ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures.

Cell (2003-03-26)
Gina M Story, Andrea M Peier, Alison J Reeve, Samer R Eid, Johannes Mosbacher, Todd R Hricik, Taryn J Earley, Anne C Hergarden, David A Andersson, Sun Wook Hwang, Peter McIntyre, Tim Jegla, Stuart Bevan, Ardem Patapoutian

Mammals detect temperature with specialized neurons in the peripheral nervous system. Four TRPV-class channels have been implicated in sensing heat, and one TRPM-class channel in sensing cold. The combined range of temperatures that activate these channels covers a majority of the relevant physiological spectrum sensed by most mammals, with a significant gap in the noxious cold range. Here, we describe the characterization of ANKTM1, a cold-activated channel with a lower activation temperature compared to the cold and menthol receptor, TRPM8. ANKTM1 is a distant family member of TRP channels with very little amino acid similarity to TRPM8. It is found in a subset of nociceptive sensory neurons where it is coexpressed with TRPV1/VR1 (the capsaicin/heat receptor) but not TRPM8. Consistent with the expression of ANKTM1, we identify noxious cold-sensitive sensory neurons that also respond to capsaicin but not to menthol.

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L-Menthol, Pharmaceutical Secondary Standard; Certified Reference Material
L-Menthol, natural, ≥99%, FCC, FG
(−)-Menthol, analytical standard
L-Menthol, ≥99%, FCC, FG
(1R,2S,5R)-(−)-Menthol, ReagentPlus®, 99%
(−)-Menthol, puriss., meets analytical specification of Ph. Eur., BP, USP, 98.0-102.0%
(−)-Menthol, primary reference standard