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High-yield conversion of (R)-2-octanol from the corresponding racemate by stereoinversion using Candida rugosa.

Biotechnology letters (2005-02-03)
Yao Nie, Yan Xu, Xiao Qing Mu, Yan Tang, Juan Jiang, Zhi Hao Sun
ABSTRACT

Whole cells of Candida rugosa catalyzed the conversion of (R)-2-octanol from the corresponding racemate with the optical purity of 97% e.e. and yield of 92% in 10 h. The product was formed through a stereoinversion involving enantioselective oxidation and asymmetric reduction with 2-octanone as the intermediate.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
(±)-2-Octanol, ReagentPlus®, ≥99.5% (GC)
Sigma-Aldrich
(±)-2-Octanol, ≥96.0% (GC)
Sigma-Aldrich
(S)-(+)-2-Octanol, 99%
Sigma-Aldrich
2-Octanol, ≥97%, FG
Sigma-Aldrich
2-Octanol, 97%