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Percy Tumbale et al.
Nature, 506(7486), 111-115 (2013-12-24)
Faithful maintenance and propagation of eukaryotic genomes is ensured by three-step DNA ligation reactions used by ATP-dependent DNA ligases. Paradoxically, when DNA ligases encounter nicked DNA structures with abnormal DNA termini, DNA ligase catalytic activity can generate and/or exacerbate DNA
Zhi-Hua Li et al.
Ecotoxicology and environmental safety, 109, 10-14 (2014-08-19)
The effect of long-term exposure to tributyltin (TBT) on the intestine-related biochemical biomarkers in common carp was investigated in this study. Fish were exposed at sub-lethal concentrations of TBT (75 ng/L, 0.75 and 7.5 μg/L) for 60 days. Multiple biomarkers
Christopher Schliehe et al.
Nature immunology, 16(1), 67-74 (2014-11-25)
Immune responses are tightly regulated to ensure efficient pathogen clearance while avoiding tissue damage. Here we report that Setdb2 was the only protein lysine methyltransferase induced during infection with influenza virus. Setdb2 expression depended on signaling via type I interferons
Matthew A Pasek et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(25), 10089-10094 (2013-06-05)
It has been hypothesized that before the emergence of modern DNA-RNA-protein life, biology evolved from an "RNA world." However, synthesizing RNA and other organophosphates under plausible early Earth conditions has proved difficult, with the incorporation of phosphorus (P) causing a
Carolina S Cerrudo et al.
The FEBS journal, 281(1), 74-87 (2014-01-08)
Here, we review current knowledge about pseudouridine synthase and archaeosine transglycosylase (PUA)-domain-containing proteins to illustrate progress in this field. A methodological analysis of the literature about the topic was carried out, together with a 'qualitative comparative analysis' to give a
S Su et al.
Poultry science, 93(5), 1217-1226 (2014-05-06)
Avian coccidiosis is a disease caused by intestinal protozoa in the genus Eimeria. Clinical signs of coccidiosis include intestinal lesions and reduced feed efficiency and BW gain. This growth reduction may be due to changes in expression of digestive enzymes
Frantisek Turecek
European journal of mass spectrometry (Chichester, England), 13(1), 89-95 (2007-09-20)
This short review outlines the tandem mass spectrometric methods for the generation and analysis of transient nucleobase radicals relevant to deoxyribonucleic acid and ribonucleic acid damage. Radical hydrogen atom adducts to uracil, adenine, cytosine and N-methylcytosine were generated by femtosecond
Bryan J Holtz et al.
American journal of physiology. Gastrointestinal and liver physiology, 307(7), G700-G710 (2014-08-12)
High levels of cholecystokinin (CCK) can stimulate pancreatic adaptive growth in which mature acinar cells divide, leading to enhanced pancreatic mass with parallel increases in protein, DNA, RNA, and digestive enzyme content. Prolonged release of CCK can be induced by
Rui Shao et al.
The Prostate, 74(9), 970-982 (2014-04-23)
Epithelial-to-mesenchymal transition (EMT) has been reported involved in the pathogenesis of fibrotic disorders and associated with stemness characteristics. Recent studies demonstrated that human benign prostatic hyperplasia (BPH) development involves accumulation of mesenchymal-like cells derived from the prostatic epithelium. However, the
Molecular biology: A second layer of information in RNA.
Silvia B V Ramos et al.
Nature, 505(7485), 621-622 (2014-01-31)
Kazuya Shirato et al.
Journal of virological methods, 258, 41-48 (2018-05-16)
Clinical detection of Middle East respiratory syndrome (MERS) coronavirus (MERS-CoV) in patients is achieved using genetic diagnostic methods, such as real-time RT-PCR assay. Previously, we developed a reverse transcription-loop-mediated isothermal amplification (RT-LAMP) assay for the detection of MERS-CoV [Virol J.
Cell Biology. NIH effort gambles on mysterious extracellular RNAs.
Mitch Leslie
Science (New York, N.Y.), 341(6149), 947-947 (2013-08-31)
Andrey Chursov et al.
Nucleic acids research, 41(Web Server issue), W486-W491 (2013-06-15)
Although multiple biological phenomena are related to temperature (e.g. elevation of body temperature due to an illness, adaptation to environmental temperature conditions, biology of coldblooded versus warm-blooded organisms), the molecular mechanisms of these processes remain to be understood. Perturbations of
Chromatin and ribonucleic acid polymerases in the eukaryotic cell.
B B Biswas
Sub-cellular biochemistry, 3(1), 27-38 (1974-03-01)
Hagen Tilgner et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(27), 9869-9874 (2014-06-26)
Personal transcriptomes in which all of an individual's genetic variants (e.g., single nucleotide variants) and transcript isoforms (transcription start sites, splice sites, and polyA sites) are defined and quantified for full-length transcripts are expected to be important for understanding individual
Massimo Dal Monte et al.
Investigative ophthalmology & visual science, 56(1), 59-73 (2014-12-17)
β-adrenergic receptors (β-ARs) regulate angiogenesis in proliferative retinopathies. We studied the effects of β1/2-AR deletion in a model of oxygen-induced retinopathy (OIR) to confirm the role of β1- and/or β2-ARs in regulating angiogenesis and to get insights into the role
Soon-Suk Kang et al.
Investigative ophthalmology & visual science, 55(1), 535-541 (2013-12-12)
To evaluate the effects of nerve growth factor (NGF), which is activated during inflammatory episodes of ocular diseases, on the apoptotic response in cultured human primary conjunctival epithelial cells (pHCECs). Levels of NGF transcripts and NGF protein in pHCEC grown
Daniel Holoch et al.
Nature reviews. Genetics, 16(2), 71-84 (2015-01-03)
Diverse classes of RNA, ranging from small to long non-coding RNAs, have emerged as key regulators of gene expression, genome stability and defence against foreign genetic elements. Small RNAs modify chromatin structure and silence transcription by guiding Argonaute-containing complexes to
Erik Kudela et al.
Acta obstetricia et gynecologica Scandinavica, 93(10), 997-1002 (2014-09-02)
To analyze different amplification patterns of 3q26 and 5p15 regions in low-grade and high-grade cervical intraepithelial neoplasia. Experimental research. Department of Obstetrics and Gynecology at a medical faculty in Slovakia. A group of 83 patients referred for colposcopic examination. Amplification
Robert N Lightowlers et al.
FEBS letters, 588(15), 2496-2503 (2014-06-10)
Mitochondrial protein synthesis is essential for all mammals, being responsible for providing key components of the oxidative phosphorylation complexes. Although only thirteen different polypeptides are made, the molecular details of this deceptively simple process remain incomplete. Central to this process
Yann Tonin et al.
The Journal of biological chemistry, 289(19), 13323-13334 (2014-04-03)
Defects in mitochondrial genome can cause a wide range of clinical disorders, mainly neuromuscular diseases. Presently, no efficient therapeutic treatment has been developed against this class of pathologies. Because most of deleterious mitochondrial mutations are heteroplasmic, meaning that wild type
Innate immunity: Making mice more human the TLR8 way.
Elisabeth Kugelberg
Nature reviews. Immunology, 14(1), 6-6 (2013-12-18)
Ricardo Saldaña-Meyer et al.
Genes & development, 28(7), 723-734 (2014-04-04)
The multifunctional CCCTC-binding factor (CTCF) protein exhibits a broad range of functions, including that of insulator and higher-order chromatin organizer. We found that CTCF comprises a previously unrecognized region that is necessary and sufficient to bind RNA (RNA-binding region [RBR])
Michael R Green et al.
Cold Spring Harbor protocols, 2021(12) (2021-12-03)
Isolation of RNA from yeast is complicated by the need to first break the thick, rigid cell wall. The protocol provided here uses a cycle of heating and freezing of cells in the presence of phenol and the detergent sodium
Sabine Ruehle et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(25), 10264-10277 (2013-06-21)
A major goal in current neuroscience is to understand the causal links connecting protein functions, neural activity, and behavior. The cannabinoid CB1 receptor is expressed in different neuronal subpopulations, and is engaged in fine-tuning excitatory and inhibitory neurotransmission. Studies using
Ribonucleic acid and hormonal control of protein synthesis.
A Korner
Progress in biophysics and molecular biology, 17, 61-98 (1967-01-01)
Eric W Brunskill et al.
Development (Cambridge, England), 141(15), 3093-3101 (2014-07-24)
We used a single cell RNA-seq strategy to create an atlas of gene expression patterns in the developing kidney. At several stages of kidney development, histologically uniform populations of cells give rise to multiple distinct lineages. We performed single cell
Shurjo K Sen et al.
American journal of human genetics, 95(1), 66-76 (2014-07-01)
Coronary artery calcification (CAC) is a heritable and definitive morphologic marker of atherosclerosis that strongly predicts risk for future cardiovascular events. To search for genes involved in CAC, we used an integrative transcriptomic, genomic, and protein expression strategy by using
Jianzhang Hu et al.
Experimental eye research, 129, 57-65 (2014-12-03)
Macrophages under the conjunctival tissue are the first line defender cells of the corneas. Elimination of these cells would lead to aggravation of fungal keratitis. To determine how the course of fungal keratitis would be altered after the activation of
Crowdsourcing. Online video game plugs players into remote-controlled biochemistry lab.
John Bohannon
Science (New York, N.Y.), 343(6170), 475-475 (2014-02-01)
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