Terrence E Riehl et al.
American journal of physiology. Gastrointestinal and liver physiology, 319(1), G63-G73 (2020-06-17)
Hyaluronic acid (HA), a glycosaminoglycan in the extracellular matrix, binds to CD44 and Toll-like receptor 4 (TLR4). We previously demonstrated that both CD44 and TLR4, but predominately TLR4, mediated HA stimulation of Lgr5+ stem cell proliferation, crypt fission, and intestinal