Aluminum toxicity and astrocyte dysfunction: a metabolic link to neurological disorders.

Journal of inorganic biochemistry (2011-11-22)
Joseph Lemire, Vasu D Appanna
RESUMO

Aluminum (Al) has been implicated in a variety of neurological diseases. However, the molecular mechanisms that enable Al to be involved in these disorders have yet to be fully delineated. Using astrocytes as a model of the cerebral cellular system, we have uncovered the biochemical networks that are affected by Al toxicity. In this review, we reveal how the inhibitory influence of Al on ATP production and on mitochondrial functions help generate globular astrocytes that are fat producing machines. These biological events may be the contributing factors to Al-triggered brain disorders.

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Sigma-Aldrich
Aluminum, foil, thickness 0.45-0.55 mm, 99.999% trace metals basis
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Aluminum, granular, <1 mm, 99.7% trace metals basis
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Aluminum, wire, diam. 1.0 mm, 99.999% trace metals basis
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Aluminum, ReagentPlus®, beads, 5-15 mm, 99.9% trace metals basis
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Aluminum, foil, thickness 0.25 mm, 99.999% trace metals basis
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Aluminum, pellets, 3-12 mm, 99.99% trace metals basis
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Aluminum, evaporation slug, diam. × L 6.3 mm × 6.3 mm, 99.999% trace metals basis
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Aluminum, wire, diam. 0.58 mm, ≥99.99% trace metals basis
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Aluminum, foil, thickness 0.13 mm, ≥99.99% trace metals basis
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Aluminum, pellets, 3-8 mesh, ≥99.999% trace metals basis
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Aluminum, ACS reagent, 99%, wire, wire diam. ~1.5 mm
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Aluminum, rod, diam. × L 3.0 mm × 100 mm, 99.999% trace metals basis
Aluminum, IRMM®, certified reference material, 0.1 mm foil
Aluminum, wire reel, 25m, diameter 0.25mm, as drawn, 99.5%
Aluminum, wire reel, 10m, diameter 0.025mm, as drawn, 99.0+%
Aluminum, honeycomb, 300x300mm, thickness 5mm, cell size 3.2mm, cell wall 0.025mm, core density 0.072g/cm3, phenolic adhesive (resin), 99.5%
Aluminum, wire reel, 500m, diameter 0.5mm, as drawn, 99.5%
Aluminum, mesh, 150x150mm, nominal aperture 0.38mm, wire diameter 0.25mm, 40x40 wires/inch, open area 37%, plain weave mesh
Aluminum, foam, 150x150mm, thickness 10mm, bulk density 0.2g/cm3, porosity 0.93, aluminum 6101 grade, 98.5%
Aluminum, foam, 150x150mm, thickness 3.2mm, bulk density 0.2g/cm3, porosity 0.93, 16 pores/cm, aluminum 6101 grade, 98.5%
Aluminum, foam, 150x150mm, thickness 30mm, bulk density 0.2g/cm3, porosity 0.93, aluminum 6101 grade, 98.5%
Aluminum, foam, 150x150mm, thickness 6.35mm, bulk density 0.2g/cm3, porosity 0.93, 16 pores/cm, aluminum 6101 grade, 98.5%
Aluminum, foam, 150x150mm, thickness 6.35mm, bulk density 0.2g/cm3, porosity 0.93, 2 pores/cm, aluminum 6101 grade, 98.5%
Aluminum, foam, 150x150mm, thickness 6.35mm, bulk density 0.2g/cm3, porosity 0.93, 4 pores/cm, aluminum 6101 grade, 98.5%
Aluminum, foam, 150x150mm, thickness 6.35mm, bulk density 0.2g/cm3, porosity 0.93, 8 pores/cm, aluminum 6101 grade, 98.5%
Aluminum, foam, 300x400mm, thickness 6.35mm, bulk density 0.2g/cm3, porosity 0.93, aluminum 6101 grade, 98.5%
Aluminum, foam, 33x140mm, thickness 20mm, bulk density 0.2g/cm3, porosity 0.93, aluminum 6101 grade, 98.5%
Aluminum, honeycomb, 150x150mm, thickness 10mm, cell size 3.2mm, cell wall 0.025mm, core density 0g/cm3, phenolic adhesive (resin), 99.5%
Aluminum, honeycomb, 150x150mm, thickness 52.3mm, cell size 6.3mm, cell wall 0.064mm, core density 0.083g/cm3, phenolic adhesive (resin), facing skin aluminum 0.55mm, 99.9%
Aluminum, honeycomb, 300x300mm, thickness 10mm, cell size 3.2mm, cell wall 0.025mm, core density 0g/cm3, phenolic adhesive (resin), 99.5%

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