Changes in mitochondrial proteins during neuroblastoma differentiation.

Biochemical and biophysical research communications (1984-04-30)
J L Vayssière, F Berthelot, B Croizat, F Gros
RESUMO

The evolution of three major mit-proteins was followed in neuroblastoma cells cultured in different conditions of differentiation. 1 methyl cyclohexane carboxylic acid (CCA) was found to stimulate the synthesis of the three mit-protein markers. This result, compared to the effects of oligomycin, an inhibitor of mitochondrial function, favours the hypothesis that CCA induces in vitro neurogenesis through a general metabolic alteration.

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1-Methyl-1-cyclohexanecarboxylic acid, 99%