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Matteo Bassetti et al.
Clinical drug investigation, 31(11), 745-758 (2011-09-06)
Invasive fungal infections are associated with a poor outcome and their incidence is rising. Amphotericin B has for a long time been the gold standard for treatment of these infections, but the conventional formulation is associated with a high incidence
Manica Balasegaram et al.
Expert opinion on emerging drugs, 17(4), 493-510 (2012-11-22)
Leishmaniasis is a parasitic disease transmitted by phlebotomine sandflies. Between 700,000 and 1.2 million cases of cutaneous leishmaniasis and between 200,000 and 400,000 cases of visceral leishmaniasis (VL), which is fatal if left untreated, occur annually worldwide. Liposomal amphotericin B
Jeremy N Day et al.
The New England journal of medicine, 368(14), 1291-1302 (2013-04-05)
Combination antifungal therapy (amphotericin B deoxycholate and flucytosine) is the recommended treatment for cryptococcal meningitis but has not been shown to reduce mortality, as compared with amphotericin B alone. We performed a randomized, controlled trial to determine whether combining flucytosine
Afaq Ahmad Khan et al.
Journal of the Indian Medical Association, 110(7), 499-500 (2013-03-26)
Non-Hodgkin's lymphoma (NHL) is predominantly a disease of lymph nodes, but extranodal involvement is not very uncommon. Palatal involvement by NHL is rare. Mucormycosis is a devastating fungal infection commonly seen in immunocompromised individuals, including those with NHL, but it
Michael Klepser
Journal of critical care, 26(2), 225-225 (2010-10-19)
Over the last 20 years, there has been an increase in the total number of invasive fungal infections (IFIs) and in infections caused by rare and emerging pathogens. This is due in part to the growing population of immunocompromised patients
D Standaert et al.
Acta clinica Belgica, 68(2), 124-127 (2013-08-24)
Leishmaniasis, an intracellular protozoal infection in which tissue macrophages are targeted, is transmitted by female sandfly bite and occurs in 98 countries. Visceral leishmaniasis (VL) is the clinical form of leishmaniasis most frequently associated with HIV, especially in Europe. Both
Treating cryptococcal meningitis in people with HIV.
BMJ (Clinical research ed.), 346, f2203-f2203 (2013-04-12)
Pirouz M Daftarian et al.
The Journal of infectious diseases, 208(11), 1914-1922 (2013-08-01)
Amphotericin B (AmB), the most effective drug against leishmaniasis, has serious toxicity. As Leishmania species are obligate intracellular parasites of antigen presenting cells (APC), an immunopotentiating APC-specific AmB nanocarrier would be ideally suited to reduce the drug dosage and regimen
Maria Teresa Montagna et al.
Journal of medical microbiology, 63(Pt 12), 1638-1643 (2014-09-12)
We determined the in vitro antifungal activity of liposomal amphotericin B (L-AmB) against 604 clinical yeast isolates. Amphotericin B deoxycholate (D-AmB) was tested in parallel against all the isolates. Susceptibility testing was performed according to the Clinical and Laboratory Standards
Amphotericin B still in the headlines.
Luigina Romani
Pathogens and global health, 106(2), 80-81 (2012-09-05)
F Robledo-Ávila et al.
Clinical & developmental immunology, 2013, 194064-194064 (2013-10-10)
Candida albicans causes opportunistic systemic infections with high mortality (30%-50%). Despite significant nephrotoxicity, amphotericin (AmB) is still used for the treatment of this serious fungal infection. Therefore, alternative treatments are urgently needed. Dialyzable leukocyte extracts have been used successfully to
Perplexity of a fungus in the sinus.
Radhika Dasararaju et al.
The American journal of medicine, 127(1), e1-e2 (2013-11-26)
John E Linley
Methods in molecular biology (Clifton, N.J.), 998, 149-157 (2013-03-27)
Perforated whole-cell patch-clamp is a variant of the patch-clamp technique used to measure the sum activity of ion channels in the plasma membrane of a single cell. Its defining feature is that electrical access to the cell is obtained through
Surjit Lidder et al.
Journal of the Royal Army Medical Corps, 159(2), 123-125 (2013-05-31)
Infection is the third commonest cause of total hip arthroplasty failure. Infections of the hip with Candida species are extremely rare with only a few reports in the literature. A case of a 76-year-old female subject is presented illustrating both
Masaki Fujita et al.
The Japanese journal of antibiotics, 66(1), 37-43 (2013-06-20)
We report a case of pulmonary aspergillosis in lung transplant recipient who was successfully treated with inhalation administration of anti-fungal agent. The case was 33-year-old female. Two years ago, she had received lung transplant because of lymphangioleiomyomatosis. One year ago
Noelle Layer et al.
JAMA ophthalmology, 132(7), 832-837 (2014-05-03)
Optisol-GS, the most common corneal storage medium in the United States, contains antibacterial but no antifungal supplementation. Most postkeratoplasty endophthalmitis and keratitis cases are now of a fungal origin. To assess the efficacy and safety of voriconazole and amphotericin B
Sóstenes Mistro et al.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 54(12), 1774-1777 (2012-04-12)
This meta-analysis of 13 studies revealed that amphotericin B delivered as a locally prepared lipid emulsion or in liposomes reduced nephrotoxicity to a similar degree, by 18.4% (relative risk [RR], 0.40 [99% confidence interval, .25-.64]; n = 459) and 18.1% (RR, 0.48
Patrícia L N Néris et al.
Experimental parasitology, 135(2), 307-313 (2013-07-31)
Leishmaniasis' treatment is based mostly on pentavalent antimonials or amphotericin B long-term administration, expensive drugs associated with severe side effects. Considering these aforementioned, the search for alternative effective and safe leishmaniasis treatments is a necessity. This work evaluated a neolignan
Ermias Diro et al.
Tropical medicine & international health : TM & IH, 20(1), 8-16 (2014-10-21)
Visceral leishmaniasis (VL) in north-west Ethiopia is causing an overwhelming case load among adult migrant workers that masked the disease burden in children. This study describes the clinical profile and explores comorbidities in paediatric VL patients. A prospective study at
Dale M Walker et al.
Environmental and molecular mutagenesis, 54(4), 268-280 (2013-04-05)
The events or factors that lead from normal cell function to conditions and diseases such as aging or cancer reflect complex interactions between cells and their environment. Cellular stress responses, a group of processes involved in homeostasis and adaptation to
Tatiane F P de Mello et al.
Experimental parasitology, 136, 27-34 (2013-11-26)
The treatment of American cutaneous leishmaniasis (ACL) is based on a small group of compounds that were developed decades ago, all of which are highly toxic and have a high rate of treatment failure. The chalcones show leishmanicidal activity, yet
Angela S Loo et al.
Expert opinion on drug safety, 12(6), 881-895 (2013-08-13)
Amphotericin B (AmB) was first approved by the US Food and Drug Administration in 1959 with sodium deoxycholate (DAmB, Fungizone®). Extensive toxicities associated with the drug led to the development of lipid formulations of AmB, including liposomal amphotericin B (L-AmB
Katrina A Brandis et al.
The Journal of biological chemistry, 288(50), 35703-35713 (2013-11-01)
Mobilization of plasma membrane (PM) cholesterol to the endoplasmic reticulum is essential for cellular cholesterol homeostasis. The mechanisms regulating this retrograde, intermembrane cholesterol transfer are not well understood. Because mutant cells with defects in PM to endoplasmic reticulum cholesterol trafficking
L Pagano et al.
Journal of chemotherapy (Florence, Italy), 23(1), 5-8 (2011-04-13)
The proportion of patients with cancers who develop invasive fungal infections has increased dramatically over the past few decades. Most of these infections are diagnosed in patients with hematological malignancies, mainly in patients with acute myeloid leukemia and those undergoing
Successful treatment of cutaneous zygomycosis with intravenous amphotericin B followed by oral posaconazole in a multivisceral transplant recipient.
Liat Ashkenazi-Hoffnung et al.
Transplantation, 90(10), 1133-1135 (2011-03-24)
Review: voriconazole for prevention or treatment of invasive fungal infections in cancer with neutropenia.
Andrew M Morris
Annals of internal medicine, 161(2), JC8-JC8 (2014-07-16)
Richard J Hamill
Drugs, 73(9), 919-934 (2013-06-04)
Because of the increasing prevalence and changing microbiological spectrum of invasive fungal infections, some form of amphotericin B still provides the most reliable and broad spectrum therapeutic alternative. However, the use of amphotericin B deoxycholate is accompanied by dose-limited toxicities
Ptosis, erythema, and rapidly decreasing vision.
Adam Zanation et al.
JAMA, 309(22), 2382-2383 (2013-06-13)
Thomas M Anderson et al.
Nature chemical biology, 10(5), 400-406 (2014-04-01)
For over 50 years, amphotericin has remained the powerful but highly toxic last line of defense in treating life-threatening fungal infections in humans with minimal development of microbial resistance. Understanding how this small molecule kills yeast is thus critical for
Ji Hong Hwang et al.
Biochimie, 95(10), 1917-1922 (2013-07-03)
In this study, the antifungal activity and mode of action(s) of hibicuslide C derived from Abutilon theophrasti were investigated. Antifungal susceptibility testing showed that hibicuslide C possessed potent activities toward various fungal strains and less hemolytic activity than amphotericin B.
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