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  • Pyrazinoic acid decreases the proton motive force, respiratory ATP synthesis activity, and cellular ATP levels.

Pyrazinoic acid decreases the proton motive force, respiratory ATP synthesis activity, and cellular ATP levels.

Antimicrobial agents and chemotherapy (2011-08-31)
Ping Lu, Anna C Haagsma, Hoang Pham, Janneke J Maaskant, Selena Mol, Holger Lill, Dirk Bald
RESUMO

Pyrazinoic acid, the active form of the first-line antituberculosis drug pyrazinamide, decreased the proton motive force and respiratory ATP synthesis rates in subcellular mycobacterial membrane assays. Pyrazinoic acid also significantly lowered cellular ATP levels in Mycobacterium bovis BCG. These results indicate that the predominant mechanism of killing by this drug may operate by depletion of cellular ATP reserves.

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Sigma-Aldrich
Pyrazinecarboxylic acid, 99%