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Li Fu et al.
The Journal of thoracic and cardiovascular surgery, 150(3), 666-672 (2015-07-07)
Vascular function is very important for maintaining circulation after cardiac surgery. Circulating microparticles (MPs) generated in various diseases play important roles in causing inflammation, coagulation, and vascular injury. However, the impact of MPs generated from patients who have valvular heart
Natalia S Rozas et al.
Journal of neurotrauma, 32(2), 149-158 (2014-07-16)
Although the mechanisms that contribute to the development of traumatic brain injury (TBI)-related deficits are not fully understood, it has been proposed that altered energy utilization may be a contributing factor. The tuberous sclerosis complex, a heterodimer composed of hamartin/Tsc-1
Xabier Osteikoetxea et al.
PloS one, 10(3), e0121184-e0121184 (2015-03-24)
In recent years the study of extracellular vesicles has gathered much scientific and clinical interest. As the field is expanding, it is becoming clear that better methods for characterization and quantification of extracellular vesicles as well as better standards to
Srinivas Akula et al.
PloS one, 10(11), e0143091-e0143091 (2015-11-17)
Serine proteases are among the most abundant granule constituents of several hematopoietic cell lineages including mast cells, neutrophils, cytotoxic T cells and NK cells. These proteases are stored in their active form in the cytoplasmic granules and in mammals are
Ruiqi Cai et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(7), 2749-2758 (2015-03-26)
Ischemia and reperfusion (I/R) injury is a common cause of many vascular and neuronal diseases. Glyceraldehyde 3-phosphate dehydrogenase (GAPDH) has been found down-regulated or dysfunctional in several tissues upon I/R injury. To investigate the role of GAPDH in retinal I/R
S I Labidi-Galy et al.
Oncogene, 34(3), 373-383 (2014-01-29)
High-grade serous ovarian carcinoma (HGSOC) and basal-like breast cancer (BLBC) share many features including TP53 mutations, genomic instability and poor prognosis. We recently reported that Elafin is overexpressed by HGSOC and is associated with poor overall survival. Here, we confirm
Cen Qian et al.
Toxins, 7(8), 2888-2905 (2015-08-08)
Two cDNA sequences of Kazal-type serine protease inhibitors (KSPIs) in Nasonia vitripennis, NvKSPI-1 and NvKSPI-2, were characterized and their open reading frames (ORFs) were 198 and 264 bp, respectively. Both NvKSPI-1 and NvKSPI-2 contained a typical Kazal-type domain. Real-time quantitative
Yun Hee Kang et al.
Oncotarget, 5(8), 2149-2160 (2014-05-09)
Tescalcin (TESC) is an EF-hand calcium binding protein that is differentially expressed in several tissues, however it is not reported that the expression and functional roles of TESC in colorectal cancer. Levels of messenger RNA (mRNA) and protein expression of
Ni Chen et al.
Journal of agricultural and food chemistry, 63(30), 6739-6748 (2015-07-15)
Vitamin C is an essential dietary nutrient that has a variety of biological functions. Recent studies have provided promising evidence for its additional health benefits, including anticancer activity. Vitamin B2, another essential dietary nutrient, often coexists with vitamin C in
Tyng-Shyan Huang et al.
Stem cells (Dayton, Ohio), 33(5), 1419-1433 (2014-12-30)
The mechanisms underlying disparate roles of the canonical Wnt signaling pathway in maintaining self-renewal or inducing differentiation and lineage specification in embryonic stem cells (ESCs) are not clear. In this study, we provide the first demonstration that self-renewal versus differentiation
Shingo Maeda et al.
The Journal of veterinary medical science, 76(8), 1119-1127 (2014-05-16)
Serine proteases elicit cellular responses via protease-activated receptor-2 (PAR-2) which is known to regulate inflammation and the immune response. Although the gastrointestinal tract is exposed to large amounts of proteolytic enzymes, the role of PAR-2 in canine inflammatory bowel disease
Dawid Deszcz et al.
The FEBS journal, 282(13), 2512-2526 (2015-04-08)
We have analyzed the natural evolution of transaminase structure and sequence between an α-transaminase serine-pyruvate aminotransferase and an ω-transaminase from Chromobacterium violaceum with < 20% sequence identity, and identified the active-site regions that are least conserved structurally. We also show
Sandra T Persson et al.
Infection and immunity, 83(12), 4673-4681 (2015-09-30)
The human skin exerts many functions in order to maintain its barrier integrity and protect the host from invading microorganisms. One such pathogen is Streptococcus pyogenes, which can cause a variety of superficial skin wounds that may eventually progress into
Melinda L Micallef et al.
BMC genomics, 16, 669-669 (2015-09-04)
Cyanobacteria are well known for the production of a range of secondary metabolites. Whilst recent genome sequencing projects has led to an increase in the number of publically available cyanobacterial genomes, the secondary metabolite potential of many of these organisms
Corina A Schmid et al.
The Journal of experimental medicine, 212(5), 775-792 (2015-04-08)
The epigenetic dysregulation of tumor suppressor genes is an important driver of human carcinogenesis. We have combined genome-wide DNA methylation analyses and gene expression profiling after pharmacological DNA demethylation with functional screening to identify novel tumor suppressors in diffuse large
Ting-Ting Chao et al.
The Journal of pharmacology and experimental therapeutics, 351(2), 352-358 (2014-09-05)
Some patients with nonsmall-cell lung cancer (NSCLC) without epidermal growth factor receptor (EGFR) mutations still respond to gefitinib and erlotinib, suggesting that there may be a mechanism(s) other than the EGFR pathway that mediates the tumoricidal effects. In the current
Daniela Schwarzenbacher et al.
Oncotarget, 6(13), 11191-11202 (2015-04-11)
Spinophilin, a putative tumor suppressor gene, has been shown to be involved in the pathogenesis of certain types of cancer, but its role has never been systematically explored in breast cancer. In this study, we determined for the first time
Antonella Di Poto et al.
Applied microbiology and biotechnology, 99(13), 5593-5603 (2015-02-17)
Staphylococcus epidermidis is the leading etiologic agent of device-related infections. S. epidermidis is able to bind, by means of the adhesins of its cell wall, the host matrix proteins filming the artificial surfaces. Thence, bacteria cling to biomaterials and infection
Beata Fuchsova et al.
Experimental cell research, 338(2), 170-182 (2015-08-01)
Adenovirus serotypes have been shown to cause drastic changes in nuclear organization, including the transcription machinery, during infection. This ability of adenovirus to subvert transcription in the host cell facilitates viral replication. Because nuclear actin and nuclear myosin I, myosin
Vladimir Tolstikov et al.
PloS one, 9(12), e114019-e114019 (2014-12-09)
Nicotinamide phosphoribosyltransferase (NAMPT) plays an important role in cellular bioenergetics. It is responsible for converting nicotinamide to nicotinamide adenine dinucleotide, an essential molecule in cellular metabolism. NAMPT has been extensively studied over the past decade due to its role as
Teresa Mairinger et al.
Analytical chemistry, 87(23), 11792-11802 (2015-10-30)
For the first time an analytical work flow based on accurate mass gas chromatography-quadrupole time-of-flight mass spectrometry (GC-QTOFMS) with chemical ionization for analysis providing a comprehensive picture of (13)C distribution along the primary metabolism is elaborated. The method provides a
Ryan M Carey et al.
International forum of allergy & rhinology, 5(9), 808-813 (2015-06-23)
Nitric oxide (NO) is an important antibacterial defense molecule produced by upper airway (sinonasal) epithelial cells. We previously showed that a bitter taste receptor expressed in airway epithelium detects quorum-sensing molecules secreted by Gram-negative bacteria and subsequently triggers bactericidal NO
Wei Wu et al.
Molecular cancer research : MCR, 12(12), 1717-1728 (2014-07-27)
Colorectal cancer metastasis is a major cause of mortality worldwide, which may only be controlled with novel methods limiting tumor dissemination and chemoresistance. High stathmin-1 (STMN1) expression was previously established as a hallmark of colorectal cancer progression and predictor of
Z D Zhang et al.
Neoplasma, 61(6), 627-637 (2014-08-26)
Studies have shown that Annexin A2 (ANXA2) is related with tumor proliferation, apoptosis, differentiation, invasion, migration, and drug resistance. The purpose of this study was to investigate the role and its mechanisms of ANXA2 in multi-drug-resistance (MDR) in gastric cancer.
Yasuko Onuma et al.
PloS one, 10(4), e0118931-e0118931 (2015-04-08)
Fibroblast growth factors (FGFs) are essential for maintaining self-renewal in human embryonic stem cells and induced pluripotent stem cells. Recombinant basic FGF (bFGF or FGF2) is conventionally used to culture pluripotent stem cells; however, because of the instability of bFGF
Anna Lena Ress et al.
Oncotarget, 5(18), 8492-8502 (2014-09-28)
The putative tumor suppressor gene spinophilin has been involved in cancer progression in several types of cancer. In this study, we explored the prognostic value of spinophilin expression in 162 colon adenocarcinoma patients. In addition, we generated stably expressing spinophilin-directed
Juan-Antonio García-Carmona et al.
Toxicology and applied pharmacology, 283(1), 42-49 (2015-01-15)
There is large body evidence indicating that stress can lead to cardiovascular disease. However, the exact brain areas and the mechanisms involved remain to be revealed. Here, we performed a series of experiments to characterize the role of CRF1 receptor
Areum Daseul Kim et al.
Journal of cellular biochemistry, 115(8), 1403-1411 (2014-04-05)
This study investigated the cytoprotective effect of Ecklonia cava-derived eckol against H2O2-induced mitochondrial dysfunction in Chang liver cells. While H2O2 augmented levels of mitochondrial reactive oxygen species (ROS), eckol decreased it. Eckol also attenuated high intracellular Ca(2+) levels stimulated by
Chien-Hua Huang et al.
Basic research in cardiology, 110(6), 59-59 (2015-10-17)
While therapeutic hypothermia improves the outcomes of individuals in cardiac arrest, the hemodynamic responses and mechanisms which underlie hypothermia-induced cardioprotection are not fully understood. Therefore, we investigated the mechanism by which induced hypothermia preserves cardiac function and protects against mitochondrial
Kai-Ming Liu et al.
The Journal of investigative dermatology, 135(11), 2603-2610 (2015-06-30)
Many biochemical pathways involved in hair and skin development have not been investigated. Here, we reported on the lesions and investigated the mechanism underlying hair and skin abnormalities in Zdhhc13(skc4) mice with a deficiency in DHHC13, a palmitoyl-acyl transferase encoded
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