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A biopharmaceutical plant on a chip: continuous micro-devices for the production of monoclonal antibodies.

Lab on a chip (2013-02-16)
Lucía D Garza-García, Leydi M Carrillo-Cocom, Diana Araiz-Hernández, Pedro Soto-Vázquez, Julián López-Meza, Eduardo J Tapia-Mejía, Sergio Camacho-León, Erika García-López, Ciro A Rodríguez-González, Mario M Alvarez
ABSTRACT

We report a proof-of-principle for the use of micro-devices as continuous bioreactors for the production of monoclonal antibodies. We culture CHO cells on the surface of PMMA "zigzag" channels textured with semi-spherical cavities coated with fibronectin, observing steady-state productivities 100 times higher than those observed in full scale systems.

MATERIALS
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Product Description

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