PET tracers based on Zirconium-89.

Current radiopharmaceuticals (2011-12-24)
Yin Zhang, Hao Hong, Weibo Cai
RESUMO

Positron emission tomography (PET) imaging with radiolabeled monoclonal antibodies has always been a dynamic area in molecular imaging. With decay half-life (3.3 d) well matched to the circulation half-lives of antibodies (usually on the order of days), (89)Zr has been extensively studied over the last decade. This review article will give a brief overview on (89)Zr isotope production, the radiochemistry generally used for (89)Zr-labeling, and the PET tracers that have been developed using (89)Zr. To date, (89)Zr-based PET imaging has been investigated for a wide variety of cancer-related targets, which include human epidermal growth factor receptor 2, epidermal growth factor receptor, prostate-specific membrane antigen, splice variant v6 of CD44, vascular endothelial growth factor, carbonic anhydrase IX, insulin-like growth factor 1 receptor, among others. With well-developed radiochemistry, commercial availability of chelating agents for (89)Zr labeling, increasingly widely available isotope supply, as well as successful proof-of-principle in pilot human studies, it is expected that PET imaging with (89)Zr-based tracers will be a constantly evolving and highly vibrant field in the near future.

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Sigma-Aldrich
Zirconium, powder, −100 mesh
Sigma-Aldrich
Zirconium, foil, thickness 0.1 mm, 99.98% trace metals basis
Sigma-Aldrich
Zirconium, sponge, ≥99% trace metals basis
Sigma-Aldrich
Zirconium, rod, diam. 6.35 mm, ≥99% trace metals basis
Zirconium, rod, 100mm, diameter 50mm, centerless ground, 99.2%
Zirconium, foil, not light tested, 50x50mm, thickness 0.006mm, 99.2%
Zirconium, rod, 1000mm, diameter 1.5mm, 99.2%
Zirconium, rod, 1000mm, diameter 12.7mm, centerless ground, 99.2%
Zirconium, rod, 1000mm, diameter 2.0mm, centerless ground, 99.2%
Zirconium, rod, 1000mm, diameter 3.0mm, centerless ground, 99.2%
Zirconium, rod, 1000mm, diameter 5.0mm, centerless ground, 99.2%
Zirconium, rod, 1000mm, diameter 6.0mm, centerless ground, 99.2%
Zirconium, rod, 1000mm, diameter 9.5mm, centerless ground, 99.2%
Zirconium, rod, 100mm, diameter 1.5mm, 99.2%
Zirconium, rod, 100mm, diameter 12.7mm, centerless ground, 99.2%
Zirconium, rod, 100mm, diameter 19.0mm, centerless ground, 99.2%
Zirconium, rod, 100mm, diameter 2.0mm, centerless ground, 99.2%
Zirconium, rod, 100mm, diameter 3.0mm, centerless ground, 99.2%
Zirconium, rod, 100mm, diameter 5.0mm, centerless ground, 99.2%
Zirconium, rod, 100mm, diameter 6.0mm, centerless ground, 99.2%
Zirconium, rod, 100mm, diameter 9.5mm, centerless ground, 99.2%
Zirconium, rod, 200mm, diameter 1.5mm, 99.2%
Zirconium, rod, 200mm, diameter 12.7mm, centerless ground, 99.2%
Zirconium, rod, 200mm, diameter 19.0mm, centerless ground, 99.2%
Zirconium, rod, 200mm, diameter 2.0mm, centerless ground, 99.2%
Zirconium, rod, 200mm, diameter 3.0mm, centerless ground, 99.2%
Zirconium, rod, 200mm, diameter 5.0mm, centerless ground, 99.2%
Zirconium, rod, 200mm, diameter 6.0mm, centerless ground, 99.2%
Zirconium, rod, 200mm, diameter 9.5mm, centerless ground, 99.2%
Zirconium, rod, 500mm, diameter 1.5mm, 99.2%

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