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Omar A A AlDeeb et al.
Profiles of drug substances, excipients, and related methodology, 38, 423-462 (2013-05-15)
Sucralose is a nonnutritive, zero-calorie artificial sweetener. It is a chlorinated sugar substitute that is about 600 times as sweet as sucrose. It is produced from sucrose when three chlorine atoms replace three hydroxyl groups. It is consumed as tablets
Jennifer L Dale et al.
Antimicrobial agents and chemotherapy, 59(7), 4094-4105 (2015-04-29)
The emergence of multidrug-resistant bacteria and the limited availability of new antibiotics are of increasing clinical concern. A compounding factor is the ability of microorganisms to form biofilms (communities of cells encased in a protective extracellular matrix) that are intrinsically
Matthew S Elitt et al.
Nature, 585(7825), 397-403 (2020-07-02)
Mutations in PLP1, the gene that encodes proteolipid protein (PLP), result in failure of myelination and neurological dysfunction in the X-chromosome-linked leukodystrophy Pelizaeus-Merzbacher disease (PMD)1,2. Most PLP1 mutations, including point mutations and supernumerary copy variants, lead to severe and fatal disease.
Ankita Misra et al.
BMC research notes, 8, 324-324 (2015-08-01)
Roscoea purpurea (Zingiberaceae) is commonly known as "kakoli". Traditionally, various parts like leaves, roots and flower etc. are used for the treatment of diabetic, hypertension, diarrhea, fever, inflammation etc. In Nepal tubers are boiled for edible purpose and also used
Hanna Szaefer et al.
Drug and chemical toxicology, 37(4), 472-479 (2014-03-04)
Apples abundant in phenolic compounds show a variety of biological activities that may contribute to health beneficial effects against cardiovascular diseases, diabetes, obesity and cancer. We investigated the effect of cloudy apple juice (CAJ) on the hepatic and mammary gland
Michael A Schumacher et al.
The Journal of physiology, 593(8), 1809-1827 (2015-01-22)
An in vitro approach to study gastric development is primary mouse-derived epithelium cultured as three-dimensional spheroids known as organoids. We have devised two unique gastric fundic-derived organoid cultures: model 1 for the expansion of gastric fundic stem cells, and model
Suzanne M K Buckley et al.
Scientific reports, 5, 11842-11842 (2015-07-04)
The application of transcription factor activated luciferase reporter cassettes in vitro is widespread but potential for in vivo application has not yet been realized. Bioluminescence imaging enables non-invasive tracking of gene expression in transfected tissues of living rodents. However the
Humberto Riera et al.
PloS one, 10(5), e0127571-e0127571 (2015-05-23)
Pyrrolidine dithiocarbamate (PDTC) known as antioxidant and specific inhibitor of NF-κB was also described as pro-oxidant by inducing cell death and reactive oxygen species (ROS) accumulation in cancer. However, the mechanism by which PDTC indices its pro-oxidant effect is unknown.
Joana E Matos et al.
Reproductive biology and endocrinology : RB&E, 13, 60-60 (2015-06-13)
In cryopreservation, oocytes are subjected to extreme hyperosmotic conditions, inducing large volume changes that, along with an abrupt temperature drop, interfere with their developmental competence. Our objectives in this work were to find conditions enabling an increase in oocyte cryosurvival
Sophia T Mundle et al.
Vaccine, 33(35), 4255-4260 (2014-12-17)
Purification of enveloped viruses such as live flavivirus vaccine candidates poses a challenge as one must retain viral infectivity to preserve immunogenicity. Here we describe a laboratory-scale purification procedure for two replication defective (single-cycle) flavivirus variants for use in a
Cui-Ying Zhang et al.
World journal of microbiology & biotechnology, 31(8), 1241-1249 (2015-05-25)
The predominant fermentable sugar in lean dough is maltose. To improve the leavening ability of baker's yeast in lean dough, maltose metabolism should be improved. Maltase (alpha-glucosidase, encoded by MAL62) and maltose permease (encoded by MAL61) are the major factors
Melissa M St Amand et al.
Biotechnology and bioengineering, 111(10), 1957-1970 (2014-04-15)
N-linked glycan distribution affects important end-use characteristics such as the bioactivity and efficacy of many therapeutic proteins, (including monoclonal antibodies), in vivo. Yet, obtaining desired glycan distributions consistently during batch-to-batch production can be challenging for biopharmaceutical manufacturers. While an appropriately
Bei Shao et al.
Physiology & behavior, 139, 224-230 (2014-12-03)
Poststroke depression (PSD) is the most common psychological sequel after stroke. Although the neurological mechanisms of PSD remain to be fully elucidated, numerous studies have implicated the calcitonin gene-related peptide (CGRP), a potent vasodilatory neuropeptide, as key modulator of the
Jehangir Cama et al.
Journal of the American Chemical Society, 137(43), 13836-13843 (2015-10-20)
Decreased drug accumulation is a common cause of antibiotic resistance in microorganisms. However, there are few reliable general techniques capable of quantifying drug uptake through bacterial membranes. We present a semiquantitative optofluidic assay for studying the uptake of autofluorescent drug
Zacnicte May et al.
Behavioural brain research, 291, 26-35 (2015-05-16)
A rarely explored subject in animal research is the effect of pre-injury variables on behavioral outcome post-SCI. Low reporting of such variables may underlie some discrepancies in findings between laboratories. Particularly, intensive task-specific training before a SCI might be important
Ashleigh Poole et al.
Journal of cellular physiology, 231(3), 650-658 (2015-07-29)
Transient FGF stimulation of various cell types results in FGF memory--a sustained blockage of efficient proliferative response to FGF and other growth factors. FGF memory establishment requires HDAC activity, indicating its epigenetic character. FGF treatment stimulates proinflammatory NFκB signaling, which
Uroš Gašić et al.
Journal of AOAC International, 97(5), 1259-1267 (2015-04-24)
Composition of phenolic compounds and the sugar content were determined as the basis for characterization of lime honey from Serbia. Particular attention was given to differences in phytochemical profiles of ripe and unripe lime honey and lime tree nectar. Melissopalynological
Soneela Ankam et al.
Biomaterials, 47, 20-28 (2015-02-16)
Pluripotent human embryonic stem cells (hESCs) have the capability of differentiating into different lineages based on specific environmental cues. We had previously shown that hESCs can be primed to differentiate into either neurons or glial cells, depending on the arrangement
David Awotwe-Otoo et al.
International journal of pharmaceutics, 490(1-2), 341-350 (2015-04-04)
The objective of the study was to analyze the effect of controlled and uncontrolled freezing step of a lyophilization process on the extent of non-enzymatic glycation and aggregation of an IgG1 formulation at two concentrations (1mg/ml and 20mg/ml). The degree
Pei-Ciao Tang et al.
Hearing research, 327, 245-256 (2015-07-18)
Sea anemones have an extraordinary capability to repair damaged hair bundles, even after severe trauma. A group of secreted proteins, named repair proteins (RPs), found in mucus covering sea anemones significantly assists the repair of damaged hair bundle mechanoreceptors both
Dana Westphal et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(39), E4076-E4085 (2014-09-18)
The pivotal step on the mitochondrial pathway to apoptosis is permeabilization of the mitochondrial outer membrane (MOM) by oligomers of the B-cell lymphoma-2 (Bcl-2) family members Bak or Bax. However, how they disrupt MOM integrity is unknown. A longstanding model
Javier Rodríguez-Grille et al.
Virology, 462-463, 49-59 (2014-08-06)
Avian reovirus non-structural protein muNS is partially cleaved in infected chicken embryo fibroblast cells to produce a 55-kDa carboxyterminal protein, termed muNSC, and a 17-kDa aminoterminal polypeptide, designated muNSN. In this study we demonstrate that muNS processing is catalyzed by
Ting-Li Dai et al.
Experimental and therapeutic medicine, 8(2), 384-390 (2014-07-11)
The canonical Wnt signaling pathway is critical for the development of midbrain dopaminergic (DA) neurons, and recent studies have suggested that disruption of this signaling cascade may underlie the pathogenesis of Parkinson's disease (PD). However, the exact role of the
Mira Polajnar et al.
PloS one, 9(7), e102500-e102500 (2014-07-23)
Alternative functions, apart from cathepsins inhibition, are being discovered for stefin B. Here, we investigate its role in vesicular trafficking and autophagy. Astrocytes isolated from stefin B knock-out (KO) mice exhibited an increased level of protein aggregates scattered throughout the
Arnis Strods et al.
Scientific reports, 5, 11639-11639 (2015-06-27)
Hepatitis B virus (HBV) core (HBc) virus-like particles (VLPs) are one of the most powerful protein engineering tools utilised to expose immunological epitopes and/or cell-targeting signals and for the packaging of genetic material and immune stimulatory sequences. Although HBc VLPs
Akiko Nakamoto et al.
Journal of nutritional science and vitaminology, 61(2), 147-153 (2015-06-09)
Oral tolerance is a phenomenon of induction of systemic unresponsiveness to antigens ingested by the oral route and loss of immune response. Studies have shown the importance of vitamin A in oral tolerance in vitro but not in an in
Agata Grazia D'Amico et al.
Journal of molecular neuroscience : MN, 54(3), 405-413 (2014-05-31)
Hyperglycemia has been identified as a risk factor responsible for micro- and macrovascular complications in diabetes. NAP (Davunetide) is a peptide whose neuroprotective actions are widely demonstrated, although its biological role on endothelial dysfunctions induced by hyperglycemia remains uninvestigated. In
Elaheh Binabaji et al.
Pharmaceutical research, 32(9), 3102-3109 (2015-04-03)
The large increase in viscosity of highly concentrated monoclonal antibody solutions can be challenging for downstream processing, drug formulation, and delivery steps. The objective of this work was to examine the viscosity of highly concentrated solutions of a high purity
Jiseon Yang et al.
NPJ biofilms and microbiomes, 7(1), 70-70 (2021-09-08)
While sequencing technologies have revolutionized our knowledge of microbial diversity, little is known about the dynamic emergent phenotypes that arise within the context of mixed-species populations, which are not fully predicted using sequencing technologies alone. The International Space Station (ISS)
Mieke H van Marion et al.
Journal of molecular and cellular cardiology, 87, 79-91 (2015-08-19)
Cardiomyocyte progenitor cells (CMPCs) are a candidate cell source for cardiac regenerative therapy. However, like other stem cells, after transplantation in the heart, cell retention and differentiation capacity of the CMPCs are low. Combining cells with biomaterials might overcome this
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