A mathematical model for calculating the shelf life of ascorbic acid solution under given conditions.

Drug development and industrial pharmacy (2011-08-05)
Jiafu Feng, Xiancheng Zhana, Shiwen Qiaob, Chaojun Wub, Longxiang Xiaob
RESUMO

The objective of this paper is to calculate the shelf life of ascorbic acid solution under given conditions by using a mathematical model. An antioxidant, sodium metabisulfite, was added to the ascorbic acid solution. The kinetic parameters of the degradation reaction of ascorbic acid and sodium metabisulfite, were investigated, respectively, and then a mathematical model was developed. According to the mathematical model, the calculated shelf lives of ascorbic acid solution were 783, 835, 873, and 885 days for specifications 2, 5, 10, and 20 mL, respectively. The results showed that the obtained mathematical model can be used to calculate the shelf life of ascorbic acid solution under given conditions.

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Sigma-Aldrich
Sodium metabisulfite, ReagentPlus®, ≥99%
Sigma-Aldrich
Sodium metabisulfite, reagent grade, 97%
Sigma-Aldrich
Sodium metabisulfite, puriss. p.a., ACS reagent, reag. Ph. Eur., dry, 98-100.5%
Supelco
Sodium metabisulfite, analytical standard
Sigma-Aldrich
Sodium metabisulfite, puriss., meets analytical specification of Ph. Eur., BP, NF, FCC, E223, dry, 97-100.5%
Sigma-Aldrich
Sodium metabisulfite, tested according to Ph. Eur.
Sigma-Aldrich
Sodium metabisulfite, anhydrous, free-flowing, Redi-Dri, ReagentPlus®, ≥99%