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Victor K Langsi et al.
Journal of chromatography. A, 1402, 17-26 (2015-06-02)
Nanometer control over the porous shell thickness of sub-2-μm-shell particles is investigated. Three seeded growth mesoporous thin shell particles for HPLC were prepared, with 0.05μm (or 50nm) porous shell layers: particle sizes 1.5μm (solid core diameters 1.4μm), 1.7μm (solid core
R Chaubey et al.
International journal of laboratory hematology, 37(2), 265-271 (2014-08-16)
The inactivation of suppressor of cytokine signaling SOCS-1, a negative regulator of cytokine pathways, by hypermethylation was shown in hematological malignancies including Myelsplastic Syndromes. So far, its prognostic relevance in myelodysplastic syndromes (MDS) patients has not been understood. Methylation status
Bogumil J Karas et al.
Nature communications, 6, 6925-6925 (2015-04-22)
Eukaryotic microalgae hold great promise for the bioproduction of fuels and higher value chemicals. However, compared with model genetic organisms such as Escherichia coli and Saccharomyces cerevisiae, characterization of the complex biology and biochemistry of algae and strain improvement has
Torkild Visnes et al.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 364(1517), 563-568 (2008-11-15)
Uracil in DNA may result from incorporation of dUMP during replication and from spontaneous or enzymatic deamination of cytosine, resulting in U:A pairs or U:G mismatches, respectively. Uracil generated by activation-induced cytosine deaminase (AID) in B cells is a normal
H Teramachi et al.
Die Pharmazie, 68(11), 909-915 (2014-01-02)
Dipeptidyl peptidase-4 (DPP-4) inhibitors and other incretin-related drugs have attracted attention as antidiabetic agents, but they are expensive. The Japanese government has adopted a policy of reducing healthcare costs, and medical institutions must provide medical care while considering economic efficiency.
Shijia Liu et al.
Analytical and bioanalytical chemistry, 407(30), 8989-8997 (2015-10-03)
A novel imidazolium-embedded N,N-dimethylaminopropyl-functionalized silica-based stationary phase (Sil-ImCl) was prepared and further used for hydrophilic interaction/reversed-phase mixed-mode chromatography. The Sil-ImCl stationary phase was respectively characterized by Fourier transform infrared spectrometry, thermogravimetric analysis, and element analysis. A variety of hydrophilic or
Benjamin L Golomb et al.
Journal of bacteriology, 197(2), 371-381 (2014-11-12)
Lactic acid bacteria have been isolated from living, harvested, and fermented plant materials; however, the adaptations these bacteria possess for growth on plant tissues are largely unknown. In this study, we investigated plant habitat-specific traits of Lactococcus lactis during growth
Fumiaki Sugiura et al.
Gan to kagaku ryoho. Cancer & chemotherapy, 40(12), 1584-1586 (2014-01-08)
Complementary DNA( cDNA) microarray technology coupled with laser microdissection has been used to identify human leukocyte antigen (HLA)-A24-restricted epitope peptides as potential targets for cancer vaccination in colorectal cancer patients. These antigenic peptides were derived from 2 different cancer-testis antigens
Martin Gilar et al.
Journal of chromatography. A, 1381, 110-117 (2015-01-22)
Sample introduction in microfluidic liquid chromatography often generates wide zones rather than peaks, especially when a large sample volume (relative to column volume) is injected. Formation of wide injection zones can be further amplified when the sample is dissolved in
Reid S Alisch et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(47), 15548-15556 (2014-11-21)
Children with an anxious temperament (AT) are at a substantially increased risk to develop anxiety and depression. The young rhesus monkey is ideal for studying the origin of human AT because it shares with humans the genetic, neural, and phenotypic
Ingrid Richter et al.
Toxicon : official journal of the International Society on Toxinology, 95, 13-22 (2015-01-01)
Marine microalgae can produce biotoxins that cause widespread poisoning in marine ecosystems and may also affect human health. While established microalgal biotoxins are detectable using chemical methods, a need remains for robust, inexpensive bioassays. Ligand-binding domains (LBDs) from a tunicate
Stephen R Hughes et al.
Journal of laboratory automation, 20(6), 621-635 (2015-02-28)
A yeast artificial chromosome (YAC) containing a multigene cassette for expression of enzymes that enhance xylose utilization (xylose isomerase [XI] and xylulokinase [XKS]) was constructed and transformed into Saccharomyces cerevisiae to demonstrate feasibility as a stable protein expression system in
Robert W Maul et al.
European journal of immunology, 44(7), 1913-1916 (2014-06-13)
During the immune response, B cells undergo a programed mutagenic cascade to promote increased affinity and expanded antibody function. The two processes, somatic hypermutation (SHM) and class switch recombination (CSR), are initiated by the protein activation-induced deaminase (AID), which converts
Yuan Wei et al.
American journal of physiology. Renal physiology, 307(7), F833-F843 (2014-08-08)
The kidney adjusts K⁺ excretion to match intake in part by regulation of the activity of apical K⁺ secretory channels, including renal outer medullary K⁺ (ROMK)-like K⁺ channels, in the cortical collecting duct (CCD). ANG II inhibits ROMK channels via
Hyun Woo Choi et al.
Scientific reports, 5, 13559-13559 (2015-09-01)
Recently, induced pluripotent stem cells (iPSCs) have been generated in vivo from reprogrammable mice. These in vivo iPSCs display features of totipotency, i.e., they differentiate into the trophoblast lineage, as well as all 3 germ layers. Here, we developed a
Li Wang et al.
The Journal of international medical research, 42(5), 1085-1092 (2014-07-13)
To investigate the clinical significance of cadherin 13 (CDH13) gene promoter methylation in the serum of patients with prostate cancer. This prospective study examined the methylation status of CDH13 in serum samples obtained from patients with primary prostate cancer and
Charlotte Stentoft et al.
Journal of chromatography. A, 1356, 197-210 (2014-07-16)
Improved nitrogen utilization in cattle is important in order to secure a sustainable cattle production. As purines and pyrimidines (PP) constitute an appreciable part of rumen nitrogen, an improved understanding of the absorption and intermediary metabolism of PP is essential.
Saxagliptin, alogliptin, and cardiovascular outcomes.
Benjamin M Scirica et al.
The New England journal of medicine, 370(5), 483-484 (2014-01-31)
Mingyao Wang et al.
Chemico-biological interactions, 206(1), 83-89 (2013-08-06)
An earlier study demonstrated that hydrolysates of all human liver DNA samples analyzed contain the DNA adduct 7-(2'-carboxyethyl)guanine (7-CEGua) with an average level of 74.6 adducts per 10(9) nucleotides. One possible source of this DNA adduct would be endogenous nitrosation
Bettina M Buchholz et al.
American journal of physiology. Gastrointestinal and liver physiology, 308(10), G852-G862 (2015-03-10)
Myocytes are nonhemopoietic in origin and functionally essential in generating gastrointestinal motility. In endotoxemia, a rapid-onset nonhemopoietic mechanism potently triggers early ileus in a Toll-like receptor 4 (TLR4)/myeloid differentiation primary response gene 88 (MyD88)-dependent manner. Moreover, synergistically with hemopoietic cells
Bethany P Cummings et al.
The Journal of endocrinology, 221(1), 133-144 (2014-03-15)
There is a need to identify strategies for type 2 diabetes prevention. Therefore, we investigated the efficacy of pioglitazone and alogliptin alone and in combination to prevent type 2 diabetes onset in UCD-T2DM rats, a model of polygenic obese type
Zhonghui Feng et al.
Molecular biology of the cell, 26(7), 1211-1224 (2015-01-30)
MLC1 is a haploinsufficient gene encoding the essential light chain for Myo1, the sole myosin‑II heavy chain in the budding yeast Saccharomyces cerevisiae. Mlc1 defines an essential hub that coordinates actomyosin ring function, membrane trafficking, and septum formation during cytokinesis
Maarten P G Massink et al.
Molecular oncology, 9(4), 877-888 (2015-01-27)
BRCA1-mutated breast carcinomas may have distinct biological features, suggesting the involvement of specific oncogenic pathways in tumor development. The identification of genomic aberrations characteristic for BRCA1-mutated breast carcinomas could lead to a better understanding of BRCA1-associated oncogenic events and could
Toru Ishikawa
World journal of gastroenterology, 14(18), 2797-2801 (2008-05-14)
Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide, including Japan. Although the development of imaging modalities has made the early diagnosis of HCC possible, surgically resectable cases are relatively uncommon because of hepatic function reserve and/or an
Phillip Edward Kunkler et al.
PloS one, 9(7), e103086-e103086 (2014-08-01)
Headache is the most common symptom associated with air pollution, but little is understood about the underlying mechanism. Nasal administration of environmental irritants activates the trigeminovascular system by a TRPA1-dependent process. This report addresses questions about the anatomical pathway involved
William B White et al.
The New England journal of medicine, 369(14), 1327-1335 (2013-09-03)
To assess potentially elevated cardiovascular risk related to new antihyperglycemic drugs in patients with type 2 diabetes, regulatory agencies require a comprehensive evaluation of the cardiovascular safety profile of new antidiabetic therapies. We assessed cardiovascular outcomes with alogliptin, a new
Yan Ma et al.
Journal of chromatography. A, 1383, 47-57 (2015-02-05)
Prototype small-size (1.0mm I.D., 5cm long) columns for reversed-phase HPLC were evaluated in relation to instrument requirements. The performance of three types of columns, monolithic silica and particulate silica (2μm, totally porous and 2.6μm, core-shell particles) was studied in the
Alexander C Roy et al.
Bioorganic & medicinal chemistry letters, 20(1), 141-144 (2009-12-17)
CTP synthase (CTPS) catalyzes the conversion of UTP to CTP and is a recognized target for the development of anticancer, antiviral, and antiprotozoal agents. Xanthine and related compounds inhibit CTPS activity (IC(50)=0.16-0.58mM). The presence of an 8-oxo function (i.e., uric
Antoine M Snijders et al.
Oncotarget, 5(12), 4011-4025 (2014-07-06)
The concept that a breast cancer patient's menstrual stage at the time of tumor surgery influences risk of metastases remains controversial. The scarcity of comprehensive molecular studies of menstrual stage-dependent fluctuations in the breast provides little insight in this observation.
Alexandre Grand-Guillaume Perrenoud et al.
Journal of chromatography. A, 1360, 275-287 (2014-08-19)
Superficially porous particles (SPP), or core shell particles, which consist of a non-porous silica core surrounded by a thin shell of porous silica, have gained popularity as a solid support for chromatography over the last decade. In the present study
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