Merck
  • Home
  • Search Results
  • A study of micronized poloxamers as lubricants in direct compression of tablets.

A study of micronized poloxamers as lubricants in direct compression of tablets.

Acta poloniae pharmaceutica (2014-01-05)
Jitka Muzíková, Barbora Vyhlídalová, Tomás Pekárek
ABSTRACT

The study evaluates the micronized poloxamers Lptrol micro127 (poloxamer 407) and Lptrol micro 68 (poloxamer 188) as lubricants in combination with the dry binders microcrystalline cellulose and spray-dried lactose. Magnesium stearate was employed as the comparative lubricant. The parameters under study included energy for friction, plasticity, ejection force, tensile strength of tablets, and disintegration time of tablets. The factors of influence were the concentration of lubricants, compression force, and mixing parameters. The lubricating effect of micronized poloxamers was smaller than that of magnesium stearate. Higher concentrations of poloxamers decreased the tensile strength of tablets from microcrystalline cellulose, shortened the disintegration time, and slightly prolonged the disintegration time in the case of spray-dried lactose. Parameters of mixing of dry binders with poloxamers influenced the tested parameters of compression more in the case of spray-dried lactose. In microcrystalline cellulose, they influenced more the tensile strength and disintegration time of tablets.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Sigmacell Cellulose, Type 20, 20 μm
Sigma-Aldrich
Sigmacell Cellulose, Type 50, 50 μm
Sigma-Aldrich
α-Cellulose, powder
Sigma-Aldrich
α-Cellulose, BioReagent, suitable for insect cell culture
Sigma-Aldrich
Magnesium stearate, puriss., meets analytical specification of Ph. Eur., BP, ≥90% stearic and palmitic acid basis, ≥40% stearic acid basis (GC), 4.0-5.0% Mg basis (calc on dry sub.)
Sigma-Aldrich
Magnesium stearate, technical grade
Sigma-Aldrich
Sigmacell Cellulose, Type 101, Highly purified, fibers
Supelco
Stearic acid, analytical standard
Supelco
Cellulose, powder, for column chromatography
Sigma-Aldrich
Avicel® PH-101, tested according to Ph. Eur.
Supelco
Cellulose, acid washed, powder, for column chromatography
Supelco
Cellulose, DS-0, powder, suitable for thin layer chromatography (TLC)
Supelco
Cellulose, DFS-0, microcrystalline, suitable for thin layer chromatography (TLC)
Sigma-Aldrich
Stearic acid, ≥95%, FCC, FG
Sigma-Aldrich
Lactose, tested according to Ph. Eur.
Supelco
Cellulose, acid washed, from spruce, for column chromatography
Supelco
Avicel® PH-101, ~50 μm particle size
Sigma-Aldrich
Cellulose, colloidal, microcrystalline
Sigma-Aldrich
Cellulose, microcrystalline, powder, 20 μm
Sigma-Aldrich
Stearic acid, reagent grade, 95%
Sigma-Aldrich
Cellulose, microcrystalline, powder
Sigma-Aldrich
Cellulose, fibers, (medium)
Sigma-Aldrich
Stearic acid, Grade I, ≥98.5% (capillary GC)
Supelco
Lactose, Anhydrous, Pharmaceutical Secondary Standard; Certified Reference Material
Supelco
Melting Point Standard 69-71°C, analytical standard
Supelco
Stearic Acid, Pharmaceutical Secondary Standard; Certified Reference Material
Stearic acid, European Pharmacopoeia (EP) Reference Standard
Lactose (anhydrous), European Pharmacopoeia (EP) Reference Standard
Supelco
Stearic acid, certified reference material, TraceCERT®