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Jianmin Chen et al.
Drug development and industrial pharmacy, 41(3), 415-422 (2014-01-01)
Coated microneedles have been paid much attention recently, and several coating strategies have been developed to address the problems during coating process. However, there are still some unresolved issues, such as, precise control requirements, microneedle substrate contamination and high processing
Yusuke Takahashi et al.
Phytotherapy research : PTR, 28(10), 1513-1519 (2014-05-07)
Evidences are accumulating that extract of Acanthopanax senticosus Harms (ASH; syn Eleutherococcus senticosus [Rupr. & Maxim.] Maxim), a shrub native to Northeastern Asia, has antiinflammatory effects. In this study, we examined prophylactic and therapeutic effects of ASH extract (ASHE) on
Rita Horvath
Journal of inherited metabolic disease, 35(4), 679-687 (2012-01-11)
Riboflavin and ubiquinone (Coenzyme Q(10), CoQ(10)) deficiencies are heterogeneous groups of autosomal recessive conditions affecting both children and adults. Riboflavin (vitamin B(2))-derived cofactors are essential for the function of numerous dehydrogenases. Genetic defects of the riboflavin transport have been detected
Immediate effect of ultraviolet-a collagen cross-linking therapy on the biomechanics and histology of the human cornea.
María A Del Buey et al.
Journal of refractive surgery (Thorofare, N.J. : 1995), 31(1), 70-71 (2015-01-20)
Alexandra C Weaver et al.
Toxins, 6(12), 3336-3353 (2014-12-24)
To evaluate the effects of the mycotoxins deoxynivalenol (DON) and zearalenone (ZEA) on pigs and the benefits of two mycotoxin mitigation strategies, gilts (n = 84, 9.1 ± 0.1 kg) were allotted to four treatments: CON (control); MT (4.8 mg/kg
Nacim Bouheraoua et al.
Investigative ophthalmology & visual science, 55(11), 7601-7609 (2014-10-30)
We compared the efficacy and early morphological changes in the cornea following conventional (C-CXL), transepithelial by iontophoresis (I-CXL), and accelerated (A-CXL) collagen cross-linking in keratoconus. A total of 45 eyes of 45 patients with progressive keratoconus who underwent corneal collagen
Author reply: To PMID 24576886.
Dalia G Said et al.
Ophthalmology, 121(12), e68-e68 (2014-08-12)
Jose L Güell et al.
Journal of refractive surgery (Thorofare, N.J. : 1995), 30(4), 286-288 (2014-04-08)
To present a case of a late, deep stromal scar in a 22-year-old patient with forme fruste keratoconus who underwent combined corneal cross-linking and photorefractive keratectomy (PRK). Topography-guided corneal cross-linking combined with corneal PRK (without complications) was performed in both
Mattias Johansson et al.
Journal of the National Cancer Institute, 106(12), doi:10-doi:10 (2014-11-08)
The etiology of renal cell carcinoma (RCC) is only partially understood, but a metabolic component appears likely. We investigated biomarkers of one-carbon metabolism and RCC onset and survival. The European Prospective Investigation into Cancer and Nutrition (EPIC) recruited 385747 participants
Stella Vitt et al.
Journal of molecular biology, 426(15), 2813-2826 (2014-06-03)
The reversible redox reaction between coenzyme F420 and H2 to F420H2 is catalyzed by an F420-reducing [NiFe]-hydrogenase (FrhABG), which is an enzyme of the energy metabolism of methanogenic archaea. FrhABG is a group 3 [NiFe]-hydrogenase with a dodecameric quaternary structure
Maria Gkika et al.
International ophthalmology, 31(4), 309-319 (2011-08-19)
Corneal collagen cross-linking (CXL) using riboflavin and ultraviolet-A irradiation is a common method of tissue stabilization and has been developed primarily to address the need of treating keratoconus. CXL's promising results on keratoconus indicated that it might be effective in
Ithar M Beshtawi et al.
Journal of cataract and refractive surgery, 39(3), 451-462 (2013-03-20)
Photodynamic collagen crosslinking (CXL) using ultraviolet-A (UVA) irradiation combined with the photosensitizer riboflavin has been introduced as a new treatment for progressive keratoconus. The results of clinical studies are promising, but the efficacy of the treatment in halting the progression
Maria De Angelis et al.
PloS one, 9(9), e107232-e107232 (2014-09-30)
Lactobacillus rossiae is an obligately hetero-fermentative lactic acid bacterium, which can be isolated from a broad range of environments including sourdoughs, vegetables, fermented meat and flour, as well as the gastrointestinal tract of both humans and animals. In order to
Peter W J Morrison et al.
International journal of pharmaceutics, 472(1-2), 56-64 (2014-06-15)
Ethylenediaminetetraacetic acid, ethylenediamine-N,N'-disuccinic acid and ethylene glycol-bis(2-aminoethylether)-N,N,N',N'-tetraacetic acid are polyaminocarboxylic acids that are able to sequester metal ions. Calcium is implicated in maintenance of intercellular matrix, zonula occludens (tight junctions) and zonula adherens of epithelium and endothelium cells. Corneal epithelium
Simultaneous determination of riboflavin phosphate and other ingredients in a multivitamin pharmaceutical preparation by on-line automated LC coupled with pre-column immobilized enzyme reactor
Ono M, et al.
Journal of Pharmaceutical and Biomedical Analysis, 29(1-2), 325-334 (2002)
Bárbara J Henriques et al.
Current medicinal chemistry, 17(32), 3842-3854 (2010-09-23)
Riboflavin, commonly known as vitamin B2, is the precursor of flavin cofactors. It is present in our typical diet, and inside the cells it is metabolized to FMN and FAD. As a result of their rather unique and flexible chemical
Katherine R Heal et al.
Rapid communications in mass spectrometry : RCM, 28(22), 2398-2404 (2014-10-11)
Vitamin B(12) is an essential nutrient for more than half of surveyed marine algae species, but methods for directly measuring this important cofactor in seawater are limited. Current mass spectrometry methods do not quantify all forms of B(12), potentially missing
Erick A Argueta et al.
FEBS letters, 589(8), 880-884 (2015-03-10)
Flavin cofactors are central to many biochemical transformations and are typically tightly bound as part of a catalytically active flavoenzyme. This work indicates that naturally occurring flavins can act as stand-alone catalysts to promote the oxidation of biosynthetically inspired heterocycles
Daniel R Cardoso et al.
Food & function, 3(5), 487-502 (2012-03-13)
Riboflavin, vitamin B₂, and flavins (as riboflavin building blocks or degradation products) are efficient photosensitizers inducing oxidative damage to light-exposed tissue and food by substrate-dependent mechanisms, for which protection is offered by specific nutrients. Phenolic and N-heterocyclic amino acids and
George D Kymionis et al.
American journal of ophthalmology, 158(4), 671-675 (2014-07-19)
To compare the corneal stromal demarcation line depth using anterior segment optical coherence tomography (AS-OCT) after corneal collagen cross-linking (CXL) using 2 different treatment protocols: the standard Dresden protocol (30 minutes with 3 mW/cm(2)) and a modified-accelerated protocol (14 minutes
Vinay Agrawal
Indian journal of ophthalmology, 61(8), 433-434 (2013-08-09)
Corneal collagen cross-linking with riboflavin and UVA light (CXL) is the only method designed to arrest the progression of keratoconus. Visual improvement generally starts 3 months after treatment. Reduction is coma seen on aberrometry in early postoperative phase is also
Yue Teng et al.
PloS one, 9(8), e106003-e106003 (2014-08-27)
2-Mercaptobenzimidazole (MBI) is widely utilized as a corrosion inhibitor, copper-plating brightener and rubber accelerator. The residue of MBI in the environment is potentially harmful. In the present work, the toxic interaction of MBI with the important antioxidant enzyme copper-zinc superoxide
Katsumi Shibata et al.
Bioscience, biotechnology, and biochemistry, 78(12), 2102-2109 (2014-08-15)
We previously reported that mild food restriction induces a reduction in tryptophan-nicotinamide conversion, which helps to explain why death secondary to pellagra is pandemic during the hungry season. In this study, we investigated the levels of B-group vitamins in the
M Hilal Sehitoglu et al.
Journal of enzyme inhibition and medicinal chemistry, 30(2), 264-269 (2014-06-19)
In the present study, in order to evaluate antioxidant and radical scavenging properties of Pistachio gum (P-Gum), different bioanalytical methods such as DPPH(•) scavenging activity, DMPD(•+) radical scavenging activity, total antioxidant activity determination by ferric thiocyanate, reducing ability Fe(3+)-Fe(2+) transformation
Arthur Hammer et al.
Investigative ophthalmology & visual science, 55(5), 2881-2884 (2014-03-29)
New corneal cross-linking (CXL) devices are capable of using higher UV-A light irradiances than used in original CXL protocols. The Bunsen-Roscoe law states that a photochemical reaction should stay constant if the delivered total energy is kept constant; however, little
Djamila Achouri et al.
Drug development and industrial pharmacy, 41(3), 493-501 (2014-02-14)
In the field of keratoconus treatment, a lipid-based liquid crystal nanoparticles system has been developed to improve the preocular retention and ocular bioavailability of riboflavin, a water-soluble drug. The formulation of this ophthalmic drug delivery system was optimized by a
Ryan A Kelley et al.
The Journal of biological chemistry, 290(8), 5041-5052 (2014-12-30)
Retbindin is a novel retina-specific protein of unknown function. In this study, we have used various approaches to evaluate protein expression, localization, biochemical properties, and function. We find that retbindin is secreted by the rod photoreceptors into the inter-photoreceptor matrix
David Tabibian et al.
Journal of refractive surgery (Thorofare, N.J. : 1995), 30(12), 855-857 (2014-12-02)
To report the use of accelerated photoactivated chromophore for keratitis-corneal collagen cross-linking (PACK-CXL) as a first-line treatment in a patient with an atypical fungal keratitis. Case report and literature review. A patient who presented with a painful peripheral corneal infiltrate
Chibuzo C Odigwe et al.
The Cochrane database of systematic reviews, (4)(4), CD008147-CD008147 (2010-04-16)
Protein Energy Malnutrition is an important cause of child morbidity and mortality in middle- and low-income countries. It has been suggested that excessive free radical activity may be responsible for the clinical manifestation of kwashiorkor. Antioxidants may be able to
Inong R Gunanti et al.
The Journal of nutrition, 144(12), 2027-2033 (2014-11-21)
Micronutrient status may be a contributing factor to the development of childhood obesity in many industrializing countries passing the nutritional transition. The few studies investigating associations between serum concentrations of vitamin B and intake of B vitamins with adiposity, however
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