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Ouardia I Yahiaoui et al.
BMC cancer, 14, 565-565 (2014-08-07)
The phosphoinositide 3- kinase (PI3K) pathway is involved in the growth of various human cancers, including lymphoid malignancies. However its role in the pathogenesis of follicular lymphoma (FL) has not been yet described. To clarify this point, biopsy tissue samples
Dov B Ballak et al.
Nature communications, 5, 4711-4711 (2014-09-04)
Cytokines of the IL-1 family are important modulators of obesity-induced inflammation and the development of systemic insulin resistance. Here we show that IL-1 family member IL-37, recently characterized as an anti-inflammatory cytokine, ameliorates obesity-induced inflammation and insulin resistance. Mice transgenic
Yanyan Li et al.
IUBMB life, 66(7), 507-518 (2014-07-06)
The invasion and chemoresistance are crucial causes of morbidity and relapse for cancer patients. Axl is implicated in the modulation of cell invasion, cancer metastasis, and chemosensitivity in human breast carcinoma cell lines. Both breast cancer cell lines and tissues
Anne Elsner et al.
World journal of gastroenterology, 20(24), 7914-7925 (2014-07-01)
To study if three clinically available small molecule kinase inhibitors (SMI), erlotinib, sunitinib and sorafenib, exert antifibrogenic effects on pancreatic stellate cells (PSC) and analyze the basis of their action. Cultured rat PSC were exposed to SMI. Cell proliferation and
Águeda González-Rodríguez et al.
Disease models & mechanisms, 7(9), 1093-1100 (2014-07-06)
Oxidative stress contributes to the progression of acute liver failure (ALF). Transcription factor nuclear factor-erythroid 2-related factor (Nrf2) serves as an endogenous regulator by which cells combat oxidative stress. We have investigated liver damage and the balance between death and
Akt1/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in mice
Cho H, et al.
The Journal of Biological Chemistry, 276(42), 38349-38352 (2001)
Jörn Tongers et al.
Journal of molecular and cellular cardiology, 74, 231-239 (2014-07-11)
The translation of cell-based therapies for ischemic tissue repair remains limited by several factors, including poor cell survival and limited target site retention. Advances in nanotechnology enable the development of specifically designed delivery matrices to address these limitations and thereby
T J Dionísio et al.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 46(7), 484-489 (2014-04-09)
This study investigated how proteins of the insulin signaling cascade could modulate insulin resistance after dexamethasone (Dexa) treatment and aerobic training. Rats were distributed into 4 groups: sedentary control (SC), sedentary+Dexa (SD), trained control (TC), and trained+Dexa (TD), and underwent
Noriyuki Hirata et al.
Biochemical and biophysical research communications, 450(1), 891-898 (2014-06-28)
The possibility of the pandemic spread of influenza viruses highlights the need for an effective cure for this life-threatening disease. Influenza A virus, belonging to a family of orthomyxoviruses, is a negative-strand RNA virus which encodes 11 viral proteins. A
Chunyan Zhao et al.
Cancer research, 74(14), 3983-3994 (2014-05-17)
Triple-negative breast cancer (TNBC) is an aggressive clinical subtype accounting for up to 20% of all breast cancers, but its malignant determinants remain largely undefined. Here, we show that in TNBC the overexpression of Fra-1, a component of the transcription
H L Zheng et al.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 46(6), 412-418 (2014-05-09)
Extracellular cysteine (Cys)/cystine (CySS) redox potential (Eh) plays a crucial role in maintaining redox homeostasis and an alteration of redox state occurs in various physiological conditions, including diabetes, cancer, and aging. This study was designed to determine whether a variation
Ying Wang et al.
Fertility and sterility, 102(1), 257-263 (2014-04-22)
To clarify the role and mechanism of interleukin (IL)-25 in regulating the biological functions of decidual stromal cells (DSCs) in human early pregnancy. Laboratory study of the effect of IL-25 induced by hCG on the proliferation of DSCs. Research laboratories.
Datong Zheng et al.
Oncology reports, 32(1), 411-418 (2014-05-09)
Hepatocellular carcinoma (HCC) is the third most common cause of cancer-related mortality worldwide. Galectin-3 (Gal-3), a multifunctional β-galactoside-binding protein, is highly expressed and associated with the prognosis of HCC. However, the functions of Gal-3 in HCC cells are not fully
P-W Cheng et al.
Acta physiologica (Oxford, England), 212(1), 28-38 (2014-07-06)
Insulin-like growth factor-1 (IGF-1) is abundantly expressed in the nucleus tractus solitarii (NTS). In a previous study, we revealed that the induction of nitric oxide (NO) production in the NTS reduces blood pressure (BP). It is well known that both
Stine Louise Jeppe Knudsen et al.
Growth factors (Chur, Switzerland), 32(5), 155-163 (2014-09-27)
EGF receptor (EGFR) and its signaling have been investigated for many years, but how its different ligands regulate signaling has not been thoroughly explored. When investigating EGFR activation and downstream signaling in HeLa cells using a panel of ligands, we
Jie Chen et al.
Journal of cellular physiology, 229(11), 1647-1659 (2014-03-13)
Hertwig's epithelial root sheath (HERS) cells participate in cementum formation through epithelial-mesenchymal transition (EMT). Previous studies have shown that transforming growth factor beta 1 (TGF-β1) and fibroblast growth factor 2 (FGF2) are involved in inducing EMT. However, their involvement in
Christiane E Koch et al.
Endocrinology, 155(5), 1806-1816 (2014-02-26)
Adiponectin, an adipocyte-derived hormone, regulates glucose and lipid metabolism. It is also antiinflammatory. During obesity, adiponectin levels and sensitivity are reduced. Whereas the action of adiponectin in the periphery is well established the neuroendocrine role of adiponectin is largely unknown.
Min Cui et al.
Molecular cancer research : MCR, 12(5), 654-659 (2014-02-01)
Small cell lung carcinoma (SCLC) is a highly metastatic tumor type with neuroendocrine features and a dismal prognosis. PTEN mutations and PIK3CA activating mutations have been reported in SCLC but the functional relevance of this pathway is unknown. The PTEN/PIK3CA
Ye-Ji Lee et al.
The Journal of pharmacology and experimental therapeutics, 350(3), 563-577 (2014-06-19)
Growth arrest-specific protein 6 (Gas6)/Mer receptor tyrosine kinase (Mer) signaling modulates cytokine secretion and helps to regulate the immune response and apoptotic cell clearance. Signaling pathways that activate an epithelial growth program in macrophages are still poorly defined. We report
Kazunori Sato et al.
Bioscience, biotechnology, and biochemistry, 78(9), 1495-1503 (2014-07-26)
Oxidative stress is recognized as one of the pathogenic mechanisms involved in neurodegenerative disease. However, recent evidence has suggested that regulation of cellular fate in response to oxidative stress appears to be dependent on the stress levels. In this study
A natural product toosendanin inhibits epithelial-mesenchymal transition and tumor growth in pancreatic cancer via deactivating Akt/mTOR signaling
Pei Z, et al.
Biochemical and Biophysical Research Communications, 493(1), 455-460 (2017)
AKT plays a central role in tumorigenesis
Testa JR and Bellacosa A
Proceedings of the National Academy of Sciences of the USA, 98(20), 10983-10985 (2001)
Karen Jung et al.
BMC cancer, 14, 328-328 (2014-06-03)
Sox2, a transcription factor and an embryonic stem cell marker, has been implicated in the pathogenesis of breast cancer (BC). YB-1 is another transcription factor that has been shown to promote stemness in BC cells. Western blotting, quantitative PCR, and
Hiroko Katayama et al.
European journal of immunology, 44(6), 1622-1632 (2014-02-19)
The intracellular adaptor Lnk (also known as SH2B3) regulates cytokine signals that control lymphohematopoiesis, and Lnk(-/-) mice have expanded B-cell, megakaryocyte, and hematopoietic stem-cell populations. Moreover, mutations in the LNK gene are found in patients with myeloproliferative disease, whereas LNK
Yong Sang Hong et al.
PloS one, 9(10), e109440-e109440 (2014-10-29)
ERBB2-directed therapy is now a routine component of therapy for ERBB2-amplified metastatic gastroesophageal adenocarcinomas. However, there is little knowledge of the mechanisms by which these tumors develop acquired resistance to ERBB2 inhibition. To investigate this question we sought to characterize
Pei-Chien Tsai et al.
Clinical and experimental pharmacology & physiology, 41(9), 716-726 (2014-06-10)
Naphtho[1,2-b]furan-4,5-dione (NFD), a bioactive component of Avicennia marina, has been shown to exhibit anticancer activity. The aim of the present study was to explore the effect of NFD on hepatocyte growth factor (HGF)-induced cell migration and invasion of MDA-MB-231 human
Liting Xue et al.
Blood, 124(3), 426-436 (2014-06-05)
Acute myeloid leukemia (AML) results from the activity of driver mutations that deregulate proliferation and survival of hematopoietic stem cells (HSCs). The fusion protein CBFβ-SMMHC impairs differentiation in hematopoietic stem and progenitor cells and induces AML in cooperation with other
Tatsushi Kodama et al.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 9(11), 1638-1646 (2014-08-22)
EML4-ALK is a driver oncogene in non-small-cell lung cancer (NSCLC) and has been developed into a promising molecular target for antitumor agents. Although EML4-ALK is reported to be formed by inversion of chromosome 2, other mechanisms of this gene fusion
Ning Yang et al.
Oncology reports, 31(6), 2651-2659 (2014-04-05)
SOX2 is a high mobility group box containing transcription factor that has been reported to be aberrantly overexpressed in various human malignancies, including laryngeal squamous cell carcinoma (LSCC). However, the potential role of SOX2 in LSCC migration and invasion remains
Margherita Galletti et al.
Biochemical pharmacology, 91(2), 181-190 (2014-07-27)
Pulmonary Arterial Hypertension (PAH) is a rare and devasting condition characterized by elevated pulmonary vascular resistance and pulmonary artery pressure leading to right-heart failure and premature death. Pathologic alterations in proliferation, migration and survival of all cell types composing the
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