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Bryan Y Kim et al.
Ophthalmology, 121(10), 2053-2058 (2014-06-09)
To describe the clinical features and management strategies in patients whose limbal stem cell (LSC) disease reversed with medical therapy. Retrospective case series. Twenty-two eyes of 15 patients seen at 3 tertiary referral centers between 2007 and 2011 with 3
Naomi L Kruhlak et al.
Toxicology mechanisms and methods, 18(2-3), 217-227 (2008-01-01)
ABSTRACT Drug-induced phospholipidosis (PL) is a condition characterized by the accumulation of phospholipids and drug in lysosomes, and is found in a variety of tissue types. PL is frequently manifested in preclinical studies and may delay or prevent the development
Ming Zhong et al.
Nutrients, 4(12), 2069-2096 (2013-02-01)
Light is both the ultimate energy source for most organisms and a rich information source. Vitamin A-based chromophore was initially used in harvesting light energy, but has become the most widely used light sensor throughout evolution from unicellular to multicellular
Reina Engle-Stone et al.
The Journal of nutrition, 144(2), 209-217 (2013-12-18)
Breast milk vitamin A (BMVA) has been proposed as an indicator of population vitamin A status but has rarely been applied in large-scale surveys or compared with conventional vitamin A biomarkers. We assessed the prevalence of, and risk factors for
Karolina Orywal et al.
Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego, 25(147), 276-279 (2008-12-31)
Retinoids are essential in cell growth and development as well as for maintenance of normal function of epithelia and vision. The metabolism of retinol is regulated by a few group of enzymes that control conversion of retinol to active retinoid
Joachim Jankowski et al.
Arteriosclerosis, thrombosis, and vascular biology, 23(7), 1231-1238 (2003-05-10)
Diadenosine polyphosphates have been demonstrated to be involved in the control of vascular tone as well as the growth of vascular smooth muscle cells and hence, possibly, in atherogenesis. In this study we investigated the question of whether diadenosine polyphosphates
Daniela Lima et al.
Journal of toxicology and environmental health. Part A, 78(12), 747-760 (2015-06-20)
Both field and experimental data examined the influence of exposure to environmental contaminant tributyltin (TBT) on marine organisms. Although most attention focused on the imposex phenomenon in gastropods, adverse effects were also observed in other taxonomic groups. It has been
S C Hung et al.
American journal of kidney diseases : the official journal of the National Kidney Foundation, 38(5), 941-947 (2001-10-31)
Patients with end-stage renal disease undergoing regular dialysis are prone to encephalopathy, but the cause is often unclear. Dialysis patients are at risk for thiamine deficiency, which may mimic many uremic complications, including encephalopathy. To determine whether unexplained encephalopathy in
Sheila M O'Byrne et al.
Journal of lipid research, 54(7), 1731-1743 (2013-04-30)
By definition, a vitamin is a substance that must be obtained regularly from the diet. Vitamin A must be acquired from the diet, but unlike most vitamins, it can also be stored within the body in relatively high levels. For
D O McGregor et al.
Kidney international, 59(6), 2267-2272 (2001-05-31)
Hyperhomocysteinemia is a risk factor for atherosclerosis that is common in chronic renal failure (CRF), but its cause is unknown. Homocysteine metabolism is linked to betaine-homocysteine methyl transferase (BHMT), a zinc metalloenzyme that converts glycine betaine (GB) to N,N dimethylglycine
D S Gill et al.
Journal of clinical pathology, 44(3), 243-245 (1991-03-01)
Plasma histamine concentrations were measured using a commercially available monoclonal antibody radioimmunoassay in 38 patients with nephrotic syndrome, end stage renal failure, those receiving haemodialysis, and those receiving continuous ambulatory peritoneal dialysis to determine whether histamine may mediate damage to
Rupsa Datta et al.
Scientific reports, 5, 9848-9848 (2015-05-21)
Presence of reactive oxygen species (ROS) in excess of normal physiological level results in oxidative stress. This can lead to a range of pathological conditions including inflammation, diabetes mellitus, cancer, cardiovascular and neurodegenerative disease. Biomarkers of oxidative stress play an
C Löser et al.
Pancreas, 5(2), 119-127 (1990-03-01)
We investigated the total, free, and acetylated polyamine concentrations in pancreatic tissue, serum, and urine of 20 patients with pancreatic cancer, 30 healthy volunteers, and 40 patients with nonmalignant, gastrointestinal diseases by reversed-phase liquid chromatography. Tissue concentrations in carcinoma compared
Kathryn A Thornton et al.
The Journal of nutrition, 144(4), 496-503 (2014-02-07)
Infection is an important cause of morbidity throughout childhood. Poor micronutrient status is a risk factor for infection-related morbidity in young children, but it is not clear whether these associations persist during school-age years. We examined the relation between blood
Emily K Heying et al.
The Journal of nutrition, 143(7), 1141-1146 (2013-05-31)
The relationship of dietary vitamin A transfer from mother to fetus is not well understood. The difference in swine offspring liver reserves was investigated between single-dose vitamin A provided to the mother post-conception compared with continuous provitamin A carotenoid dietary
Grace M Egeland et al.
Canadian journal of public health = Revue canadienne de sante publique, 95(6), 465-469 (2004-12-30)
Inuit traditional food provides ample amounts of preformed vitamin A. However, the dietary transition away from traditional food raises concerns regarding dietary adequacy. Vitamin A is an essential nutrient with inadequate and excessive exposures having adverse effects. To evaluate total
Adrienne McMahon et al.
Journal of AOAC International, 96(5), 1073-1081 (2013-11-29)
This HPLC method, with both variable UV and fluorescence detection, allows for the simultaneous determination of vitamin A palmitate, vitamin A acetate, and total vitamin E in infant, pediatric, and adult nutritional formulas. The concentration of each vitamin form is
Shaher Samrah et al.
The Journal of asthma : official journal of the Association for the Care of Asthma, 51(8), 832-838 (2014-05-02)
Reduced vitamin-D levels in patients with asthma have been associated with impaired lung function, increased airway hyper-responsiveness, and reduced glucocorticoid responsiveness. Nationwide studies revealed a considerable prevalence of vitamin-D deficiency (VDD) in Jordanian women. A case-control study was conducted to
Zhengping Zhang et al.
ACS nano, 9(3), 2405-2419 (2015-01-15)
Strategies to modify nanoparticles with biological ligands for targeted drug delivery in vivo have been widely studied but met with limited clinical success. A possible reason is that, in the blood circulation, serum proteins could rapidly form a layer of
Vitamin A supplementation in Indian children - Authors' reply.
Richard Peto et al.
Lancet (London, England), 382(9892), 594-596 (2013-08-21)
Ilona Olędzka et al.
Journal of pharmaceutical and biomedical analysis, 102, 45-53 (2014-09-23)
The purpose of this work is the evaluation of the nutritional status of patients with cystic fibrosis (CF), based on the level of vitamin C in urine and vitamins A and E in serum, using the fast, selective and fully
Poliana Coelho Cabral et al.
Nephrology (Carlton, Vic.), 10(5), 459-463 (2005-10-14)
The objective of this study was to assess the vitamin A and zinc serum levels in patients undergoing haemodialysis (HD) in the city of Recife, in the north-eastern region of Brazil. The study comprised 55 patients and 28 healthy controls.
Benito Campos et al.
Glia, 63(10), 1850-1859 (2015-05-07)
Measuring concentrations of the differentiation-promoting hormone retinoic acid (RA) in glioblastoma tissues would help to understand the reason why RA treatment has been inefficient in clinical trials involving brain tumor patients. Here, we apply a recently established extraction and measurement
On the sources of retinoic acid in the lung: understanding the local conversion of retinol to retinoic acid.
A Catharine Ross
American journal of physiology. Lung cellular and molecular physiology, 286(2), L247-L248 (2004-01-09)
Eric M Brown et al.
Nature communications, 6, 7806-7806 (2015-08-05)
Environmental enteropathy (EE) is a subclinical chronic inflammatory disease of the small intestine and has a profound impact on the persistence of childhood malnutrition worldwide. However, the aetiology of the disease remains unknown and no animal model exists to date
Rajeev Rudraraju et al.
PloS one, 9(1), e86554-e86554 (2014-01-28)
Morbidity and mortality due to viral infections are major health concerns, particularly when individuals are vitamin A deficient. Vitamin A deficiency significantly impairs mucosal IgA, a first line of defense against virus at its point of entry. Previous reports have
Helina Tadesse et al.
Human molecular genetics, 17(4), 506-524 (2007-11-14)
KH-type splicing regulatory protein (KSRP) is closely related to chick zipcode-binding protein 2 and rat MARTA1, which are involved in neuronal transport and localization of beta-actin and microtubule-associated protein 2 mRNAs, respectively. KSRP is a multifunctional RNA-binding protein that has
Benjamin S Maciejewski et al.
American journal of physiology. Gastrointestinal and liver physiology, 304(11), G958-G969 (2013-04-06)
Alterations in fat metabolism, in particular elevated plasma concentrations of free fatty acids and triglycerides (TG), have been implicated in the pathogenesis of Type 2 diabetes, obesity, and cardiovascular disease. Acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1), a member of the large family
Mohamed Mohammed El-Sayed et al.
Pakistan journal of pharmaceutical sciences, 26(6), 1189-1195 (2013-11-06)
This research was conducted to investigate two main aims; the first aim was to find if there is a relationship between insulin resistance (IR) and retinol binding protein 4 (RBP4). The second aim was to use berberis vulgaris extract and
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