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Uday Ganapathy et al.
Nature communications, 6, 7912-7912 (2015-08-11)
The human pathogen Mycobacterium tuberculosis (Mtb) likely utilizes host fatty acids as a carbon source during infection. Gluconeogenesis is essential for the conversion of fatty acids into biomass. A rate-limiting step in gluconeogenesis is the conversion of fructose 1,6-bisphosphate to...
Xiaoyan Lin et al.
Nucleic acids research, 43(1), 446-460 (2014-12-19)
The replication enzyme of RNA viruses must preferentially recognize their RNAs in an environment that contains an abundance of cellular RNAs. The factors responsible for specific RNA recognition are not well understood, in part because viral RNA synthesis takes place...
Stéphanie Chadet et al.
Journal of immunology (Baltimore, Md. : 1950), 195(2), 651-660 (2015-06-17)
High concentrations of extracellular ATP (eATP) resulting from cell damage may be found during an ischemia/reperfusion (I/R) episode at the site of injury. eATP activates purinergic receptors in dendritic cells (DCs) and may inhibit inflammation. This immunosuppressive activity could be...
Claude Saint-Ruf et al.
Journal of bacteriology, 196(17), 3059-3073 (2014-07-02)
The evolutionary success of bacteria depends greatly on their capacity to continually generate phenotypic diversity. Structured environments are particularly favorable for diversification because of attenuated clonal interference, which renders selective sweeps nearly impossible and enhances opportunities for adaptive radiation. We...
Lorenz Thurner et al.
Journal of autoimmunity, 61, 17-28 (2015-05-26)
Recently we identified in a wide spectrum of autoimmune diseases frequently occurring proinflammatory autoantibodies directed against progranulin, a direct inhibitor of TNFR1 & 2 and of DR3. In the present study we investigated the mechanisms for the breakdown of self-tolerance...
Melinda A Brindley et al.
Journal of virology, 89(2), 1230-1241 (2014-11-14)
Measles virus (MeV), a morbillivirus within the paramyxovirus family, expresses two envelope glycoproteins. The attachment (H) protein mediates receptor binding, followed by triggering of the fusion (F) protein, which leads to merger of the viral envelope with target cell membranes....
C Monzel et al.
Nature communications, 6, 8162-8162 (2015-10-07)
Stochastic displacements or fluctuations of biological membranes are increasingly recognized as an important aspect of many physiological processes, but hitherto their precise quantification in living cells was limited due to a lack of tools to accurately record them. Here we...
Lydia Chang et al.
PloS one, 10(6), e0130162-e0130162 (2015-06-16)
Ubiquilin proteins facilitate delivery of ubiquitinated proteins to the proteasome for degradation. Interest in the proteins has been heightened by the discovery that gene mutations in UBQLN2 cause dominant inheritance of amyotrophic lateral sclerosis (ALS). However, the mechanisms by which...
Jian Zheng et al.
PloS one, 9(4), e94712-e94712 (2014-04-15)
The human organic anion transporting polypeptide 1A2 (OATP1A2) is an important membrane protein that mediates the cellular influx of various substances including drugs. Previous studies have shown that PDZ-domain containing proteins, especially PDZK1 and NHERF1, regulate the function of related...
Tomohiko Ohno et al.
PloS one, 10(4), e0124081-e0124081 (2015-04-17)
Obesity and related metabolic disorders, such as diabetes mellitus, raise the risk of liver carcinogenesis. Metformin, which is widely used in the treatment of diabetes, ameliorates insulin sensitivity. Metformin is also thought to have antineoplastic activities and to reduce cancer...
Rui Zhang et al.
Journal of drug targeting, 23(5), 444-452 (2015-01-23)
Human-derived cell penetrating peptides (CPPs) have attracted much more attentions than other CPPs which are limited by their potential toxicity and immunogenicity. Previously, we identified a novel human-originated CPP (named heparin-binding domain (HBD) in this article), which derived from the...
Rebecca J Taugher et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(31), 10247-10255 (2014-08-01)
Carbon dioxide (CO2) inhalation lowers brain pH and induces anxiety, fear, and panic responses in humans. In mice, CO2 produces freezing and avoidance behavior that has been suggested to depend on the amygdala. However, a recent study in humans with...
Kenta Nakamura et al.
PloS one, 9(10), e109831-e109831 (2014-10-08)
Retinal regeneration in the adult newt is a useful system to uncover essential mechanisms underlying the regeneration of body parts of this animal as well as to find clues to treat retinal disorders such as proliferative vitreoretinopathy. Here, to facilitate...
James R Ferrell et al.
Biointerphases, 10(2), 021001-021001 (2015-03-27)
The generation of air-based plasmas under atmospheric plasma conditions was studied to assess their antimicrobial efficacy against commonly found pathogenic bacteria. The mixture of initial gases supplied to the plasma was found to be critical for the formation of bactericidal...
Jung-Yeon Kim et al.
International journal of molecular medicine, 35(6), 1651-1656 (2015-04-16)
Propionibacterium acnes (P. acnes) cause inflammatory acne and play an important role in the pathogenesis of acne by inducing inflammatory mediators. P. acnes contributes to the inflammatory responses of acne by activating inflammatory cells, keratinocytes and sebocytes to secrete pro-inflammatory...
Naotaka Sekiyama et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(30), E4036-E4045 (2015-07-15)
The eIF4E-binding protein (4E-BP) is a phosphorylation-dependent regulator of protein synthesis. The nonphosphorylated or minimally phosphorylated form binds translation initiation factor 4E (eIF4E), preventing binding of eIF4G and the recruitment of the small ribosomal subunit. Signaling events stimulate serial phosphorylation...
Young-Hee Lee et al.
Cell biochemistry and function, 33(7), 479-486 (2015-09-30)
This study investigated whether multiple bioactivity of terrein such as anti-inflammatory and anti-oxidant inhibits age-related inflammation by promoting an antioxidant response in aged human diploid fibroblast (HDF) cells. HDF cells were cultured serially for in vitro replicative senescence. To create...
Fanny Ehret et al.
Neurobiology of disease, 75, 131-141 (2015-01-04)
Could impaired adult hippocampal neurogenesis be a relevant mechanism underlying CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy)? Memory symptoms in CADASIL, the most common hereditary form of vascular dementia, are usually thought to be primarily due to...
Cinzia Casella et al.
Gynecologic oncology, 135(2), 333-341 (2014-08-20)
Determine mechanisms responsible for enhanced statin efficacy in a novel statin combination we name STOX (STatin-OXysterol). Ovarian cancer cell lines were treated with combinations of statins and oxysterols. Cell viability was determined by a modified MTT assay. Apoptosis was evaluated...
Martin S Taylor et al.
Bioorganic chemistry, 62, 64-73 (2015-08-08)
Ghrelin-O-Acyltransferase (GOAT) is an 11-transmembrane integral membrane protein that octanoylates the metabolism-regulating peptide hormone ghrelin at Ser3 and may represent an attractive target for the treatment of type II diabetes and the metabolic syndrome. Protein octanoylation is unique to ghrelin...
Kota Kato et al.
Drug metabolism and disposition: the biological fate of chemicals, 43(8), 1208-1217 (2015-05-17)
We developed murine CYP3A knockout ko chimeric mice with humanized liver expressing human P450S similar to those in humans and whose livers and small intestines do not express murine CYP3A this: approach may overcome effects of residual mouse metabolic enzymes...
Yohei Hirano et al.
Critical care (London, England), 19, 53-53 (2015-04-19)
Sepsis refers to severe systemic inflammation leading to acute lung injury (ALI) and death. Introducing novel therapies can reduce the mortality in ALI. Osteopontin (OPN), a secretory glycoprotein produced by immune reactive cells, plays a deleterious role in various inflammatory...
Yang Liu et al.
Neurochemical research, 39(9), 1797-1808 (2014-07-27)
Alpha-linolenic acid (LIN) has been shown to provide neuroprotective effects against cerebral ischemia. LIN is a potent activator of TREK-1 channel and LIN-induced neuroprotection disappears in Trek1-/- mice, suggesting that this channel is directly related to the LIN-induced resistance of...
Aleta Pupovac et al.
Immunology and cell biology, 93(1), 77-85 (2014-08-27)
Activation of the P2X7 receptor by the extracellular damage-associated molecular pattern, adenosine 5'-triphosphate (ATP), induces the shedding of cell surface molecules including the low-affinity IgE receptor, CD23, from human leukocytes. A disintegrin and metalloprotease (ADAM) 10 mediates P2X7-induced shedding of...
Souichiro Nakano et al.
Rheumatology (Oxford, England), 54(8), 1498-1506 (2015-03-04)
IL-35 is the most recently identified member of the IL-12 family. It consists of EBV-induced gene 3 (EBI3) and IL-12α chain p35. We investigated whether IL-35 enhances the in vitro immunosuppressive function of peripheral blood isolated from patients with RA....
Yang Chen et al.
Journal of proteome research, 14(9), 3693-3709 (2015-06-26)
Finding protein evidence (PE) for protein coding genes is a primary task of the Phase I Chromosome-Centric Human Proteome Project (C-HPP). Currently, there are 2948 PE level 2-4 coding genes per neXtProt, which are deemed missing proteins in the human...
Murugesan Saravanakumar et al.
The British journal of nutrition, 114(9), 1385-1394 (2015-09-09)
In our previous studies, veratric acid (VA) shows beneficial effect on hypertension and its associated dyslipidaemia. In continuation, this study was designed to investigate the effect of VA, one of the major benzoic acid derivatives from vegetables and fruits, on...
Ran Xiong et al.
Journal of virology, 89(13), 6646-6655 (2015-04-17)
Herpes simplex virus 1 (HSV-1) causes one of the most prevalent herpesviral infections in humans and is the leading etiological agent of viral encephalitis and eye infections. Our understanding of how HSV-1 interacts with the host at the cellular and...
Daniela Surico et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 36(6), 2108-2120 (2015-08-19)
Previous reports have made it hypothetically possible that human chorionic gonadotropin (hCG) could protect against the onset of pregnancy-related pathological conditions by acting as an antioxidant. In the present study we planned to examine the effects of hCG against oxidative...
Jia Liu et al.
Molecular therapy. Nucleic acids, 4, e232-e232 (2015-03-11)
Safe, efficient, and broadly applicable methods for delivering site-specific nucleases into cells are needed in order for targeted genome editing to reach its full potential for basic research and medicine. We previously reported that zinc-finger nuclease (ZFN) proteins have the...
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