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" no prazo de Papéis
Jennifer L Temple et al.
Pediatrics, 134(1), e112-e119 (2014-06-18)
Caffeine use is on the rise among children and adolescents. Previous studies from our laboratory reported gender differences in the effects of caffeine in adolescents. The purpose of this study was to test the hypotheses that gender differences in cardiovascular
Joshi John et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 307(6), R704-R710 (2014-07-18)
Histamine neurons are active during waking and largely inactive during sleep, with minimal activity during rapid-eye movement (REM) sleep. Caffeine, the most widely used stimulant, causes a significant increase of sleep onset latency in rats and humans. We hypothesized that
Laureen Colis et al.
Oncotarget, 5(12), 4361-4369 (2014-06-24)
DNA intercalation is a major therapeutic modality for cancer therapeutic drugs. The therapeutic activity comes at a cost of normal tissue toxicity and genotoxicity. We have recently described a planar heterocyclic small molecule DNA intercalator, BMH-21, that binds ribosomal DNA
Lianguo Wang et al.
Circulation research, 114(9), 1410-1421 (2014-02-27)
Sarcoplasmic reticulum (SR) Ca(2+) cycling is key to normal excitation-contraction coupling but may also contribute to pathological cardiac alternans and arrhythmia. To measure intra-SR free [Ca(2+)] ([Ca(2+)]SR) changes in intact hearts during alternans and ventricular fibrillation (VF). Simultaneous optical mapping
Rachel A Newman et al.
Perceptual and motor skills, 116(1), 280-293 (2013-07-09)
Naps are an effective strategy for maintaining alertness and cognitive performance; however, upon abrupt wakening from naps, sleep inertia (temporary performance degradation) may ensue. In the present study, attenuation of post-nap sleep inertia was attempted by administration of caffeine gum.
Elizabeth C Lowcock et al.
Nutrition and cancer, 65(3), 398-409 (2013-03-28)
Associations between caffeine and coffee consumption and breast cancer risk are uncertain, with studies suggesting inverse and null associations. Variation in cytochrome P450 1A2 (CYP1A2), a gene responsible for caffeine metabolism, may modify these associations. Cases (n = 3,062) were
Carolina Paola García et al.
Stem cell research, 12(2), 400-414 (2014-01-02)
Embryonic stem cells (ESCs) need to maintain their genomic integrity in response to DNA damage to safeguard the integrity of the organism. DNA double strand breaks (DSBs) are one of the most lethal forms of DNA damage and, if not
Biomedicine. Human stem cells from cloning, finally.
Gretchen Vogel
Science (New York, N.Y.), 340(6134), 795-795 (2013-05-21)
Yueming Zhou et al.
The Analyst, 139(21), 5387-5392 (2014-08-26)
Better sensitivity and interface of ambient sampling/ionization mass spectrometry remain a challenge. Herein, a novel, plasma-based, ambient sampling/ionization/transmission (PASIT) integrated source in a pin-to-funnel configuration was developed for the sensitive analysis of complex samples. With the funnel sleeve directly affected
Min Cheng et al.
The Canadian journal of cardiology, 30(4), 448-454 (2014-04-01)
The association between habitual caffeine intake with incident atrial fibrillation (AF) was unknown. We conducted a meta-analysis to investigate the association between chronic exposure of caffeine and the risk of AF and to evaluate the potential dose-response relation. We searched
In-Ah Lee et al.
Journal of gastroenterology, 49(8), 1206-1216 (2013-08-09)
The initial trigger of inflammatory bowel disease (IBD) can be partly attributed towards the interaction and invasion of intestinal epithelial cells (IECs) and submucosal compartments. Identifying safe and economical methods to block these interactions may help prevent the onset of
Drinking coffee burns hepatic fat by inducing lipophagy coupled with mitochondrial β-oxidation.
Wen-Xing Ding
Hepatology (Baltimore, Md.), 59(4), 1235-1238 (2013-10-12)
Yu-Chi Liu et al.
PLoS genetics, 10(3), e1004209-e1004209 (2014-03-22)
The olfactory systems of insects are fundamental to all aspects of their behaviour, and insect olfactory receptor neurons (ORNs) exhibit exquisite specificity and sensitivity to a wide range of environmental cues. In Drosophila melanogaster, ORN responses are determined by three
Mariana N Batista et al.
Archives of virology, 160(2), 399-407 (2014-12-11)
Hepatitis C is considered the major cause of cirrhosis and hepatocellular carcinoma. Conventional treatment is not effective against some hepatitis C virus (HCV) genotypes; therefore, new treatments are needed. Coffee and, more recently, caffeine, have been found to have a
Rosario Villegas et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(21), 7179-7189 (2014-05-23)
Axonal degeneration represents an early pathological event in neurodegeneration, constituting an important target for neuroprotection. Regardless of the initial injury, which could be toxic, mechanical, metabolic, or genetic, degeneration of axons shares a common mechanism involving mitochondrial dysfunction and production
Anne-Laure Gassner et al.
Journal of chromatography. A, 1353, 121-130 (2014-06-14)
Procedures for estimating the measurement uncertainty (MU) of the concentration of a given analyte in a sample are of major concern for analytical chemists. Unfortunately, it is still unclear how and why MU should be assessed. While several possibilities exist
Dimitrios Moustakas et al.
PloS one, 10(4), e0123310-e0123310 (2015-04-17)
The stimulant effect of energy drinks is primarily attributed to the caffeine they contain. Many energy drinks also contain other ingredients that might enhance the tonic effects of these caffeinated beverages. One of these additives is guarana. Guarana is a
[Adverse effects of energy drinks].
Jérôme Chevillotte
Revue de l'infirmiere, 196(196), 7-7 (2014-01-17)
Koichi Takita et al.
Respiratory physiology & neurobiology, 207, 14-21 (2014-12-17)
In a previous study, we showed that in an in vitro en bloc preparation of newborn rats perfused with standard [K(+)] (6.2mM) and high [K(+)] (11.2mM) artificial cerebrospinal fluid (aCSF), nociceptin/orphanin FQ (N/OFQ) suppresses bursting of pre-inspiratory neurons with 1:1
Martin Kronschläger et al.
Experimental eye research, 127, 179-183 (2014-08-12)
The aim of the present study was to examine if topically applied caffeine influences pupil size in ketamine/xylazine anesthetized animals. Two experiments were carried out. In the first experiment, caffeine was topically applied to one of the eyes of 10
[How much coffee is healthy?].
Franziska Etter
Praxis, 103(25), 1531-1532 (2014-12-11)
Regina Wierzejska
Roczniki Panstwowego Zakladu Higieny, 63(2), 141-147 (2012-08-30)
Caffeine is widely consumed by people of all ages. In the last period a market of caffeine-containing products, particularly energy drinks and food supplements increased. Caffeine for years is under discussion, whether has positive whether adverse impact on health. Children
Susanne Burdak-Rothkamm et al.
Cancer letters, 356(2 Pt B), 454-461 (2014-10-12)
Radiotherapy is an important treatment option for many human cancers. Current research is investigating the use of molecular targeted drugs in order to improve responses to radiotherapy in various cancers. The cellular response to irradiation is driven by both direct
Georgios Petrides et al.
The American journal of psychiatry, 172(1), 52-58 (2014-08-27)
Up to 70% of patients with treatment-resistant schizophrenia do not respond to clozapine. Pharmacological augmentation to clozapine has been studied with unimpressive results. The authors examined the use of ECT as an augmentation to clozapine for treatment-refractory schizophrenia. In a
Dong Wook Choi et al.
Biomolecules & therapeutics, 23(2), 128-133 (2015-03-15)
Although coffee is known to have antioxidant, anti-inflammatory, and antitumor properties, there have been few reports about the effect and mechanism of coffee compounds in colorectal cancer. Heat shock proteins (HSPs) are molecular chaperones that prevent cell death. Their expression
Christina Campana et al.
The American journal of emergency medicine, 32(1), 111-111 (2013-10-02)
Despite the fact that caffeine is the most commonly used stimulant in modern society, cases of caffeine overdose are relatively rare, with fatalities reported from doses of 10 g and higher (Nord J Psychiatry. 2006;60:97-106). Large doses produce symptoms associated
Dirk Bier et al.
Rapid communications in mass spectrometry : RCM, 27(8), 885-895 (2013-03-16)
In order to deepen the understanding of electrospray ionisation collision-induced dissociation (ESI-CID) fragmentation reactions of xanthine derivatives for the identification of metabolites using low-resolution liquid chromatography/mass spectrometry (LC/MS) analysis, basic experiments using caffeine (1,3,7-trimethylxanthine) as model compound have been performed.
Seira Narishige et al.
British journal of pharmacology, 171(24), 5858-5869 (2014-08-28)
Caffeine is one of the most commonly used psychoactive substances. Circadian rhythms consist of the main suprachiasmatic nucleus (SCN) clocks and peripheral clocks. Although caffeine lengthens circadian rhythms and modifies phase changes in SCN-operated rhythms, the effects on caffeine on
France Denoeud et al.
Science (New York, N.Y.), 345(6201), 1181-1184 (2014-09-06)
Coffee is a valuable beverage crop due to its characteristic flavor, aroma, and the stimulating effects of caffeine. We generated a high-quality draft genome of the species Coffea canephora, which displays a conserved chromosomal gene order among asterid angiosperms. Although
Monica L Bertoia et al.
The American journal of clinical nutrition, 97(6), 1356-1363 (2013-04-26)
Alcohol and caffeine intakes may play a role in the development of sudden cardiac death (SCD) because of their effects on cholesterol, blood pressure, heart rate variability, and inflammation. Our objective was to examine the association between long-term alcohol and
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