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Chao Zhen et al.
Journal of neuroimmunology, 280, 1-7 (2015-03-17)
Multiple sclerosis (MS) has been associated with a history of sub-optimal exposure to ultraviolet light, implicating vitamin D3 as a possible protective agent. We evaluated whether 1,25(OH)2D3 attenuates the progression of experimental autoimmune encephalomyelitis (EAE), and explored its potential mechanisms.
David Baur et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(5), 1858-1871 (2015-02-06)
Tight coupling between Ca(2+) channels and the sensor for vesicular transmitter release at the presynaptic active zone (AZ) is crucial for high-fidelity synaptic transmission. It has been hypothesized that a switch from a loosely coupled to a tightly coupled transmission
Shixuan Wang et al.
PloS one, 9(5), e95630-e95630 (2014-05-24)
FPC (fibrocystin or polyductin) is a single transmembrane receptor-like protein, responsible for the human autosomal recessive polycystic kidney disease (ARPKD). It was recently proposed that FPC undergoes a Notch-like cleavage and subsequently the cleaved carboxy(C)-terminal fragment translocates to the nucleus.
Sona Balentova et al.
Neurochemical research, 40(3), 501-513 (2014-12-10)
Ionizing radiation induces altered brain tissue homeostasis and can lead to morphological and functional deficits. In this study, adult male Wistar rats received whole-body exposure with fractionated doses of gamma rays (a total dose of 5 Gy) and were investigated
Hemant Kumar Rawat et al.
Antonie van Leeuwenhoek, 107(3), 799-811 (2015-01-07)
Owing to applications in the food and nutraceutical industries, inulinases, fructosyltransferases and sucrases have gained considerable attention in recent times. Twenty-five fungal strains were screened for production of these enzymes on three different media formulated using inulin-rich plant extracts prepared
Luiz G Maturana et al.
Brain and behavior, 3(4), 417-430 (2014-01-02)
The purpose of this study was to investigate the influence of implanting collagen with a supramolecular organization on peripheral nerve regeneration, using the sciatic nerve tubulization technique. For this purpose, adult female Sprague Dawley rats were divided into five groups:
Chun-Nun Chao et al.
Journal of translational medicine, 13, 29-29 (2015-01-28)
Diffuse large B-cell lymphoma (DLBCL) is one of the most common types of aggressive B-cell non-Hodgkin lymphoma. About one-third of patients are either refractory to the treatment or experience relapse afterwards, pointing to the necessity of developing other effective therapies
R Huang et al.
Applied and environmental microbiology, 80(23), 7212-7218 (2014-09-14)
Streptococcus gordonii is a commensal species of human oral flora. It initiates dental biofilm formation and provides binding sites for later colonizers to attach to and generate mature biofilm. Smoking is the second highest risk factor for periodontal disease, and
Katsuyoshi Fujimoto et al.
Journal of natural medicines, 68(3), 481-487 (2014-02-18)
Seven new acylated sucroses, mumeoses P-V, were isolated from the flower buds of Prunus mume, cultivated in Zhejiang province, China. Their chemical structures were elucidated on the basis of chemical and physicochemical evidence. Moreover, mumeoses C, D, and R, were
M Lupi et al.
Nanotechnology, 25(33), 335706-335706 (2014-07-31)
One of the major drawbacks that limits the clinical application of nanoparticles is the lack of preliminary investigations related to their biocompatibility, biodegradability and biodistribution. In this work, biodegradable PEGylated polymer nanoparticles (NPs) have been synthesized by using macromonomers based
Janna M Schurer et al.
The American journal of tropical medicine and hygiene, 90(6), 1184-1190 (2014-03-19)
Residents of remote and Indigenous communities might experience higher exposure to some zoonotic parasites than the general North American population. Human sero-surveillance conducted in two Saulteaux communities found 113 volunteers exposed as follows: Trichinella (2.7%), Toxocara canis (4.4%), Echinococcus (4.4%)
Mariana Ramos-Brossier et al.
Human molecular genetics, 24(4), 1106-1118 (2014-10-12)
Mutations in interleukin-1 receptor accessory protein like 1 (IL1RAPL1) gene have been associated with non-syndromic intellectual disability (ID) and autism spectrum disorder. This protein interacts with synaptic partners like PSD-95 and PTPδ, regulating the formation and function of excitatory synapses.
A Mühlstein et al.
Die Pharmazie, 69(7), 518-524 (2014-07-31)
Arylsulfatase A (ASA) deficiency is the cause of metachromatic leucodystrophy (MLD), a lysosomal storage disease associated with severe neurological disorders. Poly(butyl cyanoacrylate) (PBCA) nanoparticles overcoated with polysorbate 80 enabled the delivery of several drugs across the blood-brain barrier to the
Matthew L Kraushar et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(36), E3815-E3824 (2014-08-27)
Precise spatiotemporal control of mRNA translation machinery is essential to the development of highly complex systems like the neocortex. However, spatiotemporal regulation of translation machinery in the developing neocortex remains poorly understood. Here, we show that an RNA-binding protein, Hu
Hua Zhang et al.
Analytical chemistry, 87(5), 2878-2883 (2015-02-14)
Characterization of enzymatic reactions occurring in untreated biological samples is of increasing interest. Herein, the chemical conversion of alliin to allicin, catalyzed by allinase, in raw garlic cloves has been followed in vivo by internal extractive electrospray ionization mass spectrometry
L G Schuettpelz et al.
Leukemia, 28(9), 1851-1860 (2014-02-13)
Recent studies demonstrate that inflammatory signals regulate hematopoietic stem cells (HSCs). Granulocyte colony-stimulating factor (G-CSF) is often induced with infection and has a key role in the stress granulopoiesis response. However, its effects on HSCs are less clear. Herein, we
H Shokri
Journal de mycologie medicale, 24(3), 179-184 (2014-04-22)
To investigate the DNA fingerprinting of Candida zeylanoides (C. zeylanoides) strains and the correlation between genotyping and antifungal susceptibility of C. zeylanoides. Paper discs containing nystatin, ketoconazole, fluconazole, Zataria multiflora (Z. multiflora) and Pulicaria gnaphalodes (P. gnaphalodes) essential oils were
K Urata et al.
Journal of dental research, 94(3), 446-454 (2015-01-13)
Thermal and mechanical hypersensitivity in the injured region is a common complication. Although it is well known clinically that thermal and mechanical sensitivity of the oral mucosa is different from that of the skin, the mechanisms underlying injured pain of
Ágnes Csáki et al.
Neuroscience letters, 588, 1-6 (2014-12-30)
Neuronal chains between the retina and the pineal body were investigated. Transneuronal tracers, retrograde spreading pseudorabies virus (labeled with green fluorescent protein, memGreen-RV) and virus spreading in both ante- and retrograde directions (labeled with red fluorescent protein, Ka-VHS-mCherry-A-RV) were injected
Taylor J Schoberle et al.
PLoS genetics, 10(5), e1004336-e1004336 (2014-05-03)
Secondary metabolites are produced by numerous organisms and can either be beneficial, benign, or harmful to humans. Genes involved in the synthesis and transport of these secondary metabolites are frequently found in gene clusters, which are often coordinately regulated, being
Judit M Veres et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(49), 16194-16206 (2014-12-05)
Axo-axonic cells (AACs) in cortical regions selectively innervate the axon initial segments (AISs) of principal cells (PCs), where the action potentials are generated. These GABAergic interneurons can alter the activity of PCs, but how the efficacy of spike control correlates
Ilaria Fiorentino et al.
Experimental cell research, 330(2), 240-247 (2014-09-24)
Nanoparticle (NPs) delivery systems in vivo promises to overcome many obstacles associated with the administration of drugs, vaccines, plasmid DNA and RNA materials, making the study of their cellular uptake a central issue in nanomedicine. The uptake of NPs may
Xin Zhang et al.
Analytica chimica acta, 835, 29-36 (2014-06-24)
A glassy carbon electrode modified with poly(alizarin red)/electrodeposited graphene (PAR/EGR) composite film was prepared and applied to detect ciprofloxacin (CPFX) in the presence of ascorbic, uric acid and dopamine. The morphology and interface property of PAR/EGR films were examined by
Davide Povero et al.
PloS one, 9(12), e113651-e113651 (2014-12-04)
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in both adult and children. Currently there are no reliable methods to determine disease severity, monitor disease progression, or efficacy of therapy, other than an invasive liver biopsy.
Eric Dubuis et al.
Pain, 155(11), 2408-2417 (2014-09-25)
Complex regional pain syndrome (CRPS) is a limb-confined posttraumatic pain syndrome with sympathetic features. The cause is unknown, but the results of a randomized crossover trial on low-dose intravenous immunoglobulins (IVIG) treatment point to a possible autoimmune mechanism. We tested
Sunil K Khattar et al.
Human vaccines & immunotherapeutics, 11(2), 504-515 (2015-02-20)
The combination of multiple HIV antigens in a vaccine can broaden antiviral immune responses. In this study, we used NDV vaccine strain LaSota to generate rNDV (rLaSota/optGag) expressing human codon optimized p55 Gag protein of HIV-1. We examined the effect
Larisa Volceanov et al.
mBio, 5(5), e01802-e01814 (2014-10-09)
Chlamydia trachomatis is an obligate intracellular human pathogen that grows inside a membranous, cytosolic vacuole termed an inclusion. Septins are a group of 13 GTP-binding proteins that assemble into oligomeric complexes and that can form higher-order filaments. We report here
Yuqing Liu et al.
Meat science, 100, 139-144 (2014-12-03)
This study evaluates the effects of pre-rigor temperature control on quality traits of Chinese yellow cattle M. longissimus lumborum (LL). One stepwise chilling (SC) treatment was used on one half-carcass, involved a fast chilling (-11 ± 1 °C;0.5 m/s) for
Smita Joel et al.
ACS chemical biology, 9(7), 1595-1602 (2014-05-21)
Advancements in biotechnology have allowed for the preparation of designer proteins with a wide spectrum of unprecedented chemical and physical properties. A variety of chemical and genetic methods can be employed to tailor the protein's properties, including its stability and
Masanari Takamiya et al.
PloS one, 10(2), e0117645-e0117645 (2015-02-19)
The cornea is a central component of the camera eye of vertebrates and even slight corneal disturbances severely affect vision. The transcription factor PAX6 is required for normal eye development, namely the proper separation of the lens from the developing
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