New constituents and antiplatelet aggregation and anti-HIV principles of Artemisia capillaris.

Bioorganic & medicinal chemistry (2001-02-24)
T S Wu, Z J Tsang, P L Wu, F W Lin, C Y Li, C M Teng, K H Lee

Five new constituents including a flavonoid, artemisidin A (1), and four coumarins, artemicapins A (2), B (3), C (4) and D (5), together with 70 known compounds (6-75), have been isolated and characterized from the aerial part of Artemisia capillaris. The structures of these compounds were determined from spectral analyses and/or chemical evidence. Among them, 15 compounds (3, 6, 10, 18. 30-32, 38-41, 44, 45, 51, and 55) showed antiplatelet aggregation activity and three compounds (10, 17, and 51) demonstrated significant activity against HIV replication in H9 lymphocytic cells.

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3-Hydroxy-4-methoxycinnamic acid, predominantly trans, 97%