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r9504

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Immediate effect of ultraviolet-a collagen cross-linking therapy on the biomechanics and histology of the human cornea.
María A Del Buey et al.
Journal of refractive surgery (Thorofare, N.J. : 1995), 31(1), 70-71 (2015-01-20)
Andrew L Garfoot et al.
Infection and immunity, 82(1), 393-404 (2013-11-06)
During infection of the mammalian host, Histoplasma capsulatum yeasts survive and reside within macrophages of the immune system. Whereas some intracellular pathogens escape into the host cytosol, Histoplasma yeasts remain within the macrophage phagosome. This intracellular Histoplasma-containing compartment imposes nutritional
Arundhati Biswas et al.
PloS one, 8(3), e58190-e58190 (2013-03-14)
Two potential orthologs of the human riboflavin transporter 3 (hRFVT3) were identified in the C. elegans genome, Y47D7A.16 and Y47D7A.14, which share 33.7 and 30.5% identity, respectively, with hRFVT3. The genes are tandemly arranged, and we assign them the names
Rita Horvath
Journal of inherited metabolic disease, 35(4), 679-687 (2012-01-11)
Riboflavin and ubiquinone (Coenzyme Q(10), CoQ(10)) deficiencies are heterogeneous groups of autosomal recessive conditions affecting both children and adults. Riboflavin (vitamin B(2))-derived cofactors are essential for the function of numerous dehydrogenases. Genetic defects of the riboflavin transport have been detected
Liang Chen et al.
Fish & shellfish immunology, 47(1), 470-484 (2015-10-01)
This study investigated the effects of riboflavin on intestinal immunity, tight junctions and antioxidant status of young grass carp (Ctenopharyngodon idella). Fish were fed diets containing graded levels of riboflavin (0.63-10.04 mg/kg diet) for 8 weeks. The study indicated that
Yusuke Takahashi et al.
Phytotherapy research : PTR, 28(10), 1513-1519 (2014-05-07)
Evidences are accumulating that extract of Acanthopanax senticosus Harms (ASH; syn Eleutherococcus senticosus [Rupr. & Maxim.] Maxim), a shrub native to Northeastern Asia, has antiinflammatory effects. In this study, we examined prophylactic and therapeutic effects of ASH extract (ASHE) on
Chibuzo C Odigwe et al.
The Cochrane database of systematic reviews, (4)(4), CD008147-CD008147 (2010-04-16)
Protein Energy Malnutrition is an important cause of child morbidity and mortality in middle- and low-income countries. It has been suggested that excessive free radical activity may be responsible for the clinical manifestation of kwashiorkor. Antioxidants may be able to
Gerta Hoxhaj et al.
Science (New York, N.Y.), 363(6431), 1088-1092 (2019-03-09)
Nicotinamide adenine dinucleotide phosphate (NADP+) is essential for producing NADPH, the primary cofactor for reductive metabolism. We find that growth factor signaling through the phosphoinositide 3-kinase (PI3K)-Akt pathway induces acute synthesis of NADP+ and NADPH. Akt phosphorylates NAD kinase (NADK)
David Tabibian et al.
Journal of refractive surgery (Thorofare, N.J. : 1995), 30(12), 855-857 (2014-12-02)
To report the use of accelerated photoactivated chromophore for keratitis-corneal collagen cross-linking (PACK-CXL) as a first-line treatment in a patient with an atypical fungal keratitis. Case report and literature review. A patient who presented with a painful peripheral corneal infiltrate
Karine Meisser Redeuil et al.
Journal of chromatography. A, 1422, 89-98 (2015-11-03)
This manuscript reports a validated analytical approach for the quantification of 21 water soluble vitamins and their main circulating forms in human plasma. Isotope dilution-based sample preparation consisted of protein precipitation using acidic methanol enriched with stable isotope labelled internal
G Ravi et al.
Glycoconjugate journal, 31(3), 247-258 (2014-03-20)
D-Ribitol, a five-carbon sugar alcohol, is an important metabolite in the pentose phosphate pathway; it is an integral part of riboflavin (vitamin B2) and cell wall polysaccharides in most Gram-positive and a few Gram-negative bacteria. Antibodies specific to D-ribitol were
Nacim Bouheraoua et al.
Investigative ophthalmology & visual science, 55(11), 7601-7609 (2014-10-30)
We compared the efficacy and early morphological changes in the cornea following conventional (C-CXL), transepithelial by iontophoresis (I-CXL), and accelerated (A-CXL) collagen cross-linking in keratoconus. A total of 45 eyes of 45 patients with progressive keratoconus who underwent corneal collagen
Hiroki Yoshimatsu et al.
American journal of physiology. Gastrointestinal and liver physiology, 306(2), G102-G110 (2013-11-23)
Riboflavin, also known as vitamin B2, is transported across the biological membrane into various organs by transport systems. Riboflavin transporter RFVT3 is expressed in the small intestine and has been suggested to localize in the apical membranes of the intestinal
Xuan Chi et al.
Transfusion, 54(1), 74-85 (2013-05-10)
Pathogen reduction technologies (PRTs) can induce platelet (PLT) lesions that reduce PLT survival and recovery from circulation and may be associated with acute lung injury (ALI). Human PLTs (hPLTs) in plasma with or without single or multiple Mirasol PRT treatments
Maria Gkika et al.
International ophthalmology, 31(4), 309-319 (2011-08-19)
Corneal collagen cross-linking (CXL) using riboflavin and ultraviolet-A irradiation is a common method of tissue stabilization and has been developed primarily to address the need of treating keratoconus. CXL's promising results on keratoconus indicated that it might be effective in
Djamila Achouri et al.
Drug development and industrial pharmacy, 41(3), 493-501 (2014-02-14)
In the field of keratoconus treatment, a lipid-based liquid crystal nanoparticles system has been developed to improve the preocular retention and ocular bioavailability of riboflavin, a water-soluble drug. The formulation of this ophthalmic drug delivery system was optimized by a
Pan Cheng et al.
Cell research, 31(7), 758-772 (2021-01-21)
Ca2+ channels are essential to cell birth, life, and death. They can be externally activated by optogenetic tools, but this requires robust introduction of exogenous optogenetic genes for expression of photosensitive proteins in biological systems. Here we present femtoSOC, a
High fluence iontophoretic corneal collagen cross-linking: in vivo OCT imaging of riboflavin penetration.
Paolo Vinciguerra et al.
Journal of refractive surgery (Thorofare, N.J. : 1995), 29(6), 376-377 (2013-06-07)
Fiorella Colasuonno et al.
Oxidative medicine and cellular longevity, 2020, 6821247-6821247 (2020-08-29)
Riboflavin transporter deficiency (RTD) is a childhood-onset neurodegenerative disorder characterized by progressive pontobulbar palsy, sensory and motor neuron degeneration, sensorineural hearing loss, and optic atrophy. As riboflavin (RF) is the precursor of FAD and FMN, we hypothesize that both mitochondrial
George D Kymionis et al.
American journal of ophthalmology, 158(4), 671-675 (2014-07-19)
To compare the corneal stromal demarcation line depth using anterior segment optical coherence tomography (AS-OCT) after corneal collagen cross-linking (CXL) using 2 different treatment protocols: the standard Dresden protocol (30 minutes with 3 mW/cm(2)) and a modified-accelerated protocol (14 minutes
Erick A Argueta et al.
FEBS letters, 589(8), 880-884 (2015-03-10)
Flavin cofactors are central to many biochemical transformations and are typically tightly bound as part of a catalytically active flavoenzyme. This work indicates that naturally occurring flavins can act as stand-alone catalysts to promote the oxidation of biosynthetically inspired heterocycles
Giulio Ferrari et al.
Journal of cataract and refractive surgery, 39(4), 638-641 (2013-03-26)
Collagen crosslinking (CXL) has been proposed as a treatment for infectious keratitis. Given the insurgence of antibiotic-resistant microorganisms and frequent toxicity of topical medications, CXL may be a potential treatment for corneal infections. However, corneal infection is itself a possible
Daniel R Cardoso et al.
Food & function, 3(5), 487-502 (2012-03-13)
Riboflavin, vitamin B₂, and flavins (as riboflavin building blocks or degradation products) are efficient photosensitizers inducing oxidative damage to light-exposed tissue and food by substrate-dependent mechanisms, for which protection is offered by specific nutrients. Phenolic and N-heterocyclic amino acids and
Jose L Güell et al.
Journal of refractive surgery (Thorofare, N.J. : 1995), 30(4), 286-288 (2014-04-08)
To present a case of a late, deep stromal scar in a 22-year-old patient with forme fruste keratoconus who underwent combined corneal cross-linking and photorefractive keratectomy (PRK). Topography-guided corneal cross-linking combined with corneal PRK (without complications) was performed in both
Anastasios John Kanellopoulos
Journal of refractive surgery (Thorofare, N.J. : 1995), 29(7), 504-505 (2013-07-04)
To report a novel application of collagen cross-linking (CXL) in refractive astigmatic enhancement of previously performed astigmatic keratotomy. A 28-year-old woman with prior history of bioptics correction of high myopic astigmatism with femtosecond laser-assisted astigmatic keratotomy followed by topography-guided LASIK
Alexandra C Weaver et al.
Toxins, 6(12), 3336-3353 (2014-12-24)
To evaluate the effects of the mycotoxins deoxynivalenol (DON) and zearalenone (ZEA) on pigs and the benefits of two mycotoxin mitigation strategies, gilts (n = 84, 9.1 ± 0.1 kg) were allotted to four treatments: CON (control); MT (4.8 mg/kg
Stella Vitt et al.
Journal of molecular biology, 426(15), 2813-2826 (2014-06-03)
The reversible redox reaction between coenzyme F420 and H2 to F420H2 is catalyzed by an F420-reducing [NiFe]-hydrogenase (FrhABG), which is an enzyme of the energy metabolism of methanogenic archaea. FrhABG is a group 3 [NiFe]-hydrogenase with a dodecameric quaternary structure
Mattias Johansson et al.
Journal of the National Cancer Institute, 106(12), doi:10-doi:10 (2014-11-08)
The etiology of renal cell carcinoma (RCC) is only partially understood, but a metabolic component appears likely. We investigated biomarkers of one-carbon metabolism and RCC onset and survival. The European Prospective Investigation into Cancer and Nutrition (EPIC) recruited 385747 participants
Huilu Wu et al.
Journal of photochemistry and photobiology. B, Biology, 148, 252-261 (2015-05-20)
A V-shaped ligand 1,3-bis(1-ethylbenzimidazol-2-yl)-2-thiapropane (bebt) and its transition metal complexes, [Mn(bebt)(pic)2]·CH3OH (pic=picrate) 1, [Co(bebt)2](pic)22 and [Cu(bebt)2](pic)2·2DMF 3, have been synthesized and characterized. The coordinate forms of complexes 1 and 2 are basically alike, which can be described as six-coordinated distorted
Ali Fadlallah et al.
Journal of refractive surgery (Thorofare, N.J. : 1995), 30(10), 688-693 (2014-10-08)
To evaluate the safety and clinical outcome of combined non-topography-guided photorefractive keratectomy (PRK) and corneal collagen cross-linking (CXL) for the treatment of mild refractive errors in patients with early stage keratoconus. A retrospective, nonrandomized study of patients with early stage
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