Novel fluoroalkylated products where a CF(2)COOEt group was introduced at the alpha-position of alpha,beta-unsaturated ketones or the Reformatsky-type products have been obtained selectively by the reaction of BrCF(2)COOEt and alpha,beta-unsaturated ketones with Et(2)Zn in the presence of RhCl(PPh(3))(3) depending on the solvents. Furthermore, the novel alpha-fluoroalkylated products could synthesize by using various halofluoroalkyl compounds (R(f)-X) instead of BrCF(2)COOEt. On the other hand, this Reformatsky-type reaction by imines gave difluoro-beta-lactams or 3-amino-2,2-difluorocalboxylic esters without or with MgSO(4) . 7H(2)O, selectively.
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