Gold-catalyzed formation of heterocycles - an enabling new technology for medicinal chemistry.

Drug discovery today. Technologies (2013-09-21)
Hong C Shen, Thomas H Graham
RESUMO

Gold-catalyzed transformations allow efficient access to a wide scope of heterocyclic structures that serve as building blocks and pharmacophores in medicinal chemistry. Compared with other transition metal and Lewis acid catalysis, gold catalysis presents mechanistic divergence, excellent functional group tolerance and/or operational advantages. Emergent applications of gold catalysis have played a key role in the synthesis of biologically active molecules including a drug candidate.

MATERIAIS
Número do produto
Marca
Descrição do produto

Sigma-Aldrich
Gold, foil, thickness 0.127 mm, 99.99% trace metals basis
Sigma-Aldrich
Gold, wire, diam. 0.25 mm, ≥99.9% trace metals basis
Sigma-Aldrich
Gold, nanopowder, <100 nm particle size, 99.9% trace metals basis
Sigma-Aldrich
Gold coated microscope slide, layer thickness 100 Å, 99.999% (Au)
Sigma-Aldrich
Gold, powder, <45 μm, 99.99% trace metals basis
Sigma-Aldrich
Gold, foil, thickness 0.5 mm, 99.99% trace metals basis
Sigma-Aldrich
Gold, wire, diam. 0.5 mm, 99.99% trace metals basis
Sigma-Aldrich
Gold, beads, 1-6 mm, 99.999% trace metals basis
Sigma-Aldrich
Gold coated microscope slide, layer thickness 1000 Å, 99.999% (Au)
Sigma-Aldrich
Gold, foil, thickness 0.025 mm, 99.99% trace metals basis
Sigma-Aldrich
Gold, wire, diam. 0.5 mm, 99.999% trace metals basis
Sigma-Aldrich
Gold, powder, <10 μm, ≥99.9% trace metals basis
Sigma-Aldrich
Gold, wire, diam. 0.1 mm, 99.99% trace metals basis
Sigma-Aldrich
Gold, foil, thickness 0.1 mm, 99.99% trace metals basis
Sigma-Aldrich
Gold, wire, diam. 1.0 mm, 99.99% trace metals basis
Gold, sphere, 50pcs, diameter 0.5mm, 99.99%
Sigma-Aldrich
Gold, foil, thickness 0.25 mm, ≥99.9% trace metals basis
Sigma-Aldrich
Gold, evaporation slug, diam. × L 0.3 cm × 0.6 cm, 99.99% trace metals basis
Sigma-Aldrich
Gold, wire, diam. 1.0 mm, 99.997% trace metals basis
Gold, sphere, 100pcs, diameter 0.5mm, 99.99%
Sigma-Aldrich
Gold, foil, thickness 0.05 mm, 99.99% trace metals basis
Sigma-Aldrich
Gold, powder, <850 μm, ≥99.99% trace metals basis
Gold, sphere, 200pcs, diameter 0.5mm, 99.99%
Sigma-Aldrich
Gold, wire, diam. 0.25 mm, 99.99% trace metals basis
Sigma-Aldrich
Gold, wire, diam. 0.127 mm, 99.99% trace metals basis
Gold, tube, 200mm, outside diameter 3.0mm, inside diameter 2.8mm, wall thickness 0.10mm, as drawn, 99.95%
Gold, insulated wire, 1m, conductor diameter 0.125mm, insulation thickness 0.014mm, polyester insulation, 99.99%
Gold, insulated wire, 0.1m, conductor diameter 0.10mm, insulation thickness 0.013mm, PTFE (polytetrafluoroethylene) insulation, 99.99%
Gold, insulated wire, 0.2m, conductor diameter 0.10mm, insulation thickness 0.013mm, PTFE (polytetrafluoroethylene) insulation, 99.99%
Gold, insulated wire, 0.2m, conductor diameter 0.125mm, insulation thickness 0.016mm, PTFE (polytetrafluoroethylene) insulation, 99.99%