaminophen.

Mahmoud Mohammadi et al.

Indian pediatrics, 40(12), 1183-1186 (2004-01-15)

The present study was done to explore the relationship between the cerebrospinal fluid (CSF) glucose concentration, body temperature, seizure duration, and acetaminophen administration. Retrospective record review of 117 consecutive febrile convulsive infants aging 3 to 18 months admitted to Bahrami

Safety and efficacy of the combination acetaminophen-codeine in the treatment of pain of different origin.

F Franceschi et al.

European review for medical and pharmacological sciences, 17(16), 2129-2135 (2013-07-31)

Pain is the most common reason people see doctors in developed Countries and a very common cause of access in Emergency Department (ED). The combination acetaminophen/codeine represents the standard medication in the second step of the WHO analgesic scale and

Schisandrol B protects against acetaminophen-induced hepatotoxicity by inhibition of CYP-mediated bioactivation and regulation of liver regeneration.

Yiming Jiang et al.

Toxicological sciences : an official journal of the Society of Toxicology, 143(1), 107-115 (2014-10-17)

Acetaminophen (APAP) overdose is the most frequent cause of drug-induced acute liver failure. Schisandra sphenanthera is a traditional hepato-protective Chinese medicine and Schisandrol B (SolB) is one of its major active constituents. In this study, the protective effect of SolB

When is research clinical advice? Interpreting an exploratory study of paracetamol overdose.

Geoffrey K Isbister et al.

Clinical toxicology (Philadelphia, Pa.), 51(10), 1242-1242 (2013-11-14)

Phenotyping of CYP450 in human liver microsomes using the cocktail approach.

Dany Spaggiari et al.

Analytical and bioanalytical chemistry, 406(20), 4875-4887 (2014-06-05)

The cocktail approach is an advantageous strategy used to monitor the activities of several cytochromes P450 (CYPs) in a single test to increase the throughput of in vitro phenotyping studies. In this study, a cocktail mixture was developed with eight

Chitosan and blueberry treatment induces arginase activity and inhibits nitric oxide production during acetaminophen-induced hepatotoxicity.

Eda Ozcelik et al.

Pharmacognosy magazine, 10(Suppl 2), S217-S224 (2014-07-06)

Liver diseases have become a major problem of the worldwide. More than 50% of all cases of liver failure can be attributed to drugs. Among these, acetaminophen is the most common cause. The aim of this study was to investigate

Use of a fixed combination of acetylsalicylic acid, acetaminophen and caffeine compared with acetaminophen alone in episodic tension-type headache: meta-analysis of four randomized, double-blind, placebo-controlled, crossover studies.

Hans-Christoph Diener et al.

The journal of headache and pain, 15, 76-76 (2014-11-20)

Most patients with episodic tension-type headache treat headache episodes with over-the-counter medication. Combination analgesics containing caffeine may be more effective and as well tolerated as monotherapy. The aim of this study was to evaluate the efficacy of the combination of

Página 1 de 12